keyword
https://read.qxmd.com/read/38537231/pentafecta-evaluation-in-robot-assisted-radical-prostatectomy-by-risk-group
#1
JOURNAL ARTICLE
Víctor E Corona-Montes, Juan E Sánchez-Núñez, Rocío N Gómez-López, Gerardo Fernández-Noyola
OBJECTIVE: Radical prostatectomy is a therapeutic option in organ-confined prostate cancer. As the development of robotic systems progresses, the approach with this technology has begun to impact the functional and oncological outcomes of urological patients. The objective is to report the rate of pentafecta in patients undergoing robot-assisted radical prostatectomy (RARP) stratified by risk groups. METHOD: Retrospective, observational, descriptive study from 2013 to 2020 that included 112 patients undergoing RARP...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537072/clinicopathologic-characteristics-and-outcomes-of-prostate-cancer-incidentally-discovered-at-the-time-of-radical-cystoprostatectomy-a-population-based-cohort-study
#2
JOURNAL ARTICLE
Kan Wu, Xu Liu, Yaxiong Tang, Xianding Wang, Xiang Li
OBJECTIVE: This study aimed to comprehensively analyze the clinical characteristics and prognosis of patients with concomitant bladder cancer (BCa) and prostate cancer (PCa) using a large population-based database. METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019), we identified patient with concomitant PCa at the time of radical cystoprostatectomy (RCP). Logistic regression and propensity score matching (PSM) analyses were employed to identify risk factors and mitigate confounders, respectively...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536892/subgraph-isomorphic-decision-tree-to-predict-radical-thermochemistry-with-bounded-uncertainty-estimation
#3
JOURNAL ARTICLE
Hao-Wei Pang, Xiaorui Dong, Matthew S Johnson, William H Green
Detailed chemical kinetic models offer valuable mechanistic insights into industrial applications. Automatic generation of reliable kinetic models requires fast and accurate radical thermochemistry estimation. Kineticists often prefer hydrogen bond increment (HBI) corrections from a closed-shell molecule to the corresponding radical for their interpretability, physical meaning, and facilitation of error cancellation as a relative quantity. Tree estimators, used due to limited data, currently rely on expert knowledge and manual construction, posing challenges in maintenance and improvement...
March 27, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38536728/bis-aluminyl-magnesium-a-source-of-nucleophilic-or-radical-aluminium-centred-reactivity
#4
JOURNAL ARTICLE
Liam Griffin, Mathias Ellwanger, Jonathon Clark, William Myers, Aisling Roper, Andreas Heilmann, Simon Aldridge
The homoleptic magnesium bis(aluminyl) compound Mg[Al(NON)]2 (NON = 4,5-bis(2,6-diisopropylanilido)-2,7-di-tert-butyl -9,9-dimethylxanthene) can be accessed from K2[Al(NON)]2 and MgI2 and shown to possess a non-linear geometry (ÐAl-Mg-Al = 164.8(1)°) primarily due to the influence of dispersion interactions. This compound acts a four-electron reservoir in the reductive de-fluorination of SF6, and reacts thermally with polar substrates such as MeI via nucleophilic attack through aluminium, consistent with the QT-AIM charges calculated for the metal centres, and a formal description as a Al(I)-Mg(II)-Al(I) trimetallic...
March 27, 2024: Angewandte Chemie
https://read.qxmd.com/read/38536672/visible-light-induced-radical-addition-elimination-reaction-for-constructing-allylic-sulfones-from-sulfonyl-chlorides-and-allyl-bromides
#5
JOURNAL ARTICLE
Rui-Xue Li, Yuan Chen, Lan-Qian Huang, Zhi Guan, Yan-Hong He
Allyl sulfones are commonly present in bioactive compounds and organic building blocks. This work introduces a photocatalytic radical addition-elimination reaction involving readily accessible sulfonyl chlorides and allyl bromides. It delivers structurally diverse allylic sulfones in moderate to excellent yields, showcasing a high tolerance to functional groups. Notably, this method operates under mild reaction conditions without the need for oxidants, stoichiometric reducing metals, or additives.
