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Pablo Antonio Ysunza, Kongkrit Chaiyasate, Matthew Rontal, Kenneth Shaheen, Blake Bartholomew
BACKGROUND: Velopharyngeal insufficiency (VPI) occurs when the velopharyngeal sphincter (VPS) is unable to completely seal anatomical closure between the nasal and oral cavities during speech. Palatal repair can restore VPS function but the prevalence of VPI after repair has been reported ranging from 20% to 40%. The combination of flexible videonasopharyngoscopy (FVNP) and multiplanar videofluoroscopy (MPVF) has been reported as the best approach for assessing the VPS mechanism and planning effective surgical procedures aimed to correct VPI...
February 11, 2019: International Journal of Pediatric Otorhinolaryngology
Leonardo Guzmán-Martínez, José Pablo Tapia, Gonzalo A Farías, Andrea González, Matías Estrella, Ricardo B Maccioni
The establishment of a molecular biomarker for early detection of Alzheimer's disease (AD) is critical for diagnosis and follow up of patients, and as a quantitative parameter in the evaluation of potential new drugs to control AD. A list of blood biomarkers has been reported but none has been validated for the Alzheimer's clinic. The changes in hyperphosphorylated tau and amyloid peptide in the cerebrospinal fluid is currently used as a tool in the clinics and for research purposes, but this method is highly invasive...
February 11, 2019: Journal of Alzheimer's Disease: JAD
Juan Pablo Borges Rodrigues Maricevich, Auricelio B Cezar-Junior, Edilson Xavier de Oliveira-Junior, Jose Arthur Morais Veras E Silva, Jorge Vicente Lopes da Silva, Amanda Amorin Nunes, Nivaldo S Almeida, Hildo Rocha Cirne Azevedo-Filho
Background: Cranial reconstruction surgery is a procedure used as an attempt to reestablish the cranial bone anatomy. This study evaluates the symptomatic and aesthetic improvement of patients with cranial defects secondary to decompressive craniectomies after cranial reconstruction with customized polymethyl methacrylate (PMMA) prostheses. Secondly, we aim to divide our experience in the production of these prostheses with a low-cost method. Methods: A prospective study was carried out with patients submitted to cranioplasty at the Hospital da Restauração between 2014 and 2017...
2019: Surgical Neurology International
Bing Li, J Pablo Muñoz, Xuejian Rong, Qingtian Chen, Jizhong Xiao, Yingli Tian, Aries Arditi, Mohammed Yousuf
This paper presents a new holistic vision-based mobile assistive navigation system to help blind and visually impaired people with indoor independent travel. The system detects dynamic obstacles and adjusts path planning in real-time to improve navigation safety. First, we develop an indoor map editor to parse geometric information from architectural models and generate a semantic map consisting of a global 2D traversable grid map layer and context-aware layers. By leveraging the visual positioning service (VPS) within the Google Tango device, we design a map alignment algorithm to bridge the visual area description file (ADF) and semantic map to achieve semantic localization...
March 2019: IEEE transactions on mobile computing
Hossein Bagheri, Michael Schmitt, Pablo d'Angelo, Xiao Xiang Zhu
Currently, numerous remote sensing satellites provide a huge volume of diverse earth observation data. As these data show different features regarding resolution, accuracy, coverage, and spectral imaging ability, fusion techniques are required to integrate the different properties of each sensor and produce useful information. For example, synthetic aperture radar (SAR) data can be fused with optical imagery to produce 3D information using stereogrammetric methods. The main focus of this study is to investigate the possibility of applying a stereogrammetry pipeline to very-high-resolution (VHR) SAR-optical image pairs...
December 2018: ISPRS Journal of Photogrammetry and Remote Sensing
Pablo Druetta, Francesco Picchioni
The use of standard enhanced oil recovery (EOR) techniques allows for the improvement of oilfield performance after waterflooding processes. Chemical EOR methods modify different properties of fluids and/or rock to mobilize the remaining oil. Moreover, combined techniques have been developed to maximize the performance by using the joint properties of the chemical slugs. A new simulator is presented to study a surfactant-polymer flooding, based on a two-phase, five-component system (aqueous and oleous phases with water, petroleum, polymer, surfactant, and salt) for a 2D reservoir model...
December 20, 2018: Energy & Fuels: An American Chemical Society Journal
Paul Muleli Kioko, Pablo Requena Meana
No abstract text is available yet for this article.
