Yuliya Kan, Julia V Bondareva, Eugene S Statnik, Elizaveta V Koudan, Evgeniy V Ippolitov, Mikhail S Podporin, Polina A Kovaleva, Roman R Kapaev, Alexandra M Gordeeva, Julijana Cvjetinovic, Dmitry A Gorin, Stanislav A Evlashin, Alexey I Salimon, Fedor S Senatov, Alexander M Korsunsky
The study reveals the polymer-crosslinker interactions and functionality of hydrophilic nanofibers for antibacterial wound coatings. Coaxial electrospinning leverages a drug encapsulation protocol for a core-shell fiber composite with a core derived from polyvinyl alcohol and polyethylene glycol with amorphous silica (PVA-PEG-SiO2 ), and a shell originating from polyvinyl alcohol and graphene oxide (PVA-GO). Crosslinking with GO and SiO2 initiates the hydrogel transition for the fiber composite upon contact with moisture, which aims to optimize the drug release...
March 26, 2023: International Journal of Molecular Sciences