keyword
https://read.qxmd.com/read/38528330/eating-disorder-symptom-non-endorsers-in-hospitalised-patients-with-anorexia-nervosa-who-are-they
#21
JOURNAL ARTICLE
Irina Vanzhula, Kelsey Hagan, Sarah Ann Duck, Isabella Pan, Erin Y Wang, Joanna Steinglass, Evelyn Attia, Jennifer E Wildes, Angela S Guarda, Colleen Schreyer
OBJECTIVE: Impaired insight and illness denial are common in anorexia nervosa (AN). Missing an AN diagnosis may delay treatment and negatively impact outcomes. METHOD: The current retrospective study examined the prevalence and characteristics of AN symptom non-endorsement (i.e., scoring within the normal range on the Eating Disorder Examination Questionnaire [EDE-Q] or the Eating Disorder Examination [EDE] interview) in three independent samples of hospitalised patients with AN (N1  = 154; N2  = 300; N3  = 194)...
March 25, 2024: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://read.qxmd.com/read/38528101/non-modular-fatty-acid-synthases-yield-distinct-n-terminal-acylation-in-ribosomal-peptides
#22
JOURNAL ARTICLE
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Maolin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational modification chemistries. However, RiPPs are rarely reported as hybrid molecules incorporating biosynthetic machinery from other natural product families. Here we report lipoavitides, a class of RiPP/fatty-acid hybrid lipopeptides that display a unique, putatively membrane-targeting 4-hydroxy-2,4-dimethylpentanoyl (HMP)-modified N terminus. The HMP is formed via condensation of isobutyryl-coenzyme A (isobutyryl-CoA) and methylmalonyl-CoA catalysed by a 3-ketoacyl-(acyl carrier protein) synthase III enzyme, followed by successive tailoring reactions in the fatty acid biosynthetic pathway...
March 25, 2024: Nature Chemistry
https://read.qxmd.com/read/38528073/quantitative-assessment-of-the-erosion-and-deposition-effects-of-landslide-dam-outburst-flood-eastern-himalaya
#23
JOURNAL ARTICLE
Xiaolu Dong, Xianyan Wang, Long Yang, Zhijun Zhao, Ronald Van Balen, Xiaodong Miao, Tao Liu, Jef Vandenberghe, Baotian Pan, Martin Gibling, Huayu Lu
Both regular flow and infrequent outburst floods shape the mountain landscape, but their relative contributions have been widely debated, in part due to the paucity of quantitative data on historical outburst floods. In June 2000, an outburst flood was triggered by a landslide-dam failure in a rapidly exhumed region of the Eastern Himalaya. To investigate the role of this kind outburst flood on landscape evolution, we employ topographic differencing, satellite imagery, and 2D hydraulic simulations to quantify the equivalent erosion and deposition within ~ 80 km flood route downstream of the breach...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38528028/solar-driven-sugar-production-directly-from-co-2-via-a-customizable-electrocatalytic-biocatalytic-flow-system
#24
JOURNAL ARTICLE
Guangyu Liu, Yuan Zhong, Zehua Liu, Gang Wang, Feng Gao, Chao Zhang, Yujie Wang, Hongwei Zhang, Jun Ma, Yangguang Hu, Aobo Chen, Jiangyuan Pan, Yuanzeng Min, Zhiyong Tang, Chao Gao, Yujie Xiong
Conventional food production is restricted by energy conversion efficiency of natural photosynthesis and demand for natural resources. Solar-driven artificial food synthesis from CO2 provides an intriguing approach to overcome the limitations of natural photosynthesis while promoting carbon-neutral economy, however, it remains very challenging. Here, we report the design of a hybrid electrocatalytic-biocatalytic flow system, coupling photovoltaics-powered electrocatalysis (CO2 to formate) with five-enzyme cascade platform (formate to sugar) engineered via genetic mutation and bioinformatics, which achieves conversion of CO2 to C6 sugar (L-sorbose) with a solar-to-food energy conversion efficiency of 3...
