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https://read.qxmd.com/read/30753864/a-chalcone-derivative-suppresses-the-induction-of-tslp-in-mice-and-human-keratinocytes-and-attenuates-ova-induced-antibody-production-in-mice
#1
Ryosuke Segawa, Mika Shiraki, Shiori Sudo, Kenichi Shigeeda, Taiji Saito, Natsumi Mizuno, Takahiro Moriya, Takayuki Yonezawa, Je-Tae Woo, Masahiro Hiratsuka, Noriyasu Hirasawa
Thymic stromal lymphopoietin (TSLP) is a key epithelial-derived factor that aggravates allergic diseases. Therefore, TSLP inhibitors are candidate compounds for the treatment of allergic diseases. Previously, we reported that KCMH-1, a mouse keratinocyte cell line, constitutively produces TSLP. In this study, we tried to identify inhibitors of TSLP by screening 2169 compounds in KCMH-1 cells and found one such chalcone derivative (code no. 16D10). 16D10 inhibited TSLP expression and TSLP promoter activation in HaCaT cells, a human keratinocyte cell line...
February 9, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30747180/rapid-detection-of-hypnotics-using-surface-enhanced-raman-scattering-based-on-gold-nanoparticle-co-aggregation-in-a-wet-system
#2
Hiroki Segawa, Takao Fukuoka, Tamitake Itoh, Yuichi Imai, Yuko T Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue
Sensitive detection of drugs using a method with high qualification capability is important for forensic drug analysis. Vibrational spectroscopy is a powerful screening technique because it can provide detailed structural information of the compounds included in samples with simple experimental protocols. Among various spectroscopic techniques, surface enhanced Raman scattering (SERS) spectroscopy has attracted enormous attention owing to its ultra-high sensitivity. In this study, we developed a method for rapid detection of hypnotics using SERS with gold nanoparticle co-aggregation in a wet system...
February 12, 2019: Analyst
https://read.qxmd.com/read/30714037/draft-genome-sequence-of-clostridium-tagluense-strain-a121-t-isolated-from-a-permafrost-core-in-the-canadian-high-arctic
#3
Takumi Murakami, Hiroshi Mori, Viktoria A Shcherbakova, Yoshitaka Yoshimura, Takahiro Segawa
Clostridium tagluense strain A121T was isolated from a permafrost core in the Canadian High Arctic. This endospore-forming strain is a strictly anaerobic, Gram-positive, and psychrotolerant bacterium. This article describes the draft genome sequence of C. tagluense strain A121T .
January 2019: Microbiology resource announcements
https://read.qxmd.com/read/30684028/relationship-between-electrical-conduction-and-phasic-left-atrial-function-p-wave-signal-averaged-electrocardiography-and-time-left-atrial-volume-curve-assessments-using-two-dimensional-speckle-tracking-echocardiography
#4
Shinichiro Tanaka, Toshiyuki Noda, Masanori Kawasaki, Tomonori Segawa, Natsumi Tsugita, Takahiro Fuseya, Tomoki Kubota, Makoto Iwama, Kazuhiko Nishigaki, Sachiro Watanabe, Taro Minagawa, Hiroshige Ohashi, Shinya Minatoguchi
P-wave signal-averaged electrocardiography (P-SAECG) can detect imperceptible conduction abnormalities, and volume analysis using two-dimensional speckle-tracking echocardiography (2-DSTE) allows us to easily measure the phasic function of the left atrium (LA). Both conduction abnormalities and functional deformation of the LA may be linked to the clinical outcome; however, the exact relationship is unclear. The aim of this study was to investigate the relationship between the phasic function of the LA and electrical conduction using P-SAECG and 2-DSTE...
