keyword
https://read.qxmd.com/read/38473753/fibroblast-growth-factor-receptor-inhibitors-decrease-proliferation-of-melanoma-cell-lines-and-their-activity-is-modulated-by-vitamin-d
#21
JOURNAL ARTICLE
Anna Piotrowska, Joanna I Nowak, Justyna M Wierzbicka, Paweł Domżalski, Monika Górska-Arcisz, Rafał Sądej, Delfina Popiel, Maciej Wieczorek, Michał A Żmijewski
Regardless of the unprecedented progress in malignant melanoma treatment strategies and clinical outcomes of patients during the last twelve years, this skin cancer remains the most lethal one. We have previously documented that vitamin D and its low-calcaemic analogues enhance the anticancer activity of drugs including a classic chemotherapeutic-dacarbazine-and an antiangiogenic VEGFRs inhibitor-cediranib. In this study, we explored the response of A375 and RPMI7951 melanoma lines to CPL304110 (CPL110), a novel selective inhibitor of fibroblast growth factor receptors (FGFRs), and compared its efficacy with that of AZD4547, the first-generation FGFRs selective inhibitor...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473372/feasibility-of-introducing-a-prehabilitation-program-into-the-care-of-gynecological-oncology-patients-a-single-institution-experience
#22
JOURNAL ARTICLE
Joëlle Dhanis, Dieuwke Strijker, Luuk D Drager, Maaike van Ham, Cornelis J H M van Laarhoven, Johanna M A Pijnenborg, Anke Smits, Baukje van den Heuvel
Prehabilitation is an upcoming strategy to optimize patient's functional capacity, nutritional status, and psychosocial well-being in order to reduce surgical complications and enhance recovery. This study aims to assess the feasibility of implementing a multimodal prehabilitation program into the standard care of gynecological oncology patients at an academic hospital in terms of recruitment, adherence, and safety, which were assessed by the number of patients eligible, recruitment rate, participation rate, and adherence to individual modalities...
February 29, 2024: Cancers
https://read.qxmd.com/read/38469085/cytochrome-p450-genes-expression-in-human-prostate-cancer
#23
JOURNAL ARTICLE
Oksana Maksymchuk, Ganna Gerashchenko, Inna Rosohatska, Oleksiy Kononenko, Andriy Tymoshenko, Eduard Stakhovsky, Volodymyr Kashuba
CYP-dependent metabolites play a critical role in regulating the cell cycle, as well as the proliferative, invasive, and migratory activity of cancer cells. We conducted a study to analyze the relative gene expression of various CYPs ( CYP7B1, CYP27A1, CYP39A1, CYP51, CYP1B1, CYP3A5, CYP4F8, CYP5A1, CYP4F2, CYP2J2, CYP2E1, CYP2R1, CYP27B1, CYP24A1 ) in 41 pairs of prostate samples (tumor and conventional normal tissues) using qPCR. Our analysis determined significant individual variability in the expression levels of all studied CYPs, both in the tumor and in conventionally normal groups...
March 2024: Molecular Genetics and Metabolism Reports
https://read.qxmd.com/read/38467003/long-term-effect-of-randomization-to-calcium-and-vitamin-d-supplementation-on-health-in-older-women-postintervention-follow-up-of-a-randomized-clinical-trial
#24
JOURNAL ARTICLE
Cynthia A Thomson, Aaron K Aragaki, Ross L Prentice, Marcia L Stefanick, JoAnn E Manson, Jean Wactawski-Wende, Nelson B Watts, Linda Van Horn, James M Shikany, Thomas E Rohan, Dorothy S Lane, Robert A Wild, Rogelio Robles-Morales, Aladdin H Shadyab, Nazmus Saquib, Jane Cauley
BACKGROUND: Although calcium and vitamin D (CaD) supplementation may affect chronic disease in older women, evidence of long-term effects on health outcomes is limited. OBJECTIVE: To evaluate long-term health outcomes among postmenopausal women in the Women's Health Initiative CaD trial. DESIGN: Post hoc analysis of long-term postintervention follow-up of the 7-year randomized intervention trial of CaD. (ClinicalTrials.gov: NCT00000611). SETTING: A multicenter ( n = 40) trial across the United States...
