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Skin dermatologic treatment

Rıfkiye Küçükoğlu, Sıla Kılıç, Gizem Pınar Sun
Pemphigus vulgaris (PV) is an autoimmune blistering skin disease that, may require multiagent immunosuppressive drug therapies in severe cases. In addition to the well established corticosteroid sparing agents azathioprine, mycophenolate mofetil, and methotrexate, rituximab is being increasingly used alone or in combination in the management of PV. Due to the chronic course of the disease, the cumulative effects of these therapy agents over long follow-up periods may result in various adverse reactions, including bacterial and viral infections...
February 13, 2019: Dermatologic Therapy
Asya I Wallach, Cynthia M Magro, Andrew G Franks, Lee Shapiro, Ilya Kister
PURPOSE OF REVIEW: To describe diverse neurologic and neuroradiologic presentations of two rare, immunologically mediated skin conditions: Sweet disease and localized scleroderma (morphea). RECENT FINDINGS: Core syndromes of neuro-Sweet disease (NSD) are steroid responsiveness, recurrent meningitis, and encephalitis. Focal neurologic, neuro-vascular, and neuro-ophthalmologic syndromes have been reported recently in NSD. A variety of steroid-sparing treatments and biologics have been used for relapsing NSD...
February 12, 2019: Current Neurology and Neuroscience Reports
Doanh Le Huu, Thao Ngo Minh, Thuong Nguyen Van, Phuong Pham Thi Minh, Nghi Dinh Huu, Van Tran Cam, My Le Huyen, Minh Vu Nguyet, Mai Le Thi, Hien Do Thi Thu, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: This prospective clinical study presents the experiences with NB-UVB monotherapy in the treatment of PLC on Vietnamese patients. METHODS: We enrolled at National Hospital of Dermatology and Venereology (NHDV), Vietnam, 29 PLC patients with generalised disease involving at least 60% of the total body surface (based on Nine's Rule) and/or failed to respond to other modalities of treatment. Patients were treated with NB-UVB followed the guideline of the psoriatic treatment of AAD-2010, three times weekly...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Phuong Pham Thi Minh, Trang Trinh Minh, Doanh Le Huu, Thuong Nguyen Van, Sau Nguyen Huu, Tung Vu Thanh, Mai Le Thi, Giang Quach Thi Ha, Nghi Dinh Huu, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Hand eczema is a common chronic and relapsing skin disease with various clinical features. Hand eczema aetiology can be allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), atopic dermatitis (AD) and unknown or combination causes. If the causative agents are not detected treatment of hand eczema will be a failure. A patch test can be useful to detect causative agents in suspected allergic contact hand eczema. Then patients will avoid contacting them. This results in the improvement of hand eczema...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Thuong Nguyen Van, Tan Nguyen Manh, Phuong Pham Thi Minh, Trang Trinh Minh, Nghi Dinh Huu, Kiem Pham Cao, Quang Nguyen Huu, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Up to now, surgical excision of apocrine glands still has been a method that yields high treatment results and low rate of odour recurrent for patients, but many people worry about some serious complications that have been observed postoperatively, such as hematoma and skin necrosis. These prolong wound healing, leading to unsightly scars in the axillary fossae. AIM: We conducted this research to investigate the effects and complications of our surgical technique for axillary bromhidrosis...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Michael J Hesseler, Nikhil Shyam
The field of dermatology has seen numerous therapeutic innovations in the past decade with platelet-rich plasma recently garnering significant interest in acne scarring. This review consolidates the available evidence of platelet rich plasma for the practicing dermatologist and evaluates the current evidence up to May 31, 2018. A search was conducted in the PubMed database for "platelet rich plasma" or "platelet releasate" or "platelet gel" or "PRP" and "dermatology" or "skin" or "hair" or "cutaneous" with thirteen articles meeting the inclusion criteria...
February 8, 2019: Journal of the American Academy of Dermatology
Fariba Iraji, Mojtaba Nasimi, Ali Asilian, Gita Faghihi, Samaneh Mozafarpoor, Hossein Hafezi
INTRODUCTION: Melasma is a prevalent annoying skin hyperpigmentation disorder that commonly involves reproductive-aged females. Variety of treatments with controversial results has been recommended. The aim of the current study was to evaluate combination therapy of tranexamic acid (TA) and vitamin C with and without glutathione with mesotherapy technique for treatment of melasma. METHODS AND MATERIALS: This is a randomized clinical trial study conducted on 30 patients referred to Dermatology Clinics...