March 2019: British Journal of Psychiatry: the Journal of Mental Science
Andrea Corda, Maria Luisa Pinna Parpaglia, Giovanni Sotgiu, Rosanna Zobba, Pablo Gomez Ochoa, Jorge Prieto Ramos, Anne French
BACKGROUND: Early identification of systolic dysfunction in dogs with systemic inflammatory response syndrome (SIRS) potentially could improve the outcome and decrease mortality. OBJECTIVE: To compare 2-dimensional speckle tracking (2D-STE) with 2-dimensional (2D) and M-mode echocardiography in the evaluation of systolic function in SIRS dogs. ANIMALS: Seventeen SIRS and 17 healthy dogs. METHODS: Prospective observational case-control study...
February 17, 2019: Journal of Veterinary Internal Medicine
Xiaodong Feng, Nadia Arang, Damiano Cosimo Rigiracciolo, Joo Sang Lee, Huwate Yeerna, Zhiyong Wang, Simone Lubrano, Ayush Kishore, Jonathan A Pachter, Gabriele M König, Marcello Maggiolini, Evi Kostenis, David D Schlaepfer, Pablo Tamayo, Qianming Chen, Eytan Ruppin, J Silvio Gutkind
Activating mutations in GNAQ/GNA11, encoding Gαq G proteins, are initiating oncogenic events in uveal melanoma (UM). However, there are no effective therapies for UM. Using an integrated bioinformatics pipeline, we found that PTK2, encoding focal adhesion kinase (FAK), represents a candidate synthetic lethal gene with GNAQ activation. We show that Gαq activates FAK through TRIO-RhoA non-canonical Gαq-signaling, and genetic ablation or pharmacological inhibition of FAK inhibits UM growth. Analysis of the FAK-regulated transcriptome demonstrated that GNAQ stimulates YAP through FAK...
February 4, 2019: Cancer Cell
Jorge Javier Ramírez Argueta, Juan Pablo Díaz Molina, Ricardo Jose Ortiz Oliva, Roman Carlos Bregni, Yomara Bustamante
BACKGROUND AND OBJECTIVE: to describe the results of the treatment of invasive fungal sinusitis with nasal endoscopic surgery in an immunocompromised paediatric oncological population. METHODS: retrospective study of all patients diagnosed with invasive fungal sinusitis operated in the National Paediatric Oncology Unit between 2012 and 2016. Data taken from their medical history included: epidemiological characteristics, oncological diagnosis, haematological data, symptoms, tomographic studies, surgical interventions, results of pathology and cultures, medications received, complications, evolution and survival...
February 14, 2019: Acta Otorrinolaringológica Española
Juan Fernando Suárez-Varela Úbeda, Sara Rodríguez-Vázquez, José Antonio Ordóñez Barranco, Gilberto Vega Caldera, Pedro Pablo Pérez Alvárez, Francisco Buitrago
BACKGROUND: The efficacy of smoking cessation interventions can be quite diverse in day-to-day clinical practice. OBJECTIVE: To analyse the effectiveness in smoking cessation of multicomponent interventions carried out in groups or individually in primary care practices. METHODS: A quasi-experimental, multicentre study of 12-month follow-up of patients treated in multicomponent smoking cessation interventions was carried out in Urban health care centres in Sevilla, Spain...
February 17, 2019: Family Practice
Ana González-Mansilla, Pablo Martinez-Legazpi, Andrea Prieto, Elena Gomá, Pilar Haurigot, Candelas Pérez Del Villar, Victor Cuadrado, Antonia Delgado-Montero, Raquel Prieto, Teresa Mombiela, Esther Pérez-David, Elena Rodríguez González, Yolanda Benito, Raquel Yotti, Manuel Pérez-Vallina, Francisco Fernández-Avilés, Javier Bermejo
OBJECTIVE: To obtain reference values of aortic valve area (AVA) in a large population and to infer the risk of overestimating aortic stenosis (AS) when focusing on flow-corrected indices of severity. METHODS: We prospectively measured indices of AS in all consecutive echocardiograms performed in a large referral cardiac imaging laboratory for 1 year. We specifically analysed the distribution of AVA, indexed AVA and velocity ratio (Vratio) in patients with and without AS, the latter defined as the coexistence of valvular outflow obstruction (Vmax ≥2...
