keyword
https://read.qxmd.com/read/38516851/weakly-acidic-ph-responsive-liposomal-content-release-induced-by-histidine-modified-agents
#1
JOURNAL ARTICLE
Ayumi Kashiwada, Narumi Taoka, Yukiha Chijimi, Keiko Noguchi, Karin Shigematsu, Motofumi Miura, Toyofumi Suzuki
Internal stimuli-responsive controlled release from liposomal vesicles is an innovative approach for site-specific delivery of therapeutic drugs. In this study, to enhance the endosomal pH control of drug release from liposomes, a series of histidine-modified pH-sensitive C n -His ( n = 8, 12, 18) agents were designed and utilized as triggers for liposomal content release. The pH-dependent properties of C n -His-incorporated liposomes were characterized using dynamic light scattering, ζ-potential, and fluorescence spectroscopy...
March 22, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38329387/preparation-of-glycopeptide-modified-ph-sensitive-liposomes-for-promoting-antigen-cross-presentation-and-induction-of-antigen-specific-cellular-immunity
#2
JOURNAL ARTICLE
Eiji Yuba, Rajesh Kumar Gupta
Cross-presentation, exogenous antigen presentation onto major histocompatibility complex class I molecules on antigen presenting cells, is crucially important for inducing antigen-specific cellular immune responses for cancer immunotherapy and for the treatment of infectious diseases. One strategy to induce cross-presentation is cytosolic delivery of an exogenous antigen using fusogenic or endosomolytic molecule-introduced nanocarriers. Earlier, we reported liposomes modified with pH-responsive polymers to achieve cytosolic delivery of an antigen...
February 8, 2024: Biomaterials Science
https://read.qxmd.com/read/38293612/research-progress-of-sn38-drug-delivery-system-in-cancer-treatment
#3
REVIEW
Qing-Rui Qi, Huan Tian, Bao-Sen Yue, Bing-Tao Zhai, Feng Zhao
The active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxycamptothecin (SN38), is 100-1000 times more active than CPT-11 and has shown inhibitory effects on a range of cancer cells, including those from the rectal, small cell lung, breast, esophageal, uterine, and ovarian malignancies. Despite SN38's potent anticancer properties, its hydrophobicity and pH instability have caused substantial side effects and anticancer activity loss, which make it difficult to use in clinical settings. To solve the above problems, the construction of SN38-based drug delivery systems is one of the most feasible methods to improve drug solubility, enhance drug stability, increase drug targeting ability, improve drug bioavailability, enhance therapeutic efficacy and reduce adverse drug reactions...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38269490/liposome-enabled-bufalin-and-doxorubicin-combination-therapy-for-trastuzumab-resistant-breast-cancer-with-a-focus-on-cancer-stem-cells
#4
JOURNAL ARTICLE
Yu Gao, Andrew N Shelling, Emma Nolan, David Porter, Euphemia Leung, Zimei Wu
Breast cancer stem cells (BCSCs) play a key role in therapeutic resistance in breast cancer treatments and disease recurrence. This study aimed to develop a combination therapy loaded with pH-sensitive liposomes to kill both BCSCs and the okbulk cancer cells using trastuzumab-sensitive and resistant human epidermal growth factor receptor 2 positive (HER2+ ) breast cancer cell models. The anti-BCSCs effect and cytotoxicity of all-trans retinoic acid, salinomycin, and bufalin alone or in combination with doxorubicin were compared in HER2+ cell line BT-474 and a validated trastuzumab-resistant cell line, BT-474R...
January 25, 2024: Journal of Liposome Research
https://read.qxmd.com/read/38173599/sodium-alginate-carboxymethyl-cellulose-films-embedded-with-liposomes-encapsulated-green-tea-extract-characterization-controlled-release-application
#5
JOURNAL ARTICLE
Xin Feng, Yang Li, Zhuoyu Cui, Rongrong Tang
To maintain the freshness of the fruit during storage, sodium alginate/carboxymethyl cellulose films embedded with pH-senstive liposomes encapsulated green tea extract were developed (SA/CMC/TP-Lip). An orthogonal design was used to optimise the preparation of TP-Lip and SA/CMC/TP-Lip was prepared through response surface. The stability of TP-Lip structure was measured. The morphology of SA/CMC/TP-Lip was characterised by SEM, and the mechanical properties and oxidation resistance of films were measured. Special attention was paid to the pH sensitivity of TP-Lip and the improvement of film properties...
