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Frailty and sedentary

Asier Mañas, Borja Del Pozo-Cruz, Irene Rodríguez-Gómez, José Losa-Reyna, Leocadio Rodríguez-Mañas, Francisco J García-García, Ignacio Ara
OBJECTIVES: To determine whether or not and to what extent the association between sedentary time and frailty was moderated by moderate-to-vigorous physical activity in older adults. DESIGN: Cross-sectional. SETTING: Community-dwelling individuals. PARTICIPANTS: 749 (403 females and 346 males) white older adults. MEASUREMENTS: Sedentary time and moderate-to-vigorous physical activity were measured with accelerometers...
February 6, 2019: Journal of the American Medical Directors Association
Mariá Gonçalves Pereira da Silva, Rosimary Terezinha de Almeida
BACKGROUND: The Brazilian population is aging rapidly and it is necessary to establish tools to map the elderly population regarding its frailty, which is a common adverse condition during the aging process. The National Health Survey (PNS in Portuguese) data makes it possible. OBJECTIVE: This study aimed to construct a frailty index (FI) of the elderly Brazilian population using the PNS data, in order to compare it with the index of other population and to measure its association with social factors...
October 1, 2018: Archives of Gerontology and Geriatrics
Maria Angélica Binotto, Maria Helena Lenardt, María Del Carmen Rodríguez-Martínez
OBJECTIVE: To identify the outcomes of studies on gait speed and its use as a marker of physical frailty in community elderly. METHOD: Systematic review of the literature performed in the following databases: LILACS, SciELO, MEDLINE/PubMed, ScienceDirect, Scopus and ProQuest. The studies were evaluated by STROBE statement, and the PRISMA recommendations were adopted. RESULTS: There were 6,303 studies, and 49 of them met the inclusion criteria...
December 13, 2018: Revista da Escola de Enfermagem da U S P
D Scott Kehler, Jacqueline L Hay, Andrew N Stammers, Naomi C Hamm, Dustin E Kimber, Annette S H Schultz, Andrea Szwajcer, Rakesh C Arora, Navdeep Tangri, Todd A Duhamel
OBJECTIVE: Lifestyle factors such as physical activity are known to reduce the risk of frailty. However, less is known about the frailty-sedentary behavior relationship. A systematic review was conducted to synthesize the available evidence concerning associations between sedentary behaviors and frailty levels in adults. METHOD: MEDLINE, Embase, Web of Science, CINAHL, SPORTDiscus, Scopus, and the World Health Organization Clinical Trials Registry were searched up to August 2017 for observational studies in adults >18 years for cohort studies...
October 22, 2018: Experimental Gerontology
Zuyun Liu, Fang-Chi Hsu, Andrea Trombetti, Abby C King, Christine K Liu, Todd M Manini, Roger A Fielding, Marco Pahor, Anne B Newman, Stephen Kritchevsky, Thomas M Gill
BACKGROUND: Whether physical activity can reduce cognitive frailty-a relatively new "compound" phenotype proposed in 2013-and whether the effect of physical activity differs based on levels of inflammation are unknown. Therefore, this study aimed to evaluate the effect of physical activity on cognitive frailty and whether baseline interleukin-6 (IL-6) levels modified this effect. METHODS: We used data from the Lifestyle Interventions and Independence for Elders (LIFE) Study, a multicenter, single-blinded randomized trial conducted at eight US field centers between February 2010 and December 2013...
October 24, 2018: BMC Medicine
Isabel Rodríguez-Sánchez, Esther García-Esquinas, Arthur E Mesas, José María Martín-Moreno, Leocadio Rodríguez-Mañas, Fernando Rodríguez-Artalejo
Background: the association between pain characteristics and frailty risk is uncertain. Objective: to investigate the separate impact of the frequency, intensity and location of pain on frailty risk and its possible mechanisms. Methods: prospective cohort of 1505 individuals ≥63 years followed between 2012 and 2015 in Spain. In 2012, pain was classified into: lowest pain (Score 0), middle pain (Score 1-4) and highest pain (Score 5-6). Incident frailty was assessed in 2015 as having ≥3 Fried criteria or a Frailty Index (FI) ≥0...