March 25, 2024: Nature Communications
https://read.qxmd.com/read/38527835/-clinical-analysis-of-14-patients-aged-%C3%A2-50-years-with-high-risk-multiple-myeloma-treated-with-allogeneic-hematopoietic-stem-cell-transplantation
#25
JOURNAL ARTICLE
P Pan, J L Wang, W H Zhai, Q L Ma, D L Yang, S Z Feng, M Z Han, A M Pang, E L Jiang
Objective: To evaluate the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in young patients with high-risk multiple myeloma (HRMM) and analyzed the factors affecting patient prognosis. Methods: In this retrospective study, we analyzed the clinical data of 14 patients with HRMM with cytogenetic abnormalities or high-risk biological factors who underwent allo-HSCT at the Hematopoietic Stem Cell Transplantation Center of the Institute of Hematology & Blood Diseases Hospital between November 2016 and November 2022...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527560/transcriptomic-insights-into-the-lipotoxicity-of-high-fat-high-fructose-diet-in-rat-and-mouse
#26
JOURNAL ARTICLE
An-Qi Zhu, Ning Luo, Xiao-Ting Zhou, Min Yuan, Chu-Mei Zhang, Tian-Ling Pan, Kun-Ping Li
Along with the increasing prevalence of obesity worldwide, the deleterious effects of high-calorie diet are gradually recognized through more and more epidemiological studies. However, the concealed and chronic causality whitewashes its unhealthy character. Given an ingenious mechanism orchestrates the metabolic adaptation to high-fat high-fructose (HFF) diet and connive its lipotoxicity, in this study, an experimental rat/mouse model of obesity was induced and a comparative transcriptomic analysis was performed to probe the mystery...
March 23, 2024: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/38527277/tislelizumab-plus-chemotherapy-is-an-optimal-option-for-second-line-treatment-for-advanced-gastroesophageal-junction-adenocarcinoma
#27
JOURNAL ARTICLE
Ping Yang, Tao Pan, Ming-Kun Wang, Meng-Sheng Xiao, Shuang Zhang, Sha Liu
The development of programmed cell death receptor-1 and its ligand (PD-L1) have offered new treatment options for several cancers, but the clinical benefit of tislelizumab in the gastroesophageal junction (GEJ) adenocarcinoma is still murky. Thus, we aim to investigate the efficacy and safety of tislelizumab combined with chemotherapy in patients with GEJ cancer. In this study, 90 GEJ patients were retrospectively enrolled including 45 patients who received chemotherapy plus tislelizumab while 45 underwent chemotherapy only...
March 22, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38527247/pyrotinib-and-trastuzumab-plus-chemotherapy-serve-as-an-acceptable-neoadjuvant-regimen-exhibiting-good-efficacy-and-tolerance-in-her2-positive-breast-cancer-patients
#28
JOURNAL ARTICLE
Yibo Chen, Tianyi Zhang, Rui Zhang, Xuchen Cao
Objective: Pyrotinib, a new irreversible dual pan-human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase inhibitor blocking EGFR and HER2, has achieved a promising efficacy for advanced HER2-positive (HER2+ ) breast cancer. This study intended to further investigate the efficacy and safety of neoadjuvant pyrotinib and trastuzumab plus chemotherapy for HER2+ breast cancer treatment. Methods: Thirty-eight HER2+ breast cancer patients who received neoadjuvant pyrotinib and trastuzumab plus chemotherapy (docetaxel and carboplatin) were retrospectively reviewed...
March 25, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38526722/structure-guided-and-phage-assisted-evolution-of-therapeutic-antibodies-to-reverse-on-target-point-mutation-mediated-resistance
#29
JOURNAL ARTICLE
Xinlei Zhuang, Shuqing Chen, Liqiang Pan
Resistance to therapeutic antibodies caused by on-target point mutations is a major obstacle in anticancer therapy, creating an "unmet clinical need." To tackle this problem, researchers are developing new generations of antibody drugs that can overcome the resistance mechanisms of existing agents. We have previously reported a structure-guided and phage-assisted evolution (SGAPAE) approach to evolve cetuximab, a therapeutic antibody, to effectively reverse the resistance driven by EGFRS492R or EGFRG465R mutations, without changing the binding epitope or compromising the antibody efficacy...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38526672/degradable-silk-fibroin-based-piezoresistive-sensor-for-wearable-biomonitoring
#30
JOURNAL ARTICLE
Chunlin Pang, Fei Li, Xiaorao Hu, Keyu Meng, Hong Pan, Yong Xiang
Degradable wearable electronics are attracting increasing attention to weaken or eliminate the negative effect of waste e-wastes and promote the development of medical implants without secondary post-treatment. Although various degradable materials have been explored for wearable electronics, the development of degradable wearable electronics with integrated characteristics of highly sensing performances and low-cost manufacture remains challenging. Herein, we developed a facile, low-cost, and environmentally friendly approach to fabricate a biocompatible and degradable silk fibroin based wearable electronics (SFWE) for on-body monitoring...
