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https://read.qxmd.com/read/30779732/identification-of-whole-blood-mrna-and-microrna-biomarkers-of-tissue-damage-and-immune-function-resulting-from-amphetamine-exposure-or-heat-stroke-in-adult-male-rats
#1
Luísa Camacho, Camila S Silva, Joseph P Hanig, Robert P Schleimer, Nysia I George, John F Bowyer
This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia. Whole blood messenger RNA (mRNA) and whole blood and serum microRNA (miRNA) transcripts were identified in adult male Sprague-Dawley rats after exposure to toxic AMPH under normothermic conditions, AMPH when it produces pronounced hyperthermia, or environmentally-induced hyperthermia (EIH)...
2019: PloS One
https://read.qxmd.com/read/30776027/platelet-micrornas-and-vascular-injury
#2
Elena V Dolmatova, Kathy K Griendling
Vascular smooth muscle cell (VSMC) phenotype switching from a contractile state to a synthetic phenotype has been implicated in intimal remodeling during vascular injury. While multiple studies have focused on dedifferentiation of VSMCs, prevention of VSMC-mediated excessive repair remains poorly understood. In this issue of the JCI, Zeng et al. identified a mechanism by which platelet-derived microRNA-223 (miRNA-223) reverses VSMC dedifferentiation. The authors show that suppression of proliferation occurs after platelet internalization by VSMCs...
February 18, 2019: Journal of Clinical Investigation
https://read.qxmd.com/read/30766816/the-role-of-circulating-microrna-in-the-regulation-of-beta-cell-function-and-insulin-resistance-among-indians-with-type-2-diabetes
#3
S Sucharita, V Ashwini, J S Prabhu, S T Avadhany, V Ayyar, G Bantwal
Background: Circulating microRNA (miRNA/miR) levels are emerging out as markers of tissue level changes; however, their role in type 2 diabetes (T2D) needs to be explored. The study aimed to compare the circulating levels of the miRNA (miR9, miR30d, miR1, miR133a, miR29a, miR143) between T2D and gender matched controls and also to evaluate the strength of association between circulating miRNAs and beta cell function/insulin resistance among Indians with T2D. Subjects and Methods: Thirty T2D (25-60 years) and their gender matched controls ( n = 30) were recruited...
November 2018: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30763672/identification-of-a-novel-mir-206-notch3-pathway-regulating-mouse-myoblasts-proliferation
#4
Zengkai Zhang, Yujun Chen, Bojiang Li, Yilong Yao, Aiwen Jiang, Wei Wei, Honglin Liu, Wangjun Wu
MicroRNAs (miRNAs) are endogenous short non-coding RNAs and exert their function by targeting mRNAs of genes. miRNA-206 (miR-206) is exclusively expressed in adult skeletal muscles and plays an important role in myogenesis. However, the regulatory mechanisms of miR-206 in myoblasts proliferation and differentiation are still limited. In this study, we validated that Notch3 is a direct target gene of mouse miR-206 using dual-luciferase reporter assay and miR-206-overexpressed experiments. Furthermore, we demonstrated that the negative effect of overexpression of miR-206 and knockdown of Notch3 on C2C12 cells proliferation, and found that the effect was produced by controlling the transition of G0/G1 and S phase in C2C12 cell cycle...
February 11, 2019: Gene
https://read.qxmd.com/read/30763589/mir-1933-3p-is-upregulated-in-skeletal-muscles-of-musk-eamg-mice-and-affects-impa1-and-mrpl27
#5
Evgenii Bogatikov, Ida Lindblad, Tanel Punga, Anna Rostedt Punga
MuSK antibody seropositive (MuSK+) Myasthenia Gravis (MG) typically affects skeletal muscles of the bulbar area, including the omohyoid muscle, causing focal fatigue, weakness and atrophy. The profile of circulating extracellular microRNA (miRNA) is changed in MuSK + MG, but the intracellular miRNA profile in skeletal muscles of MuSK + MG and MuSK + experimental autoimmune MG (EAMG) remains unknown. This study elucidated the intracellular miRNA profile in the omohyoid muscle of mice with MuSK + EAMG...
