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Encephalitis lethargica

P Venegas-Francke
Lethargic encephalitis is a neurological illness that shows a wide range of symptoms and signs, including neurological and psychiatric spectrum. It presented in an epidemic way, following influaenza relapses. The last relapse started at the beginning of 20th century and it was deeply described by Constantin von Economo. The illness described first in Europe and North America, was described in many others countries including Chile. There were beautiful descriptions by Chilean physicians like Lea-Plaza, Tello, Iturra and Cienfuegos...
January 16, 2019: Revista de Neurologia
Robert R Dourmashkin, Sherman A McCall, Neil Dourmashkin, Matthew J Hannah
Background: In a previous study on encephalitis lethargica, we identified a virus related to enterovirus in autopsy brain material. Transmission electron microscopy (TEM), immunohistochemistry (IHC) and molecular analysis were employed.  Our present objective was to investigate, using a similar approach, as to whether virus-like particles (VLP) and enterovirus antigen are present in Parkinson's disease (PD) brainstem neurons. Methods: Fixed tissue from autopsy specimens of late onset PD and control brainstem tissue were received for study...
2018: F1000Research
Daniel Y Bigman, Bradford D Bobrin
Postencephalitic parkinsonism (PEP) is currently perceived as having a very close etiologic relationship with encephalitis lethargica (von Economo's disease [EL]), with PEP developing immediately after the acute phase of EL or at some time later. EL was classically described by von Economo and has somnolent-ophthalmoplegic, hyperkinetic, and amyostatic-akinetic forms. Previous cases have reported success with levodopa in PEP. We report a case with PEP showing success after administration of levodopa and carbidopa...
2018: Neuropsychiatric Disease and Treatment
Bart Lutters, Paul Foley, Peter J Koehler
We commemorate the centenary of Constantin von Economo's description of encephalitis lethargica, a mysterious disease that had a significant effect on 20th-century neuroscience. In the acute phase, encephalitis lethargica was marked by intractable somnolence, which von Economo attributed to lesions in the diencephalon, thereby paving the way for future efforts to localize the regulation of sleep in the subcortical brain. At the same time, neuropathologic findings in postencephalitic parkinsonism affirmed the role of the substantia nigra in the pathophysiology of parkinsonism...
March 20, 2018: Neurology
V M Bhat
No abstract text is available yet for this article.
November 1949: Indian Medical Gazette
H Stott
No abstract text is available yet for this article.
November 1935: Indian Medical Gazette
Grace Stapleton
No abstract text is available yet for this article.
December 1926: Indian Medical Gazette
Nisanath Ghosh
No abstract text is available yet for this article.
February 1933: Indian Medical Gazette
A Bayley de Castro
No abstract text is available yet for this article.
September 1920: Indian Medical Gazette
G T Wrench
No abstract text is available yet for this article.
March 1920: Indian Medical Gazette
J C De
No abstract text is available yet for this article.
March 1923: Indian Medical Gazette
P Ganguli
No abstract text is available yet for this article.
July 1921: Indian Medical Gazette
German E Berrios, Ivana S Markov√°
Historical epistemology is a useful method to understand the longitudinal construction of the movement disorders in psychiatry. Four periods can be identified in such a process. The first, extending from Classical times to the work of Griesinger, included disorders such as catalepsy, crocidism, epilepsy and paralysis. The second period, stretching from Griesinger to Kahlbaum, concentrated on the study of melancholia attonita, stupor and catatonia. The third period, covering the time from Kahlbaum to WWI, witnessed important conceptual shifts such as: the transformation of madness into psychoses; the redefinition of movement and motility in psychiatry; the appearance of self-contained syndromes as dyskinesias, tics, akathisia, complex disorders like the cases of encephalitis lethargica, etc...
September 20, 2017: Schizophrenia Research
A F Tredgold
No abstract text is available yet for this article.
January 15, 1925: Mental Welfare
Leslie A Hoffman, Joel A Vilensky
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
D S Davies, J O Symes, F H Edgeworth, I Walker Hall, J A Nixon
No abstract text is available yet for this article.
March 1920: Bristol Medico-chirurgical Journal
A Michael Critchley
No abstract text is available yet for this article.
1928: Bristol Medico-chirurgical Journal
Isamu Mori
Viruses have long been implicated in the pathogenesis of classical encephalitis lethargica, which was first described by Constantin von Economo in 1917. In this article, I propose the hypothesis that an airborne virus travels along the olfactory conduit to infect the olfactory bulb; this local infection or induced neuroinflammation, in turn, retrogradely targets certain neuronal populations with sleep-wake regulatory functions in the hypothalamus and midbrain, leading to the development of wakeful inactivity, a hallmark clinical feature of the disease...
June 2017: Medical Hypotheses
Johanna C M Schilder, Sandra S Overmars, Johan Marinus, Jacobus J van Hilten, Peter J Koehler
Akinesia, hypokinesia, and bradykinesia are extensively used to describe motor execution disturbances, but are applied inconsistently and cover more conditions than their Greek translations would suggest. We investigated the origins and changes in meaning of these terms over time, particularly in relation to Parkinson's disease (PD). We searched the literature from 1817 to 2015 for use and interpretation of the words akinesia, bradykinesia, hypokinesia, and PD. We found that akinesia and hypokinesia appeared as terms in the 19th century, opposite to hyperkinesia, but were used in the context of PD since 1920, while at the same time the 'bradykinetic syndrome' was introduced...
April 2017: Parkinsonism & related Disorders
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