February 16, 2019: Heart: Official Journal of the British Cardiac Society
Renato Nieto-Aguilar, Deyanira Serrato-Ochoa, Rafael Medina-Navarro, Asdrúbal Aguilera-Méndez, Karina Denisse Morales-Soto, Juan Pablo Loyola-Rodriguez, Antonio Campos, Miguel Alaminos
OBJECTIVE: To assess the retention efficiency of three types of temporary zinc oxide cement trademarks on forced eruption using intracranal wire device. METHODS: An in vitro evaluation included intracanal wire device displacement and detachment at 50g load force for 120 days and then the retention resistance at maximum load force. RESULTS: All groups of temporary zinc oxide cements were efficient to support 50g load forces after 120 days. None statistical differences were found between groups...
February 13, 2019: International Orthodontics
Pablo Rodríguez García, Juan Castañer Ramón-Llín, Elena Romera Barba, Ainhoa Sánchez Pérez, José Luis Vázquez Rojas
No abstract text is available yet for this article.
February 13, 2019: Gastroenterología y Hepatología
Isaac Pascual, Pablo Avanzas, Daniel Hernández-Vaquero, Rocío Díaz, Raquel Del Valle, Remigio Padrón, Rebeca Lorca, Victor León, María Martín, Fernando Alfonso, César Morís
BACKGROUND: The aim of this study was to assess the safety and effectiveness of valve in valve (VIV) TAVI with the autoexpandable valve, specifically in patients with failed Mitroflow (MF) bioprosthetic aortic valves. METHODS: Pilot, single center, observational and prospective study that included 45 consecutive patients with symptomatic failed MF bioprosthetic aortic valve, referred for VIV TAVI. The safety primary endpoint was a composite of early events at 30 days, defined by VARC-2 criteria...
February 1, 2019: International Journal of Cardiology
Francisca Di Pillo, Gustavo Anríquez, Pablo Alarcón, Pedro Jimenez-Bluhm, Pablo Galdames, Vanesa Nieto, Stacey Schultz-Cherry, Christopher Hamilton-West
Backyard production systems (BPS) that involve poultry are a good way to improve food security and poverty alleviation. Few studies have been carried out to quantify the contribution of poultry production to these households and the constraints they might face if a priority animal disease enters these systems. This study aims to characterize the poultry-rearing BPS in central Chile and to identify socio-economic factors associated to households' consumption of poultry. Data was collected from 384 BPS through a face-to-face semi-structured questionnaire...
March 1, 2019: Preventive Veterinary Medicine
Ricardo Alonso, Edgar Carnero Contentti, Gaston Imhoff, Pablo A Lopez, Adrian Rubstein, Santiago Tizio
Current multiple sclerosis (MS) therapeutic options have significantly increased treatment algorithm complexity. This urges physicians to take into account multiple factors in the decision-making process and make an even more thorough analysis of the risk-benefit balance. We carried out a descriptive review aiming to assess some factors that endanger the proper MS treatment fulfillment, focusing mainly on Latin American countries. Firstly, it is paramount to warrant the correct, fair and timely treatment access...
February 7, 2019: Multiple Sclerosis and related Disorders
Johnny Lisboa, Louisa Celma, Dyana Sanchez, Mathilde Marquis, Jessica Andreani, Raphael Guérois, Françoise Ochsenbein, Dominique Durand, Stéphanie Marsin, Philippe Cuniasse, J Pablo Radicella, Sophie Quevillon-Cheruel
DprA, a ubiquitous multidomain DNA-binding protein, plays a crucial role during natural transformation in bacteria. Here, we carried out the structural analysis of DprA from the human pathogen Helicobacter pylori by combining data issued from the 1.8 Å resolution X-ray structure of the Pfam02481 domain dimer (RF), the NMR structure of the carboxy-terminal domain (CTD) and the low-resolution structure of the full-length DprA dimer obtained in solution by SAXS. In particular, we sought a molecular function for the CTD, a domain that we show here is essential for transformation in H...
February 16, 2019: FEBS Journal
Isabel R Rodríguez-Ortiz, Francisco J Moreno-Pérez, Pablo Delgado, David Saldaña
The present study focuses on the development of Spanish pronominal processing. We investigate whether the pronoun interpretation problem (i.e., reflexive pronouns comprehension is resolved at an earlier age than that of personal pronouns, also known as the Delay of the Principle B Effect), which has been documented in other languages, also occurs in Spanish. For this purpose, we conducted two experiments including pronoun resolution tasks. In Experiment 1, a task adapted from the experimental paradigm proposed by Love et al...
February 15, 2019: Journal of Psycholinguistic Research
Pablo Monsivais, Oliver Francis, Robin Lovelace, Michael Chang, Emma Strachan, Thomas Burgoine
In the original version of this Article the following funding details were omitted from the Acknowledgements section.
February 15, 2019: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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