keyword
https://read.qxmd.com/read/37843359/omicron-new-variant-ba-2-86-pirola-epidemiological-biological-and-clinical-characteristics-a-global-data-based-analysis
#21
JOURNAL ARTICLE
S A Meo, A S Meo, D C Klonoff
OBJECTIVE: Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a threatening situation worldwide. The new variant of SARS-CoV-2, BA.2.86, also known as Pirola, is an Omicron subvariant that causes great concern because it has been found to contain a large number of mutations. This study aims to investigate and identify the biological and clinical characteristics of this threatening new variant of SARS-CoV-2, which is BA.2.86. MATERIALS AND METHODS: This observational study was performed in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia...
October 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37802818/-research-trends-and-hot-spots-of-chuanxiong-rhizoma-from-2010-to-2023
#22
JOURNAL ARTICLE
Kun Lian, Jia-Hao Ye, Xin Li, Zhi-Xi Hu, Lin Li
This study aims to objectively and quantitatively analyze the research status and hot spots of Chuanxiong Rhizoma and provide guidance for further research and clinical application of this herbal medicine. Firstly, the research articles involving Chuanxiong Rhizoma from 2010 to 2023 were retrieved from seven databases including Web of Science, PubMed, Medline, CNKI, VIP, Wanfang, and SinoMed. Then, NoteExpress and manual reading were employed to complete the de-duplication and screening of the articles, and the annual number of publications and journals was analyzed...
September 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37802765/-intelligent-co-design-of-material-process-and-equipment-for-manufacturing-high-quality-traditional-chinese-medicine-preparations
#23
JOURNAL ARTICLE
Bing Xu, Yan-Jiang Qiao, Shou-Ying DU, Zhi-Qiang Zhang, Wei Xiao
In the context of Pharma 4.0, the design tools that support the pharmaceutical Quality by Design(QbD) are iterating fast toward intelligent or smart design. The conventional development methods for traditional Chinese medicine(TCM) preparations have the limitations such as over dependence on experience, low dimensions for the designed experiment parameters, poor compatibility between the process and equipment, and high trial-and-error cost during process scale-up. Therefore, this paper innovatively proposed the intelligent co-design involving material, process, and equipment for manufacturing high-quality TCM preparations, and introduced the design philosophy, targets, tools, and applications with TCM oral solid dosage(OSD) as an example...
August 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37782191/bibliometric-analysis-of-intestinal-microbiota-in-diabetic-nephropathy
#24
JOURNAL ARTICLE
L-W Gao, X-Y Yang, Y-F Yu, S Yin, K-K Tong, G Hu, W-X Jian, Z Tian
OBJECTIVE: The purpose of this study is to use bibliometrics to explore the research overview and research hotspots. MATERIALS AND METHODS: The relevant literature on intestinal flora and diabetic nephropathy in the Web of Science Core Collection was sorted out, and VOSviewer, CiteSpace, Scimago Graphica and other software were used to conduct data visualization analysis on the number of publications, countries, institutions, journals, authors, keywords and citations...
September 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37778517/a-comprehensive-review-of-the-classical-prescription-yiguan-jian-phytochemistry-quality-control-clinical-applications-pharmacology-and-safety-profile
#25
REVIEW
Changcheng Lu, Siyuan Zhang, Si San Lei, Danni Wang, Bo Peng, Ruipeng Shi, Cheong-Meng Chong, Zhangfeng Zhong, Yitao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Yiguan Jian (YGJ) is a classical prescription, which employs 6 kinds of medicinal herbs including Rehmanniae Radix, Lycii Fructus, Angelicae sinensis Radix, Glehniae Radix, Ophiopogonis Radix, and Toosendan Fructus. YGJ decoction is originally prescribed in Qing Dynasty (1636 CE ∼ 1912 CE) in China, and is commonly used to treat liver diseases. There remain abundant literature investigating YGJ decoction from multiple aspects, but few reviews summarized the research and gave a precise definition, which impedes further applications and commercialization of YGJ decoction...
