Read by QxMD icon Read


Eliana Al Haddad, Damien J LaPar, Jeffrey Dayton, Elizabeth H Stephens, Emile Bacha
BACKGROUND: Congenital heart defects affect nearly 1% of all children born per year in the United States, and complete atrioventricular canal (CAVC) accounts for 2%-9%. While several patch materials have been used for septal defect closure during CAVC repair, clear superiority of one material over another has yet to be established. METHODS: A retrospective review of clinical outcomes following CAVC repair at Morgan Stanley Children's Hospital/Columbia University was performed on operations conducted from March 2010 to September 2017...
September 21, 2018: Congenital Heart Disease
Zachary M Smith, Vincent Steinmetz, Jonathan Martens, Jos Oomens, John C Poutsma
Infrared multiple photon dissociation spectroscopy was performed on protonated and cationized canavanine (Cav), a non-protein amino acid oxy-analog of arginine. Infrared spectra in the XH stretching region (3000 - 4000 cm-1 ) were obtained at the Centre Laser Infrarouge d'Orsay (CLIO) facility. Comparison of the experimental infrared spectra with scaled harmonic frequencies at the B3LYP/6-31+G(d,p) level of theory indicates that canavanine is in a canonical neutral form in CavH+ , CavLi+ , and CavNa+ ; therefore, these cations are charge-solvated structures...
June 2018: International Journal of Mass Spectrometry
William L Patrick, Richard D Mainwaring, Olaf Reinhartz, Rajesh Punn, Theresa Tacy, Frank L Hanley
BACKGROUND: Major aortopulmonary collateral arteries (MAPCAs) are frequently found in association with pulmonary atresia with ventricular septal defect (PA/VSD). However, some patients with MAPCAs do not have PA/VSD but have a variety of other "atypical" anatomic diagnoses. METHODS: This was a retrospective review of patients with MAPCAs and atypical anatomy. The 50 patients with MAPCAs could be divided into two subgroups: (1) single ventricle anatomy (n = 33) and (2) two ventricle anatomy (n = 17)...
September 2017: Annals of Thoracic Surgery
Elizabeth H Stephens, Jennifer Tingo, Marc Najjar, Betul Yilmaz, Stéphanie Levasseur, Jeffrey D Dayton, Ralph S Mosca, Paul Chai, Jan M Quaegebeur, Emile A Bacha
BACKGROUND: Repair of complete atrioventricular canal (CAVC) with tetralogy of Fallot (TOF) is a challenging operation increasingly being performed as a complete, primary repair in infancy. Previous studies have focused on perioperative outcomes; however, midterm valve function, ventricular function, and residual obstruction have received little attention. METHODS: We retrospectively reviewed 20 patients who underwent CAVC/TOF repair (January 2005 to December 2014)...
March 2017: World Journal for Pediatric & Congenital Heart Surgery
Yoshifumi Itoda, Kan Nawata, Haruo Yamauchi, Osamu Kinoshita, Mitsutoshi Kimura, Minoru Ono
Aortic insufficiency (AI) is a significant complication of long-term support of continuous flow left ventricular assist device (CF-LVAD) for patients with end-stage heart failure. A 26-year-old female with osteogenesis imperfecta (OI) was diagnosed with dilated phase hypertrophic cardiomyopathy (d-HCM)) and was implanted with Jarvik 2000, for bridge to transplantation. AI gradually developed and surgical intervention was indicated. We performed central aortic valve closure (CAVC) instead of valve replacement 20 months after CF-LVAD implantation...
March 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Rakesh Yadav, Aparna Jaswal, Sridevi Chennapragada, Prakash Kamath, Shirish M S Hiremath, Dhiman Kahali, Sumit Anand, Naresh K Sood, Anil Mishra, Jitendra S Makkar, Upendra Kaul
BACKGROUND: Several past clinical studies have demonstrated that frequent and unnecessary right ventricular pacing in patients with sick sinus syndrome and compromised atrio-ventricular conduction (AVC) produces long-term adverse effects. The safety and efficacy of two pacemaker algorithms, Ventricular Intrinsic Preference™ (VIP) and Ventricular AutoCapture (VAC), were evaluated in a multi-center study in pacemaker patients. METHODS: We evaluated 80 patients across 10 centers in India...
February 2016: Journal of Arrhythmia
Minghui Zou, Yanfei Wang, Hujun Cui, Li Ma, Shengchun Yang, Yuansheng Xia, Weidan Chen, Xinxin Chen
BACKGROUND: The aim of this study was to review the early and mid-term outcomes of the total cavopulmonary connection (TCPC) procedure and evaluate risk factors for prolonged pleural effusions. METHODS: The clinical records of 82 consecutive patients, who underwent a TCPC operation between January 2008 and December 2013, were reviewed for incidence of prolonged pleural effusions, duration of ventilation time and pleural drainage, length of intensive care unit (ICU) stay, and early and mid-term morbidity and mortality...
