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https://read.qxmd.com/read/30771605/dissymmetric-pyridyl-substituted-3-5-bis-arylidene-4-piperidones-as-anti-hepatoma-agents-by-inhibiting-nf-%C3%AE%C2%BAb-pathway-activation
#1
Bin-Rong Yao, Yue Sun, Shuang-Long Chen, Hao-Dong Suo, Yu-Long Zhang, Hao Wei, Chun-Hua Wang, Feng Zhao, Wei Cong, Wen-Yu Xin, Gui-Ge Hou
To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity for human normal heptical cell line (HHL-5, LO2), and prominently inhibited lipopolysaccharides (LPS) induced IL-6, TNF-α secretion to exert its anti-inflammatory effect...
February 7, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30771531/diverse-immune-responses-to-hbv-surface-epitope-variants-after-vaccine-booster-in-adolescents-immunized-in-infancy
#2
Ming-Wei Lai, Kung-Hao Liang, Chau-Ting Yeh
OBJECTIVES: We aimed to investigate immunity against hepatitis B surface antigen (HBsAg) mutants before and after boosters in adolescents who lost antibodies against HBsAg (anti-HBs) despite neonatal vaccination. METHODS: We recruited 142 participants from 15 to 21 years old, who had received complete vaccination in infancy but became anti-HBs-negative. Cellular immunity to HBsAg and T-cell epitope variants was assessed before and after boosters. Antibody affinity to variants was assessed after boosters...
February 13, 2019: Clinical Microbiology and Infection
https://read.qxmd.com/read/30771314/effects-of-aerobic-exercise-on-the-inflammatory-cytokine-profile-and-expression-of-lipolytic-and-thermogenic-genes-in-%C3%AE-1-ar-mice-adipose-tissue
#3
Aurora Corrêa Rodrigues, Tiago Ferreira Leal, Alexandre Jayme Lopes Dantas Costa, Franciany de Jesus Silva, Leôncio Lopes Soares, Patrícia Chakur Brum, Helen Hermana Miranda Hermsdorff, Maria do Carmo Gouveia Peluzio, Thales Nicolau Prímola-Gomes, Antônio José Natali
AIM: Investigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1 -AR-/- mice adipose tissue. MAIN METHODS: Four- to five-month-old male wild type (WT) and β1 -AR-/- mice were divided into groups: WT control (WTc) and trained (WTt); and β1 -AR-/- control (β1 -AR-/- c) and trained (β1 -AR-/- t). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks...
February 13, 2019: Life Sciences
https://read.qxmd.com/read/30765132/reduced-akkermansia-muciniphila-and-faecalibacterium-prausnitzii-levels-in-the-gut-microbiota-of-children-with-allergic-asthma
#4
M Demirci, H B Tokman, H K Uysal, S Demiryas, A Karakullukcu, S Saribas, H Cokugras, B S Kocazeybek
INTRODUCTION AND OBJECTIVES: The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in gut microbiota are reduced in patients with allergic diseases compared to healthy controls. We aimed to quantify levels of A. muciniphila and F. prausnitzii amounts using real-time quantitative PCR (qPCR) in the gut microbiota of children with allergic asthma and in healthy controls. MATERIALS AND METHODS: In total, 92 children between the ages of three and eight who were diagnosed with asthma and 88 healthy children were included in the study and bacterial DNA was isolated from the stool samples using the stool DNA isolation Kit...
February 11, 2019: Allergologia et Immunopathologia
https://read.qxmd.com/read/30764601/g-protein-coupled-receptor-120-mediates-dha-induced-apoptosis-by-regulating-ip3r-ros-and-er-stress-levels-in-cisplatin-resistant-cancer-cells
#5
Jong-Il Shin, Yong-Joon Jeon, Sol Lee, Yoon Gyeong Lee, Ji Beom Kim, Kyungho Lee
The omega-3 fatty acid docosahexaenoic acid (DHA) is known to induce apoptosis and cell cycle arrest via the induction of reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress in many types of cancers. However, the roles of DHA in drug-resistant cancer cells have not been elucidated. In this study, we investigated the effects of DHA in cisplatin-resistant gastric cancer SNU-601/cis2 cells. DHA was found to induce ROS-dependent apoptosis in these cells. The inositol 1,4,5-triphosphate receptor (IP3R) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis...
