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World class health care

Mai Kimura, Takashi Kohno, Takashi Kawakami, Masaharu Kataoka, Takahiro Hiraide, Hidenori Moriyama, Sarasa Isobe, Toshimitsu Tsugu, Yuji Itabashi, Mitsushige Murata, Shinsuke Yuasa, Keiichi Fukuda
BACKGROUND: There is no consensus on the length of hospital stay (LOHS) and post-interventional management after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We examined temporal trends with respect to LOHS and requirement for intensive care for BPA and their relationship with the incidence of BPA-related complications. METHODS: From November 2012 to September 2017, a total of 123 consecutive patients with CTEPH who underwent BPA were enrolled (age: 66...
February 2019: Canadian Journal of Cardiology
Fahreen Walimohamed, Monica Aggarwal, Linying Dong, Rory Lattimer, Zaki Hakim, David Goranson, Kiran Ubhi, Minhas Ali, Aviv Shachak, Aziz Guergachi, Karim Keshavjee
Canada has struggled to make digital health a reality. We identified 6 key issues that appear to impede progress: 1) an inability to coordinate the actions of a rapidly evolving set of stakeholders, 2) patients who lack the ability and resources to play a meaningful role in health system decision-making, 3) world-class innovation that doesn't reach the market, 4) an inability to kick-start interoperability projects that can catalyze system transformation, 5) an inability to procure early-stage innovative technologies at scale, and 6) an inability to share data seamlessly across organizational silos for patient coordination and care, health system management and research...
2019: Studies in Health Technology and Informatics
Marília Silva Paulo, Tom Loney, Luís Velez Lapão
BACKGROUND: The United Arab Emirates (UAE) is a rapidly developing high-income country that was formed from the union of seven emirates in 1971. The UAE has experienced unprecedented population growth coupled with increased rates of chronic diseases over the past few decades. Healthcare workers are the core foundation of the health system, especially for chronic care conditions, and the UAE health workforce needs to be fully prepared for the increased rates of chronic diseases in the adult population...
January 24, 2019: Human Resources for Health
I Romanet, N Graillon, M K Le Roux, L Guyot, C Chossegros, M De Boutray, J M Foletti
INTRODUCTION: With more than 270 million spectators, football - or soccer - is the most popular sport in the world. International football events generate many risky situations, including hooliganism and are an opportunity to analyze the incidence and the particularities of associated trauma. We sought to underline the potential rapid and brutal increase in maxillofacial trauma during a world-class competition. MATERIAL AND METHODS: A retrospective multicenter study of the epidemiology of maxillofacial traumas during the UEFA 2016 Cup was conducted...
January 11, 2019: Journal of Stomatology, Oral and Maxillofacial Surgery
Mania Bankova, Robert Vogt, Stephen Sun, Jamie Wolfer Saphow, Victoria Yeung, Tracy Bariexca, Veronica Semeghini, Tejal Tipnis, Catalina Lee
OBJECTIVES: To develop flavors for oral care formulations containing zinc oxide, zinc citrate and L-arginine that are stable for the toothpaste shelf life, mask the unpleasant astringency and metallic off notes of the base, have an appealing taste which pleases global consumers, stimulate regimen compliance, and therefore help deliver whole mouth health benefits to people throughout the world. METHODS: For stability evaluation, flavor materials were formulated in Dual Zinc plus Arginine base and these samples were subjected to accelerated aging which consists of exposure to a temperature of 49°C for 6 weeks...
September 2018: Journal of Clinical Dentistry
Aron Janssen, Samantha Busa, Jeremy Wernick
Gender variance and dysphoria are present across all classes, ethnicities, and experiences, including among those with severe and chronic mental illness. In these, our most vulnerable populations, adequate assessment and treatment of gender dysphoria often is overlooked despite evidence that appropriate treatment of gender dysphoria leads to improvement in psychological functioning (Smith, van Goozen, Kuiper, & Cohen-Kettenis, 2005). The World Professional Association for Transgender Health recommend in their Standards of Care that somatic and surgical treatments for gender dysphoria should be made available to those with medical or mental illness with the caveat that "[the illness] must be reasonably well-controlled (2011)...
January 3, 2019: Archives of Sexual Behavior
Carola A Huber, Matthias R Meyer, Jan Steffel, Eva Blozik, Oliver Reich, Thomas Rosemann
PURPOSE: Secondary medication prevention after acute myocardial infarction (MI) is strongly recommended in international guidelines, but actual use, adherence, and outcomes in current clinical practice are largely unknown. Therefore, the aims of this study were to determine the current adherence to medications for secondary prevention after MI and to estimate the association between medication adherence and mortality and major adverse cardiovascular events (MACE) in a large real-world population...
