keyword
https://read.qxmd.com/read/38428111/mir-146a-and-mir-146b-regulate-the-expression-of-icam-1-in-giant-cell-arteritis
#21
JOURNAL ARTICLE
Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Francesco Muratore, Luigi Boiardi, Alberto Cavazza, Alessandra Bisagni, Luca Cimino, Luca De Simone, Angelo Ghidini, Giuseppe Malchiodi, Marc Corbera-Bellalta, Maria Cinta Cid, Alessandro Zerbini, Carlo Salvarani, Stefania Croci
Giant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown. The aims of the present work were: to gain insight into the link between inflammation and miRNA up-regulation in GCA; to identify the role of miR-146a and miR-146b. Primary cultures from TABs were treated with IL-1β, IL-6, soluble IL-6R (sIL6R), IL-17, IL-22, IFNγ, LPS and PolyIC...
February 29, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38426107/urinary-mir-185-5p-is-a-biomarker-of-renal-tubulointerstitial-fibrosis-in-iga-nephropathy
#22
JOURNAL ARTICLE
Zhi-Yu Duan, Ru Bu, Shuang Liang, Xi-Zhao Chen, Chun Zhang, Qiu-Yue Zhang, Ji-Jun Li, Xiang-Mei Chen, Guang-Yan Cai
BACKGROUND: For IgA nephropathy (IgAN), tubular atrophy/interstitial fibrosis is the most important prognostic pathological indicator in the mesangial and endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy, and presence of crescents (MEST-C) score. The identification of non-invasive biomarkers for tubular atrophy/interstitial fibrosis would aid clinical monitoring of IgAN progression and improve patient prognosis. METHODS: The study included 188 patients with primary IgAN in separate confirmation and validation cohorts...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38424404/the-pharmaco-epigenetics-of-hypertension-a-focus-on-microrna
#23
REVIEW
Serge Yaacoub, Ammar Boudaka, Ali AlKhatib, Gianfranco Pintus, Amirhossein Sahebkar, Firas Kobeissy, Ali H Eid
Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, the prevalence of hypertension is projected to reach 1.5 billion people. The pathophysiology of this disease is multifaceted, as it involves nitric oxide and endothelin dysregulation, reactive oxygen species, vascular smooth muscle proliferation, and vessel wall calcification, among others...
February 29, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38414350/mir-29b-1-5p-exacerbates-myocardial-injury-induced-by-sepsis-in-a-mouse-model-by-targeting-terf2
#24
JOURNAL ARTICLE
Yaqing Jiang, Junmei Xu, Hua Zeng, Zhaojing Lin, Qiong Yi, Jiali Guo, Feng Xiao
Myocardial damage is a critical complication and a significant contributor to mortality in sepsis. MicroRNAs (miRNAs) have emerged as key players in sepsis pathogenesis. In this study, we explore the effect and mechanisms of miR-29b-1-5p on sepsis-induced myocardial damage. Sepsis-associated Gene Expression Omnibus (GEO) datasets (GSE72380 and GSE29914) are examined for differential miRNAs. The mouse sepsis-induced cardiac injury was established by Lipopolysaccharide (LPS) or cecal ligation and puncture (CLP)...
February 27, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38409638/the-effect-of-bta-mir-1296-on-the-proliferation-and-extracellular-matrix-synthesis-of-bovine-mammary-fibroblasts
#25
JOURNAL ARTICLE
Yuejie Yang, Tao Yuan, Rui Wu, Zijian Geng, Shuai Lian, Jianfa Wang
Mammary fibrosis in dairy cows is a chronic condition caused by mastitis, and can lead to serious culling of dairy cows resulting in huge economic losses in the dairy industry. MicroRNAs (miRNAs) exert an important role in regulating mammary gland health in dairy cows. This study investigated whether exosomal miRNAs in mammary epithelial cells can regulate the proliferation of bovine mammary fibroblasts (BMFBs) in mastitis. Liposome transfection technology was used to construct a cellular model of the overexpression and inhibition of miRNAs...
February 26, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38398499/mirnas-as-biomolecular-markers-for-food-safety-quality-and-traceability-in-poultry-meat-a-preliminary-study
#26
JOURNAL ARTICLE
Nada Baraldo, Luna Buzzoni, Luisa Pasti, Alberto Cavazzini, Nicola Marchetti, Annalaura Mancia
In this study, the expression and abundance of two candidate chicken (Gallus gallus; gga) microRNAs (miRNAs, miR), gga-miR-21-5p (miR-21) and gga-miR-126-5p (miR-126), have been analyzed in order to identify biomarkers for the traceability and quality of poultry meat. Two breeds of broiler chickens were tested: the most common Ross308 (fast-growing) and the high-quality Ranger Gold (slow-growing). A preliminary analysis of the two miRNAs expressions was conducted across various tissues (liver, lung, spleen, skeletal muscle, and kidney), and the three tissues (lung, spleen, and muscle) with a higher expression were chosen for further analysis...
