keyword
https://read.qxmd.com/read/38504307/cre-loxp-and-tamoxifen-induced-deletion-of-ovarian-quiescin-sulfhydryl-oxidase-2-showed-disruption-of-ovulatory-activity-in-mice
#21
JOURNAL ARTICLE
Shih-Yun Chen, Tse-En Wang, Wei-Yun Lee, Ya-Yi Yang, Hong-Chun Lai, Fuko Matsuda, Haruhiko Kosek, You-Tzung Chen, Sheng-Hsiang Li, Pei-Shiue Tsai
BACKGROUND: Quiescin sulfhydryl oxidase 2 (QSOX2) is a flavin adenine dinucleotide-dependent sulfhydryl oxidase that is known to be involved in protein folding, cell growth regulation, and redox state modification through oxidative activities. Earlier studies demonstrated the tissue and cellular localization of QSOX2 in the male reproductive tract, as well as the highly-regulated mechanism of QSOX2 protein synthesis and expression through the coordinated action of testosterone and epididymal-enriched amino acid, glutamate...
March 19, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38501340/gap-junctions-in-polycystic-ovary-syndrome-implications-for-follicular-arrest
#22
REVIEW
Ying Zhu, Hongqiu Zhu, Peijuan Wu
Gap junctions are specialized intercellular conduits that provide a direct pathway between neighboring cells, which are involved in numerous physiological processes, such as cellular differentiation, cell growth, and metabolic coordination. The effect of gap junctional hemichannels in folliculogenesis is particularly obvious, and the down-regulation of connexins is related to abnormal follicle growth. Polycystic ovary syndrome (PCOS) is a ubiquitous endocrine disorder of the reproductive system, affecting the fertility of adult women due to anovulation...
March 19, 2024: Developmental Dynamics
https://read.qxmd.com/read/38501122/a-multiscale-spatial-modeling-framework-for-the-germinal-center-response
#23
Derek P Mu, Christopher D Scharer, Norbert E Kaminski, Qiang Zhang
The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymph organs, a GC culminates in the production of high-affinity antibody-secreting plasma cells along with memory B cells. By interacting with follicular dendritic cells (FDC) and T follicular helper (Tfh) cells, GC B cells exhibit complex spatiotemporal dynamics. Driving the B cell dynamics are the intracellular signal transduction and gene regulatory network that responds to cell surface signaling molecules, cytokines, and chemokines...
January 30, 2024: bioRxiv
https://read.qxmd.com/read/38500223/trichomeless-regulator-3-is-required-for-trichome-initial-and-cuticle-biosynthesis-in-artemisia-annua
#24
JOURNAL ARTICLE
Boran Dong, Zihan Xu, Xingxing Wang, JinXing Li, Ying Xiao, Doudou Huang, Zongyou Lv, Wansheng Chen
Artemisinin is primarily synthesized and stored in the subepidermal space of the glandular trichomes of Artemisia annua. The augmentation of trichome density has been demonstrated to enhance artemisinin yield. However, existing literature lacks insights into the correlation between the stratum corneum and trichomes. This study aims to unravel the involvement of TrichomeLess Regulator 3 (TLR3), which encodes the transcription factor, in artemisinin biosynthesis and its potential association with the stratum corneum...
March 19, 2024: Mol Hortic
https://read.qxmd.com/read/38499957/dynamics-of-serum-exosome-microrna-profile-altered-by-chemically-induced-estropause-and-rescued-by-estrogen-therapy-in-female-mice
#25
JOURNAL ARTICLE
Bianka Machado Zanini, Bianca Machado de Avila, Driele Neske Garcia, Jéssica Damé Hense, Gabriel Barreto Veiga, Mariana Machado Barreto, Sarah Ashiqueali, Jeffrey B Mason, Hariom Yadav, Michal Masternak, Augusto Schneider
The decline in the ovarian reserve leads to menopause and reduced serum estrogens. MicroRNAs are small non-coding RNAs, which can regulate gene expression and be secreted by cells and trafficked in serum via exosomes. Serum miRNAs regulate tissue function and disease development. Therefore, the aim of this study was to identify miRNA profiles in serum exosomes of mice induced to estropause and treated with 17β-estradiol (E2). Female mice were divided into three groups including control (CTL), injected with 4-Vinylcyclohexene diepoxide (VCD), and injected with VCD plus E2 (VCD + E2 )...
