keyword
https://read.qxmd.com/read/33969076/salivary-duct-carcinoma-of-the-submandibular-gland-presenting-a-diagnostic-challenge-a-case-report
#21
Toshihiro Uchihashi, Shingo Kodama, Akinari Sugauchi, Shinichiro Hiraoka, Katsutoshi Hirose, Yu Usami, Susumu Tanaka, Mikihiko Kogo
BACKGROUND: Salivary duct carcinoma (SDC) is a rare, extremely aggressive malignancy that arises in the submandibular gland. It can metastasize locally early and therefore is an important differential diagnosis of metastatic disease in cervical lymph nodes or specific lymphadenitis such as tuberculous cervical lymphadenitis. CASE SUMMARY: We report a case of SDC in the submandibular gland that presented diagnostic difficulty. The lesion was coincidentally discovered through examination of the radiolucent area of the maxilla...
April 26, 2021: World Journal of Clinical Cases
https://read.qxmd.com/read/33868581/the-role-of-immune-surveillance-in-malignant-transformation-of-benign-salivary-gland-tumors
#22
JOURNAL ARTICLE
Maximilian Linxweiler, Jingming Wang, Luc G T Morris
Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). Recently, genomic analyses have provided deeper insights into the molecular biology of salivary gland cancers. However, the molecular processes that underlie the progression from PA to CA exPA are largely unknown. In this study, we used RNAseq data from CA ex PA of myoepithelial ( n = 24) or salivary duct histology ( n = 6), de novo myoepithelial carcinoma ( n = 16) and de novo salivary duct carcinoma ( n = 10), and compared their constituent immune tumor microenvironments...
March 30, 2021: Oncotarget
https://read.qxmd.com/read/33797435/mast-cells-and-proteins-related-to-myofibroblast-differentiation-par-2-il-6-and-tgf%C3%AE-1-in-salivary-cancers-a-preliminary-study
#23
JOURNAL ARTICLE
Adna B Ismerim, Iguaracyra B de Oliveira Araújo, Flávia C de Aquino Xavier, Clarissa A G Rocha, Cláudia L Macedo, Maria C T Cangussu, Valéria S Freitas, Ricardo Della Coletta, Patrícia R Cury, Jean N Santos
Salivary gland neoplasms represent an important group of cancers in the head and neck and myoepithelial cells play a key role on the development these tumors. This study evaluated the distribution of mast cells and related proteins (PAR-2, TGFβ1, IL-6) to the myofibroblastic differentiation in malignant tumors of salivary glands with and without myoepithelial differentiation. Immunohistochemical assessement for tryptase mast cells, SMA, PAR-2, TGFβ1, IL-6 was performed in 10 cases of polymorphous low-grade adenocarcinoma, 14 cases of mucoepidermoid carcinoma (MEC) and 10 cases of adenoid cystic carcinoma...
August 1, 2021: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://read.qxmd.com/read/33598797/the-potential-of-somatostatin-receptor-2-as-a-novel-therapeutic-target-in-salivary-gland-malignant-tumors
#24
JOURNAL ARTICLE
Amichay Meirovitz, Karny Shouchane-Blum, Alexander Maly, Evgeniya Bersudski, Nir Hirshoren, Ross Abrams, Aron Popovtzer, Marina Orevi, Jeffrey Weinberger
BACKGROUND: Treatment regimens for patients with metastatic or recurrent post-radiation, locoregional, unresectable salivary cancer are limited. An inverse correlation between somatostatin receptor 2 (SSTR2) and the proliferating marker Ki-67 in neuroendocrine tumors has enabled a treatment plan for metastatic disease, utilizing peptide receptor radionuclide therapy. Interestingly, healthy salivary glands express high levels of SSTR2. In this study, the presence of SSTR2, its correlation with Ki-67 in glandular salivary carcinomas and the clinical applicability thereof was determined...
May 2021: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/33581505/synergistic-efficacy-of-combined-egfr-and-hdac-inhibitors-overcomes-tolerance-to-egfr-monotherapy-in-salivary-mucoepidermoid-carcinoma
#25
JOURNAL ARTICLE
Kshitij Parag-Sharma, Jason Tasoulas, Adele M Musicant, Carlos H Viesi do Nascimento-Filho, Zhichuan Zhu, Chloe Twomey, Pengda Liu, Rogerio M Castilho, Antonio L Amelio
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland malignancy. Advanced or high-grade MECs are refractory to chemotherapy, often leading to tumor recurrence/metastasis and abysmal ~35% 5-year survival. Causal links have been established between Epithelial Growth Factor Receptor (EGFR) activation and poor outcome. Herein we investigated the therapeutic efficacy of EGFR inhibition against MEC using in vitro pre-clinical models. MATERIALS AND METHODS: Five human MEC cell lines were used in cell viability, cytotoxicity, apoptosis, cell cycle, 2D-clonogenicity, and 3D-spheroid formation assays following treatment with Erlotinib (EGFR inhibitor), SAHA (Histone Deacetylase inhibitor; HDAC) and CUDC-101 (dual EGFR-HDAC inhibitor)...
