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https://read.qxmd.com/read/30763710/comparative-analysis-using-propensity-score-matching-analysis-primary-closure-versus-patch-angioplasty-during-carotid-endarterectomy
#1
Byeoung-Hoon Chung, Seon-Hee Heo, Yang-Jin Park, Young-Wook Kim, Shin-Young Woo, Dong-Ik Kim
BACKGROUND: Primary closure (PC) and patch angioplasty (PA) during carotid endarterectomy (CEA) have been disputed in many studies. Some studies announced that PC is associated with a higher restenosis rate. The aim of this study was to evaluate the outcomes of PC and PA using propensity score matching (PSM). METHODS: Between November 1994 and October 2016, 1044 patients underwent primary CEA procedures at our institution and were retrospectively analyzed. The study endpoints included rates of ipsilateral stroke, any clinical stroke, cranial nerve palsy, hematoma, bleeding warranting repeat surgery within 30 postoperative days...
February 11, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30762763/increased-risk-of-neurodegenerative-dementia-in-women-with-migraines-a-nested-case-control-study-using-a-national-sample-cohort
#2
Sang-Yeon Lee, Jae-Sung Lim, Dong Jun Oh, Il Gyu Kong, Hyo Geun Choi
The present study aimed to evaluate the association between migraines and dementia.Data were collected from 11,438 dementia participants who were 1:4 matched by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 45,752 controls from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Dementia was diagnosed using the International Classification of Disease-10 (ICD-10) codes (G30 or F00). For the integrity of diagnoses, we included only participants ≥60 years old who had been diagnosed with an ICD-10 code twice or more during ambulatory visits for the same episode...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30761021/elevated-familial-cardiovascular-burden-among-adolescents-with-familial-bipolar-disorder
#3
Simina Toma, Lisa Fiksenbaum, Danielle Omrin, Benjamin I Goldstein
Background: Bipolar disorder (BD) is one of the most heritable medical conditions, and certain phenotypic characteristics are especially familial in BD. BD is also strongly associated with elevated and premature cardiovascular disease (CVD) morbidity and mortality. Thus, far, little is known regarding the familiality of cardiovascular risk in BD. We therefore examined the extent of CVD-related conditions among relatives of: adolescents with BD with a family history of BD (familial BD), adolescents with BD without a family history of BD (non-familial BD) and healthy controls (HC)...
2019: Frontiers in Psychiatry
https://read.qxmd.com/read/30760002/circulating-endothelial-cells-circulating-endothelial-progenitor-cells-and-circulating-microparticles-in-type-1-diabetes-mellitus
#4
Asmaa M Zahran, Ismail L Mohamed, Osama M El Asheer, Deiaaeldin M Tamer, Mohamed G M Abo-ELela, Mona H Abdel-Rahim, Omnia H B El-Badawy, Khalid I Elsayh
BACKGROUND AND AIM: Hyperglycemia in type 1 diabetes (T1D) is accompanied by endothelial cell dysfunction which is known to contribute to the pathogenesis of cardiovascular disorders. The aim of the current study was to explore the profile of circulating endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), endothelial and platelet derived micropaticles (EMPs, PMPs) and total microparticles (TMPs), in T1D children in relation to each other and to the metabolic disorders accompanying T1D...
January 2019: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/30758413/prevalence-treatment-and-control-of-dyslipidemia-in-diabetic-participants-of-two-brazilian-cohorts-a-place-far-from-heaven
#5
Nestor S Martins, Daniel S S Mello, Joaquim Barreto, Alexandre A S Soares, Ikaro Breder, Jessica Cunha, Wilson Nadruz, Otavio R Coelho Filho, José Roberto Matos-Souza, Otavio R Coelho, Daniel B Munhoz, José Carlos Quinaglia E Silva, Andrei C Sposito, Luiz Sergio F Carvalho
OBJECTIVE: Diabetes is one of the leading causes of cardiovascular mortality. Over the last years, mortality has decreased significantly, more in individuals with diabetes than in healthy ones. That is mostly due to the control of other cardiovascular risk factors. The objective of our study was to analyze the dyslipidemia control in two diabetes cohorts. METHODS: Patients from two distinct cohorts were studied, 173 patients from the BHS (Brasília Heart Study) and 222 patients from the BDS (Brazilian Diabetes Study)...