September 29, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37760709/bibliometric-analysis-of-global-research-output-on-antimicrobial-resistance-among-pneumonia-pathogens-2013-2023
#26
JOURNAL ARTICLE
Nurgul Ablakimova, Gaziza A Smagulova, Svetlana Rachina, Aigul Z Mussina, Afshin Zare, Nadiar M Mussin, Asset A Kaliyev, Reza Shirazi, Nader Tanideh, Amin Tamadon
Antimicrobial resistance (AMR) is a pressing global concern, posing significant challenges to the effective treatment of infections, including pneumonia. This bibliometric analysis aims to investigate the research output on AMR among pneumonia pathogens from 2013 to 2023. Data were extracted from the Web of Science Core Collection (WOS-CC) using an inclusive search strategy. The analysis included 152 relevant studies published in 99 different sources, involving 988 authors and yielding an average of 16.33 citations per document over the past decade...
September 6, 2023: Antibiotics
https://read.qxmd.com/read/37754783/willingness-to-pay-for-cancer-prevention-versus-treatment-in-china-implications-for-cost-effectiveness-threshold
#27
JOURNAL ARTICLE
Zixuan Zhao, Yi Yang, Weijia Wu, Hengjin Dong
:: Empirical support for the appropriate cost-effectiveness threshold (CET) in China remains sparse. OBJECTIVE: This study aimed to estimate the willingness to pay (WTP) for cancer prevention and treatment from the perspective of healthcare policy-makers (i.e.supply side) and to investigate whether there is a difference between the estimated WTP in two scenarios. METHODS: We conducted a web-based survey from May to July 2022 among experts who offering consultation to the government...
September 27, 2023: Expert Review of Pharmacoeconomics & Outcomes Research
https://read.qxmd.com/read/37718527/clinical-analysis-of-bacterial-infection-characteristics-in-lymphoma-patients-with-high-dose-chemotherapy-combined-with-autologous-hematopoietic-stem-cell-transplantation-a-single-centered-retrospective-study
#28
JOURNAL ARTICLE
Dan-Hui Sun, Di Mei, Xiao-Qin Yaoz, Yi-Hui Rong, Gui-Qiang Wang
BACKGROUND: High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation (HDT/AHSCT) is used to treat lymphoma. Although AHSCT has made considerable strides and become safer, HDT-AHSCT infection continues to be a leading cause of morbidity and mortality associated with transplantation. OBJECTIVE: To characterise pathogenic bacterial infections in HDT/AHSCT-treated lymphoma patients. The prevalence of pathogenic microorganisms and the timing of foci after transplantation, along with bloodstream infection (BSI) risk factors, can help determine the need for empirical antibiotics after AHSCT...
September 15, 2023: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/37701493/global-research-trends-of-nanotechnology-for-pain-management
#29
Yi Zhu, Yiyi Yao, Riyu Kuang, Zheng Chen, Zhen Du, Shuangquan Qu
Background: Nanotechnology has been increasingly used in healthcare during recent years. However, the systematic evaluation of research on nanotechnology for pain management is lacking. In this study, we employed a bibliometric approach to examine the status of the research and global trends of nanotechnology in relation to pain management. Methods: We selected relevant papers published in the Web of Science Core Collection database between 2013 and 2022 using search terms related to nanotechnology and pain management...
2023: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/37700611/the-state-of-astragaloside-iv-research-a-bibliometric-and-visualized-analysis
#30
REVIEW
Ning Liu, Yansu Ji, Rui Liu, Xin Jin
BACKGROUND: Astragaloside IV has emerged as a pharmaceutical monomer with great medical applications and potential. Astragaloside IV has many effects such as improving myocardial ischemia, cerebral ischemia-reperfusion injury, anti-inflammatory, analgesic, antiviral, promoting lymphocyte proliferation, and antitumor effects. However, there are few bibliometric studies on astragaloside IV. OBJECTIVES: We aim to visualize the hotspots and trends in astragaloside IV research through bibliometric analysis to further understand the future development of basic and clinical research...