January 25, 2019: Heart and Vessels
https://read.qxmd.com/read/30664940/a-steroid-alkaloid-derivative-02f04-upregulates-thymic-stromal-lymphopoietin-expression-slowly-and-continuously-through-a-novel-gq-11-rock-erk1-2-signaling-pathway-in-mouse-keratinocytes
#5
Yan Weng, Jingwen Wang, Zhifu Yang, Miaomiao Xi, Jialin Duan, Chao Guo, Ying Yin, Ryosuke Segawa, Takahiro Moriya, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Aidong Wen, Noriyasu Hirasawa
Thymic stromal lymphopoietin (TSLP), a master switch of allergic inflammation, plays an important role in the pathogenesis of allergic diseases. Although many compounds upregulate TSLP expression in vivo or in vitro, most of them are pollutants or toxicants. In the previous study, for the first time, we found that a steroid alkaloid derivative 02F04, which has a unique skeletal structure compared with other TSLP-inducing chemicals, significantly induced TSLP production in mouse keratinocytes. However, it is not investigated thoroughly that how 02F04 produces TSLP and why...
January 18, 2019: Cellular Signalling
https://read.qxmd.com/read/30592181/imprint-cytology-of-biphenotypic-sinonasal-sarcoma-of-the-paranasal-sinus-a-case-report
#6
Shintaro Sugita, Terufumi Kubo, Tomoyuki Aoyama, Jun Moriya, Tsuyoshi Okuni, Masahiko Wanibuchi, Ken Yamashita, Maki Onodera, Mitsuhiro Tsujiwaki, Keiko Segawa, Taro Sugawara, Tadashi Hasegawa
Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade spindle cell sarcoma that predominantly affects middle-aged women with multiple tumors in the sinonasal tract. BSNS shows biphenotypic expression of neural and myogenic markers on immunohistochemistry (IHC) with a specific chimeric PAX3-MAML3 fusion. The cytological features of BSNS have so far not been reported. Here, we describe a case of BSNS including findings of imprint cytology, histology, IHC, and genetic analysis. A 30-year-old woman presented with a nodular tumor that completely occupied the ethmoid sinus...
December 27, 2018: Diagnostic Cytopathology
https://read.qxmd.com/read/30566196/prevalence-of-cannabis-use-in-youths-after-legalization-in-washington-state
#7
Julia A Dilley, Susan M Richardson, Beau Kilmer, Rosalie Liccardo Pacula, Mary B Segawa, Magdalena Cerdá
No abstract text is available yet for this article.
December 19, 2018: JAMA Pediatrics
https://read.qxmd.com/read/30563837/combined-treatment-with-the-phenolics-epigallocatechin-3-gallate-and-ferulic-acid-improves-cognition-and-reduces-alzheimer-like-pathology-in-mice
#8
Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masahiro Maeda, Terrence Town
'Nutraceuticals' are well-tolerated natural dietary compounds with drug-like properties that make them attractive as Alzheimer's disease (AD) therapeutics. Combination therapy for AD has garnered attention following a recent National Institute on Aging mandate, but this approach has not yet been fully validated. In this report, we combined the two most promising nutraceuticals with complementary anti-amyloidogenic properties: the plant-derived phenolics (-)-epigallocatechin-3-gallate (EGCG, an α-secretase activator) and ferulic acid (FA, a β-secretase modulator)...
December 18, 2018: Journal of Biological Chemistry
https://read.qxmd.com/read/30556363/allergy-inhibitory-receptor-1-inhibits-autoantibody-production-via-upregulation-of-apoptotic-debris-clearance-by-macrophages
#9
Akira Iizuka, Seiji Segawa, Yuya Kondo, Shunta Kaneko, Masahiro Yokosawa, Kotona Furuyama, Haruka Miki, Satoko Tahara-Hanaoka, Akira Shibuya, Hiroto Tsuboi, Daisuke Goto, Isao Matsumoto, Shiro Shibayama, Takayuki Sumida
AIM: Allergy inhibitory receptor-1 (Allergin-1) is a newly identified immune regulatory molecule thought to influence autoantibody production. Autoantibody production, like that observed in Allergin-1-deficient mice, is crucial in the pathogenesis of several autoimmune diseases such as systemic lupus erythematosus. The purpose of this study is to clarify the regulatory role of Allergin-1-mediated autoantibody production using a murine model of thymocytic anaphylaxis. METHODS: C57BL/6 (WT) and Allergin-1-deficient mice were treated with apoptotic cells from naive thymocytes stimulated by dexamethasone...