February 8, 2019: Journal of Cosmetic Dermatology
J F Mir-Bonafé, D Saceda-Corralo, S Vañó-Galván
The advent of immune targeted therapies for cancer has radically changed the treatment and prognosis of many cancers. These drugs are called targeted therapies because they target specific pathophysiological mechanisms of cancer. This paradigm shift in cancer treatment, however, has resulted in new adverse dermatologic effects involving both the skin and its appendages. In the case of hair, targeted drugs can cause immune alterations and changes in hair growth, color, and shape. Because most targeted therapies are new, there is no single document describing all these adverse effects...
February 1, 2019: Actas Dermo-sifiliográficas
Hsiao-Chi Lai, Chang-Shen Lin, Ching-Shuang Wu, Cheng-Che E Lan
BACKGROUND: Ultraviolet B (UVB) is commonly used for treating dermatologic conditions. Recently, high irradiance UVB (HIUVB) has been suggested to be more effective for treating skin conditions as compared to its low irradiance (LI) counterpart. The biological impact of UVB radiation emitted at different irradiance on cutaneous immunity remains obscure. OBJECTIVE: This study aimed to explore the impacts of UVB radiation administered at equivalent fluence (mJ/cm2 ) but different irradiance (mW/cm2 ) on cutaneous immune response...
January 11, 2019: Journal of Dermatological Science
L G Gordon, A J Rodriguez-Acevedo, K Papier, K Khosrotehrani, N Isbel, S Campbell, A Griffin, A C Green
BACKGROUND: A long-term complication among organ transplant recipients (OTRs) is skin malignancies which are associated with level and duration of immunosuppressive treatment, sun exposure and age. Dermatological surveillance is recommended for OTRs at high risk of skin malignancies, but evidence is lacking on the benefits of such services. OBJECTIVE: To examine the economic impact on patients and on the hospital service of a multidisciplinary high-throughput skin cancer Clinic in Brisbane, Australia, dedicated to dermatological and surgical care of high-risk OTRs...
February 1, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Mayra Ianhez, Sebastião A Pinto, Helio A Miot, Ediléia Bagatin
BACKGROUND: Sun exposure may lead to actinic keratoses (AKs), field cancerization, and skin cancer. Effective treatment of AKs and field cancerization is important. Oral and topical retinoids can be used for this purpose. To compare clinical, histological, and immunohistochemical effects of oral and topical retinoid for AKs and field cancerization on face and upper limbs of immunocompetent patients, as well as the impact on quality of life, safety, and tolerability. METHODS: This study compared 10 mg/day oral isotretinoin (ISO) to 0...
January 31, 2019: International Journal of Dermatology
Ali Pashazadeh, Axel Boese, Michael Friebe
Nonmelanoma skin cancer (NMSC) is a major health concern due to its high incidence rate, its negative impact on the quality of life of patients as well as the associated economic burden to the healthcare system. Surgery is currently the primary treatment offered for skin cancer patients but not applicable or available in all cases. Radiation therapy (RT), with its long successful history in the management of cancer, has shown to be an effective alternative or complementary method in cutaneous oncology. Specifically, for dermatology applications, RT is very often the preferred option due to its favorable cosmetic results, besides the excellent control rate of the tumor...
January 31, 2019: Journal of Dermatological Treatment
Liu Shuo, Yang Ting, Wu KeLun, Zhao Rui, Zhao Rui, Wang Hang
BACKGROUND: Oily skin is one of the most common dermatological complaints. Oily skin may be accompanied by enlarged pores, acne, and seborrheic dermatitis. Moreover, oily skin has negative effects on self-perception. Most therapeutic approaches used to treat oily skin have had varying degrees of efficacy and include topical treatments, such as photodynamic therapy and lasers. However, certain of these therapies for oily skin may lead to severe side effects. With the expanding use and high safety profile of botulinum toxin type A (BoNT-A), its use in the treatment of oily skin has caused significant concerns; moreover, relevant reports have gradually accumulated to address the efficacy of BoNT-A and explore its mechanisms of action...