November 27, 2019: Molecules and Cells
https://read.qxmd.com/read/30761129/multidrug-resistant-pseudomonas-aeruginosa-accelerate-intestinal-extra-intestinal-and-systemic-inflammatory-responses-in-human-microbiota-associated-mice-with-subacute-ileitis
#6
Markus M Heimesaat, Ulrike Escher, Anne Grunau, Anja A Kühl, Stefan Bereswill
The globally rising incidences of multidrug-resistant (MDR) Pseudomonas aeruginosa (Psae) in humans and live-stock animals has prompted the World Health Organization to rate MDR Psae as serious threat for human health. Only little is known, however, regarding factors facilitating gastrointestinal Psae-acquisition by the vertebrate host and subsequently induced inflammatory sequelae. In the present study, we addressed whether subacute ileitis predisposed mice harboring a human gut microbiota for intestinal MDR Psae carriage and whether inflammatory responses might be induced following peroral challenge with the opportunistic pathogen...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30761069/transient-receptor-potential-vanilloid-1-modulates-central-inflammation-in-multiple-sclerosis
#7
Mario Stampanoni Bassi, Antonietta Gentile, Ennio Iezzi, Sara Zagaglia, Alessandra Musella, Ilaria Simonelli, Luana Gilio, Roberto Furlan, Annamaria Finardi, Girolama A Marfia, Livia Guadalupi, Silvia Bullitta, Georgia Mandolesi, Diego Centonze, Fabio Buttari
Introduction: Disease course of multiple sclerosis (MS) is negatively influenced by proinflammatory molecules released by activated T and B lymphocytes and local immune cells. The endovanilloid system plays different physiological functions, and preclinical data suggest that transient receptor potential vanilloid type 1 (TRPV1) could modulate neuroinflammation in this disorder. Methods: The effect of TRPV1 activation on the release of two main proinflammatory cytokines, tumor necrosis factor (TNF) and interleukin (IL)-6, was explored in activated microglial cells...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30754643/fluoxetine-induces-apoptosis-through-extrinsic-intrinsic-pathways-and-inhibits-erk-nf-%C3%AE%C2%BAb-modulated-anti-apoptotic-and-invasive-potential-in-hepatocellular-carcinoma-cells-in-vitro
#8
Wei-Ting Chen, Fei-Ting Hsu, Yu-Chang Liu, Cheng-Hsien Chen, Li-Cho Hsu, Song-Shei Lin
The aim of the present study was to verify the effects of fluoxetine on dysregulation of apoptosis and invasive potential in human hepatocellular carcinoma (HCC) SK-Hep1 and Hep3B cells. Cells were treated with different concentrations of fluoxetine for different times. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assays were used for testing the effects of fluoxetine on cell viability. The regulation of apoptosis signaling, and anti-apoptotic, proliferation, and metastasis-associated proteins after fluoxetine treatment were assayed by flow cytometry and Western blotting assay...
February 11, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30753988/effects-of-lactoferrin-on-x-ray-induced-intestinal-injury-in-balb-c-mice
#9
Yu-Lu Wei, Jia-Ying Xu, Ru Zhang, Zheng Zhang, Lin Zhao, Li-Qiang Qin
OBJECTIVE: Intestinal injury is common after radiotherapy. We aim to investigate the effects of lactoferrin (Lf) on X-ray-induced intestinal injury in Balb/C mice. METHODS: In assessing animal survival, a total of 40 animals were assigned randomly to 8Gy group, 2 mg Lf+8Gy group, 4 mg Lf+8Gy group, and 6 mg Lf+8Gy group. Mice were administered with Lf intraperitoneally and exposed to single whole-body X-ray irradiation. Lf administration lasted for 3 days. Survival rate was compared among groups...