January 2016: Journal of Thoracic Disease
Shinichi Fukuhara, Koji Takeda, Codruta Chiuzan, Jiho Han, Antonio R Polanco, Melana Yuzefpolskaya, Donna M Mancini, Paolo C Colombo, Veli K Topkara, Paul A Kurlansky, Hiroo Takayama, Yoshifumi Naka
OBJECTIVES: Aortic insufficiency (AI) after continuous-flow left ventricular assist device implantation can affect patient outcomes. Central aortic valve closure (CAVC) is a strategy commonly practiced; however, its efficacy has not been extensively investigated. METHODS: From March 2004 to May 2014, a total of 340 patients received a continuous-flow left ventricular assist device (89; 26.2%) as destination therapy (DT). Outcomes were compared between patients with CAVC (n = 57 [16...
January 2016: Journal of Thoracic and Cardiovascular Surgery
Rebecca C Ahrens-Nicklas, Sara L Reichert, Elaine H Zackai, Paige B Kaplan
Williams-Beuren Syndrome (WBS) is a well-described microdeletion syndrome characterized by specific dysmorphic facial features, peripheral pulmonic stenosis, supravalvular aortic stenosis, hypercalcemia, feeding difficulties, gastroesophageal reflux, short stature, and specific intellectual disabilities (such as visual spatial problems). WBS is caused by 7q11.23 deletions that contain multiple genes known to contribute to the above phenotype. We report a neonate with a complete atrioventricular canal (CAVC) defect, an atypical cardiac lesion for WBS, and few typical phenotypic features of WBS, diagnosed at 20 days of life...
December 2015: American Journal of Medical Genetics. Part A
Patrick O Myers, Pedro J del Nido, Victor Bautista-Hernandez, Gerald R Marx, Sitaram M Emani, Frank A Pigula, Michele Borisuk, Christopher W Baird
OBJECTIVES: Parachute left atrioventricular (AV) valve can complicate repair of common atrioventricular canal (CAVC), and single-ventricle palliation is sometimes preferred. The goal of this study is to review our single institutional experience in biventricular repair in this patient group. METHODS: The demographic, procedural and outcome data were obtained for all children who underwent biventricular repair for complete CAVC with parachute [single left ventricular (LV) papillary muscle] or forme fruste parachute left AV valve (closely spaced LV papillary muscles) from 2001 to 2012...
February 2016: European Journal of Cardio-thoracic Surgery
Robert D Barrett, Laura Bennet, Arlin B Blood, Guido Wassink, Alistair J Gunn
In this study, we tested the hypothesis that cerebral hypoperfusion after asphyxia and induced hypothermia is associated with reduced circulating nitrite levels as an index of nitric oxide synthase (NOS) activity. The preterm fetal sheep at 0.7 gestation (103-104 days, term = 147 days) received 25-minute umbilical cord occlusion, followed by mild whole-body cooling from 30 minutes to 72 hours after occlusion. Occlusion and induced hypothermia were independently associated with reduced carotid vascular conductance (CaVC) from 2 to 72 hours, and with transiently suppressed plasma nitrite levels at 6 hours...
December 2014: Reproductive Sciences
Lakshmanane Premkumar, Fabian Kurth, Simon Neyer, Mark A Schembri, Jennifer L Martin
The multidrug resistance-encoding IncA/C conjugative plasmids disseminate antibiotic resistance genes among clinically relevant enteric bacteria. A plasmid-encoded disulfide isomerase is associated with conjugation. Sequence analysis of several IncA/C plasmids and IncA/C-related integrative and conjugative elements (ICE) from commensal and pathogenic bacteria identified a conserved DsbC/DsbG homolog (DsbP). The crystal structure of DsbP reveals an N-terminal domain, a linker region, and a C-terminal catalytic domain...
January 31, 2014: Journal of Biological Chemistry
Christo I Tchervenkov, Pierre-Luc Bernier, Danny Del Duca, Samantha Hill, Noritaka Ota, Gordan Samoukovic, Hamad Al-Habib, Stephen Korkola
Atrioventricular canal and conotruncal anomalies are a heterogeneous group of lesions presenting unique challenges for surgical repair. These are the establishment of unobstructed pathways from left ventricle (LV) to aorta and from right ventricle (RV) to pulmonary artery, closure of the inlet ventricular septal defect (VSD) and atrial septal defect (ASD) ostium primum, and the avoidance of significant left and right atrioventricular valve (AV) regurgitation. Repair of complete atrioventricular canal (CAVC) with tetralogy of Fallot (TOF) has been most commonly achieved, either using a single-patch or a 2-patch technique...
