keyword
https://read.qxmd.com/read/38309416/parents-perspectives-on-using-a-family-medication-safety-plan-designed-to-promote-appropriate-opioid-prescription-practices-with-adolescents
#21
JOURNAL ARTICLE
Olufunmilola Abraham, Grace C Klubertanz, Ellie N Maday
BACKGROUND: Research has underscored the vulnerability of adolescents to opioid misuse, creating a call-to-action for researchers and practitioners to identify ways to reduce the youths' risk of opioid misuse. While strategies have previously been proposed, few studies have targeted and designed interventions for adolescents and their families. The Family Medication Safety Plan (FMSP) was developed to provide families with a tool to encourage early education, conversation, and promote safe use of prescription opioid medications in their homes...
February 1, 2024: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/38255104/opioid-treatment-in-primary-care-knowledge-and-practical-use-of-opioid-therapy
#22
JOURNAL ARTICLE
Aleksander Michał Biesiada, Aleksandra Ciałkowska-Rysz, Agnieszka Mastalerz-Migas
BACKGROUND: Primary care physicians play a key role in initiating opioid therapy. However, knowledge gaps in opioid use and pain management are significant barriers to providing optimal care. This research study aims to investigate the educational needs of primary care physicians regarding opioid therapy and opioid use in pain management. METHODS: A computer-assisted web interview (CAWI) protocol was used to collect data from primary care physicians. Drug selection criteria, knowledge of opioid substitutes and dosage, and practical use of opioid therapy were evaluated...
January 16, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38243899/a-novel-leu-enkephalin-prodrug-produces-pain-relieving-and-antidepressant-effects
#23
JOURNAL ARTICLE
Lukas Hohenwarter, Ernest Puil, Elham Rouhollahi, Lennart Bohrmann, Shawna Lu, Katayoun Saatchi, Urs O Häfeli, Alasdair Barr, Roland Böttger, K K DurgaRao Viswanadham, Shyh-Dar Li
Persistent pain is a significant healthcare problem with limited treatment options. The high incidence of comorbid chronic pain and depression significantly reduces life quality and complicates the treatment of both conditions. Antidepressants are less effective for pain and depression than for depression alone and they induce severe side effects. Opioids are highly efficacious analgesics, but rapid development of tolerance, dependence, and debilitating side effects limit their efficacy and safe use. Leucine-enkephalin (Leu-ENK), the endogenous delta opioid receptor agonist, controls pain and mood and produces potent analgesia with reduced adverse effects compared to conventional opioids...
February 5, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38214782/time-to-service-and-its-relationship-with-outcomes-in-workers-with-compensated-musculoskeletal-conditions-a-scoping-review
#24
REVIEW
Tesfaye Hambisa Mekonnen, Michael Di Donato, Alex Collie, Grant Russell
PURPOSE: A comprehensive review of the literature on the time between the onset of symptoms and the first episode of care and its effects on important worker outcomes in compensated musculoskeletal conditions is currently lacking. This scoping review aimed to summarize the factors associated with time to service and describe outcomes in workers with workers' compensation accepted claims for musculoskeletal conditions. METHODS: We used the JBI guidelines for scoping reviews and reported following the PRISMA-ScR protocol...
January 12, 2024: Journal of Occupational Rehabilitation
https://read.qxmd.com/read/38205948/co-crystal-of-tramadol-celecoxib-ctc-for-acute-moderate-to-severe-pain
#25
REVIEW
Richard Langford, Cesar Margarit, Adelaida Morte, Jesús Cebrecos, Mariano Sust, Esther Ortiz, José María Giménez-Arnau, Oscar de Leon-Casasola
OBJECTIVE: This narrative review aims to provide a clinical perspective on the potential role of co-crystal of tramadol-celecoxib (CTC) in the management of acute moderate-to-severe pain by synthesizing the available preclinical and clinical data, with emphasis on phase 3 trials. METHODS: A non-systematic literature review was performed using a targeted PubMed search for articles published between January 1, 2000, and May 2, 2023; all publication types were permitted, and selected articles were limited to those published in English...