October 11, 2018: Age and Ageing
A Martinez-Nicolas, J A Madrid, F J García, M Campos, M T Moreno-Casbas, P F Almaida-Pagán, A Lucas-Sánchez, M A Rol
The ageing process is associated with sleep and circadian rhythm (SCR) frailty, as well as greater sensitivity to chronodisruption. This is essentially due to reduced day/night contrast, decreased sensitivity to light, napping and a more sedentary lifestyle. Thus, the aim of this study is to develop an algorithm to identify a SCR phenotype as belonging to young or aged subjects. To do this, 44 young and 44 aged subjects were recruited, and their distal skin temperature (DST), activity, body position, light, environmental temperature and the integrated variable TAP rhythms were recorded under free-living conditions for five consecutive workdays...
October 9, 2018: Scientific Reports
Koutatsu Nagai, Kayoko Tamaki, Hiroshi Kusunoki, Yosuke Wada, Shotaro Tsuji, Masako Ito, Kyoko Sano, Manabu Amano, Soji Shimomura, Ken Shinmura
Objectives: Recently, isotemporal substitution has been developed to substitute activity time for an equivalent amount of another activity. This study employed this method to demonstrate the effects of replacing sedentary behavior (SB) time with an equivalent amount of light-intensity physical activity (LPA) and moderate-to-vigorous intensity physical activity (MVPA) on the risk for different severities of frailty. Methods: A total of 886 older adults (average age 73...
2018: Clinical Interventions in Aging
Kazuhiro Harada, Kouhei Masumoto, Narihiko Kondo
PURPOSE: Although it has been proposed that 1 spouse's health behaviors might correlate with the other spouse's health behavior among married couples, few studies have focused on sedentary behavior. This study examined whether objectively measured sedentary behavior and physical activity are correlated with each other and whether attachment to one's spouse moderates such correlations among middle-aged and older married couples. METHODS: Seventy-two couples participated in the survey...
December 2018: Research Quarterly for Exercise and Sport
Stergios A Polyzos, Andrew N Margioris
Sarcopenic obesity, a chronic condition, is today a major public health problem with increasing prevalence worldwide, which is due to progressively aging populations, the increasing prevalence of obesity, and the changes in lifestyle during the last several decades. Patients usually present to healthcare facilities for obesity and related comorbidities (type 2 diabetes mellitus, non-alcoholic fatty liver disease, dyslipidemia, hypertension, and cardiovascular disease) or for non-specific symptoms related to sarcopenia per se (e...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
Venicius Dantas da Silva, Sheilla Tribess, Joilson Meneguci, Jeffer Eidi Sasaki, Douglas de Assis Teles Santos, José Ailton Oliveira Carneiro, Jair Sindra Virtuoso Júnior
This paper aims to analyse whether time spent in sedentary behaviour was a discriminant criterion for frailty in older adults. This was a cross-sectional study conducted in a sample of 457 elderly individuals aged ≥60 years. Frailty was defined as the presence of three or more of the following criteria: Unintentional weight loss, low walking speed at a 4.57 m course, reduced manual grip strength, exhaustion and insufficient physical activity level. Participants were classified into two groups: Non-frail or frail...
June 26, 2018: International Journal of Environmental Research and Public Health
M Tsubota-Utsugi, Y Yonekura, K Tanno, M Nozue, H Shimoda, N Nishi, K Sakata, S Kobayashi
BACKGROUND: Many survivors of the Great East Japan Earthquake that occurred in 2011 were at risk of deteriorating health, especially elderly people living in disaster-stricken areas. The objectives of this prospective study were: a) to clarify the different lifestyle and psychosocial factors associated with frailty by sex among the non-disabled elderly survivors, and b) to describe the differences in characteristics stratified by the degree of disaster-related housing damage. METHODS: We followed 2261 Japanese survivors aged ≥65 years (45...
June 4, 2018: BMC Geriatrics
Daniel G Whitney, Edward A Hurvitz, Jennifer M Ryan, Maureen J Devlin, Michelle S Caird, Zachary P French, Elie C Ellenberg, Mark D Peterson
Purpose: Individuals with cerebral palsy (CP) are at increased risk for frailty and chronic disease due to factors experienced throughout the lifespan, such as excessive sedentary behaviors and malnutrition. However, little is known about noncommunicable diseases (NCDs) and multimorbidity profiles in young adults with CP. The study objective was to compare NCD and multimorbidity profiles between young adults with and without CP. Methods: A clinic-based sample of adults (18-30 years) with (n=452) and without (n=448) CP was examined at the University of Michigan Medical Center...