March 12, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38462770/feasibility-study-of-micronutrient-status-and-body-mass-index-of-newly-diagnosed-pediatric-oncology-patients-research-commentary
#25
JOURNAL ARTICLE
Paul C Rogers, Jeffrey Cheng, Alecia Lim, James E Potts
We conducted a feasibility study to evaluate micronutrients and body mass index (BMI). Fat soluble vitamins A, D, E and trace elements copper (Cu), selenium (Se), and zinc (Zn) levels were evaluated. Weight, height, BMI, and Z-scores were recorded. Side effects or specific adverse events were documented. No patient had a Z-score for height, weight, or BMI of less than 2 SD or greater than 2 SD. Ninety percent of patients had one or more micronutrient levels below normal. These results suggest that micronutrient abnormalities are common despite no obvious evidence of malnutrition...
March 10, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38456956/vitamin-d-suppresses-cd133-cd44%C3%A2-%C3%A2-cancer-stem-cell-stemness-by-inhibiting-nf-%C3%AE%C2%BAb-signaling-and-reducing-nlrp3-expression-in-triple-negative-breast-cancer
#26
JOURNAL ARTICLE
Wei Zheng, Wei Peng, Fuyong Qian, Mingshuai Zhang, Bofeng Duan, Zhifeng Fan, Yi Xie, Xiaoying Fu
BACKGROUND AND OBJECTIVE: This study aims to investigate the role of Vitamin D (VD) in regulating the stemness and survival of CD133+/CD44 + breast cancer stem cells, and to explore the role of NLRP3 in this process. METHODS: Breast cancer tissues were collected for RXRα and VDR expression analysis. A triple-negative breast cancer cell line was cultured and stem-like cells (CD133 + CD44+) isolated using flow cytometry. These cells were treated with VD, analyzing their stem-like properties, apoptosis and proliferation, as well as P65 nuclear expression and NLRP3 expression...
March 8, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38456354/implication-of-calcium-supplementations-in-health-and-diseases-with-special-focus-on-colorectal-cancer
#27
REVIEW
Shahanavaj Khan, S Needa Mosvi, Saeed Vohra, Nitesh Kumar Poddar
Calcium is a fundamental and integrative element and helps to ensure optimal health by regulating various physiological and pathological processes. While there is substantiated evidence confirming the beneficial effects of calcium in the treatment, management, and prevention of various health conditions, including cancer, conflicting studies are imperative to acknowledge the potential negative role of calcium supplementation. The studies on calcium supplementation showed that a specific dose can help in the maintenance of good human health, and in the control of different types of diseases, including cancer...
March 8, 2024: Critical Reviews in Clinical Laboratory Sciences
https://read.qxmd.com/read/38455136/unlocking-the-potential-vitamin-d-in-prostate-cancer-prevention
#28
EDITORIAL
Ayun Cassell, Solomane Konneh
Prostate cancer poses a significant health challenge globally, demanding proactive prevention strategies. This editorial explores the emerging role of vitamin D in prostate cancer prevention. While traditionally associated with bone health, vitamin D is increasingly recognized for its broader impact on immune function, cellular signaling, and cancer prevention. Epidemiological studies suggest an intriguing link between vitamin D deficiency and elevated prostate cancer risk, particularly in regions with limited sunlight exposure...
February 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38449449/frailty-of-prostate-cancer-patients-receiving-androgen-deprivation-therapy-a-scoping-review
#29
JOURNAL ARTICLE
Jeongok Park, Gi Wook Ryu, Hyojin Lee, Young Deuk Choi, Youngkyung Kim
PURPOSE: This study aimed to explore the existing literature on frailty experienced by patients with prostate cancer (PC) receiving androgen deprivation therapy (ADT). MATERIALS AND METHODS: Database and manual searches were conducted to identify relevant studies published in English, with no limitation on the year of publication, according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines. Four databases-PubMed, Cochrane Library, EMBASE, and CINAHL-were used for database searches and reference lists, related journals, and Google Scholar were used for manual searches...
November 7, 2023: World Journal of Men's Health
https://read.qxmd.com/read/38443861/adherence-to-the-evidence-based-recommendations-in-managing-bone-health-pain-and-mobility-of-patients-with-multiple-myeloma-a-mixed-method-in-the-palestinian-healthcare-system
#30
JOURNAL ARTICLE
Ramzi Shawahna, Riad Amer, Husam Salameh, Abdul-Rahman Shawahna, Mohmmad Aljondy, Mohmmad Zain-Aldain
BACKGROUND: Consensus/evidence-based recommendations for assessing, managing, and monitoring bone health, pain, and mobility in patients with multiple myeloma were developed. This study was conducted to assess the adherence of the hematologists-oncologists to the consensus/evidence-based recommendations for assessing, managing, and monitoring bone health, pain, and mobility in patients with multiple myeloma who received care in the Palestinian healthcare system. METHODS: A mixed method was used in this study...
