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https://read.qxmd.com/read/30878922/the-association-between-cold-spells-and-admissions-of-ischemic-stroke-in-hefei-china-modified-by-gender-and-age
#1
Jiaojiao Gao, Feng Yu, Zihan Xu, Jun Duan, Qiang Cheng, Lijun Bai, Yanwu Zhang, Qiannan Wei, Weizhuo Yi, Rubing Pan, Hong Su
BACKGROUND: Some studies have discovered that low ambient temperatures were associated with increased risk of the incidence of ischemic stroke. Although the frequency of extreme weather events is increasing, few studies have studied the effects of cold wave on ischemic stroke. OBJECTIVE: The purpose of this study was to explore the association between cold waves and ischemic stroke onset and further to explore how this association was modified by cold spell characteristics and individual-level factors...
March 1, 2019: Science of the Total Environment
https://read.qxmd.com/read/30878874/the-in-vitro-and-in-vivo-anti-inflammatory-effect-of-osthole-the-major-natural-coumarin-from-cnidium-monnieri-l-cuss-via-the-blocking-of-the-activation-of-the-nf-%C3%AE%C2%BAb-and-mapk-p38-pathways
#2
Huaying Fan, Zhenfang Gao, Kai Ji, Xin Li, Jingbao Wu, Yue Liu, Xuekai Wang, Haiyue Liang, Yanan Liu, Xiaoting Li, Pan Liu, Daquan Chen, Feng Zhao
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory condition of the intestines and is difficult to cure once diagnosed. The efficacy of the current clinical treatment for UC is limited. Common anti-inflammatory drugs are prone to adverse effects, while novel biological agents are expensive, although tolerated by patients. Therefore, an urgency exists to find more safe and effective drugs to treat UC. Osthole is an active constituent isolated from the fruit of Cnidium monnieri (L...
February 18, 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://read.qxmd.com/read/30878738/profiles-variability-and-predictors-of-concentrations-of-blood-trihalomethanes-and-urinary-haloacetic-acids-along-pregnancy-among-1760-chinese-women
#3
Yi-Xin Wang, Chong Liu, Ying-Jun Chen, Peng Duan, Qi Wang, Chao Chen, Yang Sun, Li-Li Huang, Liang Wang, Chen Chen, Jin Li, Song-Hua Ai, Zhen Huang, Li Sun, Zhen-Zhen Wan, An Pan, Tian-Qing Meng, Wen-Qing Lu
Blood trihalomethanes (THMs) and urinary haloacetic acids (HAAs) are the leading candidate biomarkers for disinfection byproduct (DBP) exposure. However, no studies have assessed the exposure profiles, temporal variability, and potential predictors of these biomarkers during pregnancy. Here we collected blood (n = 4304) and urine samples (n = 4165) from 1760 Chinese pregnant women during early, mid-, and late pregnancy, which were separately analyzed for 4 THMs and 2 HAAs. We calculated the intraclass correlation coefficients (ICCs) to assess the variability of these biomarkers and estimated their correlations with sociodemographic, water-use behavioral, dietary and sample collection factors using mixed models...
March 8, 2019: Environmental Research
https://read.qxmd.com/read/30878464/a-retrospective-analysis-of-data-from-forensic-toxicology-at-the-academy-of-forensic-science-in-2017
#4
Meiru Pan, Xin Wang, Yunli Zhao, Wei Liu, Ping Xiang
Knowing the specific pattern of forensic toxicology cases in a region is vital to help the local government establish an effective prevention and treatment system; currently, there have been no published reports investigating various types of forensic toxicology cases based on a large autopsy series and city size. The data in this study were obtained from records kept at the Academy of Forensic Science (AFS) between February 2017 and December 2017, and the cases were mainly from the Public Security Organs People's Police in Shanghai, China...
February 28, 2019: Forensic Science International
https://read.qxmd.com/read/30878349/the-germline-specific-expression-of-foxl3a-and-its-paralogous-foxl3b-are-associated-with-male-gonadal-differentiation-in-the-japanese-eel-anguilla-japonica
#5
Guan-Chung Wu, Shan-Ru Jeng, Yi-Tin Pan, Hau-Wen Li, Wei-Lun Ku, Chien-Ju Lin, Ching-Fong Chang
Unlike its paralog Foxl2, which is well known for its role in ovarian development in vertebrates, the function of Foxl3 is still unclear. Foxl3 is an ancient duplicated copy of Foxl2. It is present as a single copy in ray-finned fish. But, due to repeated losses, it is absent in most tetrapods. Our transcriptomic data, however, show that two Foxl3s (Foxl3a and its paralog Foxl3b) are present in Japanese eel. Foxl3a is predominantly expressed in the pituitary, and Foxl3b is predominantly expressed in the gills...