January 28, 2019: Applied Radiation and Isotopes
https://read.qxmd.com/read/30753918/effects-of-aloe-emodin-on-innate-immunity-antioxidant-and-immune-cytokines-mechanisms-in-the-head-kidney-leucocytes-of-labeo-rohita-against-aphanomyces-invadans
#10
Gunapathy Devi, Ramasamy Harikrishnan, Bilal Ahmad Paray, Mohammad K Al-Sadoon, Seyed Hossein Hoseinifar, Chellam Balasundaram
The effect of aloe-emodin incorporated diets on innate immune response, disease resistance, pro and/or anti-inflammatory cytokine gene transcription in Labeo rohita against Aphanomyces invadans is reported for the first time. In healthy and infected groups fed with 5 mg aloe-emodin enriched diet the white blood cell (WBC) count increased significantly (p > 0.05) after 6th week. In both groups fed with any enriched diet the biochemical parameters such as albumin, globulin, and albumin/globulin ratio did not vary significantly; however with 5 mg aloe-emodin diet the albumin and globulin levels increased significantly (p > 0...
February 9, 2019: Fish & Shellfish Immunology
https://read.qxmd.com/read/30753813/time-dependent-course-of-gastric-ulcer-healing-and-molecular-markers-profile-modulated-by-increased-gastric-mucosal-content-of-carbon-monoxide-released-from-its-pharmacological-donor
#11
Katarzyna Magierowska, Dominik Bakalarz, Dagmara Wójcik, Anna Chmura, Magdalena Hubalewska-Mazgaj, Sabina Licholai, Edyta Korbut, Slawomir Kwiecien, Zbigniew Sliwowski, Grzegorz Ginter, Tomasz Brzozowski, Marcin Magierowski
BACKGROUND AND PURPOSE: Besides hydrogen sulfide (H2 S) and nitric oxide (NO), carbon monoxide (CO) contributes to the maintenance of gastric mucosal integrity. We investigated increased CO bioavailability effects on time-dependent dynamics of gastric ulcer healing mediated by particular growth factors, anti-inflammatory and molecular pathways. EXPERIMENTAL APPROACH: Wistar rats with gastric ulcers induced by serosal acetic acid application (day 0) were treated i...
February 9, 2019: Biochemical Pharmacology
https://read.qxmd.com/read/30743243/in-vitro-evaluation-of-organic-extractable-matter-from-ambient-pm-2-5-using-human-bronchial-epithelial-beas-2b-cells-cytotoxicity-oxidative-stress-pro-inflammatory-response-genotoxicity-and-cell-cycle-deregulation
#12
Imane Abbas, Ghidaa Badran, Anthony Verdin, Frédéric Ledoux, Mohamed Roumie, Jean-Marc Lo Guidice, Dominique Courcot, Guillaume Garçon
A particular attention has been devoted to the type of toxicological responses induced by particulate matter (PM), since their knowledge is greatly complicated by the fact that it is a heterogeneous and often poorly described pollutant. However, despite intensive research effort, there is still a lack of knowledge about the specific chemical fraction of PM, which could be mainly responsible of its adverse health effects. We sought also to better investigate the toxicological effects of organic extractable matter (OEM) in normal human bronchial epithelial lung BEAS-2B cells...
January 31, 2019: Environmental Research
https://read.qxmd.com/read/30741053/potential-role-of-resveratrol-loaded-elastic-sorbitan-monostearate-nanovesicles-for-the-prevention-of-uv-induced-skin-damage
#13
Haidy Abbas, Rabab Kamel
This study was aiming to improve the effect of the water insoluble drug, Resveratrol, by encapsulating it in surfactant-based elastic vesicles (SLs). SLs were prepared by thin film hydration method using different ratios of Span 60 (S60) and Edge activators (EAs). The prepared spanlastics (SLs) were subjected to full in-vitro evaluation. All the SLs showed improved properties compared to the drug suspension (P < 0.05). SL5 composed of S60: Brij 35 (7:3) attained the highest drug entrapment efficiency (79...
