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Radical Scavenger

Asad Khan Tanoli, Zahid Khan, Tuba Kamal, Mohsin Ali, Mehreen Latif, Zahida Tasneem Maqsood
New series of Co+2, Ni+2, Cu+2 and Zn+2 complexes have been synthesized using a bio-active hydrazone compound 4-hydroxybenzaldehyde-N-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene), abbreviated as [HL]. Complexes were characterized using elemental analysis, FT-IR, UV-visible spectroscopy conductivity and magnetic susceptibility measurements. Results showed that the bi-dentate [HL] coordinated in a square planner manner with Cu+2 while for the rest of the M+2 ions, it coordinated in a octahedral fashion. Free ligand and its metal complexes were also studied for their antioxidant potential by employing two methods i...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Ariba Shah, Zaheeruddin Khan, Shanzay Saleem, Sidra Farid
The antioxidant potential of leaf, stem, root and flower extracts of Quisqualis indica Linn. was assessed to verify its ethnopharmacological importance. Both polar and non-polar solvents like n-hexane, chloroform, ethanol and distilled water were used to obtain crude extracts. The chloroform extract of leaves showed the maximum %age yield, i.e. 27.3% while the n-hexane extract of stem showed the minimum yield, i.e. 0.2%. Five activities including DPPH free radical scavenging activity, ABTS+ assay, Total flavonoid components (TFC), Total phenolic components (TPC) and Metal chelating Assay (MC) were employed to evaluate the antioxidant activity of the plant...
January 2019: Pakistan Journal of Pharmaceutical Sciences
M Checa, M Figueredo, A Aguinaco, F J Beltrán
A graphene oxide-titania (GO/TiO2 ) composite was synthesized via sol-gel method, and studied in aqueous Primidone mineralization with ozone and LED visible light. The photocatalyst was characterized by different techniques (XRD, TEM, SBET, TGA, UV-vis diffuse reflectance spectroscopy). The band gap value decrease from 3.14 eV for bare TiO2 samples to 2.5 eV in GO/TiO2 composites clearly shows the interaction of GO with TiO2 structure. Approximately 20 mg L-1 of Primidone was removed in less than 20 min if ozone was applied, regardless of the presence or absence of light and catalyst...
February 10, 2019: Journal of Hazardous Materials
Guan-Yi Xu, Ai-Mei Liao, Ji-Hong Huang, Jian-Guo Zhang, Kiran Thakur, Zhao-Jun Wei
Potato peel was used for the extraction of three types of polysaccharides (PW, PAL, and PAC) using water, alkaline, and acid treatments, respectively. The structure of the PP polysaccharides was examined by means of Fourier transform infrared spectroscopy (FT-IR) analysis and Gas chromatography-mass spectrometry (GC-MS). The results suggest that the extracted polysaccharides constituted essentially three functional groups; CO, CH, and OH. The polysaccharides were comprised of low proportions of proteins, 17-23% uronic acids, and approximately 70% carbohydrates...
February 13, 2019: International Journal of Biological Macromolecules
Rebecca M Haley, Victoria R Qian, Greg D Learn, Horst A von Recum
Surgical sutures are vulnerable to bacterial infections and biofilm formation. At the suture site, pain and undesirable, excess inflammation are additionally detrimental to wound healing. The development of a polymerized cyclodextrin (pCD) coated surgical suture introduces the capability to locally deliver both anti-inflammatory and anti-microbial drugs throughout the phases of acute and chronic healing. Local delivery allows for the improvement of wound healing while reducing related systemic side effects and drug resistance...
February 16, 2019: Journal of Biomedical Materials Research. Part A
Laura M Doyle, Anant Navanithan Sharma, Ganapathy Gopalrathnam, Lihua Huang, Scott Bradley
In our previous published work, we reported rapid Polysorbate80 (PS80) oxidation in histidine buffer after brief stainless steel exposure and the ability of citrate and EDTA to prevent this oxidation. The focus of our current study was to mechanistically understand PS80 oxidation by studying the impact of temperature, light, stainless steel and the role of citrate and EDTA. Additionally, PS80 oxidation was studied in three different buffer sytems: histidine, citrate, and phosphate. When the PS80 containing buffers were exposed to elevated temperature of 50 °C in glass containers, no PS80 oxidation was observed in either histidine and citrate buffer systems after 30 days; however, PS80 oxidation was observed in phosphate buffer within 14 days...