March 27, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38536585/the-key-role-of-tumor-budding-in-predicting-the-status-of-lymph-node-involvement-in-early-gastric-cancer-patients-a-clinical-multicenter-validation-in-china
#6
JOURNAL ARTICLE
Xiangyu Wang, Xiuding Yang, Fenglin Cai, Mingzhi Cai, Yong Liu, Li Zhang, Rupeng Zhang, Fangqin Xue, Yan Sun, Jingyu Deng
BACKGROUND: Accurate preoperative prediction of lymph node (LN) involvement is essential for the management of early gastric cancer (EGC). Our objective was to formulate a potent nomogram for predicting LN involvement in EGC by leveraging an innovative predictor of tumor budding. METHODS: We assembled a cohort of EGC patients who underwent radical surgery at two tertiary cancer centers. Tumor budding was stratified by using an optimal cutoff value and integrated with other clinicopathological variables to ascertain the risk factors associated with LN involvement...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38536582/aso-author-reflections-advancing-early-outcome-assessment-in-robot-assisted-radical-cystectomy-rarc-tetrafecta
#7
JOURNAL ARTICLE
Wan Song, Jiwoong Yu, Byong Chang Jeong
No abstract text is available yet for this article.
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38536516/the-role-of-oxidative-stress-in-the-pathogenesis-of-ocular-diseases-an-overview
#8
REVIEW
Miao Zhang, Ruixue Zhang, Xiaoyue Zhao, Zhongyu Ma, Jizhao Xin, Shuqin Xu, Dadong Guo
Dysregulation of oxidative stress serves as a pivotal predisposing or exacerbating factor in the intricate development of numerous pathological processes and diseases. In recent years, substantial evidence has illuminated the crucial role of reactive oxygen species (ROS) in many fundamental cellular functions, including proliferation, inflammation, apoptosis, and gene expression. Notably, producing free radicals within ROS profoundly impacts a wide range of biomolecules, such as proteins and DNA, instigating cellular damage and impairing vital cellular functions...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536104/radical-reactions-enabled-by-polyfluoroaryl-fragments-photocatalysis-and-beyond
#9
REVIEW
Mikhail O Zubkov, Alexander D Dilman
Polyfluoroarenes have been known for a long time, but they are most often used as fluorinated building blocks for the synthesis of aromatic compounds. At the same time, due to peculiar fluorine effect, they have unique properties that provide applications in various fields ranging from synthesis to materials science. This review summarizes advances in the radical chemistry of polyfluoroarenes, which have become possible mainly with the advent of photocatalysis. Transformations of the fluorinated ring via the C-F bond activation, as well as use of fluoroaryl fragments as activating groups and hydrogen atom transfer agents are discussed...
March 27, 2024: Chemical Society Reviews
https://read.qxmd.com/read/38536064/ag-in-zn-s-alloyed-nanocrystals-as-photocatalysts-of-controlled-light-mediated-radical-polymerization
#10
JOURNAL ARTICLE
Patrycja Kowalik, Piotr Bujak, Mateusz Penkala, Anna Iuliano, Ireneusz Wielgus, Karolina Peret, Adam Pron
We report on the first case of the use of nonstoichiometric ternary (Ag-In-Zn-S) semiconductor nanocrystals as photoinitiators and photocatalysts of methyl methacrylate (MMA) polymerization. Two types of nanocrystals were tested, differing in their composition and characterized by red ( λ max = 731 nm) and green ( λ max = 528 nm) photoluminescence, respectively. Exploiting their reducing properties and capability of free radical generation we demonstrate that under ultraviolet (UV) radiation they effectively photoinitiate radical polymerization of MMA whereas under visible light (blue or green) they act as photocatalysts of living radical polymerization...
March 27, 2024: Chemical Communications: Chem Comm
https://read.qxmd.com/read/38536061/direct-access-to-pyrrole-anhydrides-via-oxidative-self-coupling-of-pyrrole-carboxaldehydes
#11
JOURNAL ARTICLE
Surabhi Panday, Tapas Maity, Pratibha Bhatti, Joydev K Laha
An elegant synthesis of pyrrole-2-carboxylic acid anhydrides from pyrrole-2-carboxaldehydes using TBAI as a catalyst and tert -butyl hydroperoxide (TBHP) as an oxidant is described herein. Unlike the previous reports wherein pyrrole-2-carboxylic acids were invariably used, we report here for first time the oxidative self-coupling of N -benzyl pyrrole-2-carboxaldehydes for the synthesis of 1-benzyl-1 H -pyrrole-2-carboxylic anhydrides. In addition, a one-pot synthesis of novel pyrrole-2-carboxamides from pyrrole-2-carboxaldehydes is also reported...