December 16, 2018: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/30533034/the-plasmid-encoded-transcription-factor-ardk-contributes-to-the-repression-of-the-imp-6-metallo-%C3%AE-lactamase-gene-blaimp-6-leading-to-a-carbapenem-susceptible-phenotype-in-the-blaimp-6-positive-escherichia-coli-strain-a56-1s
#10
Takaya Segawa, Tsuyoshi Sekizuka, Satowa Suzuki, Keigo Shibayama, Mari Matsui, Makoto Kuroda
Carbapenemase-producing Enterobacteriaceae (CPE) are a global concern because these bacteria are resistant to almost all β-lactams. Horizontal interspecies gene transfer via plasmid conjugation has increased the global dissemination of CPE. Recently, an Enterobacteriaceae strain positive for carbapenemase gene but showing a carbapenem-susceptible phenotype was identified, suggesting that these susceptible strains may be challenging to detect solely via antimicrobial susceptibility tests without molecular analysis...
2018: PloS One
https://read.qxmd.com/read/30523405/systemic-network-for-dietary-inorganic-phosphate-adaptation-among-three-organs
#11
Kayo Ikuta, Hiroko Segawa, Ai Hanazaki, Toru Fujii, Ichiro Kaneko, Yuji Shiozaki, Sawako Tatsumi, Yasuko Ishikawa, Ken-Ichi Miyamoto
Inorganic phosphate (Pi) secretion from the salivary glands and dietary Pi are key Pi sources. The regulatory mechanisms of Pi homeostasis in the salivary glands are unknown. We investigated how salivary Pi concentrations are regulated by dietary Pi in mouse models. Dietary manipulation significantly changed the levels of Npt2b protein in the salivary gland ductal cells. In addition, rapid feeding on a high-Pi diet increased the saliva Pi concentrations and led to rapid endocytosis of Npt2b in the apical membranes of the duct cells...
December 6, 2018: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/30450224/predictive-factors-for-hyperglycaemic-progression-in-patients-with-schizophrenia-or-bipolar-disorder
#12
Ichiro Kusumi, Yuki Arai, Ryo Okubo, Minoru Honda, Yasuhiro Matsuda, Yukihiko Matsuda, Akihiko Tochigi, Yoshiteru Takekita, Hiroyoshi Yamanaka, Keiichi Uemura, Koichi Ito, Kiyoshi Tsuchiya, Jun Yamada, Bunta Yoshimura, Nobuyuki Mitsui, Sigehiro Matsubara, Takayuki Segawa, Nobuyuki Nishi, Yasufumi Sugawara, Yuki Kako, Ikuta Shinkawa, Kaoru Shinohara, Akiko Konishi, Junichi Iga, Naoki Hashimoto, Shinsaku Inomata, Noriko Tsukamoto, Hiroto Ito, Yoichi M Ito, Norihiro Sato
Background: Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. Aims: To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. Method: We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression...