January 2, 2024: RSC Advances
https://read.qxmd.com/read/38135054/an-automated-capillary-electrophoresis-based-method-for-drug-release-profiling-of-liposomal-doxorubicin
#6
JOURNAL ARTICLE
Savithra Jayaraj, Wenlei Jiang, Thilak Mudalige
Liposomal doxorubicin hydrochloride is an antineoplastic agent widely used against human cancers. The data from in vitro drug release test (IVRT) is essential for quality and/or bioequivalence evaluation in drug approval and post-approval regulation of liposomal drug products. However, most of the currently available IVRT methods for liposomal doxorubicin hydrochloride have experimental deficiencies associated with liposomal rupture during the separation process which is needed for selective quantification of released drug from liposomal-bound drug...
December 20, 2023: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38131275/oxygen-and-ph-responsive-theragnostic-liposomes-for-early-stage-diagnosis-and-photothermal-therapy-of-solid-tumours
#7
JOURNAL ARTICLE
Siyi Li, Qinglin Wang, Yingying Ren, Pengfei Zhong, Pengtao Bao, Shanyue Guan, Xiaochen Qiu, Xiaozhong Qu
The development of cancer treatment is of great importance, especially in the early stage. In this work, we synthesized a pH-sensitive amphiphilic ruthenium complex containing two alkyl chains and two PEG chains, which was utilized as an oxygen sensitive fluorescent probe for co-assembly with lipids to harvest a liposomal delivery system (RuPC) for the encapsulation of a photothermal agent indocyanine green (ICG). The resultant ICG encapsulated liposome (RuPC@ICG) enabled the delivery of ICG into cells via a membrane fusion pathway, by which the ruthenium complex was localized in the cell membrane for better detection of the extracellular oxygen concentration...
December 22, 2023: Biomaterials Science
https://read.qxmd.com/read/38103758/biosynthesis-characterization-magnetic-hyperthermia-and-in-vitro-toxicity-evaluation-of-quercetin-loaded-magnetoliposome-lipid-bilayer-hybrid-system-on-mcf-7-breast-cancer
#8
JOURNAL ARTICLE
Shehab Elbeltagi, Ahmad M Saeedi, Zienab E Eldin, Haifa E Alfassam, Hanan M Alharbi, Nawal Madkhali, Abo Bakr Abdel Shakor, Mohamed Abd El-Aal
Novel biocompatible and efficient hyperthermia (HT) treatment materials for breast cancer therapeutic have recently garnered significant attention, owing to their effective ablation of cancer cells and minimal damage to healthy cells. Magnetoliposome (MLs) offer multiple possibilities for utilize in cancer therapy, including smart drug delivery (SDD) mediated by alternating magnetic fields (AMF). In this work, magnesium ferrite (MgFe2 O4 ) encapsulated with liposomes lipid bilayer (MLs), Quercetin (Q)-loaded MgFe2 O4 @Liposomes (Q-MLs) nano-hybrid system were successfully synthesized for magnetic hyperthermia (MHT) and SDD applications...
December 14, 2023: Biochimica et Biophysica Acta. General Subjects
https://read.qxmd.com/read/37949274/chondroitin-sulfate-and-chitosan-coated-liposomes-as-a-novel-delivery-system-for-betanin-preparation-characterization-and-in-vitro-digestion-behavior
#9
JOURNAL ARTICLE
Yuan Guan, Yue Ning, Zhengming Xu, Chuang Zhou, Zhengang Zhao
Betanin, a water-soluble pigment known for its high bioactivity, is hindered by pH and temperature sensitivity, weak ionic strength, and low bioavailability. In this study, nanoliposome (NPS), chitosan-coated NPS (CNPS), and chondroitin sulfate-chitosan bilayer-modified nanoliposomes (SCNPS) were prepared based on a layer-by-layer electrostatic interaction method for betanin encapsulation. The increase of polymer layers from NPS to SCNPS led to a monotonic increment from 223.57 to 522.33 nm in size, from -27...
November 8, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37948136/study-on-tumour-cell-derived-hybrid-exosomes-as-dasatinib-nanocarriers-for-pancreatic-cancer-therapy
#10
JOURNAL ARTICLE
Xiaofei Zhou, Yuetang Zhuang, Xiaohong Liu, Yaowen Gu, Junting Wang, Yuchen Shi, Li Zhang, Rui Li, Yelin Zhao, Hebing Chen, Jiao Li, Hongjuan Yao, Liang Li
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death. Therefore, we intend to explore novel strategies against PDAC. The exosomes-based biomimetic nanoparticle is an appealing candidate served as a drug carrier in cancer treatment, due to its inherit abilities. In the present study, we designed dasatinib-loaded hybrid exosomes by fusing human pancreatic cancer cells derived exosomes with dasatinib-loaded liposomes, followed by characterization for particle size (119.9 ± 6...