February 15, 2019: PDA Journal of Pharmaceutical Science and Technology
Da-Ham Kim, Min-Ji Kim, Dae-Woon Kim, Gi-Yoon Kim, Jong-Kuk Kim, Yoseph Asmelash Gebru, Han-Seok Choi, Young-Hoi Kim, Myung-Kon Kim
The stem bark of Toxicodendron vernicifluum (TVSB) has been widely used as a traditional herbal medicine and food ingredients in Korea. However, its application has been restricted due to its potential to cause allergies. Moreover, there is limited data available on the qualitative and quantitative changes in the composition of its phytochemicals during fermentation. Although the Formitella fraxinea -mediated fermentation method has been reported as an effective detoxification tool, changes to its bioactive components and the antioxidant activity that takes place during its fermentation process have not yet been fully elucidated...
February 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiao Xu, Wenxiu Hu, Siduo Zhou, Chuanhai Tu, Xiudong Xia, Juanmei Zhang, Mingsheng Dong
Glutinous rice-based foods have a long history are consumed worldwide. They are also in great demand for the pursuit of novel sensory and natural health benefits. In this study, we developed a novel fermented glutinous rice product with the supplementation of Fu brick tea. Using in vitro antioxidant evaluation and phenolic compounds analysis, fermentation with Fu brick tea increased the total phenolic content and enhanced the antioxidant activity of glutinous rice, including scavenging of 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radical, 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical, and hydroxyl radical, ferric-reducing antioxidant power, and ferric ion reducing power and iron chelating capability...
February 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Braj Raj Singh, Vijai Kumar Gupta, Farah Deeba, Rajesh Bajpai, Vivek Pandey, Alim H Naqvi, Dalip Kumar Upreti, Nicholas Gathergood, Yueming Jiang, Hesham A El Enshasy, Essam Nageh Sholkamy, Ashraf A Mostafa, Abd El-Latif Hesham, Brahma N Singh
Silver-based nanostructures are suitable for many biomedical applications, but to be useful therapeutic agents, the high toxicity of these nanomaterials must be eliminated. Here, we biosynthesize nontoxic and ultra-small silver nanoclusters (rsAg@NCs) using metabolites of usnioid lichen (a symbiotic association of algae and fungi) that exhibit excellent antimicrobial activity against fluconazole (FCZ)-resistant Candida albicans that is many times higher than chemically synthesized silver nanoparticles (AgNPs) and FCZ...
January 29, 2019: Biomolecules
Ozlem Oral, Cetin Kantar
This study provides experimental results from batch and column studies to investigate diclofenac degradation by pyrite-Fenton process under variable chemical conditions (e.g., pyrite loading). Batch experiments show that diclofenac removal increased with increasing hydrogen peroxide and pyrite concentration. On the other hand, the addition of organic chelating agents such as citrate had an adverse effect on diclofenac removal by pyrite-Fenton process in batch systems due to scavenging effect of these agents for hydroxyl radicals...
February 6, 2019: Science of the Total Environment
Lei Zhao, Kai Wang, Weichao Li, Thanapop Soteyome, Hang Xiao, Zhuoyan Hu
The objective of this study was to evaluate the ability of a polyphenolic extract from longan seeds as a wound-healing material for deep second-degree burn wounds. The total phenol content of the extract reached 45.28 ± 1.22 mg GAE per g DW when 70% ethanol was used as the extraction solvent, and then AB-8 resin was used for purification. Results from the antioxidant assay in vitro (DPPH˙ and hydroxyl radical scavenging activity) and antimicrobial activity assay (ZOI, MIC and MBC) showed that the fractions eluted by 30% ethanol tend to have greater antioxidant ability, as well as higher bactericidal and antibacterial activities, than the other elution fractions...
February 15, 2019: Food & Function
Wenqiang Tan, Fang Dong, Jingjing Zhang, Xiang Zhao, Qing Li, Zhanyong Guo
Chitosan ascorbates with different substitution degrees were synthesized based on salification of chitosan and ascorbic acid at various molar ratios in water and were successfully used to prepare antioxidative films by casting for the first time. FTIR and 1H NMR spectra recorded the structural characteristics of all chitosan ascorbates, meanwhile physicochemical property and antioxidant activity of the produced chitosan ascorbate films were characterized and chitosan acetate film served as control were also measured these properties for comparison...
February 15, 2019: Journal of Agricultural and Food Chemistry
Eun-Hye Choi, Chan-Su Rha, Sri Renukadevi Balusamy, Dae-Ok Kim, Soon-Mi Shim
Two bioconversions were applied to green tea extracts (GTE) and flavonol glycoside rich fraction (FVNg) derived from insoluble green tea extract by tannase and cellulase treatment in order to obtain gallated catechins (EnzGTE) and flavonol aglycone rich fraction (FVNa), respectively. The bioaccessibility of epicatechins from GTE increased with the addition of FVNg, FVNa, and flavonol aglycone rich fraction of commercial production (FVNap). Epigallocatechin-gallate (EGCG) and epicatechin-gallate (ECG) were highly recovered 4- and 125-fold, respectively, by adding FVNap...