January 2019: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/30756513/low-serum-creatinine-and-risk-of-diabetes-the-japan-epidemiology-collaboration-on-occupational-health-study
#6
Huanhuan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Hiroko Okazaki, Makoto Yamamoto, Toshiaki Miyamoto, Masafumi Eguchi, Takeshi Kochi, Makiko Shimizu, Taizo Murakami, Kentaro Tomita, Takayuki Ogasawara, Naoko Sasaki, Akihiko Uehara, Keisuke Kuwahara, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
AIMS/INTRODUCTION: We examined a prospective association between serum creatinine levels and diabetes. MATERIALS AND METHODS: This study included 31,343 male workers without diabetes and aged between 20 and 64 years old at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either HbA1c levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL, or receiving antidiabetic treatment...
February 12, 2019: Journal of Diabetes Investigation
https://read.qxmd.com/read/30755556/relationship-between-hba1c-and-lipid-profile-seen-in-bangladeshi-type-2-diabetes-mellitus-patients-attending-birdem-hospital-a-cross-sectional-study
#7
A Begum, S R Irfan, M R Hoque, S H Habib, S Parvin, R Malek, S Akhter, S Sattar, S Sarkar
Diabetes mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Glycated hemoglobin (HbA1c) level of ≥6.5% has been included as a criterion for diagnosis of diabetes. Impaired lipid profile is commonly present in type 2 diabetes. Aim of the study was to investigate the association between serum lipid profile and blood glucose. And hypothesizing that early detection of lipid abnormalities and treatment can minimize the risk for atherogenic cardiovascular disorder and cerebrovascular calamity in patients with type 2 diabetes mellitus (T2DM)...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30747290/real-world-strategies-to-treat-hypertension-associated-with-pediatric-obesity
#8
REVIEW
Edem Binka, Tammy M Brady
PURPOSE OF REVIEW: To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity. RECENT FINDINGS: Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbingly, this rising prevalence has been paralleled by an increase in cardiovascular disease (CVD) risk factors in childhood such as hypertension, dyslipidemia, and diabetes that become manifest earlier than previously reported...
February 12, 2019: Current Hypertension Reports
https://read.qxmd.com/read/30746344/effect-of-eicosapentaenoic-acid-supplementation-on-paraoxonase-2-gene-expression-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-clinical-trial
#9
Mohammad Hassan Golzari, Mohammad Hassan Javanbakht, Ehsan Ghaedi, Hamed Mohammadi, Mahmoud Djalali
Type 2 diabetes mellitus (T2DM) is recognized as one of the most prevalent metabolic diseases, and it is mostly associated with oxidative stress, atherosclerosis and dyslipidemia. Paraoxonase 2 (PON2) due to its antioxidant properties may play a role in the atherosclerosis development. Although long-chain omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) have been shown to reduce the risk of cardiovascular disease, the exact mechanism of action is still unknown. Our goal in this study was to determine the effect of EPA administration on gene expression of PON2 in patients with T2DM...
January 2019: Clinical Nutrition Research
https://read.qxmd.com/read/30745937/betatrophin-association-with-serum-triglyceride-levels-in-obstructive-sleep-apnea-patients
#10
Bunyamin Sertogullarindan, Ahmet Ufuk Komuroglu, Rifki Ucler, Hulya Gunbatar, Aysel Sunnetcioglu, Erdem Cokluk
BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep problem, in which patients are at increased risk for metabolic and cardiovascular problems, including metabolic syndrome, diabetes mellitus (DM), and dyslipidemia. Betatrophin is a novel protein that regulates fatty acid and triglyceride (TG) metabolism and is related to obesity and metabolic abnormalities, including metabolic syndrome, DM, and dyslipidemia. Although OSA and betatrophin share common abnormalities, their relationship has not been investigated...