March 13, 2019: General and Comparative Endocrinology
https://read.qxmd.com/read/30877532/emergy-based-environmental-accounting-of-one-mining-system
#6
Hengyu Pan, Yong Geng, Xu Tian, Jeffrey Wilson, Wei Chen, Shaozhuo Zhong, Xiaoqian Song
Metal production from mineral resources is crucial for economic development. However, most mining activities usually target short-term financial benefits, rather than long-term consideration on ecological sustainability. To better understand the impact of metal production, systematic evaluation methods should be applied to complement current economic accounting tools. Under such a circumstance, this study proposes an emergy-based metal production evaluation framework, taking a life cycle perspective from the formation of mineral deposit to the final production of metal...
March 15, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30877369/idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-irvan-case-series-of-three-patients-with-multimodal-imaging
#7
Yu Jeat Chong, Abison Logeswaran, Ambreen Sarmad, Erika Marie Damato
PURPOSE: The purpose of this study was to report the clinical presentation, disease progression, treatment and complications of IRVAN. METHOD: Case series PATIENTS: Six eyes from three patients were included. RESULTS: All eyes were treated with pan-retinal photocoagulation (PRP). One eye received Ozurdex (dexamethasome implant) for persistent macular exudates and oedema. One eye received Avastin injections for retinal neovascularization. Oral steroids were given to all patients at some point during the disease process...
March 15, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/30877258/transposable-elements-drive-rapid-phenotypic-variation-in-capsella-rubella
#8
Xiao-Min Niu, Yong-Chao Xu, Zi-Wen Li, Yu-Tao Bian, Xing-Hui Hou, Jia-Fu Chen, Yu-Pan Zou, Juan Jiang, Qiong Wu, Song Ge, Sureshkumar Balasubramanian, Ya-Long Guo
Rapid phenotypic changes in traits of adaptive significance are crucial for organisms to thrive in changing environments. How such phenotypic variation is achieved rapidly, despite limited genetic variation in species that experience a genetic bottleneck is unknown. Capsella rubella , an annual and inbreeding forb (Brassicaceae), is a great system for studying this basic question. Its distribution is wider than those of its congeneric species, despite an extreme genetic bottleneck event that severely diminished its genetic variation...
March 15, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30877085/patient-driven-discovery-therapeutic-targeting-and-post-clinical-validation-of-a-novel-akt1-fusion-driven-cancer
#9
Emily K Slotkin, Daniel Diolaiti, Neerav N Shukla, Filemon S Dela Cruz, Jennifer J Clark, Gunes Gundem, Venkata D Yellapantula, Max F Levine, Daoqi You, Peilin Ma, Sagarika Pachhal, Glorymar Ibanez Sanchez, Ryma Benayed, Achim A Jungbluth, Lillian M Smyth, Audrey Mauguen, Irena Gushterova, Hongxu Ding, Lee Spraggon, Robert Darnell, Andrea Califano, Marc Ladanyi, Elli Papaemmanuil, Andrew L Kung, David M Hyman, Stephen S Roberts
Despite the important role of the PI3K/AKT/mTOR axis in the pathogenesis of cancer, to date there have been few functional oncogenic fusions identified involving the AKT genes. A 12-year-old female with a histopathologically indeterminate epithelioid neoplasm was found to harbor a novel fusion between the LAMTOR1 and AKT1 genes. Through expanded use access, she became the first pediatric patient to be treated with the oral ATP-competitive pan-AKT inhibitor ipatasertib. Treatment resulted in dramatic tumor regression demonstrating through patient-driven discovery that the fusion resulted in activation of AKT1, was an oncogenic driver, and could be therapeutically targeted with clinical benefit...