January 11, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38165803/opioidergic-signaling-contributes-to-food-mediated-suppression-of-agrp-neurons
#26
JOURNAL ARTICLE
Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, Lin Tian, Deniz Atasoy
Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite circuits as well; however, their role in homeostatic feeding remains unclear. Using a fluorescent opioid sensor, deltaLight, here we report that mediobasal hypothalamic opioid levels increase by feeding, which directly and indirectly inhibits agouti-related protein (AgRP)-expressing neurons through the μ-opioid receptor (MOR)...
January 1, 2024: Cell Reports
https://read.qxmd.com/read/38147123/laparoscopic-transverse-abdominis-plane-block-how-i-do-it-and-a-cost-efficiency-analysis
#27
JOURNAL ARTICLE
Yuki Hirata, Vijaya Gottumukkala, Jeeva Ajith, Jason A Schmeisser, Elizabeth P Ninan, Jessica E Maxwell, Rebecca A Snyder, Michael P Kim, Hop S Tran Cao, Ching-Wei D Tzeng, Brian D Badgwell, Matthew H G Katz, Naruhiko Ikoma
PURPOSE: To determine the efficacy and efficiency of laparoscopic transverse abdominis plane block (Lap-TAP) in patients undergoing pancreatoduodenectomy and gastrectomy compared to those of ultrasound-guided TAP (US-TAP). METHODS: We retrospectively analyzed the records of patients who underwent open or minimally invasive (MIS) pancreatoduodenectomy and major gastrectomy with the use of Lap-TAP or US-TAP at our institution between November 1, 2018, and September 30, 2021...
December 26, 2023: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/38138971/the-epigenetics-of-neuropathic-pain-a-systematic-update
#28
REVIEW
Gábor Pethő, Boglárka Kántás, Ádám Horváth, Erika Pintér
Epigenetics deals with alterations to the gene expression that occur without change in the nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the surrounding histone proteins have been revealed, including DNA methylation, histone acetylation, and methylation, which can either stimulate or inhibit protein expression at the transcriptional level. In the past decade, an exponentially increasing amount of data has been published on the association between epigenetic changes and the pathomechanism of pain, including its most challenging form, neuropathic pain...
December 5, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38124021/opioid-induced-hyperalgesia-and-tolerance-are-driven-by-hcn-ion-channels
#29
JOURNAL ARTICLE
Xue Han, Larissa Garcia Pinto, Bruno Vilar, Peter A McNaughton
Prolonged exposure to opioids causes an enhanced sensitivity to painful stimuli (opioid-induced hyperalgesia, OIH) and a need for increased opioid doses to maintain analgesia (opioid-induced tolerance, OIT), but the mechanisms underlying both processes remain obscure. We found that pharmacological block or genetic deletion of HCN2 ion channels in primary nociceptive neurons of male mice completely abolished OIH but had no effect on OIT. Conversely, pharmacological inhibition of central HCN channels alleviated OIT but had no effect on OIH...
December 18, 2023: Journal of Neuroscience
https://read.qxmd.com/read/38094140/intravenous-methadone-in-the-management-of-acute-postoperative-pain-in-a-chronic-cancer-pain-patient-a-case-report-and-review-of-the-literature
#30
Khang Duy Ricky Le, Jean Hua
KEY CLINICAL MESSAGE: The current landscape of literature highlights that there is insufficient well-powered and robust evidence to support the integration of intravenous methadone into current guidelines and frameworks in supporting the pain management of cancer patient with complex pain syndromes. However, there is preliminary evidence, both from the literature as well as this case study that highlights intravenous methadone may be efficaciously and safety used for the management of postoperative pain in cancer patients with chronic pain undergoing operative management...
December 2023: Clinical Case Reports
https://read.qxmd.com/read/38071124/development-and-validation-of-a-brief-screening-tool-for-over-the-counter-codeine-dependence
#31
JOURNAL ARTICLE
Jacqui McCoy, Suzanne Nielsen, Raimondo Bruno
BACKGROUND: Low-dose codeine is sold without a prescription in countries like the UK, Ireland, and South Africa. Due to misuse concerns, exploring pharmacy screening tools to identify those at risk and needing additional support is vital. OBJECTIVES: The study aims to develop and validate a brief screening tool that assesses the risk of codeine dependence with language appropriate for routine use in community pharmacies. METHOD: Scale development and validation occurred over two studies...
