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papillomavirus classification

Varvara A Ryabkova, Yuri V Shubik, Mikhail V Erman, Leonid P Churilov, Darja Kanduc, Yehuda Shoenfeld
Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 h of symptom onset) in a person with known or unknown cardiac disease. Patients with cardiomyopathies, myocarditis, ischemic heart disease and cardiac channelopathies are at risk of SCD. However, a certain percentage of autopsy-negative cases of SCD in the young (<35 years) remain unexplained even after a post-mortem genetic testing. Autoantibodies against cardiac proteins may be potentially involved in the pathogenesis of different heart diseases and in the occurrence of unexplained SCD...
February 14, 2019: Autoimmunity Reviews
K E Dean, D Shatzkes, C D Phillips
The sinonasal tract is an environment diverse with neoplasia. Given the continued discovery of entities generally specific to the sinonasal tract, the fourth edition of the World Health Organization Classification of Head and Neck Tumors was released in 2017. It describes 3 new, well-defined entities and several less-defined, emerging entities. The new entities are seromucinous hamartomas, nuclear protein in testis carcinomas, and biphenotypic sinonasal sarcomas. Emerging entities include human papillomavirus-related sinonasal carcinomas, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-deficient sinonasal carcinomas, renal cell-like adenocarcinomas, and chondromesenchymal hamartomas...
February 14, 2019: AJNR. American Journal of Neuroradiology
M Slavik, T Kazda, I Selingerová, J Šána, P Ahmad, D Gurín, M Hermanová, T Novotný, R Červená, R Dymáčková, P Burkoň, O Slabý, P Šlampa
BACKGROUND: Oropharyngeal squamous cell tumors associated with human papillomavirus infection (p16 positive tumors) have better prognosis than p16 negative tumors regardless of the more advanced stage of the disease. Tumor volume (GTVt+n) is generally an important factor affecting treatment results of ionizing radiation. The aim of this prospective non-randomized study is to evaluate the effect of tumor volume on the (chemo)radiation treatment results in a group of patients with p16 negative and p16 positive oropharyngeal tumors...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
B Mrinakova, M Ondrušová, M Švantnerová, D Ondruš
BACKGROUND: Penile cancer belongs to group of relatively rare malignancies. It represents, on average, 0.5-1% of all tumours in males globally and occurs predominantly in older individuals (&gt; 65 years). The geographical distribution of malignant cancer of the penis is reported. A higher incidence is observed in less developed parts of the world, particularly in South America, Southeast Asia, and some areas of Africa (&gt; 2.0/100,000). In Slovakia, there has been a recent increase in incidence (1...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Francesco Bussu, Camille Ragin, Paolo Boscolo-Rizzo, Davide Rizzo, Roberto Gallus, Giovanni Delogu, Patrizia Morbini, Massimo Tommasino
BACKGROUND: A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)-induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix. METHODS: This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described. RESULTS: The diagnostic gold standard for HPV-related OPSCC, focusing on E6/E7 mRNA detection, requires fresh samples...
February 12, 2019: Head & Neck
Jin-Kyoung Oh, Hwa Young Choi, Minji Han, Jae-Kwan Lee, Kyung-Jin Min, Moran Ki
OBJECTIVE: We aimed to evaluate trends in the prevalence of human papillomavirus (HPV)-related diseases in the era before the introduction of organised HPV vaccination programmes in the Republic of Korea. METHODS: This cross-sectional study used National Health Insurance Service data from 2002 to 2015 and included participants who were diagnosed with the following HPV-related diseases (codes from the International Classification of Diseases, 10th Revision): genital warts (A63...
January 24, 2019: Sexually Transmitted Infections
Anjelica Hodgson, Ekaterina Olkhov-Mitsel, Brooke E Howitt, Marisa R Nucci, Carlos Parra-Herran
AIMS: The International Endocervical Adenocarcinoma Criteria and Classification (IECC) was recently proposed as an improved method for categorising endocervical adenocarcinoma (EA) into human papillomavirus (HPV)-associated adenocarcinomas (HPVAs) and non-HPV-associated adenocarcinomas (NHPVAs). Such categorisation correlates with patient age and tumour size; however, its association with patient outcome remains to be established. METHODS: Institutional cases of EA with histological material available were selected...