March 19, 2024: GeroScience
https://read.qxmd.com/read/38499917/approaches-to-study-wound-induced-hair-neogenesis-wihn
#26
JOURNAL ARTICLE
Abhik Dutta, Dyuti Saha, Colin Jamora
Embryonic wound repair proceeds with complete regeneration of the tissue without any scar formation, whereas tissue repair in adults usually results in scars and the tissue does not completely regain its preinjured state. Wound-induced hair neogenesis (WIHN) in adult rodents results in de novo hair follicle formation in the center of large wounds, mimicking regeneration processes seen in fetal tissue. The investigation of WIHN therefore provides a unique quantitative framework for scrutinizing the mechanistic underpinnings of regenerative repair, which can have clinical implications in the context of scarless healing...
March 19, 2024: Methods in Molecular Biology
https://read.qxmd.com/read/38497393/association-of-anti-m%C3%A3-llerian-hormone-and-insulin-resistance-in-adolescent-girls-with-polycystic-ovary-syndrome
#27
JOURNAL ARTICLE
Gang Guo, Huan Zheng, Xia Wu
INTRODUCTION: Insulin resistance (IR) is confirmed as an important feature among polycystic ovary syndrome (PCOS) patients. Anti-Müllerian hormone (AMH), a vital marker of ovarian dysfunction, is proposed for inclusion in the diagnosis of PCOS in adolescents. We sought to investigate the relationship between the AMH level and IR in Chinese girls with PCOS. MATERIAL AND METHODS: 92 girls with PCOS aged 14-18 years were enrolled and divided into 2 subgroups: PCOS with IR group (n = 25) and PCOS without IR group (n = 67)...
2024: Endokrynologia Polska
https://read.qxmd.com/read/38494723/dehydroepiandrosterone-modulates-the-pten-pi3k-akt-signaling-pathway-to-alleviate-4-vinylcyclohexene-diepoxide-induced-premature-ovarian-insufficiency-in-rats
#28
JOURNAL ARTICLE
Cihan Cakir, Goktan Kuspinar, Kiper Aslan, Cengiz Bozyigit, Isil Kasapoglu, Melahat Dirican, Gurkan Uncu, Berrin Avci
Dehydroepiandrosterone (DHEA) is frequently integrated as an adjuvant in over a quarter of controlled ovarian hyperstimulation (COH) protocols, despite the ongoing debate regarding its impact. This study aimed to evaluate the efficacy and mechanism of action of DHEA on ovarian follicular development and ovarian response in rats with varying ovarian reserves. The study involved 75 rats categorized into 15 distinct groups. The ovarian tissues of rats in both the normal ovarian reserve group and the premature ovarian insufficiency (POI) group, induced by 4-vinylcyclohexene diepoxide (VCD) injection, were subjected to histomorphological and biochemical analyses following the administration of DHEA, either alone or in combination with COH...
March 16, 2024: Experimental Animals
https://read.qxmd.com/read/38493224/local-effect-of-allopregnanolone-in-rat-ovarian-steroidogenesis-follicular-and-corpora-lutea-development
#29
JOURNAL ARTICLE
Antonella Rosario Ramona Cáceres, Daniela Alejandra Cardone, María de Los Ángeles Sanhueza, Ignacio Manuel Bosch, Fernando Darío Cuello-Carrión, Graciela Beatriz Rodriguez, Leopoldina Scotti, Fernanda Parborell, Julia Halperin, Myriam Raquel Laconi
Allopregnanolone (ALLO) is a known neurosteroid and a progesterone metabolite synthesized in the ovary, CNS, PNS, adrenals and placenta. Its role in the neuroendocrine control of ovarian physiology has been studied, but its in situ ovarian effects are still largely unknown. The aims of this work were to characterize the effects of intrabursal ALLO administration on different ovarian parameters, and the probable mechanism of action. ALLO administration increased serum progesterone concentration and ovarian 3β-HSD2 while decreasing 20α-HSD mRNA expression...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38492250/new-insights-into-the-genetic-loci-related-to-egg-weight-and-age-at-first-egg-traits-in-broiler-breeder
#30
JOURNAL ARTICLE
Xiaochun Ma, Fan Ying, Zhengda Li, Lu Bai, Mengjie Wang, Dan Zhu, Dawei Liu, Jie Wen, Guiping Zhao, Ranran Liu
Egg weight (EW) and age at first egg (AFE) are economically important traits in breeder chicken production. The genetic basis of these traits, however, is far from understood, especially for broiler breeders. In this study, genetic parameter estimation, genome-wide association analysis, meta-analysis, and selective sweep analysis were carried out to identify genetic loci associated with EW and AFE in 6,842 broiler breeders. The study found that the heritability of EW ranged from 0.42 to 0.44, while the heritability of AFE was estimated at 0...
