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https://read.qxmd.com/read/30781452/chitosan-based-carbon-quantum-dots-for-biomedical-applications-synthesis-and-characterization
#1
Łukasz Janus, Marek Piątkowski, Julia Radwan-Pragłowska, Dariusz Bogdał, Dalibor Matysek
Rapid development in medicine and pharmacy has created a need for novel biomaterials with advanced properties such as photoluminescence, biocompability and long-term stability. The following research deals with the preparation of novel types of N -doped chitosan-based carbon quantum dots. Nanomaterials were obtained with simultaneous nitrogen-doping using biocompatible amino acids according to Green Chemistry principles. For the carbon quantum dots synthesis chitosan was used as a raw material known for its biocompability...
February 16, 2019: Nanomaterials
https://read.qxmd.com/read/30778526/changes-in-dermal-thickness-in-biopsy-study-of-histologic-findings-after-a-single-injection-of-polycaprolactone-based-filler-into-the-dermis
#2
JongSeo Kim
BACKGROUND: During aging, facial skin thins, atrophies, and loses elasticity. Subdermal filler injections can volumize and treat wrinkles but cannot directly change dermal thickness. Polycaprolactone (PCL)-fillers can improve skin texture and quality through dermal thickening and inducing neocollagenesis. Through biopsy study, evidence of neocollagenesis will be introduced. OBJECTIVES: In this single clinic prospective-study, 13 patients received a single injection of diluted 0...
February 19, 2019: Aesthetic Surgery Journal
https://read.qxmd.com/read/30776674/generation-of-induced-pluripotent-stem-cell-line-zzui0012-a-from-a-patient-with-fahr-s-disease-caused-by-a-novel-mutation-in-slc20a2-gene
#3
Qinxian Zhang, Zhuo Li, Huifang Sun, Shoutao Zhang, Jin Zhang, Yanlin Wang, Hui Fang, Yuming Xu
Several SLC20A2 mutations have been implicated as potential causes of Fahr's disease, a subtype of primary familial brain calcification (PFBC), but very few patient-derived induced pluripotent stem cell (iPSC) models have been established. We have identified a novel SLC20A2 mutation in a family with Fahr's disease. We subsequently obtained dermal fibroblasts from a patient in this family. These fibroblasts were successfully transformed into iPSCs by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and L-MYC...
January 28, 2019: Stem Cell Research
https://read.qxmd.com/read/30776180/naringenin-as-an-opener-of-mitochondrial-potassium-channels-in-dermal-fibroblasts
#4
Rafal Pawel Kampa, Anna Kicinska, Wieslawa Jarmuszkiewicz, Monika Pasikowska-Piwko, Barbara Dolegowska, Renata Debowska, Adam Szewczyk, Piotr Bednarczyk
Flavonoids belong to a large group of polyphenolic compounds that are widely present in plants. Certain flavonoids, including naringenin, have cytoprotective properties. Although the antioxidant effect has long been thought to be a crucial factor accounting for the cellular effects of flavonoids, mitochondrial channels have emerged recently as targets for cytoprotective strategies. In the present study, we characterized interactions between naringenin and the mitochondrial potassium (mitoBKC a and mitoKATP ) channels recently described in dermal fibroblasts...
February 18, 2019: Experimental Dermatology
https://read.qxmd.com/read/30776155/imaging-of-ph-and-po-2-gives-insight-in-molecular-processes-of-irradiated-cells
#5
Yvonne Reinders, Robert J Meier, Gregor Liebsch, Fabian Pohl, Stephan Schreml, Lukas Prantl, Frank Haubner
One of the major challenges in radiation therapy is the interference with tissue repair processes due to hypoxic characteristics and pH dysregulation. In this study, we present dual imaging of pH and oxygenation in vitro based on luminescent biocompatible sensor foils that allow studying the effects of irradiation on different cell types in culture. Different sensitivities of fibroblast and oral squamous carcinoma cells were observed by complementing oxygen and pH differences with proliferation assays. This study highlights especially the distinct role of oxygen after irradiation and the difference in proliferation processes of irradiated normal dermal cells in contrast to irradiated tumor cells...
