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Vitamin D Cancer

Androniki Naska, Pagona Lagiou
No abstract text is available yet for this article.
March 18, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Mary Waterhouse, Dallas R English, Bruce K Armstrong, Catherine Baxter, Briony Duarte Romero, Peter R Ebeling, Gunter Hartel, Michael G Kimlin, Donald S A McLeod, Rachel L O'Connell, Jolieke C van der Pols, Alison J Venn, Penelope M Webb, David C Whiteman, Rachel E Neale
Background: Many observational studies have reported an association between vitamin D and non-skeletal health outcomes. The D-Health Trial was launched to determine if supplementing the older population with high monthly doses of Vitamin D can prevent cancer and premature mortality. The intervention is ongoing but here we provide a detailed statistical analysis plan for the primary and secondary outcomes of the D-Health Trial. Methods/design: The D-Health Trial is a double-blind, randomized, placebo-controlled trial...
June 2019: Contemporary Clinical Trials Communications
Dominique Svm Clement, Margot Et Tesselaar, Monique E van Leerdam, Rajaventhan Srirajaskanthan, John K Ramage
Symptoms of gastroenteropancreatic located neuroendocrine neoplasms (GEP-NENs) are often related to food intake and manifest as abdominal pain or diarrhoea which can influence patients nutritional status. Malnutrition is common in cancer patients and influences quality of life, treatment options and survival but is also present in up to 40% of patients with GEP-NENs. As part of malnutrition there are often deficiencies in fat-soluble vitamins, mainly vitamin D. Little knowledge exists on trace elements. Several factors influence the development of malnutrition such as size and localisation of the primary tumour as well as metastases, side effects from treatment but also hormone production of the tumour itself...
March 14, 2019: World Journal of Gastroenterology: WJG
Bianca M Arendt, Anastasia Teterina, Paulina Pettinelli, Elena M Comelli, David W L Ma, Scott K Fung, Ian D McGilvray, Sandra E Fischer, Johane P Allard
OBJECTIVE: The aim of this study was to determine whether hepatic gene expression related to hepatocellular carcinoma (HCC) is associated with disease severity and modifiable lifestyle factors in non-alcoholic fatty liver disease (NAFLD). METHODS: In a cross-sectional study, the associations between hepatic gene expression and liver histology, insulin resistance, anthropometrics, diet, and physical activity were assessed in patients with non-alcoholic steatohepatitis (NASH; n = 19) or simple steatosis (SS; n = 20)...
December 13, 2018: Nutrition
Nabeela A Khan, Konrad H Stopsack, Emma H Allott, Travis Gerke, Edward L Giovannucci, Lorelei A Mucci, Philip W Kantoff
BACKGROUND: Higher intratumoral cholesterol synthesis is associated with a worse prognosis in prostate cancer. The vitamin D-regulated enzyme sterol-27-hydroxylase (CYP27A1) converts cholesterol to 27-hydroxycholesterol, potentially lowering intracellular cholesterol levels. We hypothesized that low CYP27A1 expression is associated with high cholesterol synthesis, low vitamin D signaling, and higher risk of lethal prostate cancer. METHODS: In 404 patients from the prospective prostate cancer cohorts within the Health Professionals Follow-up Study (HPFS) and the Physicians' Health Study (PHS), we assessed intratumoral CYP27A1 expression and proxies of cholesterol synthesis using transcriptome profiling, prediagnostic plasma 25-hydroxyvitamin D (25(OH)D, n = 132) and intratumoral vitamin D receptor protein expression (VDR, n = 300)...
March 13, 2019: Cancer Epidemiology, Biomarkers & Prevention
Regan L Bailey, Shinyoung Jun, Alison L Eldridge
FITS (the Feeding Infants and Toddlers Study) 2016 is a national, cross-sectional survey to evaluate the diets and feeding practices of US infants and children <48 months (n = 3,235). Dietary intakes were assessed using 24-h recalls, including a replicate subsample (n = 799), to estimate usual intake distributions and compliance with dietary reference intakes using the National Cancer Institute method. Infant feeding practices and 1-day food group consumption were assessed by age and participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)...
2019: Nestlé Nutrition Institute Workshop Series
Alice Barros Câmara, Igor Augusto Brandãob
BACKGROUND: Vitamin D (VD) deficiency affects individuals of different ages in many countries. VD deficiency may be related to several diseases, including cancer. OBJECTIVE: This study aimed to review the relationship between VD deficiency and cancer. METHOD: We describe the proteins involved in cancer pathogenesis and how those proteins can be influenced by VD deficiency. We also investigated a relationship between cancer death rate and solar radiation...