December 2023: Artificial Cells, Nanomedicine, and Biotechnology
https://read.qxmd.com/read/37937394/a-state-of-the-art-liposome-technology-for-glioblastoma-treatment
#11
REVIEW
Ikram Hasan, Shubham Roy, Ehexige Ehexige, Runling Wu, Yu Chen, Zhengyuan Gao, Bing Guo, Chunqi Chang
Glioblastoma (GBM) is a challenging problem due to the poor BBB permeability of cancer drugs, its recurrence after the treatment, and high malignancy and is difficult to treat with the currently available therapeutic strategies. Furthermore, the prognosis and survival rate of GBM are still poor after surgical removal via conventional combination therapy. Owing to the existence of the formidable blood-brain barrier (BBB) and the aggressive, infiltrating nature of GBM growth, the diagnosis and treatment of GBM are quite challenging...
November 8, 2023: Nanoscale
https://read.qxmd.com/read/37921708/stromal-and-tumor-immune-microenvironment-reprogramming-through-multifunctional-cisplatin-based-liposomes-boosts-the-efficacy-of-anti-pd-1-immunotherapy-in-pancreatic-cancer
#12
JOURNAL ARTICLE
Hang Yu, Wenting Zhu, Caiyan Lin, Menglei Jia, Xiaoxiao Tan, Zhongwen Yuan, Senglin Feng, Pengke Yan
The dense stromal barrier in pancreatic cancer tissues blocks intratumoral delivery and distribution of chemotherapeutics and therapeutic antibodies, causing poor chemoimmunotherapy responses. We designed a multi-targeted pH-sensitive liposome which encapsulates cisplatin (Pt) in its water core (denoted as ATF@Pt Lps) and shows high affinity for uPAR receptors in pancreatic cancer cells, tumor-associated macrophages, and cancer-associated fibroblasts. Systemic administration of ATF@Pt Lps enabled overcoming the central stromal cellular barrier and effective drug delivery into tumor cells, resulting in a strong therapeutic response in a Panc02 cell derived transplanted tumor mouse model...
November 3, 2023: Biomaterials Science
https://read.qxmd.com/read/37917127/capric-acid-and-myristic-acid-permeability-enhancers-in-curved-liposome-membranes
#13
JOURNAL ARTICLE
Samaneh Davoudi, Koen Raemdonck, Kevin Braeckmans, An Ghysels
Liposomes are considered as advanced drug delivery systems for cancer treatment. A generation of pH-sensitive liposomes is being developed that use fatty acids (FAs) as a trigger for drug release in tumor tissues. However, FAs are also known to enhance permeability, and it is unclear whether FAs in liposomes may cause drug leakage or premature drug release. The passive permeability of the drug through the membrane of the liposome is thus a crucial factor for timely drug delivery. To investigate how the curvature and lipid composition of liposomes affect their passive permeability, coarse-grained molecular dynamics were performed...
November 2, 2023: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/37884209/prodrug-based-strategy-with-a-two-in-one-liposome-for-cerenkov-induced-photodynamic-therapy-and-chemotherapy
#14
JOURNAL ARTICLE
Huihui Liu, Qing Wang, Jingru Guo, Kai Feng, Yiling Ruan, Zhihao Zhang, Xin Ji, Jigang Wang, Tao Zhang, Xiaolian Sun
Cerenkov radiation induced photodynamic therapy (CR-PDT) can tackle the tissue penetration limitation of traditional PDT. However, co-delivery of radionuclides and photosensitizer may cause continuous phototoxicity in normal tissues during the circulation. 5-aminolevulinic acid (ALA) which can intracellularly transform into photosensitive protoporphyrin IX (PpIX) is a cancer-selective photosensitizer with negligible side effect. However, the hydrophilic nature of ALA and the further conversion of PpIX to photoinactive Heme severely hinder the therapeutic benefits of ALA-based PDT...
October 24, 2023: Journal of Controlled Release
https://read.qxmd.com/read/37867342/design-and-preparation-of-ph-sensitive-cytotoxic-liposomal-formulations-containing-antitumor-colchicine-analogues-for-target-release
#15
JOURNAL ARTICLE
Ekaterina S Shchegravina, Daria S Tretiakova, Alsu R Sitdikova, Sofia D Usova, Ivan A Boldyrev, Anna S Alekseeva, Elena V Svirshchevskaya, Elena L Vodovozova, Alexey Yu Fedorov
Herein, we describe the synthesis of pH-sensitive lipophilic colchicine prodrugs for liposomal bilayer inclusion, as well as preparation and characterization of presumably stealth PEGylated liposomes with above mentioned prodrugs. These formulations liberate strongly cytotoxic colchicinoid derivatives selectively under slightly acidic tumor-associated conditions, ensuring tumor-targeted delivery of the compounds. The design of the prodrugs is addressed to pH-triggered release of active compounds in the slight acidic media, that corresponds to tumour microenvironment, while keeping sufficient stability of the whole formulation at physiological pH...