February 11, 2021: Oral Oncology
https://read.qxmd.com/read/32853681/recommendations-for-the-use-of-next-generation-sequencing-ngs-for-patients-with-metastatic-cancers-a-report-from-the-esmo-precision-medicine-working-group
#26
REVIEW
F Mosele, J Remon, J Mateo, C B Westphalen, F Barlesi, M P Lolkema, N Normanno, A Scarpa, M Robson, F Meric-Bernstam, N Wagle, A Stenzinger, J Bonastre, A Bayle, S Michiels, I Bièche, E Rouleau, S Jezdic, J-Y Douillard, J S Reis-Filho, R Dienstmann, F André
Next-generation sequencing (NGS) allows sequencing of a high number of nucleotides in a short time frame at an affordable cost. While this technology has been widely implemented, there are no recommendations from scientific societies about its use in oncology practice. The European Society for Medical Oncology (ESMO) is proposing three levels of recommendations for the use of NGS. Based on the current evidence, ESMO recommends routine use of NGS on tumour samples in advanced non-squamous non-small-cell lung cancer (NSCLC), prostate cancers, ovarian cancers and cholangiocarcinoma...
November 2020: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/32576478/development-of-sentinel-lymph-node-biopsy-technique-in-patients-with-salivary-gland-cancer-using-the-ideal-framework
#27
JOURNAL ARTICLE
Clare Schilling, Gopinath Gnanasegaran, Selvam Thavaraj, Boris Vojnovic, Rose Ngu, Mark McGurk
BACKGROUND: Salivary cancer is rare and comprises a variety of histological subtypes and clinical behaviors. There is no agreed method of estimating the risk of occult metastasis or managing the clinically N0 neck.Sentinel node biopsy (SNB) may offer a solution but previous studies have not produced a reliable imaging protocol. This study uses novel technology and trial methodology to develop a reliable SNB technique, with primary aim to identify peri-and intraglandular sentinel nodes...
November 2020: European Journal of Surgical Oncology
https://read.qxmd.com/read/32537654/serum-and-saliva-levels-of-cancer-antigen-15-3-carcinoembryonic-antigen-estradiol-vaspin-and-obestatin-as-biomarkers-for-the-diagnosis-of-breast-cancer-in-postmenopausal-women
#28
JOURNAL ARTICLE
Hyder Farahani, Jamal Amri, Mona Alaee, Fathollah Mohaghegh, Mohammad Rafiee
OBJECTIVE: To find suitable biomarkers for diagnosis of Breast cancer in serum and saliva; also, to examine the correlation between salivary and serum concentrations of suitable biomarkers. METHODS: This case-control study included 30 women with breast cancer as a case group and 30 healthy women as a matched control group. Blood and saliva specimens were collected from all participants. We evaluated serum and salivary cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), estradiol, vaspin, and obestatin concentrations...
June 15, 2020: Laboratory Medicine
https://read.qxmd.com/read/32067683/targeted-therapy-for-advanced-salivary-gland-carcinoma-based-on-molecular-profiling-results-from-mypathway-a-phase-iia-multiple-basket-study
#29
JOURNAL ARTICLE
R Kurzrock, D W Bowles, H Kang, F Meric-Bernstam, J Hainsworth, D R Spigel, R Bose, H Burris, C J Sweeney, M S Beattie, S Blotner, K Schulze, V Cuchelkar, C Swanton
BACKGROUND: Systemic therapy options for salivary cancers are limited. MyPathway (NCT02091141), a phase IIa study, evaluates targeted therapies in non-indicated tumor types with actionable molecular alterations. Here, we present the efficacy and safety results for a subgroup of MyPathway patients with advanced salivary gland cancer (SGC) matched to targeted therapies based on tumor molecular characteristics. PATIENTS AND METHODS: MyPathway is an ongoing, multiple basket, open-label, non-randomized, multi-center study...