March 5, 2024: BMC Cancer
https://read.qxmd.com/read/38440355/the-relationship-between-vdr-gene-polymorphisms-bsm1-and-apa1-with-breast-cancer-risk
#31
JOURNAL ARTICLE
Hengameh Mozaffarizadeh, Fariborz Mokarian, Mansoor Salehi, Seyyed Mohammad Reza Hakimian, Elham Moazam, Amirmohammad Amoozadehsamakoosh, Majid Hosseinzadeh, Mahdieh Behnam, Mohaddeseh Behjati, Alma Naseri, Marzieh Lotfi, Fatemeh Tohidi
Background  In addition to its multifaceted physiological functions, vitamin D is recognized for its protective role against cancer. To manifest its effects, vitamin D engages with the vitamin D receptor ( VDR ) gene responsible for its encoding. Investigations have unveiled that polymorphisms within the VDR gene exert influence over the expression and/or functionality of the VDR protein. Notably, certain VDR gene polymorphisms have emerged as particularly pertinent in the context of tumorigenesis, including Fok1 (rs2228570), Bsm1 (rs1544410), Taq1 (rs771236), and Apa1 (rs7975232)...
January 2024: Global medical genetics
https://read.qxmd.com/read/38439172/cancer-treatment-induced-bone-loss
#32
JOURNAL ARTICLE
Yong Jun Choi
Cancer treatment-induced bone loss (CTBL) is associated with anti-tumor treatments, including endocrine therapies, chemotherapeutic treatments, radiotherapy, glucocorticoids, and tyrosine kinase inhibitors. Osteoporosis, characterized by the loss of bone mass, can increase the risk of fractures, leading to mortality and long-term disability, even after cancer remission. Cancer and osteoporosis have marked clinical and pathogenetic similarities. Both have a multifactorial etiology, affect the geriatric population, and markedly influence quality of life...
March 5, 2024: Korean Journal of Internal Medicine
https://read.qxmd.com/read/38423506/exposure-to-uv-radiation-in-lifeguards-on-barcelona-s-beaches-an-underestimated-occupational-risk
#33
JOURNAL ARTICLE
P Giavedoni, A Combalia, N Espinosa, J Aguilera, Susana Puig
BACKGROUND: The development of skin cancer is closely related to high exposure to UV radiation. Lifeguards are at an increased risk of excessive sun exposure. Objectives The main objective of this study was to measure the exposure of Barcelona's beach lifeguards to UV radiation. METHODS: Measurements in the work chair were taken every 30 minutes on a typical working day from 10:45 am to 19:15 pm. These measurements were carried out on four different days. These data were used to calculate the erythematous doses received during working hours, as well as those potentially received throughout the summer season...
February 27, 2024: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/38412982/-venous-thromboembolism-was-is-new-in-the-revised-awmf-guideline
#34
JOURNAL ARTICLE
Birgit Linnemann, Katja Sibylle Mühlberg, Robert Klamroth
For the diagnosis of a lower-extremity deep vein thrombosis (LEDVT), venous duplex ultrasound is the method of first choice. If a qualified ultrasonography is not timely available, D-dimer testing, and limited ultrasound protocols (point-of-care ultrasound, POCUS) can contribute to therapeutic decision-making when clinical probability is low. A DOAC-based treatment regimen is preferable to a vitamin K antagonist for both acute therapy and secondary prophylaxis of venous thromboembolism (VTE). Treatment with DOACs is unproblematic up to a body weight (BW) of 120 kg or a body mass index (BMI) of 40 kg/m²...
March 2024: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/38410461/dietary-vitamin-d-is-a-novel-modulator-of-tumor-engraftment-through-regulation-of-gc-protein-abundance
#35
Lo Danahy, Caela Long, Ted J Hofmann, Zahra Tara, Julian Mark, Jeffrey D Roizen
The vitamin D binding protein, the GC protein, is a multifunctional protein that binds circulating vitamin D and also increases macrophage killing of tumor cells. Injecting exogenous GC protein concurrent with experimental tumor implant decreases tumor engraftment rate. Until now serum abundance of this protein was thought to be controlled by estrogen, glucocorticoids and inflammatory cytokines, but, not by vitamin D itself(1, 2). Nonetheless, increasing dietary vitamin D is thought to increase serum vitamin D, which is 98% bound by the GC protein...
