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Iron absorption and vitamin C

S Sourabh, P Bhatia, R Jain
Treatment in IRIDA focuses on use of intravenous iron preparations to circumvent oral absorptive defect resulting from high levels of hepcidin due to TMPRSS6 gene variations. However, recent case reports and recommendations on atypical microcytic hypochromic anemias advocate use of oral iron and vitamin c trial before parenteral iron, as the same results in comparable improvement in haemoglobin. We prospectively evaluated our IRIDA cohort (n = 7) with oral iron and vitamin c dose over a period of 10 weeks and noted complete response in majority (6/7 = 86%) with >2 g/dL rise in Hb along with significant improvement of other iron related indices...
December 13, 2018: Blood Cells, Molecules & Diseases
Luca Pecoraro, Lucia Martini, Franco Antoniazzi, Giorgio Piacentini, Angelo Pietrobelli
Vitamin C is an organic compound that is almost ubiquitous in the daily diet of individuals. There are clear indications of supplementation when secondary deficiency is detected related with reduced dietary intake or reduced absorption. On the other hand, indications for supplementation concerning an increased need are controversial. Several authors have studied the role of vitamin C as an adjuvant in the treatment of diseases that may affect children and adolescents. These diseases affect all organs and systems: specifically, vitamin C supplementation could play a role in respiratory, neurological, psychiatric, oncohematological, nephrological, ophthalmological and nutritional disorders...
December 4, 2018: International Journal of Food Sciences and Nutrition
Huan He, Yang Qiao, Zeyu Zhang, Zelong Wu, Dan Liu, Zhangping Liao, Dong Yin, Ming He
Vitamin C, an excellent reducing agent, aids in increasing absorbable ferrous iron in iron deficiency anemia. As an efficient antioxidant, it is still unknown whether vitamin C exerts protective effects against liver damage caused by iron excess and whether mitochondria are the target effectors of the above effects. In this study, 48 mice were randomly divided into a control group, iron-overload group, TAU-treated + iron-overload group and vitamin C-treated + iron-overload group with 12 mice per group. The mice were fed 4 months on pellet diets supplemented with iron in the form of ferrocene...
October 17, 2018: Food & Function
Dripta Roy Choudhury, Krishnapillai Madhavan Nair, Nagalla Balakrishna, Kankipati Vijaya Radhakrishna, Sudip Ghosh, Sylvia Fernandez Rao
Iron deficiency anemia (IDA) is a significant public health issue in India affecting nearly all vulnerable segments of the population. Causes of IDA include low consumption of iron-rich foods combined with poor iron bioavailability of nonheme iron sources. To date, interventions aimed at correcting IDA focus on increasing iron intake through iron supplementation or fortification strategies. In contrast, dietary diversification is a long-term sustainable approach to improve bioavailable iron intake. In this context, the inclusion of vitamin C-rich fruits in the regular diet has proven to improve iron absorption, but the effect on iron status is inconclusive...
August 21, 2018: Annals of the New York Academy of Sciences
Timothy H Ciesielski, Joel Schwartz, David C Bellinger, Russ Hauser, Chitra Amarasiriwardena, David Sparrow, Robert O Wright
BACKGROUND: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism. Our aim was to evaluate associations between common HFE and Transferrin polymorphisms and toenail cadmium levels among older men. METHODS: In a longitudinal cohort of men age 51-97, the Normative Aging Study (NAS), we evaluated toenail cadmium concentrations and missense single nucleotide polymorphisms (SNPs) in the HFE and Transferrin genes...
October 2018: Environment International
Majed M AbuKhader
AIM: To assess the suitability of iron content and the nutritional benefits of selected fortified food products marketed for 4-8 year old children in Oman. METHODS: Forty-five fortified foods, which are available in Omani markets, were classified into four groups based on food type and composition: ready-to-eat (RTE) breakfast cereals (two groups), malted milk drinks and milk powder formulas. The nutrition panel displayed on the products' outer package was used as a source of content values for iron and other nutrients...
June 2018: Nutrition and Health
Christopher R D'Adamo, James S Novick, Termeh M Feinberg, Valerie J Dawson, Larry E Miller
OBJECTIVE: Iron deficiency is the most common nutrient deficiency in the world. While deficiency can often be resolved through dietary supplementation with iron, adverse events are common and frequently preclude compliance. The objective of this study was to determine whether a food-derived dietary supplement containing a low dose of iron and nutrients that increase iron absorption could resolve iron deficiency with fewer adverse events than reported at higher doses. METHODS: A pilot clinical trial (NCT02683369) was conducted among premenopausal women with nonanemic iron deficiency that was verified by blood screening...