March 5, 2024: Poultry Science
https://read.qxmd.com/read/38492249/nr5a1-and-nr5a2-regulate-follicle-development-in-chicken-gallus-gallus-by-altering-proliferation-apoptosis-and-steroid-hormone-synthesis-of-granulosa-cells
#31
JOURNAL ARTICLE
Ruixue Nie, Haoyu Tian, Wenhui Zhang, Fuwei Li, Bo Zhang, Hao Zhang
Chicken ovarian follicle development is regulated by complex and dynamic gene expression. Nuclear receptor 5A1 and 5A2 (NR5A1 and NR5A2, respectively) are key genes that regulate steroid hormone production and gonadal development in mammals; however, studies on follicular development in the chicken ovary are scarce. In this study, we investigated the functions of NR5A1 and NR5A2 on follicle development in chickens. The results showed that the expression of NR5A1 and NR5A2 was significantly higher in small yellow follicles and F5...
March 6, 2024: Poultry Science
https://read.qxmd.com/read/38490420/mechanistic-interplay-of-dual-environmental-stressors-bisphenol-a-and-cadmium-induced-ovarian-follicular-damage-and-hepatocyte-dysfunction-in-vivo
#32
JOURNAL ARTICLE
Gokul Sudhakaran, P Snega Priya, B Haridevamuthu, Raghul Murugan, Jagan Kannan, Mikhlid H Almutairi, Bader O Almutairi, Ajay Guru, Jesu Arockiaraj
This study investigates the individual and combined toxic effects of Bisphenol A (BPA) and Cadmium (Cd) in zebrafish, recognizing the complex mixture of pollutants organisms encounter in their natural environment. Examining developmental, neurobehavioral, reproductive, and physiological aspects, the study reveals significant adverse effects, particularly in combined exposures. Zebrafish embryos exposed to BPA + Cd exhibit synergistically increased mortality, delayed hatching, and morphological abnormalities, emphasizing the heightened toxicity of the combination...
March 13, 2024: Science of the Total Environment
https://read.qxmd.com/read/38487530/fcry-is-a-key-molecule-controlling-maternal-blood-igy-transfer-to-yolks-during-egg-development-in-avian-species
#33
JOURNAL ARTICLE
Mayuko Okamoto, Ryo Sasaki, Koki Ikeda, Kasumi Doi, Fumiya Tatsumi, Kenzi Oshima, Takaaki Kojima, Shusei Mizushima, Keisuke Ikegami, Takashi Yoshimura, Kyohei Furukawa, Misato Kobayashi, Fumihiko Horio, Atsushi Murai
Maternal immunoglobulin transfer plays a key role in conferring passive immunity to neonates. Maternal blood immunoglobulin Y (IgY) in avian species is transported to newly-hatched chicks in two steps: 1) IgY is transported from the maternal circulation to the yolk of maturing oocytes, 2) the IgY deposited in yolk is transported to the circulation of the embryo via the yolk sac membrane. An IgY-Fc receptor, FcRY, is involved in the second step, but the mechanism of the first step is still unclear. We determined whether FcRY was also the basis for maternal blood IgY transfer to the yolk in the first step during egg development...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38487264/translational-frontiers-insight-from-lymphatics-in-skin-regeneration
#34
REVIEW
Yujia Jiang, Mirna Perez-Moreno
The remarkable regenerative ability of the skin, governed by complex molecular mechanisms, offers profound insights into the skin repair processes and the pathogenesis of various dermatological conditions. This understanding, derived from studies in human skin and various model systems, has not only deepened our knowledge of skin regeneration but also facilitated the development of skin substitutes in clinical practice. Recent research highlights the crucial role of lymphatic vessels in skin regeneration. Traditionally associated with fluid dynamics and immune modulation, these vessels are now recognized for interacting with skin stem cells and coordinating regeneration...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38486276/efficacy-and-safety-of-follitropin-delta-for-ovarian-stimulation-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles-a-systematic-review-with-meta-analysis
#35
REVIEW
Stefano Palomba, Donatella Caserta, Paolo Emanuele Levi-Setti, Andrea Busnelli
BACKGROUND: Follitropin delta is a novel recombinant follicle stimulating hormone preparation uniquely expressed in a human fetal retinal cell line by recombinant DNA technology. To date, no systematic review was available about the safety and the efficacy of the follitropin delta. The objective of this study was systematically reviewing the available literature and to provide updated evidence regarding the efficacy-safety profile of follitropin delta when compared to other gonadotropin formulations for ovarian stimulation in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles...
