Min Zhang, Ye Bai, Yutong Wang, Huijie Cui, Wenqiang Zhang, Li Zhang, Peijing Yan, Mingshuang Tang, Yunjie Liu, Xia Jiang, Ben Zhang
BACKGROUND: General obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat distribution on GSD. METHODS: We first investigated the observational association of central adiposity, characterized by waist-to-hip ratio (WHR), with GSD risk using data from UK Biobank (N=472,050). We then explored the genetic relationship using summary statistics from the largest genome-wide association study of GSD ( ncase =43,639, ncontrol =506,798) as well as WHR, with and without adjusting for body mass index (BMI) (WHR: n =697,734; WHRadj BMI: n =694,649)...
2024: Frontiers in Endocrinology