2018: Clinical Epidemiology
Dustin Scott Kehler
Physical activity and sedentary behaviours are associated with frailty. However, it is unknown if different accumulation patterns of these behaviours are linked with frailty. Four studies were conducted: the first 3 determined if bouts of moderate-vigorous physical activity (MVPA) and patterns of sedentary behaviours were associated with frailty (study 1), and if sex (study 2) and cardiovascular disease (CVD) status (study 3) affected these associations. Study 4 systematically reviewed the evidence to determine if preoperative physical activity and sedentary behaviours were linked to postcardiac surgical outcomes...
June 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Javad Razjouyan, Aanand D Naik, Molly J Horstman, Mark E Kunik, Mona Amirmazaheri, He Zhou, Amir Sharafkhaneh, Bijan Najafi
Background: The geriatric syndrome of frailty is one of the greatest challenges facing the U.S. aging population. Frailty in older adults is associated with higher adverse outcomes, such as mortality and hospitalization. Identifying precise early indicators of pre-frailty and measures of specific frailty components are of key importance to enable targeted interventions and remediation. We hypothesize that sensor-derived parameters, measured by a pendant accelerometer device in the home setting, are sensitive to identifying pre-frailty...
April 26, 2018: Sensors
Julian Alcazar, Carlos Rodriguez-Lopez, Ignacio Ara, Ana Alfaro-Acha, Irene Rodríguez-Gómez, Roberto Navarro-Cruz, Jose Losa-Reyna, Francisco J García-García, Luis M Alegre
INTRODUCTION: The actual mechanisms leading to a reduced muscle power and functional ability in older adults are poorly understood. We investigated the association between different force-velocity (F-V) profiles and impaired muscle power, physical and cognitive function, frailty, and health-related quality of life (HRQoL) in older people. METHODS: Physical function (habitual gait speed, timed up-and-go test, sit-to-stand and stair-climbing ability), cognitive function, HRQoL and frailty were evaluated in 31 older subjects (70-85 years)...
July 15, 2018: Experimental Gerontology
Qin Zhang, Huanyu Guo, Haifeng Gu, Xiaohong Zhao
Background: Frailty associated with aging increases the risk of falls, disability, and death. We investigated gender-associated factors for frailty. Methods: Data of 3,079 geriatric subjects were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 database. After excluding 1,126 subjects with missing data on frailty, medical history and survival, data of 1,953 patients were analyzed. Main endpoints were frailty prevalence, mortality rates and causes of death...
2018: PeerJ
D Scott Kehler, Ian Clara, Brett Hiebert, Andrew N Stammers, Jacqueline L Hay, Annette Schultz, Rakesh C Arora, Navdeep Tangri, Todd A Duhamel
OBJECTIVES: To determine if bouts of moderate-vigorous physical activity (MVPA) and patterns of sedentary behavior are associated with frailty. METHOD: Accelerometry from community-dwelling adults ≥50 years old (n = 2317) enrolled in the 2003-04 and 2005-06 National Health and Nutrition Examination Survey were used. Bouted (≥10 min) and sporadic (<10 min) durations of MVPA were analyzed based on meeting 0%, 1-49%, 50-99%, and ≥100% of physical activity guidelines (150 min/week of MVPA)...
April 2018: Experimental Gerontology
Catharine R Gale, Riccardo E Marioni, Iva Čukić, Sebastien F Chastin, Philippa M Dall, Manon L Dontje, Dawn A Skelton, Ian J Deary
Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936...
2018: Clinical Epigenetics
Collin F Payne, Alisha Wade, Chodziwadziwa W Kabudula, Justine I Davies, Angela Y Chang, F Xavier Gomez-Olive, Kathleen Kahn, Lisa F Berkman, Stephen M Tollman, Joshua A Salomon, Miles D Witham
BACKGROUND: Frailty is a key predictor of death and dependency, yet little is known about frailty in sub-Saharan Africa despite rapid population ageing. We describe the prevalence and correlates of phenotypic frailty using data from the Health and Aging in Africa: Longitudinal Studies of an INDEPTH Community cohort. METHODS: We analysed data from rural South Africans aged 40 and over. We used low grip strength, slow gait speed, low body mass index, and combinations of self-reported exhaustion, decline in health, low physical activity and high self-reported sedentariness to derive nine variants of a phenotypic frailty score...
December 28, 2017: BMC Geriatrics
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