November 2018: BJPsych Open
https://read.qxmd.com/read/30443006/the-relationship-between-repeated-measurement-of-casual-and-24-h-urinary-sodium-to-potassium-ratio-in-patients-with-chronic-kidney-disease
#13
Yuka Okuyama, Haruhito A Uchida, Toshiyuki Iwahori, Hiroyoshi Segawa, Ayako Kato, Hidemi Takeuchi, Yuki Kakio, Ryoko Umebayashi, Masashi Kitagawa, Hitoshi Sugiyama, Katsuyuki Miura, Hirotsugu Ueshima, Jun Wada
This study aimed to clarify the relationship between repeated measurements of casual (spot) and 24-h urinary sodium-to-potassium (Na/K) ratios in patients with chronic kidney disease (CKD). A total of 61 inpatients with CKD, 31 in stage 1-3 (eGFR [estimated glomerular filtration rate] ≥ 30 ml/min/1.73 m2 ) and 30 in stage 4-5 (eGFR < 30 ml/min/1.73 m2 ), aged 20-85 consuming a low-sodium diet (NaCl [sodium chloride] 6 g/day) were recruited. Urinary Na, K, and Na/K ratios were measured in both casual urine samples and 2-day, 24 h urine samples, and then analyzed by correlation and Bland-Altman analyses...
November 15, 2018: Journal of Human Hypertension
https://read.qxmd.com/read/30404814/placenta-specific-8-suppresses-il-18-production-through-regulation-of-autophagy-and-is-associated-with-adult-still-disease
#14
Seiji Segawa, Yuya Kondo, Yuji Nakai, Akira Iizuka, Shunta Kaneko, Masahiro Yokosawa, Kotona Furuyama, Hiroto Tsuboi, Daisuke Goto, Isao Matsumoto, Takayuki Sumida
Adult Still disease (ASD) is a systemic disorder of unknown etiology characterized by high spiking fever, rash, and arthritis. The purpose of this study was to identify genes specifically associated with the active phase of the disease. In this study, we have reported that placenta specific 8 (PLAC8) was a newly specific gene involved in ASD. DNA microarray and validation analysis using human monocytes revealed that the expression of PLAC8 was significantly higher in active-ASD patients than in inactive-ASD patients and healthy controls...
November 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://read.qxmd.com/read/30389435/elamipretide-promotes-mitophagosome-formation-and-prevents-its-reduction-induced-by-nutrient-excess-in-ins1-%C3%AE-cells
#15
Anton Petcherski, Kyle M Trudeau, Dane M Wolf, Mayuko Segawa, Jennifer Lee, Evan P Taddeo, Jude T Deeney, Marc Liesa
Elamipretide is a tetrapeptide that restores defects in mitochondrial function, binds to cardiolipin, and is being tested in clinical trials for mitochondria-related diseases. However, whether elamipretide modulates mitochondrial quality control and dynamics, processes essential to preserve mitochondrial function, is unclear. Thus, we tested the effects of elamipretide on mitochondrial morphology, mitophagosome formation, and their early disruption induced by excess nutrients in INS1 β-cells. Elamipretide treatment was sufficient to increase engulfment of mitochondria into autophagosomes in control INS1 β-cells, without inducing widespread changes in mitochondrial morphology or membrane potential...
October 30, 2018: Journal of Molecular Biology
https://read.qxmd.com/read/30355768/phospholipid-flippases-enable-precursor-b-cells-to-flee-engulfment-by-macrophages
#16
Katsumori Segawa, Yuichi Yanagihashi, Kyoko Yamada, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata
ATP11A and ATP11C, members of the P4-ATPases, are flippases that translocate phosphatidylserine (PtdSer) from the outer to inner leaflet of the plasma membrane. Using the W3 T lymphoma cell line, we found that Ca2+ ionophore-induced phospholipid scrambling caused prolonged PtdSer exposure in cells lacking both the ATP11A and ATP11C genes. ATP11C -null ( ATP11C -/y ) mutant mice exhibit severe B-cell deficiency. In wild-type mice, ATP11C was expressed at all B-cell developmental stages, while ATP11A was not expressed after pro-B-cell stages, indicating that ATP11C -/y early B-cell progenitors lacked plasma membrane flippases...