March 27, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38535980/humanin-inhibits-lymphatic-endothelial-cells-dysfunction-to-alleviate-myocardial-infarction-reperfusion-injury-via-bnip3-mediated-mitophagy
#12
JOURNAL ARTICLE
Lu Chen, Xiaohua Yang, Kai Wang, Lina Guo, Cao Zou
OBJECTIVE: Acute myocardial infarction (AMI) ranks among the top contributors to sudden death and disability worldwide. It should be noted that current therapies always cause increased reperfusion damage. Evidence suggests that humanin (HN) reduces mitochondrial dysfunction to have cardio-protective effects against MI-reperfusion injury. In this context, we hypothesized that HN may attenuate MI-reperfusion injury by alleviating lymphatic endothelial cells dysfunction through the regulation of mitophagy...
March 27, 2024: Free Radical Research
https://read.qxmd.com/read/38535940/persulfate-based-advanced-oxidation-process-for-chlorpyrifos-degradation-mechanism-kinetics-and-toxicity-assessment
#13
JOURNAL ARTICLE
Youxin Xu, Chenxi Zhang, Haobing Zou, Guangrong Chen, Xiaomin Sun, Shuguang Wang, Huifang Tian
Persulfate-based advanced oxidation process has been proven to be a promising method for the toxic pesticide chlorpyrifos (CPY) degradation in wastewater treatment. However, due to the limitation for the short-lived intermediates detection, a comprehensive understanding for the degradation pathway remains unclear. To address this issue, density functional theory was used to analyze the degradation mechanism of CPY at the M06-2X/6-311++G(3df,3pd)//M06-2X/6-31+G(d,p) level, and computational toxicology methods were employed to explore the toxicity of CPY and its degradation products...
March 9, 2024: Toxics
https://read.qxmd.com/read/38535936/identification-and-mechanistic-analysis-of-toxic-degradation-products-in-the-advanced-oxidation-pathways-of-fluoroquinolone-antibiotics
#14
JOURNAL ARTICLE
Shuhai Sun, Zhonghe Wang, Qikun Pu, Xinao Li, Yuhan Cui, Hao Yang, Yu Li
The degradation of fluoroquinolones (FQs) via advanced oxidation processes (AOPs) is a promising avenue, yet the complete mineralization of certain FQ molecules remains elusive, raising concerns about the formation of toxic by-products. This study delineates five primary AOP degradation pathways for 16 commercially available FQ molecules, inferred from existing literature. Density functional theory (DFT) was employed to calculate the bond dissociation energies within these pathways to elucidate the correlation between bond strength and molecular architecture...
March 6, 2024: Toxics
https://read.qxmd.com/read/38535894/prognostic-impact-of-primary-tumour-location-after-curative-resection-in-stage-i-iii-colorectal-cancer-a-single-centre-retrospective-study
#15
JOURNAL ARTICLE
Manabu Inoue, Yukihide Kanemitsu, Shunsuke Tsukamoto, Konosuke Moritani, Yasuyuki Takamizawa, Hiroyuki Daiko
OBJECTIVE: The relationship of tumour site with post-recurrence course and outcome after primary surgery in resectable colorectal cancer is unclear. This study investigated the prognostic impact of primary tumour location following radical resection without preoperative treatment in Stage I-III colorectal cancer. METHODS: We analyzed 3770 patients with Stage I-III colorectal cancer who underwent curative resection at our hospital during 2000-15. We defined the right-sided colon as the cecum, ascending colon and transverse colon, and the left-sided colon as the descending colon, sigmoid and rectosigmoid junction...