January 24, 2019: Journal of Clinical Pathology
Emi Dika, Michela Starace, Annalisa Patrizi, Pieralessandro A Fanti, Bianca Maria Piraccini
BACKGROUND: There is no consensus on the classification, grading, and the treatment of nail squamous cell carcinoma (NSCC). OBJECTIVE: The aim of the study was to propose a possible classification of NSCC. MATERIALS AND METHODS: Nail squamous cell carcinoma referred from January 2006 till December 2014 was included. On the basis of the clinical presentation, patients with NSCC were divided in 2 groups. Group A tumors presented as nodular or ulcerated masses of the nail bed, whereas Group B tumors presented as hyperkeratotic bands...
January 21, 2019: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Yuhua Yao, Huimin Xu, Manzhi Li, Zhaohui Qi, Bo Liao
BACKGROUND: Some studies have shown that human papillomavirus (HPV) is strongly associated with cervical cancer. As we all know, cervical cancer still remains the fourth most common cancer, affecting women worldwide. Thus, it is both challenging and essential to detect risk types of human papillomaviruses. METHODS: In order to discriminate whether HPV type is highly risky or not, many epidemiological and experimental methods have been proposed recently. For HPV risk type prediction, there also have been a few computational studies which are all based on machine learning (ML) techniques, but adopt different feature extraction methods...
January 17, 2019: Current Drug Metabolism
J M Vahl, T K Hoffmann
Neck dissection (ND) is an essential component of treatment in head and neck squamous cell carcinoma (HNSCC). The extent of ND depends on primary tumor location and T and N stage. Trials have demonstrated improved survival for cN+ status with therapeutic ND as well as for cN0 status with selective ND if the primary has a high incidence of occult metastasis. The accuracy of the procedure is of prognostic relevance. In the prognostic model of the TNM classification, the parameter "N" does not only reflect the number of affected lymph nodes, but also their size and extranodal tumor extension...
January 8, 2019: HNO
Mouna Jendoubi-Ferchichi, Latifa Satouri, Fatma Ghoul, Monia Malek-Mellouli, Abdel Moneem Derbel, Mohamed Kamel Makni, Hédi Reziga, Ali Baba, Mohamed Zili, Michel Segondy, Ridha Khelifa
Background: High-risk human papillomavirus (HPV) types are the main etiological factors for cervical cancer. HPV16 and HPV18 are generally the most common forms associated with development of high-grade cervical lesions. This study was undertaken to identify intratypic variants of HPV16 and HPV18 among women with cervical lesions in Tunisia. Materials and Methods: DNA was extracted from cervical samples collected from 49 women. using a PureLinkTM Genomic DNA mini Kit (Invitrogen). E6 and L1 open reading frames (ORF) were amplified by PCR and viral DNA amplicons were subjected to automated sequencing using Big Dye Terminators technology (Applied Biosystems)...
December 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
James Howard, Raghav C Dwivedi, Liam Masterson, Prasad Kothari, Harry Quon, F Christopher Holsinger
BACKGROUND: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Traditional management of OPSCC has been with radiotherapy with or without chemotherapy, as this was shown to have similar survival to open surgery but with significantly lower morbidity...
December 14, 2018: Cochrane Database of Systematic Reviews
Susan Müller, Sonja C Boy, Terrence A Day, Kelly R Magliocca, Mary S Richardson, Philip Sloan, Wanninayake M Tilakaratne, Rosnah B Zain, Lester D R Thompson
The International Collaboration on Cancer Reporting is a nonprofit organization whose goal is to develop evidence-based, internationally agreed-upon standardized data sets for each cancer site for use throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to the objective of improved patient management and enhanced epidemiologic research. Carcinomas of the oral cavity continue to represent a significant oncologic management burden, especially as changes in alcohol and tobacco use on a global scale contribute to tumor development...
November 30, 2018: Archives of Pathology & Laboratory Medicine
Martin J Bullock, Jonathan J Beitler, Diane L Carlson, Isabel Fonseca, Jennifer L Hunt, Nora Katabi, Philip Sloan, S Mark Taylor, Michelle D Williams, Lester D R Thompson
Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tract, nasopharynx, oropharynx, hypopharynx, oral cavity, and larynx), along with bone tumors, skin cancers, melanomas, and other tumor categories...
November 30, 2018: Archives of Pathology & Laboratory Medicine
Shin Hye Yoo, Chan-Young Ock, Bhumsuk Keam, Sung Joon Park, Tae Min Kim, Jin Ho Kim, Yoon Kyung Jeon, Eun-Jae Chung, Seong Keun Kwon, J Hun Hah, Tack-Kyun Kwon, Kyeong Chun Jung, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Background/Aims: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not all HPV-positive HNSCCs are curable, and some patients have a poor prognosis. The purpose of this study was to identify poor prognostic factors in patients with HPV-positive HNSCC. Methods: Patients who received a diagnosis of HNSCC and tested positive for HPV from 2000 to 2015 at a single hospital site (n = 152) were included in this retrospective analysis...