January 2019: Annals of Thoracic Medicine
https://read.qxmd.com/read/30745630/clinical-profile-of-androgenic-alopecia-and-its-association-with-cardiovascular-risk-factors
#11
Rita V Vora, Rahul Krishna Suresh Kumar Kota, Rochit R Singhal, Gopikrishnan Anjaneyan
Context: Androgenic alopecia (AGA) is a hereditary androgen-dependent disorder, characterized by gradual conversion of terminal hair into miniaturized hair and defined by various patterns. Common age group affected is between 30 and 50 years. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include diabetes and prediabetes, abdominal obesity, dyslipidemia, and hypertension. The relationship between androgenic alopecia and MetS is still poorly understood. Aim: The aim was to study the clinical profile of androgenic alopecia and its association with cardiovascular risk factors...
January 2019: Indian Journal of Dermatology
https://read.qxmd.com/read/30739937/prevalence-of-cardiovascular-risk-factors-in-apparently-healthy-urban-adult-population-of-kathmandu
#12
Om Murti Anil, Randhir Sagar Yadav, Nitesh Shrestha, Sachit Koirala, Shumneva Shrestha, Om Murti Nikhil, Manisha Baidar, Nabin Chaudhary, Chandni Jaishwal, Navin Sagar Yadav, Aabhushan Bikram Mahara, Roshan Kumar Jha, Amod Kumar Poudyal
BACKGROUND: Cardiovascular diseases account for most deaths and major proportion of disabilities worldwide. Major cardiovascular risk factors are implicated in almost 75% of cardiovascular diseases. There has been a rapid increase in prevalence of such risk factors in apparently healthy young adults of urban population. This study aimed to find prevalence of such risk factors in order to implement preventive strategies against cardiovascular diseases in our setting. METHODS: A free heart camp was organized following wide dissemination of information through print, online, TV, radio and social media...
January 28, 2019: Journal of Nepal Health Research Council
https://read.qxmd.com/read/30733849/verapamil-attenuated-prediabetic-neuropathy-in-high-fat-diet-fed-mice-through-inhibiting-txnip-mediated-apoptosis-and-inflammation
#13
Lingling Xu, Xiaopu Lin, Meiping Guan, Yanmei Zeng, Yingshan Liu
Diabetic neuropathy (DN) is a common and severe complication of diabetes mellitus. There is still a lack of an effective treatment to DN because of its complex pathogenesis. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of thioredoxin, has been shown to be associated with diabetic retinopathy and nephropathy. Herein, we aim to investigate the role of TXNIP in prediabetic neuropathy and therapeutic potential of verapamil which has been shown to inhibit TXNIP expression. The effects of mediating TXNIP on prediabetic neuropathy and its exact mechanism were performed using high-fat diet- (HFD-) induced diabetic mice and palmitate-treated neurons...
2019: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/30733469/application-of-latent-class-analysis-to-identify-metabolic-syndrome-components-patterns-in-adults-tehran-lipid-and-glucose-study
#14
Noushin Sadat Ahanchi, Farzad Hadaegh, Abbas Alipour, Arash Ghanbarian, Fereidoun Azizi, Davood Khalili
In this study, using latent class analysis (LCA), we investigated whether there are any homogeneous subclasses of individuals exhibiting different profiles of metabolic syndrome (MetS) components. The current study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS), a population-based cohort including 6448 subjects, aged 20-50 years. We carried out a LCA on MetS components and assessed the association of some demographic and behavioral variables with membership of latent subclasses using multinomial logistic regression...
February 7, 2019: Scientific Reports
https://read.qxmd.com/read/30732904/association-between-serum-selenium-level-and-the-prevalence-of-diabetes-mellitus-in-u-s-population
#15
Shinje Moon, Hye Soo Chung, Jae Myung Yu, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Yoo-Kyung Park, Sang Nam Yoon
OBJECTIVE: Selenium seems to be a risk factor for diabetes mellitus (DM) in recent studies, opposite to the previous expectation that it may contribute to prevent DM. The authors aimed to ascertain the relationship between selenium and DM. METHODS: Data were collected from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. A multivariate logistic regression analysis with adjustment for age, sex, race/ethnicity, hypertension, dyslipidemia and body mass index was conducted to evaluate the odds ratio for DM...
