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Warburg Effect Immune

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https://read.qxmd.com/read/30783517/oxygen-in-the-tumor-microenvironment-effects-on-dendritic-cell-function
#1
REVIEW
Laurent M Paardekooper, Willemijn Vos, Geert van den Bogaart
Solid tumors grow at a high speed leading to insufficient blood supply to tumor cells. This makes the tumor hypoxic, resulting in the Warburg effect and an increased generation of reactive oxygen species (ROS). Hypoxia and ROS affect immune cells in the tumor micro-environment, thereby affecting their immune function. Here, we review the known effects of hypoxia and ROS on the function and physiology of dendritic cells (DCs). DCs can (cross-)present tumor antigen to activate naive T cells, which play a pivotal role in anti-tumor immunity...
January 25, 2019: Oncotarget
https://read.qxmd.com/read/30781344/targeting-tumor-microenvironment-for-cancer-therapy
#2
REVIEW
Catarina Roma-Rodrigues, Rita Mendes, Pedro V Baptista, Alexandra R Fernandes
Cancer development is highly associated to the physiological state of the tumor microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from different anatomical locations, common features can be found in the TME maturation of epithelial-derived tumors. Genetic alterations in tumor cells result in hyperplasia, uncontrolled growth, resistance to apoptosis, and metabolic shift towards anaerobic glycolysis (Warburg effect). These events create hypoxia, oxidative stress and acidosis within the TME triggering an adjustment of the extracellular matrix (ECM), a response from neighbor stromal cells (e...
February 15, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30721235/modulation-of-the-immune-response-and-infection-pattern-to-leishmania-donovani-in-visceral-leishmaniasis-due-to-arsenic-exposure-an-in-vitro-study
#3
Ghufran Ahmed, Ajit K Thakur, Pushpanjali, Snehil, Sanjay K Chaturvedi, Pushkar Shivam, Fauzia Jamal, Manish K Singh, Sanjiva Bimal, Subhankar K Singh, Sunil K Choudhary, Pradeep Das, Shyam Narayan
The arsenic contamination of ground water in visceral leishmaniasis (VL) endemic areas in Bihar, India leads to human exposure through drinking water. Possibly, the consumed arsenic (As) accumulates in the tissues of VL patients, who subsequently internalize intracellular amastigotes to confer resistance against chemotherapy to the parasite, leading to modulation in the host's immune response. This hypothesis appears to be consistent with the in vitro findings that in arsenic-exposed parasites, the mitochondrial membrane potential became depolarized, whereas the reduced thiol and lactate production was overexpressed with enhanced glucose consumption; therefore, the reduced thiol possibly supports an immunosuppressive state in the host cells...
2019: PloS One
https://read.qxmd.com/read/30634708/involvement-of-hpv-infection-in-the-release-of-macrophage-migration-inhibitory-factor-in-head-and-neck-squamous-cell-carcinoma
#4
Nadège Kindt, Géraldine Descamps, Jérôme R Lechien, Myriam Remmelink, Jean-Marie Colet, Ruddy Wattiez, Guy Berchem, Fabrice Journe, Sven Saussez
Human papilloma virus (HPV) infection has been well-established as a risk factor in head and neck squamous cell carcinoma (HNSCC). The carcinogenic effect of HPV is mainly due to the E6 and E7 oncoproteins, which inhibit the functions of p53 and pRB, respectively. These oncoproteins could also play a role in the Warburg effect, thus favoring tumor immune escape. Here, we demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) is expressed at higher levels in HPV-negative patients than in HPV-positive patients...