March 25, 2024: Discov Nano
https://read.qxmd.com/read/38526604/bioinformatics-based-screening-and-analysis-of-the-key-genes-involved-in-the-influence-of-antiangiogenesis-on-myeloid-derived-suppressor-cells-and-their-effects-on-the-immune-microenvironment
#31
JOURNAL ARTICLE
XiangFei Zhao, RuGang Zhao, JuYi Wen, Xia Zhang, ShanShan Wu, Juan Fang, JunPeng Ma, LiPin Gao, Yi Hu
This study aimed to screen differentially expressed genes (DEGs) involved in the influence of antiangiogenic therapy on myeloid-derived suppressor cell (MDSC) infiltration and investigate their mechanisms of action. Data on DEGs after the action of antiangiogenic drugs in a pan-cancer context were obtained from the Gene Expression Omnibus (GEO) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the clusterProfiler package in R software...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38526296/prognostic-value-of-poly-microorganisms-detected-by-droplet-digital-pcr-and-pathogen-load-kinetics-in-sepsis-patients-a-multi-center-prospective-cohort-study
#32
JOURNAL ARTICLE
Yuanhan Zhao, Ke Lin, Haocheng Zhang, Yanliang Zhang, Shaling Li, Shengguo Zhang, Wei Zhang, Aiming Zhou, Yangyang Zhuang, Jie Chen, Caixia Wu, Wei Zhou, Xiaoju He, Qiaoyan Yue, Meng Zhang, Yan Huang, Liang Li, Liang Hong, Fujing Cai, Lisu Huang, Zhengshang Ruan, Shanshan Xu, Yan Zhang, Xiaohua Chen, Jie Chen, Ying Ye, Tingting Bian, Jiabin Li, Jun Yin, Xiang Li, Lijing Jiang, Chen Lei, Jun Liu, Ying Zhang, Jialin Jin, Jingwen Ai, Jingye Pan, Wenhong Zhang
This study aimed to investigate the prognostic value of a novel droplet digital polymerase chain reaction (DDPCR) assay in sepsis patients. In this prospective cohort study, univariable and multivariable Cox regressions were used to assess risk factors for 28-day mortality. We also monitored pathogen load together with clinical indicators in a subgroup of the cohort. A total of 107 sepsis patients with positive baseline DDPCR results were included. Detection of poly-microorganisms [adjusted hazard ratio (HR) = 3...
March 25, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38526238/targeted-neuroinflammation-mitigation-using-inflammasome-inhibiting-nanoligomers-is-therapeutic-in-an-experimental-autoimmune-encephalomyelitis-mouse-model
#33
JOURNAL ARTICLE
Sadhana Sharma, Sydney Risen, Vincenzo S Gilberto, Sean Boland, Anushree Chatterjee, Julie A Moreno, Prashant Nagpal
Multiple sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages of life. This disease affects the spinal cord and brain and is characterized by severe neuroinflammation, demyelination, and subsequent neuronal damage, resulting in symptoms like loss of mobility. While untargeted and pan-immunosuppressive therapies have proven to be disease-modifying and manage (or prolong the time between) symptoms in many patients, a significant fraction are unable to achieve remission...
March 25, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38526194/humanistic-health-management-and-cancer-associations-of-psychology-nutrition-and-exercise-with-cancer-progression-and-pathogenesis
#34
REVIEW
Chenchen Li, Junfeng Zhang, Pengcheng Pan, Junjie Zhang, Xinyi Hou, Yan Wang, Guoping Chen, Pir Muhammad, Rui L Reis, Lin Ding, Yanli Wang
The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a personalized treatment plan may become a breakthrough point...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38526134/nephropathia-epidemica-caused-by-puumala-virus-in-bank-voles-scania-southern-sweden
#35
JOURNAL ARTICLE
Jiaxin Ling, Elin Economou Lundeberg, Anishia Wasberg, Inês R Faria, Sanja Vucicevic, Bo Settergren, Åke Lundkvist
In 2018, a local case of nephropathia epidemica was reported in Scania, southern Sweden, more than 500 km south of the previously known presence of human hantavirus infections in Sweden. Another case emerged in the same area in 2020. To investigate the zoonotic origin of those cases, we trapped rodents in Ballingslöv, Norra Sandby, and Sörby in southern Sweden during 2020‒2021. We found Puumala virus (PUUV) in lung tissues from 9 of 74 Myodes glareolus bank voles by screening tissues using a hantavirus pan-large segment reverse transcription PCR...