February 6, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38397207/curcumin-changed-the-number-particle-size-and-mirna-profile-of-serum-exosomes-in-roman-laying-hens-under-heat-stress
#27
JOURNAL ARTICLE
Kai Kang, Wen Gao, Yanfeng Cui, Mei Xiao, Lilong An, Jiang Wu
Exosomes have the ability to transport RNA/miRNAs and possess immune modulatory functions. Heat stress, a significant limiting factor in the poultry industry, can induce oxidative stress and suppress the immune responses of laying hens. In this study, we investigated the expression profiles of serum exosomes and their miRNAs in Roman laying hens who were fed a diet with either 0 or 200 mg/kg curcumin under heat stress conditions. The numbers of exosomes were significantly higher in both the HC (heat stress) and HT (heat stress with 200 mg/kg curcumin) groups compared to the NC (control) group and NT (control with 200 mg/kg curcumin) group ( p < 0...
February 8, 2024: Genes
https://read.qxmd.com/read/38396855/the-role-of-mirnas-to-detect-progression-stratify-and-predict-relevant-clinical-outcomes-in-bladder-cancer
#28
REVIEW
Maria Iyali Torres-Bustamante, Jorge Raul Vazquez-Urrutia, Fabiola Solorzano-Ibarra, Pablo Cesar Ortiz-Lazareno
Bladder cancer (BC) is one of the most common types of cancer worldwide, with significant differences in survival depending on the degree of muscle and surrounding tissue invasion. For this reason, the timely detection and monitoring of the disease are important. Surveillance cystoscopy is an invasive, costly, and uncomfortable procedure to monitor BC, raising the need for new, less invasive alternatives. In this scenario, microRNAs (miRNAs) represent attractive prognostic tools given their role as gene regulators in different biological processes, tissue expression, and their ease of evaluation in liquid samples...
February 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38396545/transcriptome-data-revealed-the-circrna-mirna-mrna-regulatory-network-during-the-proliferation-and-differentiation-of-myoblasts-in-shitou-goose
#29
JOURNAL ARTICLE
Rongqin Huang, Jiahui Chen, Xu Dong, Xiquan Zhang, Wen Luo
CircRNA, a recently characterized non-coding RNA (ncRNA) variant, functions as a molecular sponge, exerting regulatory control by binding to microRNA (miRNA) and modulating the expression of downstream proteins, either promoting or inhibiting their expression. Among poultry species, geese hold significant importance, prized by consumers for their delectable taste and rich nutritional content. Despite the prominence of geese, research on the growth and development of goose muscle, particularly the regulatory role of circRNAs in goose muscle formation, remains insufficiently explored...
February 8, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38396500/buffalo-bbu-mir-493-5p-promotes-myoblast-proliferation-and-differentiation
#30
JOURNAL ARTICLE
Liyin Zhang, Dandan Zhong, Chengxuan Yao, Qingyou Liu, Deshun Shi, Mingsheng Jiang, Jian Wang, Zhaocheng Xiong, Hui Li
In recent years, the meat and dairy value of buffaloes has become a major concern in buffalo breeding, and the improvement of buffalo beef quality is key to protecting buffalo germplasm resources and solving the problem of beef supply. MiRNAs play a significant role in regulating muscle development. However, the precise mechanism by which they regulate the development of buffalo skeletal muscles remains largely unexplored. In this study, we examined miRNA expression profiles in buffalo myoblasts during the proliferation and differentiation stages...
February 6, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38395831/identification-of-circrna-associated-cerna-networks-in-the-longissimus-dorsi-of-yak-under-different-feeding-systems
#31
JOURNAL ARTICLE
Xiaoming Ma, Xian Guo, La Yongfu, Tong Wang, Pengjia Bao, Min Chu, Xiaoyun Wu, Ping Yan, Chunnian Liang
BACKGROUND: Yaks (Bos grunniens), prized for their ability to thrive in high-altitude environments, are indispensable livestock in the plateau region. Modifying their feeding systems holds significant promise for improving their growth and meat quality. Tenderness, a key determinant of yak meat quality and consumer appeal, is demonstrably influenced by dietary regimen. Indoor feeding regimes have been shown to enhance tenderness by lowering shear stress and optimizing pH values. CircRNAs, well-known modulators of circulatory function, also play a crucial role in skeletal muscle development across various animal species...