May 2018: Journal of the American College of Nutrition
K S Akinwande, O A Morenikeji, O G Arinola
Adequate nutrition is essential for normal growth of children but helminth infection is proposed to cause nutritional deficiencies. This study was carried out to assess the nutritional status of helminth infected school aged children in semi-urban communities of South-West Nigeria. Two hundred children from primary schools in Akinyele Local Government of Oyo State, Nigeria participated in the study. Anthropometric measurements were analyzed using the WHO AnthroPlus software. Kato Katz method was used to detect ova of helminths in the stool while serum levels of iron, zinc, selenium, ferritin, transferrin, vitamin A, vitamin C and haptoglobin were measured using High Performance Liquid Chromatography and Atomic Absorption Spectophotometry as appropriate...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
K Madhavan Nair, Little Flower Augustine
Plant foods are endowed with micronutrients but an understanding of bioavailability is essential in countries primarily dependent on plant based foods. Bioavailability depends majorly on food synergies. This review examines the nature of certain food synergies and methods to screen and establish it as a strategy to control micronutrient deficiency in the populations. Strong evidence on the synergistic effect of inclusion of vitamin C rich fruits and non-vegetarian foods in enhancing the bioavailability of iron has been demonstrated...
January 1, 2018: Food Chemistry
Amanda D French, Warren C Conway, Jaclyn E Cañas-Carrell, David M Klein
Due to long term declines of American Woodcock (Scolopax minor) and widespread distribution of environmentally available lead (Pb) throughout their geographic range, it is important to assess if Pb exposure is a potential contributor to these declines. Woodcock are exposed to Pb through various environmental sources and are known to exhibit relatively high bone-Pb concentrations. Absorption of Pb by birds, and woodcock specifically, is not well understood. Some studies show that interactions among calcium, phosphorus, iron, zinc, and vitamin D levels may play an important role in Pb absorption...
September 2017: Bulletin of Environmental Contamination and Toxicology
Dylan T Dahlquist, Trent Stellingwerff, Brad P Dieter, Donald C McKenzie, Michael S Koehle
Iron deficiency has ergolytic effects on athletic performance. Exercise-induced inflammation impedes iron absorption in the digestive tract by upregulating the expression of the iron regulatory protein, hepcidin. Limited research indicates the potential of specific macro- and micronutrients on blunting exercise-induced hepcidin. Therefore, we investigated the effects of postexercise supplementation with protein and carbohydrate (CHO) and vitamins D3 and K2 on the postexercise hepcidin response. Ten highly trained male cyclists (age: 26...
October 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Yuanyuan Chen, Jian Li, Jin Wei, Atufa Kawan, Li Wang, Xuezhen Zhang
Cyanobacterial blooms and their associated toxins pose a great threat to human beings. The situation is even worse for those whose drinking water source is a cyanotoxin-polluted water body. Therefore, efficient and safe treatments urgently need to be developed. The present study verified the application of vitamin C on the inhibition of toxic Microcystis aeruginosa. Our results showed that vitamin C drove the Fenton reaction and significantly sterilized cultures of M. aeruginosa. The algicidal activity of vitamin C was dependent on its involvement in iron (Fe) metabolism...
January 5, 2017: Journal of Hazardous Materials
Tanjim Sultana, Maria V DeVita, Michael F Michelis
PURPOSE: Functional iron deficiency (FID) is a major cause of persistent anemia in dialysis patients and also contributes to a suboptimal response to erythropoietin (Epo) administration. Vitamin C acts as an enzyme cofactor and enhances mobilization of the ferrous form of iron to transferrin thus increasing its bioavailability. High-dose intravenous vitamin C has been shown to decrease the Epo requirement and improve hemoglobin levels in previous studies. This study assessed the effect of low-dose oral vitamin C on possible reduction in Epo dose requirements in stable hemodialysis patients with FID...
September 2016: International Urology and Nephrology
Günay Eskici
Soccer is one of the most widely played and complex sports in the world, where success depends on technical, tactical and physical skills of the players. Studies to improve performance in soccer have often focused on technique and tactics. However, nutrition is one of the most important factors influencing athletic performance of the players. The duration of matches is long and the training is intense. This leads to increased requirements for energy and nutrients, as well as increased reactive oxygen radicals and hence increased muscle damage...