March 26, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38535850/effect-of-the-season-on-blood-changes-of-oxidative-stress-index-in-the-italian-mediterranean-buffalo-bubalis-bubalis
#16
JOURNAL ARTICLE
Giovanna De Matteis, Susana Flores-Villalva, Emanuela Rossi, Maria Chiara La Mantia, Roberto Steri, Vittoria Lucia Barile, David Meo Zilio
Studies in cattle have shown that high temperatures increase the production of reactive oxygen species (ROS) causing an imbalance between ROS and the ability of antioxidant systems to detoxify and remove the reactive intermediates. As such studies remain limited in buffalo, the effect of temperature on oxidative stress was investigated through the oxidative stress index (OSi). Blood samples were collected from 40 buffaloes over 12 time points distributed over two years (2021, 2022). Samples were taken monthly during the hot and cold seasons...
March 4, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535754/structure-and-morphology-of-red-pigments-based-on-sepiolite
#17
JOURNAL ARTICLE
I Carrillo, E Atanes-Sánchez, F Fernández-Martínez
Sepiolite is an important raw fibrous material. A method to prepare red pigments based on sepiolite through the thermal treatment of sepiolite with sulfur and sodium sulfide hydrate is reported. Sepiolite was heated until 800 °C in order to remove zeolitic water, the first coordinated water, the second coordinated water, and structural hydroxyls. Several [S/Na2 S]molar ratios in the range 0.5-7 were employed. The properties of these pigments were studied by different analytical techniques, such as colorimetric analysis, thermal analysis, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction and scanning electron microscopy...
March 27, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38535646/fe-3-o-4-tio-2-microspheres-harnessing-o-2-release-and-ros-generation-for-combination-cdt-pdt-ptt-chemotherapy-in-tumours
#18
JOURNAL ARTICLE
Bo Zhao, Xiuli Hu, Lu Chen, Xin Wu, Donghui Wang, Hongshui Wang, Chunyong Liang
In the treatment of various cancers, photodynamic therapy (PDT) has been extensively studied as an effective therapeutic modality. As a potential alternative to conventional chemotherapy, PDT has been limited due to the low Reactive Oxygen Species (ROS) yield of photosensitisers. Herein, a nanoplatform containing mesoporous Fe3 O4 @TiO2 microspheres was developed for near-infrared (NIR)-light-enhanced chemodynamical therapy (CDT) and PDT. Titanium dioxide (TiO2 ) has been shown to be a very effective PDT agent; however, the hypoxic tumour microenvironment partly affects its in vivo PDT efficacy...
March 10, 2024: Nanomaterials
https://read.qxmd.com/read/38535501/bamboo-based-biochar-a-still-too-little-studied-black-gold-and-its-current-applications
#19
REVIEW
Silvana Alfei, Omar Ginoble Pandoli
Biochar (BC), also referred to as "black gold", is a carbon heterogeneous material rich in aromatic systems and minerals, preparable by the thermal decomposition of vegetable and animal biomasses in controlled conditions and with clean technology. Due to its adsorption ability and presence of persistent free radicals (PFRs), BC has demonstrated, among other uses, great potential in the removal of environmental organic and inorganic xenobiotics. Bamboo is an evergreen perennial flowering plant characterized by a short five-year growth period, fast harvesting, and large production in many tropical and subtropical countries worldwide, thus representing an attractive, low-cost, eco-friendly, and renewable bioresource for producing BC...
March 20, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535472/anti-inflammatory-activity-of-cyanobacteria-pigment-extracts-physiological-free-radical-scavenging-and-modulation-of-inos-and-lox-activity
#20
JOURNAL ARTICLE
Lécia Rodrigues, Janaína Morone, Guilherme Scotta Hentschke, Vitor Vasconcelos, Graciliana Lopes
Cyanobacteria are among the oldest organisms colonizing Earth. Their great biodiversity and ability to biosynthesize secondary metabolites through a variety of routes makes them attractive resources for biotechnological applications and drug discovery. In this pioneer study, four filamentous cyanobacteria ( Cephalothrix lacustris LEGE 15493, Leptolyngbya boryana LEGE 15486, Nodosilinea nodulosa LEGE 06104 and Leptothoe sp. LEGE 11479) were explored for their anti-inflammatory potential in cell and cell-free in vitro bioassays, involving different inflammatory mediators and enzymes...
March 12, 2024: Marine Drugs
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