March 2019: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/30732711/modifiable-risk-factors-in-young-adults-with-first-myocardial-infarction
#16
Srikanth Yandrapalli, Christopher Nabors, Abhishek Goyal, Wilbert S Aronow, William H Frishman
BACKGROUND: Modifiable risk factors (RFs) play an important role in the development and prognosis of acute myocardial infarction (AMI). OBJECTIVES: This study sought to study the prevalence rates of modifiable RFs during a first AMI, sex/race differences, and temporal trends in U.S. young adults. METHODS: This was a retrospective cohort analysis of the U.S. National Inpatient Sample years 2005 and 2015 to identify adults 18 to 59 years of age hospitalized for a first AMI...
February 12, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30723473/spred2-regulates-high-fat-diet-induced-adipose-tissue-inflammation-and-metabolic-abnormalities-in-mice
#17
Takahiro Ohkura, Teizo Yoshimura, Masayoshi Fujisawa, Toshiaki Ohara, Rie Marutani, Kaya Usami, Akihiro Matsukawa
Chronic low-grade inflammation in visceral adipose tissues triggers the development of obesity-related insulin resistance, leading to the metabolic syndrome, a serious health condition with higher risk of cardiovascular disease, diabetes, and stroke. In the present study, we investigated whether Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, plays a role in the development of high fat diet (HFD)-induced obesity, adipose tissue inflammation, metabolic abnormalities, and insulin resistance...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30723097/fructose-induced-hypertriglyceridemia-in-rhesus-macaques-is-attenuated-with-fish-oil-or-apoc3-rna-interference
#18
Andrew A Butler, Candice A Price, James L Graham, Kimber L Stanhope, Sarah King, Yu-Han Hung, Praveen Sethupathy, So Wong, James Hamilton, Ronald M Krauss, Andrew A Bremer, Peter J Havel
Dyslipidemia and insulin resistance are significant adverse outcomes of consuming high-sugar diets. Conversely, dietary fish oil reduces plasma lipids. Diet-induced dyslipidemia in a rhesus model better approximates the pathophysiology of human metabolic syndrome than rodent models. Here we investigated relationships between metabolic parameters and hypertriglyceridemia in rhesus macaques consuming a high fructose diet (n=59) and determined effects of fish oil supplementation or RNA interference (RNAi) on plasma apoC3 and TG concentrations...
February 5, 2019: Journal of Lipid Research
https://read.qxmd.com/read/30721736/antidiabetic-effects-of-olea-europaea-l-leaves-in-diabetic-rats-induced-by-high-fat-diet-and-low-dose-streptozotocin
#19
Camille Gaube Guex, Fernanda Ziegler Reginato, Patrícia Romualdo de Jesus, Juliana Calil Brondani, Gilberti Helena Hübscher Lopes, Liliane de Freitas Bauermann
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance, and dyslipidemia. It has broad occurrence worldwide, affecting millions of people, and can cause serious complications. The olive (Olea europaea L.) has important pharmacological functions, including anti-inflammatory, antioxidant, and hypoglycemic activities. Olive leaves are used in traditional medicine for diabetes and hypertension. AIM OF THE STUDY: To evaluate the effect of the ethanolic extract of olive leaves (EEOL) on the metabolism of rats with diabetes induced by a high-fat diet and low dose of streptozotocin (STZ)...
February 2, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30719309/remission-of-type-2-diabetes-and-pleiotropic-effects-of-long-term-testosterone-treatment-for-late-onset-hypogonadism-a-case-report
#20
Ahmad Haider, Karim Haider, Farid Saad, Markolf Hanefeld
For obese type 2 diabetes patients, weight reduction is one of the most important measures but fails in most cases. Testosterone deficiency can be the reason for such failure. This case presents a 57-year-old man who was referred to a urologist due to benign prostatic hyperplasia and erectile dysfunction. He had type 2 diabetes, was overweight, and had hypertension and dyslipidemia. The blood test revealed testosterone deficiency. Under testosterone therapy, the patient lost 10 kg; cardiometabolic parameters returned to normal and lower urinary tract symptoms disappeared; complete remission of diabetes was recorded...
2019: SAGE Open Medical Case Reports
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