February 10, 2019: Journal of Liposome Research
https://read.qxmd.com/read/30736422/cgrp-induces-differential-regulation-of-cytokines-from-satellite-glial-cells-in-trigeminal-ganglia-and-orofacial-nociception
#14
Shaista Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Oshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama, Yoshizo Matsuka
Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG) secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) modulates pain transmission through neuron-glia signaling, contributing to various orofacial pain conditions. The present study aimed to investigate the role of satellite glial cells (SGC) in TG in causing cytokine-related orofacial nociception in response to IG administration of CGRP. For that purpose, CGRP alone (10 μL of 10-5 M), Minocycline (5 μL containing 10 μg) followed by CGRP with one hour gap (Min + CGRP) were administered directly inside the TG in independent experiments...
February 7, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30733792/screening-of-anti-inflammatory-phytocompounds-from-crateva-adansonii-leaf-extracts-and-its-validation-by-in-silico-modeling
#15
Rathinavel Thirumalaisamy, Subramanian Ammashi, Govarthanan Muthusamy
Anti-inflammatory phytocompounds from Crateva adansonii DC leaf extracts were identified by GCMS analysis and its anti-inflammatory potential was evaluated by in silico molecular docking study against inflammatory molecular targets. Three different (Aqueous, Methanol and Petroleum ether) dried leaf extracts of Crateva adansonii were obtained from soxhlet extraction method. Preliminary phytoconstituents analysis of three different leaf extracts of C. adansonii confirmed the presence of various major classes of bioactive phytoconstituents such as polyphenols (tannins and flavonoids), steroids, alkaloid, coumarin, carbohydrate and terpenoids ...
December 2018: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/30732883/a-multifunctional-bis-nor-meptazinol-oxalamide-hybrid-with-metal-chelating-property-ameliorates-cu-ii-induced-spatial-learning-and-memory-deficits-via-preventing-neuroinflammation-and-oxido-nitrosative-stress-in-mice
#16
Xiaofang Tan, Yan Zhou, Ping Gong, Huifeng Guan, Baichuan Wu, Lina Hou, Xuemei Feng, Wei Zheng, Juan Li
Excess copper exposure is a risk factor of neurodegeneration related to Alzheimer's disease (AD). Evidence indicates that, besides promoting amyloid β aggregation, activation of neuroinflammation and oxido-nitrosative stress (two key pathophysiological processes of AD) may also play important roles in Cu(II)-induced neuronal injury. Therefore, the copper-chelating strategy has gained attention in search for new anti-AD drugs. We previously reported a novel multifunctional compound N1 ,N2 -bis(3-(S)-meptazinol-propyl) oxalamide (ZLA), a bis-(-)-nor-meptazinol-oxalamide hybrid with properties of dual binding site acetylcholinesterase (AChE) inhibition and Cu(II)/Zn(II) chelation...
March 2019: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/30732820/long-term-local-pdgf-delivery-using-porous-microspheres-modified-with-heparin-for-tendon-healing-of-rotator-cuff-tendinitis-in-a-rabbit-model
#17
Seok Kang, Joon Shik Yoon, Jae Yong Lee, Hak-Jun Kim, Kyeongsoon Park, Sung Eun Kim
In this study, we prepared the platelet-derived growth factor-containing porous microspheres modified with heparin (PDGF/Hep-PMSs) and investigated their anti-inflammatory and tendon healing effects on rotator cuff (RC) tendinitis rabbit model. PDGF/Hep-PMSs suppressed the mRNA levels of six pro-inflammatory cytokines (i.e., MMP-3, MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α) in inflamed tenocytes. Long-term local delivery of PDGF/Hep-PMSs into tendon tissues of RC tendinitis decreased the mRNA levels of six pro-inflammatory cytokines and increased the mRNA levels of anti-inflammatory cytokines including IL-4, IL-10, and IL-13...