January 10, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30439456/altered-cancer-metabolism-in-mechanisms-of-immunotherapy-resistance
#5
REVIEW
Rishab Ramapriyan, Mauricio S Caetano, Hampartsoum B Barsoumian, Ana Carolina P Mafra, Erika Pereira Zambalde, Hari Menon, Efrosini Tsouko, James W Welsh, Maria Angelica Cortez
Many metabolic alterations, including the Warburg effect, occur in cancer cells that influence the tumor microenvironment, including switching to glycolysis from oxidative phosphorylation, using opportunistic modes of nutrient acquisition, and increasing lipid biosynthesis. The altered metabolic landscape of the tumor microenvironment can suppress the infiltration of immune cells and other functions of antitumor immunity through the production of immune-suppressive metabolites. Metabolic dysregulation in cancer cells further affects the expression of cell surface markers, which interferes with immune surveillance...
November 12, 2018: Pharmacology & Therapeutics
https://read.qxmd.com/read/30165351/increased-lactate-in-gastric-cancer-tumor-infiltrating-lymphocytes-is-related-to-impaired-t-cell-function-due-to-mir-34a-deregulated-lactate-dehydrogenase-a
#6
Wang Ping, Hu Senyan, Gu Li, Chen Yan, Lu Long
BACKGROUND/AIMS: Lactate is one of the products of glycolysis and is a hallmark of the Warburg effect. Glycolysis is found in tumor as well as immune cells. However, the effects of lactate on the function of tumor-infiltrating T cells (TILs) are rarely reported. METHODS: In the present study, we investigated lactate and other glycolysis-related metabolites within TILs of human gastric cancer (GC). Lactate concentration was determined by liquid chromatography-mass spectrometry...
2018: Cellular Physiology and Biochemistry
https://read.qxmd.com/read/30062063/combined-effects-of-fh-e404d-and-acox2-r409h-cause-metabolic-defects-in-primary-cardiac-malignant-tumor
#7
Xiangyu Zhou, Mengjia Xu, Weijia Zeng, Zhongzhong Chen, Guohui Lu, Yun Gong, Richard H Finnell, Huasheng Xiao, Bin Qiao, Hongyan Wang
Primary malignant cardiac tumors (PMCTs) are extremely rare. The apparent immunity of the heart to invasive cancer has attracted considerable interest given the continuously rising incidence of cancer in other organs. This study aims to determine the conditions that could result in cardiac carcinoma and expand our understanding of cardiac tumor occurrence. We report two cases: a male (Patient-1) with primary cardiac malignant fibrous histiocytoma (MFH) and a female (Patient-2) with primary cardiac angiosarcoma...
2018: Cell Death Discovery
https://read.qxmd.com/read/30035102/b7h3-as-a-promoter-of-metastasis-and-promising-therapeutic-target
#8
REVIEW
Peixin Dong, Ying Xiong, Junming Yue, Sharon J B Hanley, Hidemichi Watari
B7H3 (also known as CD276, an immune checkpoint molecule) is aberrantly overexpressed in many types of cancer, and such upregulation is generally associated with a poor clinical prognosis. Recent discoveries indicate a crucial role for B7H3 in promoting carcinogenesis and metastasis. This review will focus on the latest developments relating specifically to the oncogenic activity of B7H3 and will describe the upstream regulators and downstream effectors of B7H3 in cancer. Finally, we discuss the emerging roles of microRNAs (miRNAs) in inhibiting B7H3-mediated tumor promotion...
2018: Frontiers in Oncology
https://read.qxmd.com/read/29959989/metabolic-reprogramming-for-cancer-cells-and-their-microenvironment-beyond-the-warburg-effect
#9
REVIEW
Linchong Sun, Caixia Suo, Shi-Ting Li, Huafeng Zhang, Ping Gao
While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival...
June 28, 2018: Biochimica et biophysica acta. Reviews on cancer
https://read.qxmd.com/read/29857814/how-the-warburg-effect-supports-aggressiveness-and-drug-resistance-of-cancer-cells
#10
Philippe Icard, Seth Shulman, Diana Farhat, Jean-Marc Steyaert, Marco Alifano, Hubert Lincet
Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic metabolism. However, their proliferation is marked by a shift towards increasing glycolytic metabolism even in the presence of O2 (Warburg effect). HIF1, a major hypoxia induced transcription factor, promotes a dissociation between glycolysis and the tricarboxylic acid cycle, a process limiting the efficient production of ATP and citrate which otherwise would arrest glycolysis. The Warburg effect also favors an intracellular alkaline pH which is a driving force in many aspects of cancer cell proliferation (enhancement of glycolysis and cell cycle progression) and of cancer aggressiveness (resistance to various processes including hypoxia, apoptosis, cytotoxic drugs and immune response)...