February 16, 2024: Research Square
https://read.qxmd.com/read/38404648/severe-hypercalcemia-caused-by-calcium-alkali-syndrome-after-15%C3%A2-years-of-postoperative-hypoparathyroidism-in-a-patient-with-undiagnosed-hyperaldosteronism
#36
Natália Diel Boufleuer, Dimitris V Rados, Tatiana Zambonato, Clara K Maraschin, Beatriz D Schaan
INTRODUCTION: The triad of hypercalcemia, metabolic alkalosis, and acute kidney injury associated with ingesting high doses of calcium and absorbable bases characterizes the calcium-alkali syndrome. Clinical Case . We report the case of a patient with postthyroidectomy hypoparathyroidism 15 years ago due to differentiated thyroid cancer who presented with severe hypercalcemia. He had adequate control of calcemia for many years on treatment with calcitriol and calcium carbonate and hypertension treated with amlodipine, losartan, and hydrochlorothiazide...
2024: Case Reports in Endocrinology
https://read.qxmd.com/read/38398891/ancestry-specific-polygenic-risk-score-dietary-patterns-physical-activity-and-cardiovascular-disease
#37
JOURNAL ARTICLE
Dale Hardy, Jane Garvin, Tesfaye Mersha
It is unknown whether the impact of high diet quality and physical activity depends on the level of polygenic risk score (PRS) in different ancestries. Our cross-sectional study utilized de-identified data from 1987-2010 for self-reported European Americans (n = 6575) and African Americans (n = 1606). The high-risk PRS increased ASCVD risk by 59% (Risk Ratio (RR) = 1.59; 95% Confidence Interval:1.16-2.17) in the highest tertile for African Americans and by 15% (RR = 1.15; 1.13-1.30) and 18% (RR = 1.18; 1.04-1...
February 19, 2024: Nutrients
https://read.qxmd.com/read/38396804/the-potential-use-of-vitamin-d3-and-phytochemicals-for-their-anti-ageing-effects
#38
REVIEW
Kazuki Santa, Yoshio Kumazawa, Kenji Watanabe, Isao Nagaoka
Unlike other vitamins, vitamin D3 is synthesised in skin cells in the body. Vitamin D3 has been known as a bone-related hormone. Recently, however, it has been considered as an immune vitamin. Vitamin D3 deficiency influences the onset of a variety of diseases. Vitamin D3 regulates the production of proinflammatory cytokines such as tumour necrosis factor-α (TNF-α) through binding to vitamin D receptors (VDRs) in immune cells. Since blood levels of vitamin D3 (25-OH-D3) were low in coronavirus disease 2019 (COVID-19) patients, there has been growing interest in the importance of vitamin D3 to maintaining a healthy condition...
February 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38388181/daily-diet-and-nutrition-risk-factors-for-gastric-cancer-incidence-in-a-japanese-population
#39
JOURNAL ARTICLE
Ayaka Takasu, Takuji Gotoda, Sho Suzuki, Chika Kusano, Chiho Goto, Hideki Ishikawa, Hirofumi Kogure
BACKGROUND/AIMS: : Nutritional factors associated with gastric cancer (GC) are not completely understood. We aimed to determine the effect of nutrient intake on the incidence of GC. METHODS: : This was a post hoc analysis of a prospective trial that evaluated modalities for GC screening in participants aged 30 to 74 years living in high-risk areas for GC in Japan between June 2011 and March 2013. The patients were followed up for GC incidence for 6 years. All participants completed a self-administered food frequency questionnaire (FFQ) upon enrollment before GC screening...
February 23, 2024: Gut and Liver
https://read.qxmd.com/read/38388112/dietary-patterns-linked-to-lower-odds-of-malnutrition-are-associated-with-all-cause-and-cancer-mortality-in-adults-with-cancer
#40
JOURNAL ARTICLE
Annie R Curtis, Katherine M Livingstone, Robin M Daly, Gavin Abbott, Nicole Kiss
OBJECTIVES: Dietary patterns, characterised by protein, polyunsaturated fatty acids, and vitamin D, reduce the odds of malnutrition in cancer survivors. However, it is unclear whether these dietary patterns also improve prognosis. This study prospectively examined associations between dietary patterns linked to lower odds of malnutrition and the risk of all-cause and cancer mortality in adult cancer survivors from the UK Biobank cohort. DESIGN: Prospective observational study...
February 2024: Journal of Nutrition, Health & Aging
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