December 2015: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Georg Lietz, Harold C Furr, Bryan M Gannon, Michael H Green, Marjorie Haskell, Veronica Lopez-Teros, Janet A Novotny, Amanda C Palmer, Robert M Russell, Sherry A Tanumihardjo, Carolien A Van Loo-Bouwman
BACKGROUND: Retinol isotope dilution (RID) methodology provides a quantitative estimate of total body vitamin A (VA) stores and is the best method currently available for assessing VA status in adults and children. The methodology has also been used to test the efficacy of VA interventions in a number of low-income countries. Infections, micronutrient deficiencies (eg, iron and zinc), liver disease, physiological age, pregnancy, and lactation are known or hypothesized to influence the accuracy of estimating total body VA stores using the isotope dilution technique...
June 2016: Food and Nutrition Bulletin
Molly A Moor, Miguel A Fraga, Richard S Garfein, Judith Harbertson, Alfonso Rodriguez-Lainz, Hooman H Rashidi, John P Elder, Stephanie K Brodine
Anemia is a public health problem in Mexico. This study sought to determine the prevalence and correlates of anemia among women and children residing in a rural farming region of Baja California, Mexico. An existing partnership between universities, non-governmental organizations, and an underserved Mexican community was utilized to perform cross-sectional data collection in 2004-2005 (Wave 1) and in 2011-2012 (Wave 2) among women (15-49 years) and their children (6-59 months). All participants completed a survey and underwent anemia testing...
August 2016: Journal of Community Health
Z K Bakhmulaeva, S A Magadova
Micronutrient content in Pearl Zala, Pearl Saba, Creamy, and Amber Muscat varieties of grape has been determined. The ultimate analysis has been made by the atomic-absorption flame photometry; ascorbic acid has been determined by the titrometric analysis; rutin, niacin, and carotene have been studied by the colorimetric method. It has been found that the content of potassium (2673.8 mg/kg), calcium (349.0 mg/kg), iron (35.9 mg/kg), silicon (611.3 mg/kg), manganese (0.89 mg/kg) and vitamin C (5.3 mg/dm3) was the highest in Pearl Zala grapes, while the content of zinc (0...
2015: Voprosy Pitaniia
Carlos Walter Sobrado, Rodolfo Delfini Cançado, Lucas Faraco Sobrado, Marcos Onofre Frugis, Marcel Faraco Sobrado
OBJECTIVES: Anemia is the most common hematological alteration in patients with Crohn's disease, and is frequently related to intestinal inflammatory activity. Its cause is multifactorial and mostly associated with absolute iron deficiency (iron deficiency anemia) and/or functional iron deficiency (inflammation anemia or anemia of chronic disease). It may also be identified through other causes, such as folic acid or vitamin B12 deficiency and secondary to adverse effects from medications (salicylic derivatives and immunosuppressive drugs)...
December 2015: Arquivos de Gastroenterologia
Renee A Mischler, Seth M Armah, Breanne N Wright, Samer G Mattar, Arthur D Rosen, Nana Gletsu-Miller
BACKGROUND: Iron deficiency is common after Roux-en-Y gastric bypass (RYGB) surgery, but there is no consensus on the optimal diet quality and quantity for restoring and preserving iron status. OBJECTIVES: The authors explored the impact of dietary and supplemental sources of iron and absorptive factors on iron status. SETTING: Academic, United States. METHODS: In a cross-sectional cohort of individuals who underwent RYGB, nutrient intakes from food and supplements were measured using 3-day food records...
March 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
I E Mbaeyi-Nwaoha, N O Uchendu
Breakfast cereals was formulated from blends of acha and fermented okara (soybean residue). Acha grains were cleaned, winnowed, washed, dried (at 50 °C for 4 h) and milled into flour. Okara was processed from soybean seed through the stepwise procedure of cleaning, soaking, washing, milling and sieving. The residue was divided into five portions, fermented differently for 0, 12, 24, 36, and 48 h and then dried at 50 °C for 6 h. Acha flour (UFAC) was milled and blended at 50, 60, 70, 80, 90, 100 % ratio with milled okara flour...
January 2016: Journal of Food Science and Technology
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