February 11, 2019: Neuroscience Research
https://read.qxmd.com/read/30733582/normalization-strategies-differently-affect-circulating-mirna-profile-associated-with-the-training-status
#6
Martina Faraldi, Marta Gomarasca, Veronica Sansoni, Silvia Perego, Giuseppe Banfi, Giovanni Lombardi
MicroRNAs are fine regulators of the whole-body adaptive response but their use as biomarkers is limited by the lack of standardized pre- and post-analytical procedures. This work aimed to compare different normalization approaches for RT-qPCR data analyses, in order to identify the most reliable and reproducible method to analyze circulating miRNA expression profiles in sedentary and highly-trained subjects. As the physically active status is known to affect miRNA expression, they could be effective biomarkers of the homeostatic response...
February 7, 2019: Scientific Reports
https://read.qxmd.com/read/30717351/the-possible-role-of-complete-loss-of-myostatin-in-limiting-excessive-proliferation-of-muscle-cells-c2c12-via-activation-of-micrornas
#7
Peixuan Huang, Daxin Pang, Kankan Wang, Aishi Xu, Chaogang Yao, Mengjing Li, Wenni You, Qiushuang Wang, Hao Yu
Myostatin (MSTN) is a member of the TGF-β superfamily that negatively regulates skeletal muscle growth and differentiation. However, the mechanism by which complete MSTN deletion limits excessive proliferation of muscle cells remains unclear. In this study, we knocked out MSTN in mouse myoblast lines using a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) system and sequenced the mRNA and miRNA transcriptomes. The results show that complete loss of MSTN upregulates seven miRNAs targeting an interaction network composed of 28 downregulated genes, including TGFB1 , FOS and RB1 ...
February 2, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30715622/mir-449a-5p-mediates-mitochondrial-dysfunction-and-phenotypic-transition-by-targeting-myc-in-pulmonary-arterial-smooth-muscle-cells
#8
Chen Zhang, Cui Ma, Lixin Zhang, Linlin Zhang, Fengying Zhang, Mingfei Ma, Xiaodong Zheng, Min Mao, Tingting Shen, Daling Zhu
MicroRNAs have been considered to participate in pulmonary arterial hypertension (PAH) and regulate numerous disease pathways in pulmonary vasculature. However, the molecular role in the pathologies has not yet been fully uncovered, particularly in the view of energy metabolism and vascular smooth muscle cell phenotypic regulation. Here, several altered miRNAs are founded in genome-wide miRNA sequencing analysis, in which miR-449a-5p was identified as a probable candidate in hypoxic PAH and verified such a decreasing trend...
February 4, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30708219/you-are-what-you-eat-sequence-analysis-reveals-how-plant-micrornas-may-regulate-the-human-genome
#9
Bahareh Kashani, Mansoor Hasani Bidgoli, Seyed Abolfazl Motahari, Nafiseh Sedaghat, Mohammad Hossein Modarressi
BACKGROUND: Nutrigenomic has revolutionized our understanding of nutrition. As plants make up a noticeable part of our diet, in the present study we chose microRNAs of edible plants and investigated if they can perfectly match human genes, indicating potential regulatory functionalities. METHODS: miRNAs were obtained using the PNRD database. Edible plants were separated and microRNAs in common in at least four of them entered our analysis. Using vmatchPattern, these 64 miRNAs went through four steps of refinement to improve target prediction: Alignment with the whole genome (2581 results), filtered for those in gene regions (1371 results), filtered for exon regions (66 results) and finally alignment with the human CDS (41 results)...
January 23, 2019: Computers in Biology and Medicine
https://read.qxmd.com/read/30701698/lncirs1-controls-muscle-atrophy-via-sponging-mir-15-family-to-activate-igf1-pi3k-akt-pathway
#10
Zhenhui Li, Bolin Cai, Bahareldin Ali Abdalla, Xuenong Zhu, Ming Zheng, Peigong Han, Qinghua Nie, Xiquan Zhang
BACKGROUND: Recent studies indicate important roles for long noncoding RNAs (lncRNAs) in the regulation of gene expression by acting as competing endogenous RNAs (ceRNAs). However, the specific role of lncRNAs in skeletal muscle atrophy is still unclear. Our study aimed to identify the function of lncRNAs that control skeletal muscle myogenesis and atrophy. METHODS: RNA sequencing was performed to identify the skeletal muscle transcriptome (lncRNA and messenger RNA) between hypertrophic broilers and leaner broilers...
