Qiang Wang, Marta Martínez-Bonet, Taehyeung Kim, Jeffrey A Sparks, Kazuyoshi Ishigaki, Xiaoting Chen, Marc Sudman, Vitor Aguiar, Sangwan Sim, Marcos Chiñas Hernandez, Darren J Chiu, Alexandra Wactor, Brian Wauford, Miranda C Marion, Maria Gutierrez-Arcelus, John Bowes, Stephen Eyre, Ellen Nordal, Sampath Prahalad, Marite Rygg, Vibeke Videm, Soumya Raychaudhuri, Matthew T Weirauch, Carl D Langefeld, Susan D Thompson, Peter A Nigrovic
TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using Immunochip data from 3,939 patients with juvenile idiopathic arthritis (JIA) and 14,412 control individuals, we identified 132 plausible common non-coding variants, reduced serially by single-nucleotide polymorphism sequencing (SNP-seq), electrophoretic mobility shift, and luciferase studies to the single variant rs7034653 in the third intron of TRAF1 ...
November 8, 2023: Cell Genom