February 24, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38392333/effect-of-cb1-receptor-deficiency-on-mitochondrial-quality-control-pathways-in-gastrocnemius-muscle
#32
JOURNAL ARTICLE
Rosalba Senese, Giuseppe Petito, Elena Silvestri, Maria Ventriglia, Nicola Mosca, Nicoletta Potenza, Aniello Russo, Francesco Manfrevola, Gilda Cobellis, Teresa Chioccarelli, Veronica Porreca, Vincenza Grazia Mele, Rosanna Chianese, Pieter de Lange, Giulia Ricci, Federica Cioffi, Antonia Lanni
This study aims to explore the complex role of cannabinoid type 1 receptor (CB1) signaling in the gastrocnemius muscle, assessing physiological processes in both CB1+/+ and CB1-/- mice. The primary focus is to enhance our understanding of how CB1 contributes to mitochondrial homeostasis. At the tissue level, CB1-/- mice exhibit a substantial miRNA-related alteration in muscle fiber composition, characterized by an enrichment of oxidative fibers. CB1 absence induces a significant increase in the oxidative capacity of muscle, supported by elevated in-gel activity of Complex I and Complex IV of the mitochondrial respiratory chain...
February 11, 2024: Biology
https://read.qxmd.com/read/38388757/microrna-expression-and-oxidative-stress-markers-in-pectoral-muscle-of-broiler-chickens-fed-diets-supplemented-with-phytobiotics-composition
#33
JOURNAL ARTICLE
Karolina A Chodkowska, Marcin Barszcz, Anna Tuśnio
Phytobiotic compositions are commercially used in broiler production, mostly to improve general health and the production parameters. Moreover, some of their active substances may change the expression of miRNA in different tissues. Therefore, the purpose of this study was to evaluate the effect of the phytobiotic composition (PBC) containing white mustard, calamus, turmeric, and common ivy on production parameters, oxidative stress markers and expression of selected miRNAs in pectoral muscle of broiler chickens...
February 22, 2024: Scientific Reports
https://read.qxmd.com/read/38385696/sex-differences-in-neuromuscular-and-biological-determinants-of-isometric-maximal-force
#34
JOURNAL ARTICLE
Gaia Giuriato, Maria Grazia Romanelli, Desirée Bartolini, Gianluca Vernillo, Anna Pedrinolla, Tatiana Moro, Martino Franchi, Elena Locatelli, Mehran Emadi Andani, Fabio Giuseppe Laginestra, Chiara Barbi, Gloria Fiorini Aloisi, Valentia Cavedon, Chiara Milanese, Elisa Orlandi, Tonia De Simone, Stefania Fochi, Cristina Patuzzo, Giovanni Malerba, Paolo Fabene, Massimo Donadelli, Anna Maria Stabile, Alessandra Pistilli, Mario Rende, Francesco Galli, Federico Schena, Massimo Venturelli
AIM: Force expression is characterized by an interplay of biological and molecular determinants that are expected to differentiate males and females in terms of maximal performance. These include muscle characteristics (muscle size, fiber type, contractility), neuromuscular regulation (central and peripheral factors of force expression), and individual genetic factors (miRNAs and gene/protein expression). This research aims to comprehensively assess these physiological variables and their role as determinants of maximal force difference between sexes...
February 22, 2024: Acta Physiologica
https://read.qxmd.com/read/38383173/urinary-exosomal-mir-17-5p-accelerates-bladder-cancer-invasion-by-repressing-its-target-gene-arid4b-and-regulating-the-immune-microenvironment
#35
JOURNAL ARTICLE
Hejia Yuan, Tianqi Wang, Peng Peng, Zhunan Xu, Fan Feng, Yuanshan Cui, Jian Ma, Jitao Wu
BACKGROUND: Urothelial bladder cancer (BCa) is a common malignant tumor of the urinary system. It has been identified that exosomal miRNAs contribute to the development of BCa. However, its significance and mechanism in the malignant biological behavior of BCa remain unclear. In this study, the influence of exosomal miRNAs on BCa progression was investigated. METHODS: High-throughput sequencing was conducted to analyze the microRNA-expression profile in urinary exosomes to screen out the key miRNA of muscle-invasive bladder cancer (MIBC)...
January 22, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38382189/whole-transcriptome-sequencing-reveals-a-melanin-related-cerna-regulatory-network-in-the-breast-muscle-of-xichuan-black-bone-chicken
#36
JOURNAL ARTICLE
Ruiting Li, DongHua Li, Shuohui Xu, Pengwei Zhang, Zhiyuan Zhang, Fumin He, Wenting Li, Guirong Sun, Ruirui Jiang, Zhuanjian Li, Yadong Tian, Xiaojun Liu, Xiangtao Kang
The economic losses incurred due to reduced muscle pigmentation highlight the crucial role of melanin-based coloration in the meat of black-bone chickens. Melanogenesis in the breast muscle of black-bone chickens is currently poorly understood in terms of molecular mechanisms. This study employed whole-transcriptome sequencing to analyze black and white breast muscle samples from black-bone chickens, leading to the identification of 367 differentially expressed (DE) mRNAs, 48 DElncRNAs, 104 DEcircRNAs, and 112 DEmiRNAs involved in melanin deposition...