January 30, 2019: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/30701530/restoration-of-microrna-30b-expression-alleviates-vascular-calcification-through-the-mtor-signaling-pathway-and-autophagy
#11
Tian-Hua Xu, Xiao-Bo Qiu, Zi-Tong Sheng, Yi-Ran Han, Jian Wang, Bin-Yao Tian, Li Yao
Pathological calcification represents an event that consequently leads to a distinct elevation in the morbidity and mortality of patients with chronic kidney disease (CKD) in addition to strengthening its correlation with hyperphosphatemia. Epigenomic regulation by specific microRNAs (miRNAs) is reported to be involved in ectopic calcification. However, the finer molecular mechanisms governing this event remain unclear. Hence, this study aimed to identify the potential miRNAs involved in vascular calcification (VC) development and progression...
January 31, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30700445/microrna-dysregulation-and-non-muscle-invasive-bladder-cancer-prognosis
#12
Angeline S Andrew, Margaret R Karagas, Florian R Schroeck, Carmen J Marsit, Alan R Schned, Jason R Pettus, David A Armstrong, John D Seigne
BACKGROUND: The high rate of non-muscle invasive bladder cancer recurrence is a major challenge in patient management. microRNAs (miRNAs) functionally regulate tumor cell proliferation and invasion, and have strong potential as biomarkers, since they are robust to degradation. The objective of this project was to identify reproducible prognostic miRNAs in resected non-muscle invasive bladder tumor tissue that are predictive of the recurrent tumor phenotype. METHODS: We utilized patients diagnosed with primary non-muscle invasive bladder cancer in three independent cohorts for a biomarker discovery / validation approach...
January 30, 2019: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/30699200/characterization-of-a-novel-microrna-mir-188-elevated-in-serum-of-muscular-dystrophy-dog-model
#13
Hiroyuki Shibasaki, Michihiro Imamura, Sayuri Arima, Jun Tanihata, Mutsuki Kuraoka, Yasunari Matsuzaka, Fumiaki Uchiumi, Sei-Ichi Tanuma, Shin'ichi Takeda
MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression at the post-transcriptional level. Several miRNAs are exclusively expressed in skeletal muscle and participate in the regulation of muscle differentiation by interacting with myogenic factors. These miRNAs can be found at high levels in the serum of patients and animal models for Duchenne muscular dystrophy, which is expected to be useful as biomarkers for their clinical conditions. By miRNA microarray analysis, we identified miR-188 as a novel miRNA that is elevated in the serum of the muscular dystrophy dog model, CXMDJ...
2019: PloS One
https://read.qxmd.com/read/30692507/spif-promotes-myoblast-differentiation-and-utrophin-expression-while-inhibiting-fibrosis-in-duchenne-muscular-dystrophy-via-the-h19-mir-675-let-7-and-mir-21-pathways
#14
Daria Morgoulis, Peter Berenstein, Simona Cazacu, Gila Kazimirsky, Amir Dori, Eytan R Barnea, Chaya Brodie
Duchenne muscular dystrophy (DMD) is a progressive, lethal, X-linked disease of skeletal and cardiac muscles caused by mutations in the dystrophin gene. Loss of dystrophin leads to muscle fiber damage and impairment of satellite cell asymmetric division, which are essential for muscle regeneration. These processes ultimately result in muscle wasting and the replacement of the degenerating muscles by fibrogenic cells, a process that leads to the generation of fibrotic tissues. Preimplantation factor (PIF) is an evolutionary conserved 15-amino acid peptide secreted by viable mammalian embryos...
January 28, 2019: Cell Death & Disease
https://read.qxmd.com/read/30690256/correlation-between-estrogen-plasma-level-and-mirnas-in-muscle-of-piedmontese-cattle
#15
E Martignani, S Miretti, L Vincenti, M Baratta
A loss-of-function mutation of the myostatin gene has a very high prevalence in the Piedmontese cattle breed. The effect of such mutation is a double-muscle phenotype because of hypertrophy. However, differences in muscle mass development can still be detected in individuals of this breed. Such differences must be generated by other factors controlling skeletal muscle development. MicroRNAs are short noncoding RNA molecules that modulate gene expression at a post-transcriptional level. MicroRNAs have been demonstrated to be involved in skeletal muscle development, and some of them are controlled by steroid hormone signaling...