March 15, 2019: Cancer Discovery
https://read.qxmd.com/read/30876822/evaluating-heteroplasmic-variations-of-the-mitochondrial-genome-from-whole-genome-sequencing-data
#10
Mengqin Duan, Liang Chen, Qinyu Ge, Na Lu, Junji Li, Xuan Pan, Yi Qiao, Jing Tu, Zuhong Lu
BACKGROUND: Detecting heteroplasmic variations in the mitochondrial genome can help identify potential pathogenic possibilities, which is significant for disease prevention. The development of next-generation sequencing changed the quantification of mitochondrial DNA (mtDNA) heteroplasmy from scanning limited recorded points to the entire mitochondrial genome. However, due to the presence of nuclear mtDNA homologous sequences (nuMTs), maximally retaining real variations while excluding falsest heteroplasmic variations from nuMTs and sequencing errors presents a dilemma...
March 12, 2019: Gene
https://read.qxmd.com/read/30876476/hiv-late-presentation-and-advanced-hiv-disease-among-patients-with-newly-diagnosed-hiv-aids-in-southwestern-china-a-large-scale-cross-sectional-study
#11
Xi Hu, Bingyu Liang, Chongxing Zhou, Junjun Jiang, Jiegang Huang, Chuanyi Ning, Jie Liu, Bo Zhou, Ning Zang, Jinzhen Lai, Rongfeng Chen, Yanyan Liao, Peijiang Pan, Xin Liu, Guanghua Lan, Xianwu Pang, Li Ye, Zhiyong Shen, Hao Liang
OBJECTIVE: This study aimed to investigate the prevalence of HIV late presentation and advanced HIV disease and to identify the factors associated with HIV late presentation and advanced HIV disease among patients with newly diagnosed HIV/AIDS in the Guangxi Zhuang Autonomous Region, in Southwestern China. METHODS: Patients with newly diagnosed HIV registered in the HIV surveillance system of Guangxi Centers for Disease Control between January 2012 and December 2016 were included in this study...
March 16, 2019: AIDS Research and Therapy
https://read.qxmd.com/read/30876317/full-field-ultrafast-oscilloscope-based-on-temporal-imaging
#12
Zhi Qiao, Xue Pan, Yudong Yao, Xiaochao Wang, Wei Fan, Xuechun Li
As the ultrafast laser has been developed, the measurement of ultra-speed transient and dynamic processes has gained much attention. An ultrafast oscilloscope based on the optical stretch method is promising to address this problem, but the measurement is restricted to the temporal profile. This means that the temporal phase is lost. In this work, we propose a full-field ultrafast oscilloscope using two temporal phase retrieval methods: the temporal annealing Gerchberg-Saxton (TAGS) algorithm and temporal ptychography...
March 4, 2019: Optics Express
https://read.qxmd.com/read/30876147/three-dimensional-space-optimization-for-near-field-ptychography
#13
An Pan, Baoli Yao
A multiple slices approach in ptychography, termed 3ePIE algorithm, solves the multiple scattering problems of thick samples, which is crucial to biomedical imaging and in situ studies. However, it is unclear how many slices need to be separated and what the distance is between each layer respectively, while these two parameters are sensitive and crucial to the recovery of thick samples. The traditional method is to separate the sample with the same interval for convenience and to test the number of sections for the best reconstructions, which is reasonable for continuous samples and has achieved great results...
February 18, 2019: Optics Express
https://read.qxmd.com/read/30876045/high-efficiency-broadband-vortex-beam-generator-based-on-transmissive-metasurface
#14
Shiwei Tang, Xike Li, Weikang Pan, Jun Zhou, Tao Jiang, Fei Ding
Vortex beam has attracted growing attention in recent years due to its remarkable abilities in the communication system since it is believed to be an effective way to improve the channel capacity efficiency. However, available vortex beam generators suffer from the issues of complex configurations, low efficiency as well as narrow bandwidths, especially for the transmissive case. Here, we proposed a broadband transmissive metasurface to generate vortex beam with l=1 in a broad band ranging from 8GHz to 13 GHz...
February 18, 2019: Optics Express
https://read.qxmd.com/read/30875970/environmental-remediation-applications-of-carbon-nanotubes-and-graphene-oxide-adsorption-and-catalysis
#15
REVIEW
Yanqing Wang, Can Pan, Wei Chu, Adavan Kiliyankil Vipin, Ling Sun
Environmental issues such as the wastewater have influenced each aspect of our lives. Coupling the existing remediation solutions with exploring new functional carbon nanomaterials (e.g., carbon nanotubes, graphene oxide, graphene) by various perspectives shall open up a new venue to understand the environmental issues, phenomenon and find out the ways to get along with the nature. This review makes an attempt to provide an overview of potential environmental remediation solutions to the diverse challenges happening by using low-dimensional carbon nanomaterials and their composites as adsorbents, catalysts or catalysts support towards for the social sustainability...