February 8, 2024: Poultry Science
https://read.qxmd.com/read/38381592/hucmscs-delay-muscle-atrophy-after-peripheral-nerve-injury-through-exosomes-by-repressing-muscle-specific-ubiquitin-ligases
#37
JOURNAL ARTICLE
Jian Chen, Yaqiong Zhu, Hui Gao, Xianghui Chen, Dan Yi, Mo Lin Li, Li Wang, Guanhui Xing, Siming Chen, Jie Tang, Yuexiang Wang
Cell therapy based on mesenchymal stem cells (MSCs) alleviates muscle atrophy caused by diabetes and aging,however, the impact of human umbilical cord mesenchymal stem cells on muscle atrophy following nerve injury and the underlying mechanisms remain unclear. In this study, we evaluated the therapeutic efficacy of human umbilical cord MSCs (hucMSCs) and hucMSC-derived exosomes (hucMSC-EXOs) for muscle atrophy following nerve injury and identified the underlying molecular mechanisms. Sciatic nerve crush injury in rats and the induction of myotubes in L6 cells were used to determine the ameliorating effect of hucMSCs and hucMSC-EXOs on muscle atrophy...
February 21, 2024: Stem Cells
https://read.qxmd.com/read/38374991/expression-of-mirna-29c-in-the-carotid-plaque-and-its-association-with-diabetic-mellitus
#38
JOURNAL ARTICLE
Hua Wang, Peipei Mai, Fang He, Yanfang Zhang
BACKGROUND: Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transformation of vascular smooth muscle cells (VSMCs) in diabetes mice, eventually leading to plaque formation and bleeding. However, such studies are rare and limited to animal experiments. METHODS: In our study, 40 patients were divided into a diabetic mellitus (DM) group and a non-DM group according to whether they were diagnosed with DM...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38370005/circulating-mir-206-mir-181b-and-mir-21-as-promising-biomarkers-in-hypothyroidism-and-their-relationship-to-related-hyperlipidemia-and-hepatic-steatosis
#39
JOURNAL ARTICLE
Asmaa Mohammed, Olfat G Shaker, Mahmoud A F Khalil, Abeer K Abu-El-Azayem, Amira Samy, Shaimaa A Fathy, Mohamed M K AbdElguaad, Fatma A M Mahmoud, Randa Erfan
Background: Thyroid hormones (THs) signaling has profound effects on many physiological processes. The regulation of THs signaling in various tissues involves the action of microRNAs (miRNAs) on thyroid deiodinases and receptors. THs regulate the expression of certain miRNAs and their target messenger RNAs (mRNAs) in various tissues and cells. The modulation of miRNA levels by THs affects their functions in processes such as liver lipid metabolism, skin physiology, and muscle and heart performance. Aim: This research aimed to investigate miR-181b, miR-206, and miR-21 in the serum of patients with subclinical and overt hypothyroidism to determine their possible role in the diagnosis of the disease and their relationship to clinical disorders related to hypothyroidism...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38347587/mesenchymal-stem-cell-derived-extracellular-vesicles-exert-pro-angiogenic-and-pro-lymphangiogenic-effects-in-ischemic-tissues-by-transferring-various-micrornas-and-proteins-including-itga5-and-nrp1
#40
JOURNAL ARTICLE
Anna Łabędź-Masłowska, Luisa Vergori, Sylwia Kędracka-Krok, Elżbieta Karnas, Sylwia Bobis-Wozowicz, Małgorzata Sekuła-Stryjewska, Michał Sarna, Ramaroson Andriantsitohaina, Ewa K Zuba-Surma
Mesenchymal stem cells/stromal cells (MSCs)-derived extracellular vesicles (EVs) mediate pro-regenerative effects in damaged ischemic tissues by regulating angiogenesis. MSCs-EVs modulate functions of cells including endogenous mature cells, progenitors and stem cells, resulting in restoration of blood flow. However, the mechanisms underlying such MSC-EV activity still remain poorly understood. The present study analyzes biological effects of bone marrow (BM) MSC-EVs on endothelial cells (ECs) in ischemic tissues both in in vitro and in vivo conditions and elucidates the molecular mechanisms underlying the tissue repair...
February 12, 2024: Journal of Nanobiotechnology
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