November 24, 2023: Research in Social & Administrative Pharmacy: RSAP
https://read.qxmd.com/read/38069569/single-port-robotic-radical-prostatectomy-using-transvesical-and-transperineal-access-in-patients-with-a-hostile-abdomen
#32
JOURNAL ARTICLE
Ethan Ferguson, Roxana Ramos-Carpinteyro, Nicolas Soputro, Jaya Sai Chavali, Albert Geskin, Jihad Kaouk
Introduction Prostate cancer diagnosis and treatment is challenging in surgically complex patients. Radical prostatectomy can be performed without peritoneal entry using novel single port (SP) transperineal (TP) and transvesical (TV) approaches. We sought to examine the outcomes of radical prostatectomy using novel TP and TV approaches in patients with extensive prior abdominal surgeries. Materials and Methods From 2019 to 2023, 51 patients with extensive prior abdominal surgeries were identified who underwent TP (18) and SP TV (33) robotic radical prostatectomy...
December 9, 2023: Journal of Endourology
https://read.qxmd.com/read/38045783/methodology-and-findings-of-randomized-clinical-trials-on-pharmacologic-and-non-pharmacologic-interventions-to-treat-renal-colic-pain-a-review
#33
REVIEW
Justyna Boblewska, Bartosz Dybowski
INTRODUCTION: Renal colic pain is considered one of the most excruciating pains ever experienced and ranks as one of the most common urological emergencies. Despite existing established recommendations, new therapies and their combinations are continuously being tested. The aim of this systematic review is to analyze and compare studies involving pharmacologic and non-pharmacologic interventions used in the treatment of renal colic pain. MATERIAL AND METHODS: This systematic review was conducted following the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement...
2023: Central European Journal of Urology
https://read.qxmd.com/read/38026463/regional-analgesia-for-cesarean-delivery-a-narrative-review-toward-enhancing-outcomes-in-parturients
#34
REVIEW
Matthew Silverman, Nicholas Zwolinski, Ethan Wang, Nishita Lockwood, Michael Ancuta, Evan Jin, Jinlei Li
INTRODUCTION: With the current surge on peripheral nerve blocks in post-cesarean pain management and the historical lack of unequivocal evidence supporting its universal use, this review intended to re-examine the extended scope of literature on regional anesthesia and postoperative analgesia in low-transverse cesarean section. METHODS: A literature search was conducted up to April 2023 using PubMed to identify articles relevant to our search words "cesarean section", "neuraxial morphine", "post-cesarean analgesia", as well as the name of each individual nerve block...
2023: Journal of Pain Research
https://read.qxmd.com/read/38025909/psychostimulant-misuse-among-american-indian-alaskan-native-or-native-hawaiian-college-students-in-the-u-s-from-2015-to-2019
#35
JOURNAL ARTICLE
Fares Qeadan, Sydney Ross, William A Barbeau, Erin F Madden, Kamilla L Venner, Kevin English
INTRODUCTION: This study examines factors associated with psychostimulant misuse, including polysubstance use and social factors, among the understudied American Indian/Alaska Native/Native Hawaiian (AI/AN/NH) college student population. METHODS: Data were from the 2015 to 2019 American College Health Association-National College Health Assessment IIc (ACHA-NCHA IIc) survey. Multivariable logistic regression models and odds ratios were used to estimate associations between psychostimulant misuse and potential risk and protective factors among AI/AN/NH college students, including licit and illicit substance use, social support, relationship factors, exposure to violence or abuse, mental health symptoms, drug and alcohol education, and sample demographics...
2023: Substance Abuse: Research and Treatment
https://read.qxmd.com/read/38024442/first-100-cases-of-transvesical-single-port-robotic-radical-prostatectomy
#36
JOURNAL ARTICLE
Roxana Ramos-Carpinteyro, Ethan L Ferguson, Jaya S Chavali, Albert Geskin, Jihad Kaouk
OBJECTIVE: To describe the surgical technique and report the early outcomes of the transvesical (TV) approach to single-port (SP) robot-assisted radical prostatectomy. METHODS: All procedures were performed at a single center by one surgeon. We identified the first 100 consecutive patients with clinically localized prostate cancer that underwent SP TV robot-assisted radical prostatectomy using the da Vinci SP robotic surgical system. Data were collected prospectively and analyzed with descriptive statistics...
