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Isoflavones breast

Xinwei Jiang, Chunting Cao, Weiwei Sun, Zisheng Chen, Xusheng Li, Lutfun Nahar, Satyajit D Sarker, Milen I Georgiev, Weibin Bai
Scandenolone, an isoflavone, has shown anti-cancer potential. In this study, we extracted scandenolone from Cudrania tricuspidata fruit and evaluated its anti-breast cancer effects as well as toxicity in cell and animal models. In cell model, scandenolone suppressed the breast cancer MCF-7 cells viability, ceased mitotic cell cycle, decreased mitochondrial membrane potential, up-regulated cleaved caspase-3 and promoted the phosphorylation of p53. Additionally, this isoflavone promoted cell apoptosis and induced a sustained activation of the phosphorylation of p38 and ERK, but not JNK and Akt...
February 9, 2019: Food and Chemical Toxicology
Alina Uifalean, Hermann Rath, Elke Hammer, Corina Ionescu, Cristina Adela Iuga, Michael Lalk
PURPOSE: The aim of this study was to evaluate the anti-angiogenic properties of soy isoflavones using two breast cancer cell lines, by measuring the concentration of 30 cytokines involved in angiogenesis using a multiplex glass slide ELISA-based array. METHODS: Estrogen-dependent MCF-7 cells and estrogen-independent MDA-MB-231 cells were exposed to genistein (Gen), daidzein (Dai) and a soy seed extract (Ext) for 72 hrs, at selected concentration levels. The conditioned medium was analyzed using a glass slide, multiplex sandwich ELISA-based platform with fluorescent detection which allowed the identification and the quantification of 30 angiogenesis-related cytokines...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Monika Kmetová Sivoňová, Peter Kaplán, Zuzana Tatarková, Lucia Lichardusová, Róbert Dušenka, Jana Jurečeková
Androgens and androgen receptor (AR) play a critical role not only in normal prostate development, but also in prostate cancer. For that reason, androgen deprivation therapy (ADT) is the primary treatment for prostate cancer. However, the majority of patients develop castration-resistant prostate cancer, which eventually leads to mortality. Novel therapeutic approaches, including dietary changes, have been explored. Soy isoflavones have become a focus of interest because of their positive health benefits on numerous diseases, particularly hormone-related cancers, including prostate and breast cancers...
February 2019: Molecular and Clinical Oncology
Yan-Bei Tu, Tong Xiao, Gui-Yi Gong, Ya-Qi Bian, Yan-Fang Li
A new isoflavone, milletenol A (1), along with four known flavonoids (2-5) were isolated from the seeds of Millettia pachycarpa. The structure of 1 was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound 1 and 2 showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO4 -stimulated inflammation was effectively alleviated by compound 1 in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates...
January 12, 2019: Natural Product Research
Neha Jaiswal, Juber Akhtar, Satya Prakash Singh, Farogh Ahsan
Genistein is the natural isoflavone and a phytoestrogen with a broad range of pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces apoptosis and cell proliferation inhibition, differentiates cancer cells. Added health benefits include the reduction of osteoporosis by suppressing osteoclasts and lymphocyte functions, decreased the risk of cardiovascular attacks and relieved postmenopausal problems. Genistein traditionally used in Chinese and Ayurvedic medicine and are found to be associated with lower risk of breast, prostate and lung cancer...
December 5, 2018: Drug Research
Mohammed A Islam, Guido J E J Hooiveld, Johannes H J van den Berg, Vera van der Velpen, Albertinka J Murk, Ivonne M C M Rietjens, F X Rolaf van Leeuwen
This toxicogenomic study was conducted to predict (post)menopausal human health effects of commercial soy supplementation using ovariectomized rats as a model. Different target tissues (i.e. breast, uterus and sternum) and non-target tissues (i.e. peripheral blood mononuclear cells (PBMC), adipose and liver) of ovariectomized F344 rats exposed to a commercially available soy supplement for eight weeks, were investigated. Changes in gene expression in these tissues were analysed using whole-genome microarray analysis...
2018: Toxicology Reports
Shumin Qiu, Chongmin Jiang
BACKGROUND: Some studies have investigated the association between soy and isoflavones consumption and breast cancer survival, but the results are far from conclusive. Accordingly, we performed a systematic review and meta-analysis to explore this issue. METHODS: We performed a comprehensive search of Web of Science, PubMed, and Embase from inception to January 2018. The summary hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a random effects model...