May 2018: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://read.qxmd.com/read/29844288/the-effect-of-light-exposure-at-night-lan-on-carcinogenesis-via-decreased-nocturnal-melatonin-synthesis
#11
REVIEW
Aldo Giudice, Anna Crispo, Maria Grimaldi, Andrea Polo, Sabrina Bimonte, Mario Capunzo, Alfonso Amore, Giovanni D'Arena, Pellegrino Cerino, Alfredo Budillon, Gerardo Botti, Susan Costantini, Maurizio Montella
In mammals, a master clock is located within the suprachiasmatic nucleus (SCN) of the hypothalamus, a region that receives input from the retina that is transmitted by the retinohypothalamic tract. The SCN controls the nocturnal synthesis of melatonin by the pineal gland that can influence the activity of the clock's genes and be involved in the inhibition of cancer development. On the other hand, in the literature, some papers highlight that artificial light exposure at night (LAN)-induced circadian disruptions promote cancer...
May 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/29629338/metabolic-symbiosis-and-immunomodulation-how-tumor-cell-derived-lactate-may-disturb-innate-and-adaptive-immune-responses
#12
REVIEW
Alexandre Morrot, Leonardo Marques da Fonseca, Eduardo J Salustiano, Luciana Boffoni Gentile, Luciana Conde, Alessandra Almeida Filardy, Tatiany Nunes Franklim, Kelli Monteiro da Costa, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima
The tumor microenvironment (TME) is composed by cellular and non-cellular components. Examples include the following: (i) bone marrow-derived inflammatory cells, (ii) fibroblasts, (iii) blood vessels, (iv) immune cells, and (v) extracellular matrix components. In most cases, this combination of components may result in an inhospitable environment, in which a significant retrenchment in nutrients and oxygen considerably disturbs cell metabolism. Cancer cells are characterized by an enhanced uptake and utilization of glucose, a phenomenon described by Otto Warburg over 90 years ago...
2018: Frontiers in Oncology
https://read.qxmd.com/read/29603622/metabolic-reprogramming-of-host-cells-upon-bacterial-infection-why-shift-to-a-warburg-like-metabolism
#13
REVIEW
Pedro Escoll, Carmen Buchrieser
The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogramming of immune cells, a field of investigation called immunometabolism. However, the specific mechanisms and processes underlying metabolic changes of host cells upon bacterial infection remain poorly understood. Several recent reports have reported that mammalian cells infected with intracellular bacteria have an altered metabolism that resembles the Warburg effect seen in cancer cells...
June 2018: FEBS Journal
https://read.qxmd.com/read/29599194/dimethyl-fumarate-targets-gapdh-and-aerobic-glycolysis-to-modulate-immunity
#14
Michael D Kornberg, Pavan Bhargava, Paul M Kim, Vasanta Putluri, Adele M Snowman, Nagireddy Putluri, Peter A Calabresi, Solomon H Snyder
Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, thereby presenting a potential therapeutic target in autoimmune disease. Dimethyl fumarate (DMF), a derivative of the Krebs cycle intermediate fumarate, is an immunomodulatory drug used to treat multiple sclerosis and psoriasis. Although its therapeutic mechanism remains uncertain, DMF covalently modifies cysteine residues in a process termed succination. We found that DMF succinates and inactivates the catalytic cysteine of the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in mice and humans, both in vitro and in vivo...