February 18, 2019: Experimental Dermatology
https://read.qxmd.com/read/30774336/green-synthesis-of-multifunctional-peg-carboxylate-%C3%AF-back-bonded-gold-nanoconjugates-for-breast-cancer-treatment
#6
Mani Gajendiran, Heejung Jo, Kyobum Kim, Sengottuvelan Balasubramanian
Background: Surface functionalization of gold nanoparticles (AuNPs) has emerged as a promising field of research with enormous biomedical applications. The folate (FA)-attached polymer-gold nanoconjugates play vital role in targeting the cancer cells. Methods: AuNPs were synthesized by using di- or tri-carboxylate-polyethylene glycol (PEG) polymers, including citrate-PEG (CPEG), malate-PEG (MAP), and tartrate-PEG (TAP), as a reducing and stabilizing agent. After synthesis of polymer-AuNPs, the freely available hydroxyl and carboxylate groups of CPEG, MAP, and TAP were used to attach a cancer cell-targeting agent, FA, via a 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxy succinimide coupling reaction to obtain FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanocon-jugates, respectively...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30774262/histological-changes-of-immediate-skin-expansion-of-the-distal-limb-of-rats
#7
Ahmed Khalaf Ali, Adamu Abdul Abubakar, Ubedullah Kaka, Zamri Radzi, Nurul Hayah Khairuddin, Md Sabri Mohd Yusoff, Mohamad Yusof Loqman
Aim: Tissue expansion is an applicable technique to reconstruct many surgical defects. The aim of this research was to evaluate the histological changes caused by immediate skin tissue expansion in rats as an animal model. Materials and Methods: Immediate skin tissue expansion in 18 adult female rats was performed using three different sizes (small, medium, and big) of polymethylmethacrylate tissue expanders at the dorsal surface of the metatarsal area of the right limb...
December 2018: Veterinary World
https://read.qxmd.com/read/30773827/in-vitro-comparative-study-of-human-mesenchymal-stromal-cells-from-dermis-and-adipose-tissue-for-application-in-skin-wound-healing
#8
Helena Debiazi Zomer, Gisele Kristina Dos Santos Varela, Priscilla Barros Delben, Diana Heck, Talita da Silva Jeremias, Andrea Gonçalves Trentin
Novel strategies combining cell therapy, tissue engineering and regenerative medicine have been developed to treat major skin wounds. Although mesenchymal stromal cells (MSCs) from different tissues have similar stem cell features, such as self-renewing mesodermal differentiation potential and expression of immunophenotypic markers, they also have distinct characteristics. Therefore, we aimed to characterize the application of MSCs derived from the dermis and adipose tissue (DSCs and ASCs, respectively) in cutaneous wound healing by in vitro approaches...
February 18, 2019: Journal of Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/30773278/hypomorphic-mutations-in-tonsl-cause-sponastrime-dysplasia
#9
Hae Ryung Chang, Sung Yoon Cho, Jae Hoon Lee, Eunkyung Lee, Jieun Seo, Hye Ran Lee, Denise P Cavalcanti, Outi Mäkitie, Helena Valta, Katta M Girisha, Chung Lee, Kausthubham Neethukrishna, Gandham S Bhavani, Anju Shukla, Sheela Nampoothiri, Shubha R Phadke, Mi Jung Park, Shiro Ikegawa, Zheng Wang, Martin R Higgs, Grant S Stewart, Eunyoung Jung, Myeong-Sok Lee, Jong Hoon Park, Eun A Lee, Hongtae Kim, Kyungjae Myung, Woosung Jeon, Kyoungyeul Lee, Dongsup Kim, Ok-Hwa Kim, Murim Choi, Han-Woong Lee, Yonghwan Kim, Tae-Joon Cho
SPONASTRIME dysplasia is a rare, recessive skeletal dysplasia characterized by short stature, facial dysmorphism, and aberrant radiographic findings of the spine and long bone metaphysis. No causative genetic alterations for SPONASTRIME dysplasia have yet been determined. Using whole-exome sequencing (WES), we identified bi-allelic TONSL mutations in 10 of 13 individuals with SPONASTRIME dysplasia. TONSL is a multi-domain scaffold protein that interacts with DNA replication and repair factors and which plays critical roles in resistance to replication stress and the maintenance of genome integrity...
February 8, 2019: American Journal of Human Genetics
https://read.qxmd.com/read/30771688/dynamic-histological-events-and-molecular-changes-in-excisional-wound-healing-of-diabetic-db-db-mice
#10
Xiao Tian Wang, Claire C McKeever, Peter Vonu, Charles Patterson, Paul Y Liu
BACKGROUND: Wound contraction and re-epithelialization over the entire healing process had never been histologically examined daily in diabetic mouse wounds. Correlating morphological characters with molecular changes may be essential to understand the potential mechanism of impeded diabetic wound healing. MATERIALS AND METHODS: In 99 db/db and 63 db/m mice, dorsal-paired 8 mm-diameter wounds were created. Wound contraction and re-epithelialization were histologically analyzed daily-six wounds per group each day...
