Thomas Aldersley, John Lawrenson, Paul Human, Gasnat Shaboodien, Blanche Cupido, George Comitis, Rik De Decker, Barend Fourie, Lenise Swanson, Alexia Joachim, Phaphama Magadla, Malebogo Ngoepe, Liam Swanson, Alistair Revell, Raj Ramesar, Andre Brooks, Nicole Saacks, Bianca De Koning, Karen Sliwa, John Anthony, Ayesha Osman, Bernard Keavney, Liesl Zühlke
Objectives: The PartneRships in cOngeniTal hEart disease (PROTEA) project aims to establish a densely phenotyped and genotyped Congenital Heart Disease (CHD) cohort for southern Africa. This will facilitate research into the epidemiology and genetic determinants of CHD in the region. This paper introduces the PROTEA project, characterizes its initial cohort, from the Western Cape Province of South Africa, and compares the proportion or "cohort-prevalences" of CHD-subtypes with international findings. Methods: PROTEA is a prospective multicenter CHD registry and biorepository...
2021: Frontiers in Pediatrics