September 12, 2023: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/37622541/computer-aided-drug-design-course-for-pharmacy-major-students-in-shenyang-pharmaceutical-university-following-the-covid-19-pandemic-challenges-and-opportunities
#31
JOURNAL ARTICLE
Min Huang, Yue Du, Yajing Liu, Yanfang Zhao, Yongxue Guo, Dan Liu, Linxiang Zhao, Jian Wang
The computer-aided drug design (CADD) course that spans biochemistry, computational chemistry, medicinal chemistry, and other cutting-edge sciences is considered an important course by pharmaceutical universities in China. The course teaches students how drugs bind to protein targets and exert their biological activities using computer tools, and covers the basic principles of drug development and optimization. Due to the lockdown and social distancing measures adopted during the coronavirus disease 2019 (COVID-19) pandemic, the CADD course in Shenyang Pharmaceutical University was briefly suspended...
August 25, 2023: Biochemistry and Molecular Biology Education
https://read.qxmd.com/read/37619417/building-a-novel-self-iterative-clinical-pharmacist-intervention-model-in-psychiatric-hospital-application-and-evaluation
#32
JOURNAL ARTICLE
Jianhong Wu, Linghe Qiu, Xiaoyan Huang, Qin Zhou, Yuan Shen
Clinical pharmacist intervention (CPI) in psychiatric hospital has not been widely developed in China. This study aimed to establish a real-time dynamic self-iterative CPI model in The Affiliated Mental Health Center of Jiangnan University and evaluated its effect. We focused on the running data in 2021 and 2022. The number of interventions, intervention types and intervention strategies were evaluated. In 2021 and 2022, a total of 443 interventions were reported. Among them, 271 (61.17 %) were identified during ward rounds by physicians, pharmacists and nurses...
August 19, 2023: Asian Journal of Psychiatry
https://read.qxmd.com/read/37606119/analysis-of-the-factors-influencing-male-infertility-of-reproductive-age-in-jinan
#33
JOURNAL ARTICLE
S Li, X Shen, X-X Qin, S Fang, J Chen, H-J Yang
OBJECTIVE: The World Health Organization (WHO) defines infertility as a person failing to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. Infertility includes female infertility and male infertility. The aim of this paper is to study the etiology of infertility and related influencing factors in men of reproductive age in Jinan. PATIENTS AND METHODS: In this study, 172 male infertile patients who attended the Department of Assisted Reproduction of Shandong Provincial Maternal and Child Health Hospital in Shandong, China and the Infertility Clinic of Jinan Central Hospital in Shandong, China from August 2021 to April 2022 are selected as the study population (infertility group)...
August 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37599147/illness-severity-assessment-of-older-adults-in-critical-illness-using-machine-learning-elder-icu-an-international-multicentre-study-with-subgroup-bias-evaluation
#34
MULTICENTER STUDY
Xiaoli Liu, Pan Hu, Wesley Yeung, Zhongheng Zhang, Vanda Ho, Chao Liu, Clark Dumontier, Patrick J Thoral, Zhi Mao, Desen Cao, Roger G Mark, Zhengbo Zhang, Mengling Feng, Deyu Li, Leo Anthony Celi
BACKGROUND: Comorbidity, frailty, and decreased cognitive function lead to a higher risk of death in elderly patients (more than 65 years of age) during acute medical events. Early and accurate illness severity assessment can support appropriate decision making for clinicians caring for these patients. We aimed to develop ELDER-ICU, a machine learning model to assess the illness severity of older adults admitted to the intensive care unit (ICU) with cohort-specific calibration and evaluation for potential model bias...
October 2023: The Lancet. Digital health
https://read.qxmd.com/read/37549321/how-industrial-policy-could-accelerate-innovation-in-the-life-sciences
#35
JOURNAL ARTICLE
James C Robinson
The US is expanding public investment in the technology-based industries, including the life sciences, in a move driven by anger, fear, and hope. Anger at high drug prices is leading to downward pressures and eroding traditional private-sector funding for research and development, fear of China's technological and political ambitions is creating bipartisan support for intervention, and the successful development of COVID-19 vaccines has spurred hope for analogous publicly funded breakthroughs in other therapeutic domains...
August 2023: Health Affairs
https://read.qxmd.com/read/37548201/the-value-of-rack1-and-peripheral-blood-m2-m1-monocyte-ratio-on-the-prognosis-of-patients-with-oral-squamous-cell-carcinoma
#36
JOURNAL ARTICLE
Hui Liu, Ran Wu, Lei Bi, Xiaoliang Xu, Hui Chen
This study is to evaluate the effect of receptor for activated c kinase 1 (RACK1) and peripheral blood M2/M1 monocytes ratio on the prognosis of patients with oral squamous cell carcinoma (OSCC). A total of 115 OSCC patients who underwent radical surgery in North China University of Science and Technology Affiliated Hospital from January 2015 to December 2015 were included in the experimental group and 34 healthy individuals after a physical examination during the same period were included in the control group...