February 13, 2019: Journal of Surgical Research
https://read.qxmd.com/read/30765116/fermentation-parameters-and-conditions-affecting-levan-production-and-its-potential-applications-in-cosmetics
#11
Marta Domżał-Kędzia, Agnieszka Lewińska, Anna Jaromin, Marek Weselski, Robert Pluskota, Marcin Łukaszewicz
Levan is a polysaccharide composed of fructose units with β-2,6-glycoside bonds. Microorganisms synthesize levan by levansucrase as a mixture of low- and high-molecular-weight fractions. Due to its properties, it has a wide range of applications in cosmetics, pharmaceuticals, food and medicine; it appears that the molecular weight of levan might impact its industrial use. To obtain one fraction of levan after biotransformation, ethanol precipitation with an increasing volume of alcohol was conducted. This precipitation process was also optimized...
February 11, 2019: Bioorganic Chemistry
https://read.qxmd.com/read/30761457/overexpression-of-apoptosis-related-protein-survivin-in-fibroblasts-from-patients-with-systemic-sclerosis
#12
Mohammad Bagher Mahmoudi, Ehsan Farashahi Yazd, Farhad Gharibdoost, Mohammad Hasan Sheikhha, Elham Karimizadeh, Ahmadreza Jamshidi, Mahdi Mahmoudi
BACKGROUND/OBJECTIVES: Recent studies suggest that, in addition to activation and hypersecretion of matrix components, fibroblasts from patients with systemic sclerosis (SSc) are resistant to apoptosis. Previous studies have shown that survivin, a member of inhibition of apoptosis (IAP) family, plays an important role in apoptosis resistance. Accordingly, we decided to study the expression of the most important members of IAP family in SSc fibroblasts, which can block apoptosis either by binding and inhibiting caspases or through caspase-independent mechanisms...
February 13, 2019: Irish Journal of Medical Science
https://read.qxmd.com/read/30758328/impact-of-adult-attention-deficit-hyperactivity-disorder-and-medication-status-on-sleep-wake-behavior-and-molecular-circadian-rhythms
#13
A N Coogan, M Schenk, D Palm, A Uzoni, J Grube, A H Tsang, I Kolbe, N M McGowan, R Wandschneider, M Colla, H Oster, J Thome, F Faltraco
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition that has been strongly associated with changes in sleep and circadian rhythms. Circadian rhythms are near 24-h cycles that are primarily generated by an endogenous circadian timekeeping system, encoded at the molecular level by a panel of clock genes. Stimulant and non-stimulant medication used in the management of ADHD has been shown to potentially impact on circadian processes and their behavioral outputs. In the current study, we have analyzed circadian rhythms in daily activity and sleep, and the circadian gene expression in a cohort of healthy controls (N = 22), ADHD participants not using ADHD-medication (N = 17), and participants with ADHD and current use of ADHD medication (N = 17)...
February 6, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://read.qxmd.com/read/30758129/fabrication-and-evaluation-of-bacterial-nanocellulose-poly-acrylic-acid-graphene-oxide-composite-hydrogel-characterizations-and-biocompatibility-studies-for-wound-dressing
#14
Xiang Yi Chen, Hao Ran Low, Xin Yi Loi, Laura Merel, Mohd Amin Mohd Cairul Iqbal
Graphene oxide (GO) is a potential material for wound dressing due to its excellent biocompatibility and mechanical properties. This study evaluated the effects of GO concentration on the synthesis of bacterial nanocellulose (BNC)-grafted poly(acrylic acid) (AA)-graphene oxide (BNC/P(AA)/GO) composite hydrogel and its potential as wound dressing. Hydrogels were successfully synthesized via electron-beam irradiation. The hydrogels were characterized by their mechanical properties, bioadhesiveness, water vapor transmission rates (WVTRs), water retention abilities, water absorptivity, and biocompatibility...
February 13, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30755653/in-situ-bioprinting-of-autologous-skin-cells-accelerates-wound-healing-of-extensive-excisional-full-thickness-wounds
#15
Mohammed Albanna, Kyle W Binder, Sean V Murphy, Jaehyun Kim, Shadi A Qasem, Weixin Zhao, Josh Tan, Idris B El-Amin, Dennis D Dice, Julie Marco, Jason Green, Tao Xu, Aleksander Skardal, James H Holmes, John D Jackson, Anthony Atala, James J Yoo
The early treatment and rapid closure of acute or chronic wounds is essential for normal healing and prevention of hypertrophic scarring. The use of split thickness autografts is often limited by the availability of a suitable area of healthy donor skin to harvest. Cellular and non-cellular biological skin-equivalents are commonly used as an alternative treatment option for these patients, however these treatments usually involve multiple surgical procedures and associated with high costs of production and repeated wound treatment...