March 12, 2019: Anti-cancer Agents in Medicinal Chemistry
F J Navarro-Triviño, S Arias-Santiago, Y Gilaberte-Calzada
In recent years, the growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and certain skin conditions. As dermatologists, we need to understand, among other aspects, how vitamin D is synthesized and the main sources in humans, as well as plasma levels and the factors that can modify them. Of particular interest are the latest discoveries about the role of vitamin D in skin diseases such as lupus erythematosus, ichthyosis, atopic dermatitis, hidradenitis suppurativa, acne, alopecia areata, androgenetic alopecia, melanoma, and nonmelanoma skin cancer...
March 8, 2019: Actas Dermo-sifiliográficas
Giorgia Sebastiani, Ana Herranz Barbero, Cristina Borrás-Novell, Miguel Alsina Casanova, Victoria Aldecoa-Bilbao, Vicente Andreu-Fernández, Mireia Pascual Tutusaus, Silvia Ferrero Martínez, María Dolores Gómez Roig, Oscar García-Algar
Vegetarian and vegan diets have increased worldwide in the last decades, according to the knowledge that they might prevent coronary heart disease, cancer, and type 2 diabetes. Althought plant-based diets are at risk of nutritional deficiencies such as proteins, iron, vitamin D, calcium, iodine, omega-3, and vitamin B12, the available evidence shows that well planned vegetarian and vegan diets may be considered safe during pregnancy and lactation, but they require a strong awareness for a balanced intake of key nutrients...
March 6, 2019: Nutrients
Alicia K Heath, Allison Hodge, Peter R Ebeling, Darryl W Eyles, David Kvaskoff, Daniel D Buchanan, Graham G Giles, Elizabeth J Williamson, Dallas R English
BACKGROUND: The role of vitamin D in cancer risk remains controversial and limited data exist on associations between vitamin D and subtypes of specific cancers. We investigated associations between circulating 25-hydroxyvitamin D (25(OH)D) and risk of colorectal, breast, and prostate cancers, including subtypes. METHODS: A case-cohort study within the Melbourne Collaborative Cohort Study included 547 colorectal, 634 breast, and 824 prostate cancers, and a sex-stratified random sample of participants (n=2,996)...
March 6, 2019: Cancer Epidemiology, Biomarkers & Prevention
Yumie Takata, Xiao-Ou Shu, Maciej S Buchowski, Heather M Munro, Wanqing Wen, Mark D Steinwandel, Margaret K Hargreaves, William J Blot, Qiuyin Cai
PURPOSE: We prospectively examined associations of lung cancer risk with food intake of B vitamins involved in one-carbon metabolism and the use of folic acid-containing supplements among a low-income population of black and white adults in the Southeastern US. METHODS: Within the Southern Community Cohort Study, we included 1064 incident lung cancer cases among 68,236 participants aged 40-79 years at study enrollment. Food intake and the use of folic acid-containing supplements were assessed using a validated food frequency questionnaire at study enrollment...
March 5, 2019: European Journal of Nutrition
Virginia Lope, María José Toribio, Beatriz Pérez-Gómez, Adela Castelló, Antonio Mena-Bravo, María Ángeles Sierra, Pilar Lucas, María Del Carmen Herrán-Vidaurrázaga, Carmen González-Vizcayno, Marina Nieves Pino, Inmaculada Cruz-Campos, Mª José Roca-Navarro, Nuria Aragonés, Isabelle Romieu, Mercedes Martínez-Cortés, María D Luque de Castro, Marina Pollán
The role of vitamin D in mammographic density is still unclear. This study examines the association between serum 25-hydroxyvitamin D (25(OH)D) and mammographic density, overall and by specific women characteristics. DDM-Madrid is a cross-sectional study that recruited 1403 premenopausal women in a breast radiodiagnosis unit of Madrid City Council. Information was collected with a questionnaire and plasma 25(OH)D was measured by solid-phase extraction on-line coupled to liquid chromatography-tandem mass spectrometry...
March 2, 2019: Journal of Steroid Biochemistry and Molecular Biology
Aixia Sui, Yongbing Xu, Baogen Pan, Tao Guo, Jiang Wu, Yongqing Shen, Junjie Yang, Xiaoqiang Guo
Vitamin D is a fat-soluble vitamin and plays an important role in calcium absorption and bone development, whose lack can cause a variety of diseases, including cancer. Human epidemiological studies suggested that vitamin D3 deficiency might increase glioma incidence, but molecular mechanism is less understood. In this study, we show that 1,25-dihydroxyvitamin D3 (the active form of vitamin D3) induces senescence of glioma cells and increases the expression of senescence markers, INK4A and cyclin-dependent kinase inhibitor 1A (CDKN1A)...