October 23, 2023: Journal of Liposome Research
https://read.qxmd.com/read/37848888/engineering-sirna-therapeutics-challenges-and-strategies
#16
REVIEW
Syed Saqib Ali Zaidi, Faria Fatima, Syed Aqib Ali Zaidi, Dezhong Zhou, Wuquan Deng, Shuai Liu
Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA) has approved multiple siRNA-based therapeutics, many biological barriers limit their use for treating diseases. Such limitations include challenges concerning systemic or local administration, short half-life, rapid clearance rates, nonspecific binding, cell membrane penetration inability, ineffective endosomal escape, pH sensitivity, endonuclease degradation, immunological responses, and intracellular trafficking...
October 18, 2023: Journal of Nanobiotechnology
https://read.qxmd.com/read/37780808/sulfonated-polystyrenes-ph-and-mg-2-insensitive-amphiphilic-copolymers-for-detergent-free-membrane-protein-isolation
#17
JOURNAL ARTICLE
Miroslav Janata, Sachin Gupta, Eva Čadová, Pavla Angelisová, Bankala Krishnarjuna, Ayyalusamy Ramamoorthy, Václav Hořejší, Vladimír Raus
Amphiphilic polymers are increasingly applied in the detergent-free isolation and functional studies of membrane proteins. However, the carboxylate group present in the structure of many popular variants, such as styrene-maleic acid (SMA) copolymers, brings limitations in terms of polymer sensitivity to precipitation at acidic pH or in the presence of divalent metal cations. Herein, we addressed this problem by replacing carboxylate with the more acidic sulfonate groups. To this end, we synthesized a library of amphiphilic poly[styrene- co -(sodium 4-styrene sulfonate)] copolymers (termed SSS), differing in their molecular weight and overall polarity...
October 17, 2023: European Polymer Journal
https://read.qxmd.com/read/37765110/molecular-resonance-imaging-of-the-caix-expression-in-mouse-mammary-adenocarcinoma-cells
#18
JOURNAL ARTICLE
Claudia Quattrociocchi, Alberto Mangia, Silvio Aime, Valeria Menchise, Daniela Delli Castelli
The carbonic anhydrase isoform IX (hCAIX) is one of the main players in extracellular tumor pH regulation, and it is known to be overexpressed in breast cancer and other common tumors. hCA IX supports the growth and survival of tumor cells, and its expression is correlated with metastasis and resistance to therapies, making it an interesting biomarker for diagnosis and therapy. The aim of this work deals with the development of an MRI imaging probe able to target the extracellular non-catalytic proteoglycan-like (PG) domain of CAIX...
September 14, 2023: Pharmaceuticals
https://read.qxmd.com/read/37753066/photodynamic-cationic-ultrasmall-copper-oxide-nanoparticles-loaded-liposomes-for-alleviation-of-mrsa-biofilms
#19
JOURNAL ARTICLE
Xiangjun Chen, Wenting Li, Xueling Li, Keke Li, Guilong Zhang, Wei Hong
INTRODUCTION: As we enter the post-antibiotic era, the rise of antibiotic-resistant pathogenic bacteria is becoming a serious threat to public health. This problem is further complicated by antibiotic-resistant biofilms, for which current treatment options are limited. METHODS: To tackle this challenge, we propose a novel approach that involves the use of photodynamic cationic pH-sensitive liposomes loaded with ultra-small copper oxide (Ce6@Lipo/UCONs) to effectively eliminate drug-resistant bacteria and eradicate biofilms while minimizing safety concerns and the risk of resistance development...
2023: International Journal of Nanomedicine
https://read.qxmd.com/read/37740415/regulation-of-ion-homeostasis-for-enhanced-tumor-radio-immunotherapy
#20
JOURNAL ARTICLE
Rui Qian, Xuan Yi, Teng Liu, Hua Chen, Yuhong Wang, Lin Hu, Lingchuan Guo, Kai Yang, Haijun Deng
Intra/extracellular ion content affects the growth and metastasis of tumor cells, as well as the efficacy of various antitumor therapies. Herein, a carbonic anhydrase inhibitor (CAI) is loaded onto pH-responsive calcium carbonate (CaCO3 ) nanoparticles and then modify theses nanoparticles with liposomes to obtain biocompatible CaCO3 /CAI@Lipsome (CCL) for enhance tumor radio-immunotherapy. CCL can specially decompose in tumor microenvironment, releasing calcium ion (Ca2+ ) and CAI, as well as increasing the pH value of extracellular fluid...
September 22, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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