April 2010: World Journal for Pediatric & Congenital Heart Surgery
Lisa C A D'Alessandro, Brande C Latney, Prasuna C Paluru, Elizabeth Goldmuntz
Disease causing mutations for heterotaxy syndrome were first identified in the X-linked laterality gene, ZIC3. Mutations typically result in males with situs ambiguus and complex congenital heart disease; however affected females and one male with isolated d-transposition of the great arteries (d-TGA) have been reported. We hypothesized that a subset of patients with heart defects common to heterotaxy but without laterality defects would have ZIC3 mutations. We also sought to estimate the prevalence of ZIC3 mutations in sporadic heterotaxy...
April 2013: American Journal of Medical Genetics. Part A
A J Agopian, Mousumi Moulik, Monesha Gupta-Malhotra, Lisa K Marengo, Laura E Mitchell
BACKGROUND: Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non-syndromic CAVC. Risk factors for non-syndromic CAVC have not been well established. METHODS: To assess the relationship between risk for non-syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry...
November 2012: Paediatric and Perinatal Epidemiology
Susheel Kumar, Mary Donofrio, Lowell Frank, Dingchao He, Richard Jonas
Common atrioventricular canal (CAVC) is a common congenital heart lesion resulting from a defect in development of the endocardial cushions during early embryogenesis. Depending on the type of defect, CAVC can encompass a spectrum of lesions ranging from partial atrioventricular (AV) canal to complete AV canal. We describe a case of CAVC with unique anatomy in a 4-month-old male infant with Down syndrome.
April 2011: Pediatric Cardiology
Nan-Koong Wang, Ching-Tsuen Shen, Meng-Shin Lin
BACKGROUND: In response to increasing demand for a more sophisticated newborn baby health examination, we designed and performed echocardiographic screenings on a voluntary and self-paid basis. METHODS: From 1997 to 2005, 10,000 newborn babies had received the echocardiographic examination on the next day after birth. The echocardiographic examinations were performed by a single sonographer. RESULTS: As well as physically patent ductus arteriosus (PDA) (2420 cases), and patent foramen ovale (PFO) (5813 cases), we also found atrial septal defect (ASD) (161 cases), muscular-type ventricular septal defect (VSD) (123 cases), perimembranous type VSD (58 cases), coarctation of the aorta (COA) (1 case), pulmonic stenosis (PS) (1 case), peripheral pulmonic stenosis (PPS) (15 cases), common atrioventricular canal (CAVC) (1 case), transposition of the great arteries (TGA) (3 cases), double outlets of the right ventricle (DORV) (2 cases), tetralogy of Fallot (TF) (2 cases), hypertrophic cardiomyopathy (2 cases), dextrocardia (2 cases) and cardiac tumor (2 cases)...
January 2007: Acta Paediatrica Taiwanica, Taiwan Er Ke Yi Xue Hui za Zhi
Carl L Backer, Robert D Stewart, Frédérique Bailliard, Angela M Kelle, Catherine L Webb, Constantine Mavroudis
BACKGROUND: The purpose of this study was to compare the modified single-patch technique to the two-patch technique for infants with complete atrioventricular canal (CAVC) defects. METHODS: Between January 2000 and June 2006, 55 infants underwent CAVC repair. Twenty-six patients had a modified single-patch technique; 29 patients had a two-patch technique. Trisomy 21 was present in 23 of 26 and 26 of 29 patients (p = not significant [ns]). Mean age was 4.4 +/- 1...
December 2007: Annals of Thoracic Surgery
Carl Lewis Backer, Robert D Stewart, Constantine Mavroudis
Surgical management of pediatric patients with the diagnosis of complete atrioventricular canal (CAVC) is accomplished by using one of three procedures: (1) the classic single-patch, (2) two-patch, or (3) modified single-patch technique. Of these, the modified single-patch is currently the best technique available for repair of CAVC. The goal of this review is to describe our experience with the modified single-patch technique and explain how it evolved into our procedure of choice for repair of CAVC in our pediatric population...
2007: Seminars in Thoracic and Cardiovascular Surgery
Luis Alesandro Larrazabal, Pedro J del Nido, Kathy J Jenkins, Kimberlee Gauvreau, Ronald Lacro, Steve D Colan, Frank Pigula, Oscar J Benavidez, Francis Fynn-Thompson, John E Mayer, Emile A Bacha
BACKGROUND: Although adequacy of repair after congenital heart surgery is a crucial determinant of clinical outcome, there is no current method of assessment. We sought to develop a process to measure the adequacy of repair for a diverse group of congenital heart procedures. METHODS: Selected surgical procedures, consisting of repair of ventricular septal defect (VSD), tetralogy of Fallot (TOF), complete common atrioventricular canal (CAVC), and arterial switch operation, were divided into component subprocedures, each of which was assessed separately...
January 2007: Annals of Thoracic Surgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"