April 2024: Emerging Infectious Diseases
https://read.qxmd.com/read/38526107/ultrafast-spectroscopy-study-of-dna-photophysics-after-proflavine-intercalation
#36
JOURNAL ARTICLE
Jie Zhou, Xueli Wang, Menghui Jia, Xiaoxiao He, Haifeng Pan, Jinquan Chen
Proflavine (PF), an acridine DNA intercalating agent, has been widespread applied as an anti-microbial and topical antiseptic agent due to its ability to suppress DNA replication. On the other hand, various studies show that PF intercalation to DNA can increase photogenotoxicity and has potential chances to induce carcinomas of skin appendages. However, the effects of PF intercalation on the photophysical and photochemical properties of DNA have not been sufficiently explored. In this study, the excited state dynamics of the PF intercalated d(GC)9 • d(GC)9 and d(AT)9 • d(AT)9 DNA duplex are investigated in an aqueous buffer solution...
March 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38526047/first-in-human-trial-evaluating-safety-and-pharmacokinetics-of-at-752-a-novel-nucleotide-prodrug-with-pan-serotype-activity-against-dengue-virus
#37
JOURNAL ARTICLE
Xiao-Jian Zhou, Jason Lickliter, Maureen Montrond, Laura Ishak, Keith Pietropaolo, Dayle James, Bruce Belanger, Arantxa Horga, Janet Hammond
UNLABELLED: AT-752 is a novel guanosine nucleotide prodrug inhibitor of the dengue virus (DENV) polymerase with sub-micromolar, pan-serotype antiviral activity. This phase 1, double-blind, placebo-controlled, first-in-human study evaluated the safety, tolerability, and pharmacokinetics of ascending single and multiple oral doses of AT-752 in healthy subjects. AT-752 was well tolerated when administered as a single dose up to 1,500 mg or when administered as multiple doses up to 750 mg three times daily (TID)...
March 25, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38526033/huayu-qutan-recipe-promotes-lipophagy-and-cholesterol-efflux-through-the-mtorc1-tfeb-abca1-scarb1-signal-axis
#38
JOURNAL ARTICLE
Yue Li, Jiaxiang Pan, J J Jiajia Yu, Xize Wu, Guanlin Yang, Xue Pan, Guoyuan Sui, Mingyang Wang, Meijia Cheng, Shu Zhu, He Tai, Honghe Xiao, Lili Xu, Jin Wu, Yongju Yang, Jing Tang, Lihong Gong, Lianqun Jia, Dongyu Min
This study aims to investigate the mechanism of the anti-atherosclerosis effect of Huayu Qutan Recipe (HYQT) on the inhibition of foam cell formation. In vivo, the mice were randomly divided into three groups: CTRL group, MOD group and HYQT group. The HYQT group received HYQT oral administration twice a day (20.54 g/kg/d), and the plaque formation in ApoE-/- mice was observed using haematoxylin-eosin (HE) staining and oil red O (ORO) staining. The co-localization of aortic macrophages and lipid droplets (LDs) was examined using fluorescent labelling of CD11b and BODIPY fluorescence probe...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38525965/theoretical-insights-into-the-structural-mechanical-and-electronic-properties-of-bcc-c40-carbon
#39
JOURNAL ARTICLE
Ying Ma, Pan Ying, Kun Luo, Yingju Wu, Baozhong Li, Julong He
Novel materials displaying multiple exceptional properties are the backbone of the advancement of various industries. In the field of carbon materials, the combination of different properties has been extensively developed to satisfy diverse application scenarios, for instance, conductivity paired with exceptional hardness, outstanding toughness coupled with super-hardness, or heat resistance combined with super-hardness. In this work, a new carbon allotrope, bcc-C40 carbon, was predicted and investigated using first-principles calculations based on density functional theory...
March 25, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38525823/primary-ntrk-rearranged-spindle-cell-neoplasm-of-the-gastrointestinal-tract-a-clinicopathological-and-molecular-analysis-of-8-cases
#40
JOURNAL ARTICLE
Xiaojiao Gao, Song Xu, Peipei Zhu, I Weng Lao, Lin Yu, Jian Wang
NTRK-rearranged spindle cell neoplasm occurs predominantly in the superficial or deep soft tissues of extremities or trunk. Occurrence in the visceral organs is extremely rare. Herein, we describe 8 cases of NTRK-rearranged spindle cell neoplasm that arose primarily in the gastrointestinal tract. Patients included 5 males and 3 females with age at presentation ranging from 6 to 63 years (median: 29.5 years). Tumors occurred in the colon (n=3), small intestine (n=2), rectum (n=2), and stomach (n=1). Tumor size ranged from 3...
March 25, 2024: American Journal of Surgical Pathology
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