November 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30329028/advanced-glycation-end-product-accumulation-is-associated-with-low-skeletal-muscle-mass-weak-muscle-strength-and-reduced-bone-density-the-nagahama-study
#17
Yasuharu Tabara, Tome Ikezoe, Mikihiro Yamanaka, Kazuya Setoh, Hiroaki Segawa, Takahisa Kawaguchi, Shinji Kosugi, Takeo Nakayama, Noriaki Ichihashi, Tadao Tsuboyama, Fumihiko Matsuda
Background: The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods: This study investigated a general population of 9,203 patients (mean age, 57.8 years). Skeletal muscle mass was measured by bioelectrical impedance analysis, whereas accumulation of AGEs was assessed by skin autofluorescence (SAF-AGE). The muscle strength of upper and lower limbs and usual gait speed were measured in a portion of older (≥60 years of age) participants (n = 1,934)...
October 11, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30326272/engineering-a-bispecific-antibody-with-a-common-light-chain-identification-and-optimization-of-an-anti-cd3-epsilon-and-anti-gpc3-bispecific-antibody-ery974
#18
Hirotake Shiraiwa, Atsushi Narita, Mika Kamata-Sakurai, Takahiro Ishiguro, Yuji Sano, Naoka Hironiwa, Takashi Tsushima, Hiroaki Segawa, Toshiaki Tsunenari, Yosuke Ikeda, Yoko Kayukawa, Mizuho Noguchi, Tetsuya Wakabayashi, Akihisa Sakamoto, Hiroko Konishi, Taichi Kuramochi, Mika Endo, Kunihiro Hattori, Junichi Nezu, Tomoyuki Igawa
The antibody drug market is rapidly expanding, and various antibody engineering technologies are being developed to create antibodies that can provide better benefit to patients. Although bispecific antibody drugs have been researched for more than 30 years, currently only a limited number of bispecific antibodies have achieved regulatory approval. Of the few successful examples of industrially manufacturing a bispecific antibody, the "common light chain format" is an elegant technology that simplifies the purification of a whole IgG-type bispecific antibody...
October 13, 2018: Methods: a Companion to Methods in Enzymology
https://read.qxmd.com/read/30319559/high-throughput-flaa-short-variable-region-sequencing-to-assess-campylobacter-diversity-in-fecal-samples-from-birds
#19
Qian Zhang, Gabriel A Al-Ghalith, Mayumi Kobayashi, Takahiro Segawa, Mitsuto Maeda, Satoshi Okabe, Dan Knights, Satoshi Ishii
Current approach to identify sources of human pathogens is largely dependent on the cultivation and isolation of target bacteria. For rapid pathogen source identification, culture-independent strain typing method is necessary. In this study, we designed new primer set that broadly covers flaA short variable region (SVR) of various Campylobacter species, and applied the flaA SVR sequencing method to examine the diversity of Campylobacter spp. in geese fecal samples ( n = 16) with and without bacteria cultivation...
2018: Frontiers in Microbiology
https://read.qxmd.com/read/30317447/analysis-of-opossum-kidney-napi-iic-sodium-dependent-phosphate-transporter-to-understand-pi-handling-in-human-kidney
#20
Toru Fujii, Yuji Shiozaki, Hiroko Segawa, Shiori Nishiguchi, Ai Hanazaki, Miwa Noguchi, Ruri Kirino, Sumire Sasaki, Kazuya Tanifuji, Megumi Koike, Mizuki Yokoyama, Yuki Arima, Ichiro Kaneko, Sawako Tatsumi, Mikiko Ito, Ken-Ichi Miyamoto
BACKGROUND: The role of Na+ -dependent inorganic phosphate (Pi) transporters in the human kidney is not fully clarified. Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is caused by loss-of-function mutations in the IIc Na+ -dependent Pi transporter (NPT2c/Npt2c/NaPi-IIc) gene. Another Na+ -dependent type II transporter, (NPT2A/Npt2a/NaPi-IIa), is also important for renal Pi reabsorption in humans. In mice, Npt2c deletion does not lead to hypophosphatemia and rickets because Npt2a compensates for the impaired Pi reabsorption...
October 13, 2018: Clinical and Experimental Nephrology
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