October 31, 2018: European Journal of Nutrition
Soo-Yeon Ahn, Mun Seok Jo, Dahae Lee, Seon-Eun Baek, Jiwon Baek, Jae Sik Yu, Jeyun Jo, Hwayoung Yun, Ki Sung Kang, Jeong-Eun Yoo, Ki Hyun Kim
Pueraria lobata root (PLR), well known as Kudzu root, has recently become commercially available in Western dietary supplements for menopausal symptoms. The scientific basis for its action has been attributed to the action of phytoestrogens. This study aimed to investigate the estrogen-like activity of isoflavonoids isolated from P. lobata root and their safety with respect to their effect on breast cancer cell proliferation. In an E-screen assay, crude MeOH extract of PLR significantly increased the proliferation of MCF-7 cells in a concentration-dependent manner...
October 10, 2018: Bioorganic Chemistry
Paramita Basu, Camelia Maier
Breast cancer is one of the leading causes of cancer-related morbidity and mortality among women worldwide. Phytoestrogens, plant-derived polyphenols that structurally and functionally mimic 17β-estradiol, the mammalian estrogen hormone, are known to modulate multiple molecular targets in breast cancer cells. The structural and chemical similarities to estradiol enable phytoestrogens to exert estrogenic or antiestrogenic activities by binding to the estrogen receptors. Although phytoestrogens have low affinity for estrogen receptors, they are able to compete with 17β-estradiol for the ligand-binding domain of the receptors...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Alexander J Nielsen, James McNulty
The discovery of biologically active polyphenolic natural products, including chalcones, stilbenes, flavanones, and isoflavones as steroidal mimics has proven to be a subject of considerable importance in medicine. Some of these natural compounds have been shown to modulate key human metabolic processes via steroidal hormone receptors, or to inhibit crucial enzymes involved in the biosynthesis of steroidal hormones themselves. Isoflavone polyphenolics such as genistein are well known for this "phytoestrogenic" biological activity...
September 1, 2018: Medicinal Research Reviews
S Hüser, S Guth, H G Joost, S T Soukup, J Köhrle, L Kreienbrock, P Diel, D W Lachenmeier, G Eisenbrand, G Vollmer, U Nöthlings, D Marko, A Mally, T Grune, L Lehmann, P Steinberg, S E Kulling
Isoflavones are secondary plant constituents of certain foods and feeds such as soy, linseeds, and red clover. Furthermore, isoflavone-containing preparations are marketed as food supplements and so-called dietary food for special medical purposes to alleviate health complaints of peri- and postmenopausal women. Based on the bioactivity of isoflavones, especially their hormonal properties, there is an ongoing discussion regarding their potential adverse effects on human health. This review evaluates and summarises the evidence from interventional and observational studies addressing potential unintended effects of isoflavones on the female breast in healthy women as well as in breast cancer patients and on the thyroid hormone system...
September 2018: Archives of Toxicology
Lingping Kong, Xin Li, Hong Wang, Guangyao He, Anzhou Tang
The incidence of nasopharyngeal carcinoma (NPC) in China is relatively higher than that throughout the rest of the world, and NPC is geographically distributed. Long non-coding RNA (lncRNA) plays a key role in the development of tumors. Recent studies have found that the lncRNA Ewing sarcoma-associated transcript 1 (EWSAT1) is highly expressed in various tumors and also in NPCs. The isoflavone calycosin, which is a typical Chinese herbal medicine, can inhibit the growth of breast cancer, colorectal cancer, osteosarcoma and other cancers...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Marziyeh Vahid Dastjerdi, Bita Eslami, Maryam Alsadat Sharifi, Ashraf Moini, Leila Bayani, Hoda Mohammad Khani, Sadaf Alipour
Background: Phytoestrogens treatment to relieve hot flushes in menopausal women was considered recently. However, the actual effectiveness and safety are not clear. Methods: Randomized clinical trial (IRCT#20100706004329N5) was performed in 204 patients who complained of hot flushes in Arash Women's Hospital, Tehran, Iran from 2013-2015. The first group received 50 mg isoflavone (group A) once daily and the second group received placebo (group B) in the same regimen...
March 2018: Iranian Journal of Public Health
Martin Jj Ronis, Horacio Gomez-Acevedo, Kartik Shankar, Neha Sharma, Michael Blackburn, Rohit Singhal, Kelly E Mercer, Thomas M Badger
The isoflavone phytoestrogens found in the soy protein isolate used in soy infant formulas have been shown to have estrogenic actions in the developing male reproductive tract resulting in reproductive toxicity. However, few studies have examined potential estrogenicity of soy protein isolate as opposed to that of pure isoflavones. In this study, we fed weanling male Sprague-Dawley rats a semi-purified diet with casein or soy protein isolate as the sole protein source from postnatal day 21 to 33. Additional groups were fed casein or soy protein isolate and treated s...