April 1, 2019: Carbohydrate Polymers
https://read.qxmd.com/read/30725388/clinical-outcomes-of-advanced-stage-cancer-patients-treated-with-sequential-immunotherapy-in-phase-1-clinical-trials
#18
Dylan J Martini, Yuan Liu, Julie M Shabto, Colleen Lewis, Meredith R Kline, Hannah Collins, Mehmet Akce, Haydn T Kissick, Bradley C Carthon, Walid L Shaib, Olatunji B Alese, Rathi N Pillai, Conor E Steuer, Christina S Wu, David H Lawson, Ragini R Kudchadkar, Viraj A Master, Bassel F El-Rayes, Suresh S Ramalingam, Taofeek K Owonikoko, R Donald Harvey, Mehmet Asim Bilen
Background Given the increasing number of available immunotherapeutic agents, more patients are presenting after failing immunotherapy in need of new treatment options. In this study, we investigated the clinical outcomes of patients treated with sequential immunotherapy. Methods We performed a retrospective review of 90 advanced stage cancer patients treated on immunotherapy-based phase 1 clinical trials at Winship Cancer Institute from 2009 to 2017. We included 49 patients with an immune checkpoint inhibitor (ICI)-indicated histology...
February 6, 2019: Investigational New Drugs
https://read.qxmd.com/read/30723583/interleukin-1-receptor-antagonist-levels-predict-favorable-outcome-after-bermekimab-a-first-in-class-true-human-interleukin-1%C3%AE-antibody-in-a-phase-iii-randomized-study-of-advanced-colorectal-cancer
#19
Razelle Kurzrock, Tamas Hickish, Lucjan Wyrwicz, Mark Saunders, Qian Wu, Michael Stecher, Prasant Mohanty, Charles A Dinarello, John Simard
Bermekimab is a true human monoclonal antibody that targets interleukin-1alpa (IL-1α), an inflammation-mediating alarmin. IL-1 receptor antagonist (IL-1Ra) is a natural molecule that blocks IL-1α activity by occupying the IL-1 receptor. The effect of endogenous IL-1Ra levels on the effectiveness of bermekimab is unknown. We investigated whether pre-treatment levels of circulating IL-1Ra, assessed by an enzyme-linked immunoassay, correlated with achievement of the primary outcome endpoint (effect on lean body mass and symptoms at week 8) in a Phase III study (2:1 randomization) of bermekimab versus placebo (each with best supportive care) in advanced colorectal cancer...
2019: Oncoimmunology
https://read.qxmd.com/read/30721933/coronary-artery-plaque-characteristics-and-treatment-with-biologic-therapy-in-severe-psoriasis-results-from-a-prospective-observational-study
#20
Youssef A Elnabawi, Amit K Dey, Aditya Goyal, Jacob W Groenendyk, Jonathan H Chung, Agastya D Belur, Justin Rodante, Charlotte L Harrington, Heather L Teague, Yvonne Baumer, Andrew Keel, Martin P Playford, Veit Sandfort, Marcus Y Chen, Benjamin Lockshin, Joel M Gelfand, David A Bluemke, Nehal N Mehta
Aims: The use of biologic therapy has increased over the past decade well beyond primary autoimmune diseases. Indeed, a recent trial using an anti-IL-1beta antibody reduced second myocardial infarction (MI) in those who have had MI. Psoriasis is a chronic inflammatory disease often treated with biologics when severe, is associated with increased risk of MI, in part driven by high-risk coronary plaque phenotypes by coronary computed tomography angiography (CCTA). We hypothesized that we would observe a reduction in inflammatory-driven phenotypes of coronary plaque, including non-calcified coronary plaque burden and lipid-rich necrotic core in those treated with biologic therapy after one-year compared with non-biologic therapy...
February 5, 2019: Cardiovascular Research
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