March 1, 2019: Journal of Cellular Physiology
Ashish Sharma, Rahul Janak Sinha, Vishwajeet Singh, Gaurav Garg, Samarth Agarwal, Siddharth Pandey
OBJECTIVE: Maintaining the optimum bone health is one of the important concerns in patients with prostate cancer, but it usually remains neglected. Failure to screen these patients is detrimental to both the length and the quality of life. The estimation of bone mineral density (BMD) and more recently the World Health Organization's fracture risk assessment (FRAX) algorithm in appropriate patients is recommended by several specialty organizations/associations at the time of instituting androgen deprivation therapy (ADT) for metastatic and high-risk individuals...
February 20, 2019: Turkish Journal of Urology
Konstantinos Voskarides
Cancer incidence is inexplicably high in cold countries. This has been revealed by recent genetic and epidemiological studies. These studies used data from the GLOBOCAN-2012 database, for 186 populations and for a variety of cancer types. Cancer incidence in Nordic people is particularly high for the frequent cancer forms, like breast, prostate and colon cancer. A relationship of cancer with cold is suspected since Inuit and Alaska Indians that live in even more extreme low temperatures have the higher cancer rates in the world...
February 28, 2019: Scandinavian Journal of Public Health
L Pierret, M Suppa, S Gandini, V Del Marmol, J Gutermuth
Vitamin D seems to be associated with a protective effect in a vast range of diseases, including cardiovascular, autoimmune and oncologic conditions. Since ultraviolet (UV) B light is the most important prerequisite for the cutaneous synthesis of vitamin D, sunbeds are able to increase serum vitamin D levels, although only transiently in most cases. In this scenario, the artificial tanning industry relentlessly tries to promote the use of sunbeds as a 'safe' therapeutic measure to achieve an adequate serum vitamin D status...
March 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
R M Lucas, S Yazar, A R Young, M Norval, F R de Gruijl, Y Takizawa, L E Rhodes, C A Sinclair, R E Neale
The Montreal Protocol has limited increases in the UV-B (280-315 nm) radiation reaching the Earth's surface as a result of depletion of stratospheric ozone. Nevertheless, the incidence of skin cancers continues to increase in most light-skinned populations, probably due mainly to risky sun exposure behaviour. In locations with strong sun protection programs of long duration, incidence is now reducing in younger age groups. Changes in the epidemiology of UV-induced eye diseases are less clear, due to a lack of data...
February 27, 2019: Photochemical & Photobiological Sciences
N Keum, D H Lee, D C Greenwood, J E Manson, E Giovannucci
BACKGROUND: Previous meta-analyses of randomized controlled trials (RCTs) of vitamin D supplementation and total cancer incidence and mortality found inconsistent results, and most included trials administered generally low doses of vitamin D (≤ 1100 IU/day). We updated the meta-analysis by incorporating recent RCTs that have tested higher doses of vitamin D supplements. MATERIALS AND METHODS: PubMed and Embase were searched from the inception to November, 2018...
February 22, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Jing Zhang, Suzhen Yang, Bing Xu, Ting Wang, Ying Zheng, Fei Liu, Fenggang Ren, Jiong Jiang, Haitao Shi, Baicang Zou, Xiaolan Lu, Shemin Lu, Lei Dong
OBJECTIVES: The role of p62 in cancer is controversial. Evidence has shown that p62 is upregulated in different cancers and promotes tumour growth, such as in liver cancer and lung cancer. However, a recent study showed that the downregulation of p62 in hepatic stellate cells (HSCs) promotes hepatocellular carcinoma (HCC) development. How p62 is regulated in colorectal cancer (CRC) remains largely unknown. In this study, we aimed to investigate the roles and molecular mechanisms of p62 in CRC...
February 22, 2019: Cell Proliferation
Miodrag N Krstic, Dragana D Mijac, Dusan D Popovic, Aleksandra Pavlovic Markovic, Tomica Milosavljević
BACKGROUND: Cancer is the second leading cause of death worldwide next to cardiovascular diseases. Despite the advancement in screening, early diagnosis, and development in treatment technology in last several decades, cancer incidence overall, particularly that of gastrointestinal (GI) cancers, is far from being controlled, and is expected to increase worldwide. SUMMARY: Although numerous preclinical and population-based clinical studies have already made important progress in restraining the overall cancer incidence and mortality, the full potential of preventive strategy is still far from being realized, and remains at an early stage...
February 15, 2019: Digestive Diseases
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