March 15, 2019: Nanomaterials
https://read.qxmd.com/read/30875934/polymeric-co-delivery-systems-in-cancer-treatment-an-overview-on-component-drugs-dosage-ratio-effect
#16
REVIEW
Jiayi Pan, Kobra Rostamizadeh, Nina Filipczak, Vladimir P Torchilin
Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Ideally, combination therapy inhibits tumor growth through multiple pathways by enhancing the performance of each individual therapy, often resulting in a synergistic effect. Polymeric nanoparticles prepared from block co-polymers have been a popular platform for co-delivery of combinations of drugs associated with the multiple functional compartments within such nanoparticles...
March 15, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30875926/cellular-gene-expression-during-hepatitis-c-virus-replication-as-revealed-by-ribosome-profiling
#17
Gesche K Gerresheim, Jochen Bathke, Audrey M Michel, Dmitri E Andreev, Lyudmila A Shalamova, Oliver Rossbach, Pan Hu, Dieter Glebe, Markus Fricke, Manja Marz, Alexander Goesmann, Stephen J Kiniry, Pavel V Baranov, Ivan N Shatsky, Michael Niepmann
BACKGROUND: Hepatitis C virus (HCV) infects human liver hepatocytes, often leading to liver cirrhosis and hepatocellular carcinoma (HCC). It is believed that chronic infection alters host gene expression and favors HCC development. In particular, HCV replication in Endoplasmic Reticulum (ER) derived membranes induces chronic ER stress. How HCV replication affects host mRNA translation and transcription at a genome wide level is not yet known. METHODS: We used Riboseq (Ribosome Profiling) to analyze transcriptome and translatome changes in the Huh-7...
March 15, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30875732/urban-tree-species-classification-using-a-worldview-2-3-and-lidar-data-fusion-approach-and-deep-learning
#18
Sean Hartling, Vasit Sagan, Paheding Sidike, Maitiniyazi Maimaitijiang, Joshua Carron
Urban areas feature complex and heterogeneous land covers which create challenging issues for tree species classification. The increased availability of high spatial resolution multispectral satellite imagery and LiDAR datasets combined with the recent evolution of deep learning within remote sensing for object detection and scene classification, provide promising opportunities to map individual tree species with greater accuracy and resolution. However, there are knowledge gaps that are related to the contribution of Worldview-3 SWIR bands, very high resolution PAN band and LiDAR data in detailed tree species mapping...
March 14, 2019: Sensors
https://read.qxmd.com/read/30875579/new-insights-on-the-understanding-of-the-high-adsorption-of-bisphenol-compounds-on-reduced-graphene-oxide-at-high-ph-values-via-charge-assisted-hydrogen-bond
#19
Peng Wang, Di Zhang, Huan Tang, Hao Li, Bo Pan
The adsorption characteristics and mechanisms of ionic organic compounds dependent on their dissociation species are still unclear, which hindered the understanding of their environmental behavior and risks. This study compared the sorption of four bisphenol compounds (BCs) on graphite adsorbents, with a specific emphasis on the roles of charge assisted hydrogen bond (CAHB). The negative correlations between the localized orbital locator integrated π over plane index and the single point adsorption coefficient Kd of the four BCs indicated that π-π interaction was an important mechanism for BCs adsorption on graphite adsorbents...
March 4, 2019: Journal of Hazardous Materials
https://read.qxmd.com/read/30875189/piezo-phototronic-effect-enhanced-efficient-flexible-perovskite-solar-cells
#20
Junlu Sun, Qilin Hua, Ranran Zhou, Dongmei Li, Wenxi Guo, Xiaoyi Li, Guofeng Hu, Chongxin Shan, Qingbo Meng, Lin Dong, Caofeng Pan, Zhong Lin Wang
Tremendous work has been made recently to improve the power conversion efficiencies (PCEs) of the perovskite solar cells (PSCs); the best reported value is now over 23%. However, further improving the PCEs of PSCs is challenged by material's properties, device stability and packaging technologies. Here, we report a new approach to raise the PCEs of flexible PSCs via introducing the piezo-phototronic effect in the PSCs via growing an array of ZnO nanowires on flexible plastic substrates, which act as the electron-transport layer for PSC...
March 15, 2019: ACS Nano
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