January 29, 2019: Journal of Cosmetic Dermatology
Carly Dunn, McKenna Boyd, Ida Orengo
With manned missions to Mars on the horizon, understanding and preparing for the medical conditions these astronauts might face becomes vital. According to the literature, the most commonly reported medical events in space are dermatological in nature. Dermatologic conditions rarely threaten an astronaut's life or the mission. However, manifestations and management of dermatologic events become an important consideration in anticipation of spaceflights to Mars and beyond. Given the limited number of articles written about dermatological conditions in this specific population, this review summarizes current knowledge related to dermatology in space...
November 15, 2018: Dermatology Online Journal
Álvaro Díaz-González, Marco Sanduzzi-Zamparelli, Víctor Sapena, Ferran Torres, Neus LLarch, Gemma Iserte, Alejandro Forner, Leonardo da Fonseca, José Ríos, Jordi Bruix, María Reig
BACKGROUND: The positive results of the REFLECT trial in terms of survival (sorafenib vs lenvatinib) offer a new first-line option for hepatocellular carcinoma. Additionally, the expected results of immunotherapy could change the first-line treatment in hepatocellular carcinoma or the clinical trial design in first and second-line. AIMS: To evaluate the impact of dermatologic adverse events under sorafenib in hepatocellular carcinoma patients as a clinical marker to predict prognosis and critically evaluate outcomes within trials...
January 29, 2019: Alimentary Pharmacology & Therapeutics
Anil Kumar Bhatta, Uma Keyal, Yeqiang Liu
High frequency ultrasound (HFUS) refers to the ultrasound probe frequency of more than 10 MHz. HFUS has shorter wavelengths, is absorbed more easily, and is therefore not as penetrating. This explains its use for superficial structures and hence its increasing application in the field of dermatology. HFUS is a simple, reliable, and noninvasive technique that is being used along with the physical examination for the assessment, diagnosis, and management of many dermatologic conditions. In addition, it can also be used for the evaluation of normal skin structure...
December 2018: Discovery Medicine
Ronald B. Vender, Anneke Andriessen, Benjamin Barankin, Anatoli Freiman, Dimitrios Kyritsis, Loukia-Maria Mistos, Jennifer Salsberg, Laetitia Amar
Introduction: The skin of subjects with dry, flaking, and/or scaling conditions is characterized by decreased water and skin lipids content among other findings. It is well understood that daily use of gentle cleansers and moisturizers may help to restore and maintain an optimal skin barrier function. A cohort study of patients with dry skin was developed to evaluate efficacy of daily use of a ceramide containing cleanser and cream that also has salicylic acid. Methods: Thirty-five adults with mild-to-moderate dry skin conditions were recruited from four dermatology centers in Canada...
January 1, 2019: Journal of Drugs in Dermatology: JDD
Fran E. Cook-Bolden, Susan H. Weinkle, Eric Guenin, Varsha Bhatt
Background: Acne vulgaris (acne) is the most common dermatologic disease seen in a racially, geographically, politically, culturally, and socioeconomically diverse Hispanic population. Despite their growing demographics in the US, there are few studies evaluating acne treatment in this population. Potential for skin irritation and dryness, as well as pigmentary changes are key concerns. The first lotion formulation of tretinoin was developed using novel polymerized emulsion technology to provide an important alternative option to treat these acne patients who may be sensitive to the irritant effects of other tretinoin formulations...
January 1, 2019: Journal of Drugs in Dermatology: JDD
Franchesca D. Choi, Calvin T. Sung, Margit L.W. Juhasz, Natasha Atanaskova Mesinkovsk
Importance: The use of nutraceuticals such as collagen for skincare has been rising, but regulations are lacking on quality, absorption, and efficacy. To address this knowledge gap, clinical studies regarding the potential effects of collagen-based dietary supplements on skin are being completed. Objective: To review the literature and assess available randomized-controlled trials using collagen supplementation for treatment efficacy regarding skin quality, anti-aging benefits, and potential application in medical dermatology...
January 1, 2019: Journal of Drugs in Dermatology: JDD
Th Damsin, J Collignon, E Lebas, F Libon, B Dezfoulian, A F Nikkels
The spectrum of the mucocutaneous adverse effects of directed oncologic therapies, such as anti-EGFR, anti-VEGF, anti-TK and anti-BRAF, presents similarities but also differences compared to that of the classic chemotherapeutics. This article reviews the dermatological toxicities of the targeted therapies, with 11 clinical cases, including mucositis and oral toxicities, the acne-like eruptions, nail changes and complications, the «hand/foot» syndrome, radiosensitization, alopecias, xerosis and skin fissures...
January 2019: Revue Médicale de Liège
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