May 2018: Experimental Biology and Medicine
Fozia A Adem, Victor Kuete, Armelle T Mbaveng, Matthias Heydenreich, Andreas Koch, Albert Ndakala, Beatrice Irungu, Abiy Yenesew, Thomas Efferth
A new isoflavone, 4'-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2'-dimethoxy-3',4'-methylenedioxyisoflavone, 6,7,3'-trimethoxy-4',5'-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6aR,11aR)-maackiain and (6aR,11aR)-edunol...
April 16, 2018: Natural Product Research
Fedora Grande, Bruno Rizzuti, Maria A Occhiuzzi, Giuseppina Ioele, Teresa Casacchia, Fabrizio Gelmini, Rita Guzzi, Antonio Garofalo, Giancarlo Statti
The physiological responses to estrogen hormones are mediated within specific tissues by at least two distinct receptors, ER and ER. Several natural and synthetic molecules show activity by interacting with these proteins. In particular, a number of vegetal compounds known as phytoestrogens shows estrogenic or anti-estrogenic activity. The majority of these compounds belongs to the isoflavones family and the most representative one, genistein, shows anti-proliferative effects on various hormone-sensitive cancer cells, including breast, ovarian and prostate cancer...
April 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jun Bai, Bin-Jian Yang, Xin Luo
5-hydroxy-4'-nitro-7-propionyloxy-genistein (HNPG), a novel synthetic isoflavone derivative, was demonstrated to possess antitumor activity in gastric cancer and breast cancer in vitro , but its antitumor effect and mechanism in ovarian cancer has not been characterized. The aim of the present study was to investigate the effects of HNPG on inhibiting the proliferation and invasion in human ovarian cancer A2780 cell lines of cisplatin resistance (A2780/DDP) and elucidate its underlying molecular mechanism. The results indicated that HNPG presented with marked antitumor activity against A2780/DDP cells in vitro , significantly inhibited the rates of proliferation, clone formation, invasion and metastasis, and markedly induced apoptosis in dose- and time-dependent manner...
April 2018: Oncology Letters
Masumeh Sanaei, Fraidoon Kavoosi, Ali Valiani, Mohamed Amin Ghobadifar
Background: One of the main causes of mortality is hepatocellular carcinoma (HCC) which accounts for the third leading cause of deaths and one in forty deaths worldwide. The flavonoids, natural antioxidant compounds, account for a major group of polyphenolic compounds. One of the major isoflavones in soybean is genistein (GE) which can inhibit proliferation and induce apoptosis. Isoflavones, major type of phenolic materials, derived from dietary plants and medicinal herbs play a significant role in cancer prevention and treatment...
2018: International Journal of Preventive Medicine
Ruijuan Zhou, Hongjiu Chen, Junpeng Chen, Xuemei Chen, Yu Wen, Leqin Xu
BACKGROUND: Astragalus membranaceus (AM) is a commonly used herb in traditional Chinese medicine (TCM), which has been used as an essential tonic to treat various diseases for more than 2000 years. In this study, we aimed to investigate the biological effects of extract from AM on breast cancer cell and its mechanism. METHODS: To prepare the extract, dried AM were ground and extracted with water extraction-ethanol supernatant method. Then the main isoflavones in the extract was detect by HPLC analysis...
March 9, 2018: BMC Complementary and Alternative Medicine
Adriana Moura Vieira, Poliana Guiomar de Almeida Brasiel, Maíra Schuchter Ferreira, Kacia Mateus, Mariana Sarto Figueiredo, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, José Otavio do Amaral Corrêa, Fernando Cesar Ferraz Lopes, Paulo Henrique Fonseca da Silva, Céphora Maria Sabarense, Sheila Cristina Potente Luquetti Dutra, Aline Silva de Aguiar
PURPOSE: To evaluate the effects of maternal dietary soybean during lactation on the milk composition, body composition, lipid profile and glucose homeostasis of dams and offspring at weaning (21 days) and adulthood (150 days). METHODS: Lactating rats were divided into: casein control (C): casein diet; soy (S): soybean diet; soy oil control (SOC): casein diet, but with fat content similar to the S group. RESULTS: At 21 days, S mothers showed lower estradiol, total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglycerides (TG) in serum; and lower TC and TG in milk...
May 2018: Endocrine
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