April 27, 2018: Science
https://read.qxmd.com/read/29593748/high-mobility-group-nucleosome-binding-protein-1-as-endogenous-ligand-induces-innate-immune-tolerance-in-a-tlr4-sirtuin-1-dependent-manner-in-human-blood-peripheral-mononuclear-cells
#15
Rob J W Arts, Po-Kai Huang, De Yang, Leo A B Joosten, Jos W M van der Meer, Joost J Oppenheim, Mihai G Netea, Shih-Chin Cheng
High-mobility group nucleosome-binding protein 1 (HMGN1) functions as a non-histone chromatin-binding protein in the cell nucleus. However, extracellular HMGN1 acts as an endogenous danger-associated inflammatory mediator (also called alarmin ). We demonstrated that HMGN1 not only directly stimulated cytokine production but also had the capacity to induce immune tolerance by a TLR4-dependent pathway, similar to lipopolysaccharide (LPS)-induced tolerance. HMGN1-induced tolerance was accompanied by a metabolic shift associated with the inhibition of the induction of Warburg effect (aerobic glycolysis) and histone deacetylation via Sirtuin-1...
2018: Frontiers in Immunology
https://read.qxmd.com/read/29502308/biochemistry-of-proinflammatory-macrophage-activation
#16
REVIEW
Yannic Nonnenmacher, Karsten Hiller
In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases...
June 2018: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/29404815/intra-cellular-lactate-concentration-in-t-lymphocytes-from-septic-shock-patients-a-pilot-study
#17
Thibaut Girardot, Thomas Rimmelé, Guillaume Monneret, Julien Textoris, Fabienne Venet
BACKGROUND: Sepsis-associated hyperlactatemia is a widely used biomarker, associated with initial severity and poor outcomes. This increased circulating lactate concentration has been proposed to result in part from a mismatch between oxygen delivery and demand in organs. However, other mechanisms may participate. In particular, a metabolic reprogramming similar to the Warburg effect initially described in cancer cells could lead to increased lactate production by immune cells such as T lymphocytes after sepsis...
February 5, 2018: Intensive Care Medicine Experimental
https://read.qxmd.com/read/29290768/modulated-electro-hyperthermia-induced-loco-regional-and-systemic-tumor-destruction-in-colorectal-cancer-allografts
#18
Tamas Vancsik, Csaba Kovago, Eva Kiss, Edina Papp, Gertrud Forika, Zoltan Benyo, Nora Meggyeshazi, Tibor Krenacs
Background: Modulated electro-hyperthermia (mEHT), a non-invasive intervention using 13.56 MHz radiofrequency, can selectively target cancers due to their elevated glycolysis (Warburg-effect), extracellular ion concentration and conductivity compared to normal tissues. We showed earlier that mEHT alone can provoke apoptosis and damage associated molecular pattern (DAMP) signals in human HT29 colorectal cancer xenografts of immunocompromised mice. Materials: Here we tested the mEHT induced stress and immune responses in C26 colorectal cancer allografts of immunocompetent (BALB/c) mice between 12-72 h post-treatment...
2018: Journal of Cancer
https://read.qxmd.com/read/29279329/purine-nucleotide-metabolism-regulates-expression-of-the-human-immune-ligand-mica
#19
Michael T McCarthy, Gerard Moncayo, Thomas K Hiron, Niels A Jakobsen, Alessandro Valli, Tomoyoshi Soga, Julie Adam, Christopher A O'Callaghan
Expression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or "stressed" cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA is recognized by the activating immune cell receptor natural killer group 2D (NKG2D), providing a mechanism by which immune cells can identify and potentially eliminate pathological cells. Immune recognition through NKG2D is implicated in cancer, atherosclerosis, transplant rejection, and inflammatory diseases, such as rheumatoid arthritis...
March 16, 2018: Journal of Biological Chemistry
https://read.qxmd.com/read/29212301/convergence-of-cancer-metabolism-and-immunity-an-overview
#20
REVIEW
Chi Van Dang, Jung-Whan Kim
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells...
January 1, 2018: Biomolecules & Therapeutics
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