December 24, 2018: Clinical Therapeutics
Manfred Paul Stapff
AIM: To evaluate the effect on cardiovascular outcomes of sodium-glucose co-transporter-2 (SGLT2) inhibitors in a real world setting by analyzing electronic medical records. METHODS: We used TriNetX, a global federated research network providing statistics on electronic health records (EHR). The analytics subset contained EHR from approximately 38 Million patients in 35 Health Care Organizations in the United States. The records of 46,909 patients who had taken SGLT2 inhibitors were compared to 189,120 patients with dipeptidyl peptidase (DPP) 4 inhibitors...
December 15, 2018: World Journal of Diabetes
Nahum Méndez-Sánchez, Felipe Zamarripa-Dorsey, Arturo Panduro, Emma Purón-González, Edgar Ulises Coronado-Alejandro, Carlos Alejandro Cortez-Hernández, Fátima Higuera de la Tijera, José Luis Pérez-Hernández, Eira Cerda-Reyes, Heriberto Rodríguez-Hernández, Vania César Cruz-Ramón, Oscar Lenin Ramírez-Pérez, Nancy Edith Aguilar-Olivos, Olga Fabiola Rodríguez-Martínez, Samantha Cabrera-Palma, Guillermo Cabrera-Álvarez
AIM: To investigate the main current etiologies of cirrhosis in Mexico. METHODS: We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period (January 2012-December 2017)...
December 6, 2018: World Journal of Clinical Cases
E Alagna, O E Santangelo, D D Raia, V Gianfredi, S Provenzano, A Firenze
INTRODUCTION: In Italy, as in the rest of the world, the number of homeless people is increasing considerably. Many of them suffer from chronic conditions, mental health problems and addiction to alcohol, drugs or smoking, and need complex medical care. Their health status is often exacerbated by greater difficulty in accessing primary care. The aim of the present study was to assess health conditions of homeless people living in Palermo, Southern Italy, and to find ways to limit the spread of common infectious diseases that can be prevented by vaccination...
January 2019: Annali di Igiene: Medicina Preventiva e di Comunità
Lorenzo Domenichini, Valentina Branzi, Martina Smorti
Road traffic injuries represent a serious public health problem and are one of leading cause of death, injury and disability around the world. Road accidents are often caused by an accumulation of factors; however, drivers appear to be by far the most decisive one. The driver's behaviour is complex and depends on reflex (or involuntary) and voluntary driving actions. The first class of actions (reflex actions) are typical human reactions that remain inaccessible to awareness and refer to the direct interaction between the road user and the characteristics of the road and its surrounding environment...
December 11, 2018: Accident; Analysis and Prevention
Lisa Bohlmann, David M P De Oliveira, Ibrahim M El-Deeb, Erin B Brazel, Nichaela Harbison-Price, Cheryl-Lynn Y Ong, Tania Rivera-Hernandez, Scott A Ferguson, Amanda J Cork, Minh-Duy Phan, Amelia T Soderholm, Mark R Davies, Graeme R Nimmo, Gordon Dougan, Mark A Schembri, Gregory M Cook, Alastair G McEwan, Mark von Itzstein, Christopher A McDevitt, Mark J Walker
The World Health Organization reports that antibiotic-resistant pathogens represent an imminent global health disaster for the 21st century. Gram-positive superbugs threaten to breach last-line antibiotic treatment, and the pharmaceutical industry antibiotic development pipeline is waning. Here we report the synergy between ionophore-induced physiological stress in Gram-positive bacteria and antibiotic treatment. PBT2 is a safe-for-human-use zinc ionophore that has progressed to phase 2 clinical trials for Alzheimer's and Huntington's disease treatment...
December 11, 2018: MBio
Jacqueline Dinnes, Jonathan J Deeks, Naomi Chuchu, Lavinia Ferrante di Ruffano, Rubeta N Matin, David R Thomson, Kai Yuen Wong, Roger Benjamin Aldridge, Rachel Abbott, Monica Fawzy, Susan E Bayliss, Matthew J Grainge, Yemisi Takwoingi, Clare Davenport, Kathie Godfrey, Fiona M Walter, Hywel C Williams
BACKGROUND: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion by a clinician are usually the first in a series of 'tests' to diagnose skin cancer, dermoscopy has become an important tool to assist diagnosis by specialist clinicians and is increasingly used in primary care settings. Dermoscopy is a magnification technique using visible light that allows more detailed examination of the skin compared to examination by the naked eye alone...
December 4, 2018: Cochrane Database of Systematic Reviews
M A C Koole, D Kauw, M M Winter, D A J Dohmen, I I Tulevski, R de Haan, G A Somsen, M P Schijven, D Robbers-Visser, B J M Mulder, B J Bouma, M J Schuuring
BACKGROUND: Arrhythmias and heart failure are common and invalidating sequelae in adult patients with congenital heart disease (CHD). Mobile health (m-Health) enables daily monitoring and a timely response that might prevent deterioration. We present an observational prospective registry to evaluate feasibility of an m‑Health telemonitoring program for managing arrhythmia, heart failure and blood pressure in symptomatic adults with CHD. METHODS: Symptomatic adult patients with CHD are enrolled in an m‑Health telemonitoring program, which evaluates single-lead ECG, blood pressure and weight measurements...