November 16, 2018: Korean Journal of Internal Medicine
Denisse A Gutiérrez, Armando Varela-Ramírez, Miriam Rodríguez-Esquivel, Mónica G Mendoza-Rodríguez, Jorge T Ayala-Sumuano, David Pineda, Efraín Garrido-Guerrero, Florinda Jiménez-Vega, Saúl Aguilar, Miguel Quiñones, María J Nambo, Pedro Chávez-Olmos, Keiko Taniguchi-Ponciano, Daniel Marrero-Rodriguez, Pablo Romero-Morelos, Joanna P Castro, Cindy Bandala, Andrea Carrillo-Romero, Beatriz González-Yebra, Mauricio Salcedo
BACKGROUND: This study presents a prediction of putative miRNA within several Human Papillomavirus (HPV) types by using bioinformatics tools and a strategy based on sequence and structure alignment. Currently, little is known about HPV miRNAs. METHODS: Computational methods have been widely applied in the identification of novel miRNAs when analyzing genome sequences. Here, ten whole-genome sequences from HPV-6, -11, -16, -18, -31, -33, -35, -45, -52, and -58 were analyzed...
November 3, 2018: Archives of Medical Research
Keegan M Lyons, Samantha L Butler
Anal squamous cell carcinoma is a relatively rare diagnosis, but its incidence has continued to rise. Anal squamous cell carcinoma and its precursor lesion, anal intraepithelial neoplasia (AIN), are human papillomavirus (HPV)-associated squamous neoplasias. High-risk HPV subtypes cause cellular proliferation in the anal transformation zone mucosa leading to similar dysplastic changes as seen in the cervix. Unified cytologic and histologic classification systems have emerged for all HPV-associated squamous lesions of the lower anogenital tract due to recent advancements in the understanding of these lesions...
November 2018: Clinics in Colon and Rectal Surgery
Andreia Albuquerque, Elisabete Rios, Rui Medeiros
Histological grading of squamous intraepithelial lesions or intraepithelial neoplasia is fundamental for clinical management and for assessment of the risk of progression. Biomarkers are important for assisting correct grading of these lesions, reducing inter and intraobserver variability and most promising, for prognosis. Although p16 is the most studied biomarker in this setting, there are several other biomarkers that have been studied, reflecting also the need to find a better single or association option that can be more suitable, especially for classification purposes...
October 19, 2018: Histology and Histopathology
Philipp Baumeister, Alessandra Hollmann, Julia Kitz, Artemis Afthonidou, Florian Simon, Julius Shakhtour, Brigitte Mack, Gisela Kranz, Darko Libl, Martin Leu, Markus A Schirmer, Martin Canis, Claus Belka, Horst Zitzelsberger, Ute Ganswindt, Julia Hess, Mark Jakob, Kristian Unger, Olivier Gires
Locally advanced head and neck squamous cell carcinomas (HNSCC) have limited prognosis due to frequent treatment failure. Currently, TNM-classification and human papillomavirus (HPV) infection are the sole clinical prognosticators of outcome. Tumor heterogeneity and stemness based on epithelial-mesenchymal-transition reportedly associate with therapy resistance. The capacity of epithelial marker EpCAM (EpEX), stemness regulator Sox2 and mesenchymal marker vimentin to predict clinical outcome of HSNCC patients was assessed upon immunohistochemistry staining in two cohorts of HNSCC patients treated with surgery and adjuvant radio (chemo) therapy (n = 94) and primary radio (chemo) therapy (n = 94), respectively...
October 1, 2018: Scientific Reports
Vivian M Spaans, Daniëlla A Scheunhage, Bianca Barzaghi, Cor D de Kroon, Gert J Fleuren, Tjalling Bosse, Ekaterina S Jordanova
OBJECTIVE: Recently, the pattern of invasion in usual-type human papillomavirus-associated endocervical adenocarcinoma (AC) was put forward as a novel variable to select patients with favourable prognosis. Based on destructiveness of stromal invasion, three patterns were proposed: A - no destructive stromal invasion, B - focal destructive stromal invasion, and C - diffuse destructive stromal invasion. We aimed to independently validate the clinical significance of this classification-system in 82 AC patients, and explored associations between invasion pattern and somatic mutations...
November 2018: Gynecologic Oncology
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