March 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/37540670/erratum-using-multiple-light-scattering-to-examine-the-stability-of-phyllanthus-emblica-l-extracts-obtained-with-different-extraction-methods
#37
JOURNAL ARTICLE
(no author information available yet)
An erratum was issued for: Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods. The Authors section was updated from: Haozhou Huang1 Mengqi Li2 Chuanhong Luo3 Sanhu Fan4 Taigang Mo4 Li Han3 Dingkun Zhang3 Junzhi Lin5 1 Innovative Institute of Chinese Medicine and Pharmacy/Academy for Interdiscipline, Chengdu University of Traditional Chinese Medicine 2 Sichuan Nursing Vocational College 3 School of Pharmacy/School of Modern Chinese Medicine Industry, State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China 4 Sanajon Pharmaceutical Group 5 TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine to Haozhou Huang1,2 Mengqi Li3 Chuanhong Luo4 Sanhu Fan5 Taigang Mo5 Li Han4 Dingkun Zhang4 Junzhi Lin6 1 State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy/Academy for Interdiscipline, Chengdu University of Traditional Chinese Medicine 2 Meishan Hospital of Chengdu University of Traditional Chinese Medicine 3 Sichuan Nursing Vocational College 4 State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine 5 Sanajon Pharmaceutical Group 6 TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine...
August 4, 2023: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/37521034/a-bibliometric-analysis-of-mesenchymal-stem-cell-derived-exosomes-in-acute-lung-injury-acute-respiratory-distress-syndrome-from-2013-to-2022
#38
JOURNAL ARTICLE
Wenyu Zhou, Song Hu, Yutong Wu, Huan Xu, Lina Zhu, Huimin Deng, Sheng Wang, Yuanli Chen, Huanping Zhou, Xin Lv, Quanfu Li, Hao Yang
BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-exosomes) have been found to effectively improve the systemic inflammatory response caused by acute lung injury and acute respiratory distress syndrome (ALI/ARDS), regulate systemic immune disorders, and help injured cells repair. The purpose of this study was to take a holistic view of the current status and trends of MSC-exosomes research in ALI/ARDS. METHODS: Bibliometrix, Citespace and VOSviewer software were used for bibliometric analysis of the data...
2023: Drug Design, Development and Therapy
https://read.qxmd.com/read/37475064/-distinguishing-between-artemisia-stolonifera-and-a-argyi-by-specific-pcr-of-leaves-and-non-glandular-trichomes
#39
JOURNAL ARTICLE
Ya-Chen Zhao, Shuang-Ge Li, Hui Li, Yi-Mei Liu, Ting-Ting Zhao, Yu-Huan Miao, Da-Hui Liu, Lu-Qi Huang
Artemisia stolonifera is a relative of A. argyi. The two species are difficult to be distinguished due to the similarity in leaf shape and have even less distinctive features after processing. This study aims to establish a method to quickly distinguish between them. At the same time, we examined the reasonability and applicability of the specific polymerase chain reaction(PCR) method. The C/T single nucleotide polymorphism was detected at the position 202 of the sequence, based on which specific primers were designed to identify these two species...
July 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37382022/-citespace-knowledge-map-of-research-status-and-trends-of-croci-stigma
#40
JOURNAL ARTICLE
Yu-Xuan Zhang, Bo-Shen Li, Rong-Hui Fan, Xiao-Lin Li, Mao-Xing Li
This study retrieved Croci Stigma related literature from CNKI, Wanfang, VIP, and Web of Science database, and used bibliometrics and CiteSpace 6.1.R2 software to analyze the published Croci Stigma related articles in Chinese and English from 2000 to 2022. The authors, research institutions, and keywords were visualized and analyzed, and the current status and development trend of Croci Stigma research was summarized by combining the information extraction methods. A total of 1 846 Chinese articles and 2 703 English articles were screened out and included...
June 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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