February 15, 2019: Journal of Agricultural and Food Chemistry
Ramzi A Mothana, Jamal M Khaled, Ali A El-Gamal, Omar M Noman, Ashok Kumar, Mohamed F Alajmi, Adnan J Al-Rehaily, Mansour S Al-Said
Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate the cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species growing in Saudi Arabia namely P. cylindraceus Hocst...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Marta Domżał-Kędzia, Agnieszka Lewińska, Anna Jaromin, Marek Weselski, Robert Pluskota, Marcin Łukaszewicz
Levan is a polysaccharide composed of fructose units with β-2,6-glycoside bonds. Microorganisms synthesize levan by levansucrase as a mixture of low- and high-molecular-weight fractions. Due to its properties, it has a wide range of applications in cosmetics, pharmaceuticals, food and medicine; it appears that the molecular weight of levan might impact its industrial use. To obtain one fraction of levan after biotransformation, ethanol precipitation with an increasing volume of alcohol was conducted. This precipitation process was also optimized...
February 11, 2019: Bioorganic Chemistry
Sun Qing, Qiu Shoutian, Gu Hongyan, Yao Ming, Mallappa Kumara Swamy, Uma Rani Sinniah, Ahmad Umar, Mohd Sayeed Akhtar
This study reports the biosynthesis of silver nanoparticles (AgNPs) using methanolic leaf extract of Pogostemon cablin Benth. (Patchouli) as a reducing agent, and their potent biological (antibacterial, antioxidant and anticancer) activities. The P. cablin extract when exposed to silver nitrate reduced silver ions to form crystalline AgNPs within 1 h of incubation at room-temperature. UV-visible spectra showed a sharp surface plasmon resonance (SPR) at around 430 nm for the biosynthesized AgNPs and the XRD pattern indicated the crystalline planes of the face centered cubic silver...
July 1, 2019: Journal of Nanoscience and Nanotechnology
Alfredo Bottone, Milena Masullo, Paola Montoro, Cosimo Pizza, Sonia Piacente
INTRODUCTION: Prunus dulcis Mill. is a plant cultivated for the production of its edible seeds, known as sweet almonds. In the last decades almond demand has highly increased due to their wide use in the industrial manufacturing of almond-based foods; this has led to a huge production of waste materials, mainly corresponding to shells and husks. OBJECTIVE: To achieve a deeper understanding of the chemical composition of almond husks with the aim of exploring these byproducts as a source of bioactives to be used in nutraceutical and cosmetic formulations...
February 14, 2019: Phytochemical Analysis: PCA
Nuraniye Eruygur, Esra Ucar, Hüseyin Aşkın Akpulat, Keyhan Shahsavari, Seyed Mehdi Safavi, Danial Kahrizi
Hypericum lydium Boiss. is a perennial plant of the Hypericaceae family, which has been used in particular to treat depression. The aim of this study was to determine in vitro antioxidant, antimicrobial activities, anticholinesterase (acetylcholinesterase (AChE)/butyrylcholinesterase (BChE)), antidiabetic activities (α-glucosidase/α-amylase) and Tyrosinase inhibitor activity of methanol and water extracts of H. lydium. Also, gene expression has been evaluated in the shoot and root by microarray technology...
February 14, 2019: Molecular Biology Reports
Wei Tong, Yanhua Xiong, Shun Duan, Xiaokang Ding, Fu-Jian Xu
The design of novel antibacterial materials has attracted increasing attention for combating bacterial infections. Herein, we conjugated zinc(ii) monoamino phthalocyanine (ZnMAPc) to poly(glycidyl methacrylate) (PGMA) via a ring-opening reaction, and the excess epoxy groups were scavenged by ethylenediamine (ED). The resultant macro-photosensitizer (PGED-Pc) can be easily dispersed in aqueous solution to form self-assembled nanoparticles and generate reactive oxygen species for inactivation of bacteria when exposed to light illumination...
February 14, 2019: Biomaterials Science
Deepak M Kasote, Guddadarangavvanahally K Jayaprakasha, Bhimanagouda S Patil
Antioxidant levels are key parameters for studies of food quality, stress responses, and plant health. Herein, we have demonstrated that excised leaf disc has both radical scavenging activity and reducing power, and used this concept to develop 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and potassium permanganate reduction (PPR) leaf disc assays. Reaction time and reagent concentration for these assays were optimized using leaves from spinach, kale, collards, mustard, and watermelon...
February 13, 2019: Scientific Reports
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