January 2019: Netherlands Heart Journal
Vincent J Willey, Sheldon Kong, Bingcao Wu, Amit Raval, Todd Hobbs, Andrea Windsheimer, Gaurav Deshpande, Ozgur Tunceli, Brian Sakurada, Jonathan R Bouchard
Background: Diabetes is associated with substantial clinical and economic burdens on patients and on the US healthcare system. Treatment options for patients with type 1 or type 2 diabetes have increased significantly, from only 3 drug classes in 1995 to more than 12 distinct classes today. Although several of the newer treatments are reported to have improved efficacy and safety profiles, they are often substantially more costly than older medications. Consequently, as drug options increase, the cost of diabetes management continues to grow...
September 2018: American Health & Drug Benefits
Benjamin Chimukangara, Ayesha Bm Kharsany, Richard J Lessells, Kogieleum Naidoo, Soo-Yon Rhee, Justen Manasa, Tiago Gräf, Lara Lewis, Cherie Cawood, David Khanyile, Karidia Diallo, Kassahun A Ayalew, Robert Shafer, Gillian Hunt, Deenan Pillay, Salim Karim Abdool, Tulio de Oliveira
INTRODUCTION: There is evidence of increasing levels of pre-treatment HIV drug resistance (PDR) in Southern Africa. We used data from two large population-based HIV surveillance studies to estimate prevalence of PDR in KwaZulu-Natal, the province with the highest HIV prevalence in South Africa. METHODS: Sanger sequencing was performed on samples obtained from a longitudinal HIV surveillance programme (study A, 2013-2014) and the HIV Incidence Provincial Surveillance System (study B, 2014-2015)...
November 15, 2018: AIDS Research and Human Retroviruses
C T Yeam, S Chia, H C C Tan, Y H Kwan, W Fong, J J B Seng
The aim of this review was to identify factors that influence patients' adherence to anti-osteoporotic therapy. Factors identified that were associated with poorer medication adherence included polypharmacy, older age, and misconceptions about osteoporosis. Physicians need to be aware of these factors so as to optimize therapeutic outcomes for patients. INTRODUCTION: To identify factors that influence patients' adherence to anti-osteoporotic therapy. METHODS: A systematic review of literature was performed for articles published up till January 2018 using PubMed®, PsychINFO®, Embase®, and CINAHL®...
December 2018: Osteoporosis International
Samuel R Nyman, Christopher Hayward, Wendy Ingram, Peter Thomas, Sarah Thomas, Michael Vassallo, James Raftery, Helen Allen, Yolanda Barrado-Martín
BACKGROUND: Falls are a public health issue for the older adult population and more so for people with dementia (PWD). Compared with their cognitively intact peers, PWD are at higher risk of falls and injurious falls. This randomised controlled trial aims to test the clinical and cost effectiveness of Tai Chi to improve postural balance among community-dwelling PWD and to assess the feasibility of conducting a larger definitive trial to reduce the incidence of falls among PWD. METHODS: A 3-centre parallel group randomised controlled trial with embedded process evaluation...
November 3, 2018: BMC Geriatrics
Abolanle Saheed Adekunle, John Adekunle Oyedele Oyekunle, Ibitomilola Janet Ola, Olaoluwa Ruth Obisesan, Nobanathi Wendy Maxakato
The study was carried out to determine the presence and concentration of polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs) in some personal care products in Nigeria. Commonly used consumer care products grouped into four classes, namely: plastics, cosmetics, disinfectants and washing products, were purchased from some supermarkets in Ile-Ife, Nigeria. The solid samples were pulverized and the PAHs and OCPs were extracted with n-hexane and dichloromethane, respectively using Soxhlet extraction method, while the liquid samples were extracted using liquid-liquid extraction method...
2018: Toxicology Reports
Giuseppe Di Tano, Andrea Di Lenarda, Domenico Gabrielli, Nadia Aspromonte, Renata De Maria, Maria Frigerio, Massimo Iacoviello, Andrea Mortara, Adriano Murrone, Federico Nardi, Fabrizio Oliva, Roberto Pontremoli, Marino Scherillo, Michele Senni, Stefano Urbinati, Michele Massimo Gulizia
Sacubitril/valsartan, the first-in-class angiotensin receptor neprilysin inhibitor (ARNI), is the first medication to demonstrate a mortality benefit in patients with chronic heart failure and reduced ejection fraction (HFrEF) since the early 2000s. Sacubitril/valsartan simultaneously suppresses renin-angiotensin-aldosterone system activation through blockade of angiotensin II type 1 receptors and enhances the activity of vasoactive peptides including natriuretic peptides, through inhibition of neprilysin, the enzyme responsible for their degradation...
October 2018: Giornale Italiano di Cardiologia
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