February 12, 2019: Scientific Reports
https://read.qxmd.com/read/30755532/inhibition-of-ezh2-prevents-fibrosis-and-restores-normal-angiogenesis-in-scleroderma
#16
Pei-Suen Tsou, Phillip Campbell, M Asif Amin, Patrick Coit, Shaylynn Miller, David A Fox, Dinesh Khanna, Amr H Sawalha
Scleroderma (SSc) is a complex disease that involves activation of the immune system, vascular complications, and tissue fibrosis. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) mediates trimethylation of lysine 27 of histone 3 (H3K27me3), which acts as a repressive epigenetic mark. Both EZH2 and H3K27me3 were elevated in SSc dermal fibroblasts and endothelial cells compared with healthy controls. EZH2 inhibitor DZNep halted fibrosis both in vitro and in vivo. In SSc fibroblasts, DZNep dose-dependently reduced the expression of profibrotic genes and inhibited migratory activity of SSc fibroblasts...
February 12, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30753353/the-curious-case-of-dermal-fibroblasts-cell-identity-loss-may-be-a-mechanism-underlying-cardiovascular-aging
#17
Ileana Badi
No abstract text is available yet for this article.
February 6, 2019: Cardiovascular Research
https://read.qxmd.com/read/30744036/the-contribution-of-magnetic-nanoparticles-to-ferrogel-biophysical-properties
#18
Felix A Blyakhman, Emilia B Makarova, Fedor A Fadeyev, Daiana V Lugovets, Alexander P Safronov, Pavel A Shabadrov, Tatyana F Shklyar, Grigory Yu Melnikov, Iñaki Orue, Galina V Kurlyandskaya
Iron oxide γ-Fe₂O₃ magnetic nanoparticles (MNPs) were fabricated by laser target evaporation technique (LTE) and their structure and magnetic properties were studied. Polyacrylamide (PAAm) gels with different cross-linking density of the polymer network and polyacrylamide-based ferrogel with embedded LTE MNPs (0.34 wt.%) were synthesized. Their adhesive and proliferative potential with respect to human dermal fibroblasts were studied. At the same value of Young modulus, the adhesive and proliferative activities of the human dermal fibroblasts on the surface of ferrogel were unexpectedly much higher in comparison with the surface of PAAm gel...
February 8, 2019: Nanomaterials
https://read.qxmd.com/read/30742402/cu-atcun-derivatives-of-sub5-exhibit-enhanced-antimicrobial-activity-via-multiple-modes-of-action
#19
Jessica L Alexander, Zechariah Thompson, Zhen Yu, J A Cowan
Antimicrobial peptides (AMP's) are short, amphipathic peptides that are typically cationic in sequence and display broad-spectrum activity against bacteria, fungi, and protists. Herein, we report the effect of appending the amino terminal copper and nickel binding motif (ATCUN) to Sub5. The Cu-ATCUN derivatives show a two to three-fold increase in antimicrobial activity for a variety of microbes, relative to Sub5, with MICs as low as 0.3 ± 0.1 µM towards Enterococcus faecium. Sub5 and the ATCUN derivatives bind both plasmid DNA and 16s A-site rRNA with low micromolar affinity...
February 11, 2019: ACS Chemical Biology
https://read.qxmd.com/read/30741930/flavones-hydroxylated-at-5-7-3-and-4-ameliorate-skin-fibrosis-via-inhibiting-activin-receptor-like-kinase-5-kinase-activity
#20
Yifan Zhang, Jing Wang, Sizheng Zhou, Zhibo Xie, Chuandong Wang, Ya Gao, Jia Zhou, Xiaoling Zhang, Qingfeng Li
Skin fibrosis is mainly characterized by excessive collagen deposition. Studies have recently identified a number of flavonoids with variable structures that have the potency of inhibiting collagen synthesis and thus attenuating organ fibrosis. In this study, we found that flavones with 5, 7, 3', 4' hydroxy substitution reduced collagen expression most efficiently. Among those flavones, luteolin, quercetin, and myricetin were selected for follow-up. In vivo, the three compounds ameliorated skin fibrosis and reduced collagen deposition...
February 11, 2019: Cell Death & Disease
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