March 14, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38484784/the-spatio-temporal-distribution-of-aromatase-cytochrome-in-ovary-throughout-the-canine-oestrous-cycle
#36
JOURNAL ARTICLE
L Lindh, M P Kowalewski, S K Goericke-Pesch, H Lindeberg, G Schuler, O A T Peltoniemi
CONTEXT: New animal welfare legislation and ethical guidelines encourage alternative approaches for canine contraception, instead of surgical gonadectomy which is considered invasive and unjustified in healthy dogs. AIMS: Reversible contraception might be achieved by inhibition of aromatase (CYP19), an enzyme catalysing the conversion of androgens to oestrogens. This study provides insights into the spatio-temporal expression and distribution of aromatase in canine ovarian tissue...
March 15, 2024: Reproduction, Fertility, and Development
https://read.qxmd.com/read/38484673/expression-of-izumo1-and-juno-in-the-gonads-of-domestic-cats-felis-catus
#37
JOURNAL ARTICLE
Phakjira Sanguansook, Watchareewan Rodprasert, Chenphop Sawangmake, Lourdes Gimeno, José Luis Ferran, Pilar Sòria-Monzó, Manuel Avilés, Mª José Izquierdo Rico, Kaywalee Chatdarong
Because of the time-consuming nature of surgical neutering and the rapid rate of reproduction among domestic cats, it is crucial to investigate alternative, nonsurgical methods of contraception for this species. Sperm protein IZUMO1 and its oocyte receptor JUNO have been proposed as potential targets for nonsurgical contraceptives. This study aimed to demonstrate (1) the protein coding sequence of feline IZUMO1 and JUNO, (2) gene expression in specific organs by measuring mRNA levels in different visceral tissues, and (3) the expression of IZUMO1 and JUNO during sperm maturation and folliculogenesis, respectively...
March 1, 2024: Theriogenology
https://read.qxmd.com/read/38481039/lineage-specific-requirements-of-alx4-function-in-craniofacial-and-hair-development
#38
JOURNAL ARTICLE
Yu Lan, Zhaoming Wu, Han Liu, Rulang Jiang
BACKGROUND: Disruption of ALX4 causes autosomal dominant parietal foramina and autosomal recessive frontonasal dysplasia with alopecia, but the mechanisms involving ALX4 in craniofacial and other developmental processes are not well understood. Although mice carrying distinct mutations in Alx4 have been previously reported, the perinatal lethality of homozygous mutants together with dynamic patterns of Alx4 expression in multiple tissues have hindered systematic elucidation of the cellular and molecular mechanisms involving Alx4 in organogenesis and disease pathogenesis...
March 13, 2024: Developmental Dynamics
https://read.qxmd.com/read/38481037/the-role-of-the-beautician-in-reducing-striae
#39
REVIEW
Monika Rusztowicz, Karolina Chilicka, Michael H Gold, Renata Szyguła, Sławomir Wilczyński, Barbara Błońska-Fajfrowska
INTRODUCTION: Striae distensae are a permanent skin defect that can affect 50%-90% of the population. The appearance of the changes resembles spindle-shaped skin bands. The skin in this area is wrinkled, thin and looks like a scar. Most often, the changes are found on the skin of the abdomen, buttocks, breasts, thighs, and back. The appearance of striae means that the skin in this area has no hair follicles, sebaceous, and sweat glands. This skin is flabby, not very elastic and, what is very characteristic, the pigmentation of the skin affected by striae is much lower than in healthy skin...
March 13, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38478424/4d-label-free-quantitative-proteomic-analysis-identifies-crabp1-as-a-novel-candidate-gene-for-litter-size-in-rabbits
#40
JOURNAL ARTICLE
Zhiyuan Bao, Yang Chen, Jiali Li, Jiawei Cai, Jie Yang, Pin Zhai, Bohao Zhao, Xinsheng Wu
In commercial rabbit breeding, litter size is a crucial reproductive trait. This trait directly determines the reproductive ability of female rabbits and is crucial for evaluating the production efficiency. We here compared differentially expressed proteins of in the ovary tissue from New Zealand female rabbits with high (H) and low (L) litter sizes by using 4D label-free quantitative proteomic technology and identified 92 differential proteins. The biological functions of these proteins were revealed through gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses...
March 13, 2024: Biology of Reproduction
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