October 2023: Asian Journal of Urology
https://read.qxmd.com/read/38002614/risk-factors-for-severe-pain-and-impairment-of-daily-life-activities-after-cesarean-section-a-prospective-multi-center-study-of-11-932-patients
#37
JOURNAL ARTICLE
Norah L A Emrich, Laura Tascón Padrón, Marcus Komann, Christin Arnold, Johannes Dreiling, Winfried Meißner, Brigitte Strizek, Ulrich Gembruch, Jorge Jiménez Cruz
Cesarean section (CS) is the most widely performed and one of the most painful surgeries. This study investigated postoperative pain after CS using patient-related outcomes (PROs) to identify risk factors for severe pain. The secondary outcome was to evaluate the influence of surgery indication (primary CS (PCS) vs. urgent CS (UCS)). This multi-center, prospective cohort study included data submitted to the pain registry "quality improvement in postoperative pain treatment" (QUIPS) between 2010 and 2020. In total, 11,932 patients were evaluated...
November 9, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37985490/robotic-surgery-for-inguinal-and-ventral-hernia-repair-a-systematic-review-and-meta-analysis
#38
REVIEW
Nicola de'Angelis, Carlo Alberto Schena, David Moszkowicz, Cyril Kuperas, Régis Fara, Sébastien Gaujoux, Jean-François Gillion, Caroline Gronnier, Jérôme Loriau, Muriel Mathonnet, Olivier Oberlin, Manuela Perez, Yohann Renard, Benoît Romain, Guillaume Passot, Patrick Pessaux
BACKGROUND: This systematic review and meta-analysis assessed the effectiveness of robotic surgery compared to laparoscopy or open surgery for inguinal (IHR) and ventral (VHR) hernia repair. METHODS: PubMed and EMBASE were searched up to July 2022. Meta-analyses were performed for postoperative complications, surgical site infections (SSI), seroma/hematoma, hernia recurrence, operating time (OT), intraoperative blood loss, intraoperative bowel injury, conversion to open surgery, length of stay (LOS), mortality, reoperation rate, readmission rate, use of opioids, time to return to work and time to return to normal activities...
January 2024: Surgical Endoscopy
https://read.qxmd.com/read/37971637/robotic-retroperitoneal-lymph-node-dissection-for-paratesticular-rhabdomyosarcoma-in-adolescents-a-case-series
#39
JOURNAL ARTICLE
Cody N Clark, Jennifer Smith, Molly E Fuchs, Christina B Ching, Daniel G DaJusta
Robotic assisted (RA) retroperitoneal lymph node dissection (RPLND) has grown in popularity as it offers decreased morbidity and faster recovery compared to the open technique. Proponents of open surgery raised concerns about the oncological fidelity of the RA approach for testicular tumors where complete resection is needed. In boys > 10 years with paratesticular rhabdomyosarcoma (RMS), RPLND is indicated for staging purposes only. In this population, the RA technique should provide its benefits without concerns for oncological compromise...
November 16, 2023: Journal of Robotic Surgery
https://read.qxmd.com/read/37962927/exploring-perceptions-about-paracetamol-tramadol-and-codeine-on-twitter-using-machine-learning-quantitative-and-qualitative-observational-study
#40
JOURNAL ARTICLE
Federico Carabot, Carolina Donat-Vargas, Javier Santoma-Vilaclara, Miguel A Ortega, Cielo García-Montero, Oscar Fraile-Martínez, Cristina Zaragoza, Jorge Monserrat, Melchor Alvarez-Mon, Miguel Angel Alvarez-Mon
BACKGROUND: Paracetamol, codeine, and tramadol are commonly used to manage mild pain, and their availability without prescription or medical consultation raises concerns about potential opioid addiction. OBJECTIVE: This study aims to explore the perceptions and experiences of Twitter users concerning these drugs. METHODS: We analyzed the tweets in English or Spanish mentioning paracetamol, tramadol, or codeine posted between January 2019 and December 2020...
November 14, 2023: Journal of Medical Internet Research
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