Savine Vicart, Jérôme Franques, Françoise Bouhour, Armelle Magot, Yann Péréon, Sabrina Sacconi, Aleksandra Nadaj-Pakleza, Anthony Behin, Noël Zahr, Marianne Hézode, Emmanuel Fournier, Christine Payan, Lucette Lacomblez, Bertrand Fontaine
The MYOMEX study was a multicentre, randomised, double-blind, placebo-controlled, cross-over study aimed to compare the effects of mexiletine vs. placebo in patients with myotonia congenita (MC) and paramyotonia congenita (PC). The primary endpoint was the self-reported score of stiffness severity on a 100 mm visual analogic scale (VAS). Mexiletine treatment started at 200 mg/day and was up-titrated by 200 mg increment each three days to reach a maximum dose of 600 mg/day for total treatment duration of 18 days for each cross-over period...
November 2021: Neuromuscular Disorders: NMD