December 19, 2018: Domestic Animal Endocrinology
https://read.qxmd.com/read/30678306/integrative-analyses-of-genes-associated-with-subcutaneous-insulin-resistance
#16
Manoj Kumar Pujar, Basavaraj Vastrad, Chanabasayya Vastrad
: Insulin resistance is present in the majority of patients with non-insulin-dependent diabetes mellitus (NIDDM) and obesity. In this study, we aimed to investigate the key genes and potential molecular mechanism in insulin resistance. Expression profiles of the genes were extracted from the Gene Expression Omnibus (GEO) database. Pathway and Gene Ontology (GO) enrichment analyses were conducted at Enrichr. The protein⁻protein interaction (PPI) network was settled and analyzed using the Search Tool for the Retrieval of Interacting Genes (STRING) database constructed by Cytoscape software...
January 22, 2019: Biomolecules
https://read.qxmd.com/read/30678104/substantial-dysregulation-of-mirna-passenger-strands-underlies-the-vascular-response-to-injury
#17
Karine Pinel, Louise A Diver, Katie White, Robert A McDonald, Andrew H Baker
Vascular smooth muscle cell (VSMC) dedifferentiation is a common feature of vascular disorders leading to pro-migratory and proliferative phenotypes, a process induced through growth factor and cytokine signaling cascades. Recently, many studies have demonstrated that small non-coding RNAs (miRNAs) can induce phenotypic effects on VSMCs in response to vessel injury. However, most studies have focused on the contribution of individual miRNAs. Our study aimed to conduct a detailed and unbiased analysis of both guide and passenger miRNA expression in vascular cells in vitro and disease models in vivo...
January 23, 2019: Cells
https://read.qxmd.com/read/30676868/quadriceps-mir-542-3p-and-5p-are-elevated-in-copd-and-reduce-function-by-inhibiting-ribosomal-and-protein-synthesis
#18
Roser Farre-Garros, Jen Y Lee, S Amanda Natanek, Martin Connolly, Avan A Sayer, Harnish P Patel, Cyrus Cooper, Michael I Polkey, Paul R Kemp
Reduced physical performance reduces quality of life in patients with COPD. Impaired physical performance is, in part, a consequence of reduced muscle mass and function, which is accompanied by mitochondrial dysfunction. We recently showed that miR-542-3p and miR-542-5p were elevated in a small cohort of COPD patients and more markedly in critical care patients. In mice these miRNAs promoted mitochondrial dysfunction suggesting that they would affect physical performance in patients with COPD but we did not explore the association of these miRNAs with disease severity or physical performance further...
January 24, 2019: Journal of Applied Physiology
https://read.qxmd.com/read/30675230/actg1-and-tlr3-are-biomarkers-for-alcohol-associated-hepatocellular-carcinoma
#19
Bing Gao, Shicheng Li, Zhen Tan, Leina Ma, Jia Liu
Alcohol consumption is a risk factor for the development of hepatocellular carcinoma (HCC); however, the association between alcohol and HCC remains unknown. The present study aimed to identify key genes related to alcohol-associated HCC to improve the current understanding of the pathology of this disease. Alcohol-associated and non-alcohol-associated HCC samples in the GSE50579 dataset of the Gene Omnibus Database were analyzed to investigate altered gene expression. Integrated bioinformatics methods were employed to clarify the biological functions of the differentially expressed genes (DEGs), including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein-protein interactions (PPIs)...
February 2019: Oncology Letters
https://read.qxmd.com/read/30671223/cardiac-progenitor-reprogramming-for-heart-regeneration
#20
REVIEW
Behnam Ebrahimi
Myocardial infarction leads to the loss of a huge number of cardiomyocytes and the reparatory response to this phenomenon is scar tissue formation, which impairs heart function. Direct reprogramming technology offers an alternative strategy for the generation of functional cardiomyocytes not only in vitro , but also in vivo in the site of injury. Results have demonstrated cardiac tissue regeneration and improvement in heart function after myocardial infarction following local injection of vectors encoding reprogramming transcription factors or miRNAs...
September 2018: Cell Regeneration
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