March 2020: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/31958633/vdr-in-salivary-gland-homeostasis-and-cancer
#30
JOURNAL ARTICLE
Kara A DeSantis, Samantha L Robilotto, Mark Matson, Noor M Kotb, Cathryn M Lapierre, Zenab Minhas, Alana A Leder, Khushbakht Abdul, Emily M Facteau, JoEllen Welsh
The vitamin D receptor (VDR) and its ligand 1,25(OH)2 D3 (1,25D) impact differentiation and exert anti-tumor effects in many tissues, but its role in salivary gland has yet to be defined. Using immunohistochemistry (IHC), we have detected strong VDR expression in murine and human salivary gland ducts. Compared to normal gland, VDR protein expression was retained in differentiated human pleomorphic adenoma (PA) but was undetectable in undifferentiated PA and in carcinomas, suggesting deregulation of VDR during salivary cancer progression...
January 17, 2020: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/31471126/carcinoma-ex-pleomorphic-adenoma-a-review-of-incidence-demographics-risk-factors-and-survival
#31
JOURNAL ARTICLE
Avigeet Gupta, Sina Koochakzadeh, David M Neskey, Shaun A Nguyen, Eric J Lentsch
PURPOSE: Identify variables that are independent predictors of survival in carcinoma ex pleomorphic adenoma (CXPA) of the major salivary glands using a population-based database and evaluate the incidence and management strategies for this rare malignancy. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was queried for all cases of major salivary gland CXPA from 1973 to 2015. RESULTS: Of the 619 patients identified, the parotid gland was the most common site of involvement (76...
November 2019: American Journal of Otolaryngology
https://read.qxmd.com/read/30706564/marked-responses-to-pemetrexed-chemotherapy-for-metastatic-adenocarcinoma-of-the-parotid-gland-case-series
#32
Paul V Viscuse, Katharine Price
BACKGROUND: There are no proven systemic therapies for metastatic adenocarcinoma of the salivary glands. Pemetrexed use in adenocarcinoma of the salivary glands has not been previously described. METHODS: Retrospective case reports and literature review. RESULTS: Two patients with metastatic salivary gland adenocarcinoma were treated with single-agent pemetrexed with marked response and clinical benefit. Case 1 describes a sustained clinical response for 8 months after failing several lines of chemotherapy...
February 1, 2019: Head & Neck
https://read.qxmd.com/read/30528947/the-limited-role-of-elective-neck-dissection-in-patients-with-cn0-salivary-gland-carcinoma
#33
JOURNAL ARTICLE
Kai Qian, Kai Guo, Xiaoke Zheng, Wenyu Sun, Tuanqi Sun, Lili Chen, Ding Ma, Yi Wu, Qinghai Ji, Zhuoying Wang
PURPOSE: To evaluate whether elective neck dissection (END) was beneficial for cN0 patients with salivary gland carcinoma. MATERIALS AND METHODS: The rates of regional failure-free survival and disease-free survival were calculated using Kaplan-Meier methods and Cox models. The risk factors for occult lymph node metastasis (OLNM) in cN0 patients undergoing END was analyzed using logistic regression. A nomogram was formulated to calculate the estimated probability of OLNM...
November 22, 2018: Journal of Cranio-maxillo-facial Surgery
https://read.qxmd.com/read/30370820/a-systematic-review-and-meta-analysis-of-subsequent-malignant-neoplasm-risk-after-radioactive-iodine-treatment-of-thyroid-cancer
#34
JOURNAL ARTICLE
Chi Yun Yu, Omar Saeed, Alyse S Goldberg, Shafaq Farooq, Rouhi Fazelzad, David P Goldstein, Richard W Tsang, James D Brierley, Shereen Ezzat, Lehana Thabane, Charlie H Goldsmith, Anna M Sawka
BACKGROUND: The potential risk of subsequent malignant neoplasms (SMNs) after radioactive iodine (RAI) treatment of thyroid cancer (TC) is an important concern. METHODS: A systematic review was updated comparing the risk of SMNs in TC patients treated with RAI to TC patients without RAI. Six electronic databases were searched (up to March, 2018), supplemented with a hand search. Two reviewers independently screened citations, reviewed full-text papers, and critically appraised/abstracted data...
November 27, 2018: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30263102/acquisition-of-resistance-to-androgen-deprivation-therapy-in-salivary-duct-carcinoma-a-case-report
#35
Koichiro Wasano, Kouhei Sakurai, Taiji Kawasaki, Kimihide Kusafuka, Masao Kasahara, Naoki Kondo, Ken-Ichi Inada, Kaoru Ogawa
Salivary duct carcinoma is a relatively rare salivary cancer, and most cases are androgen receptor -positive. Salivary duct carcinoma growth is suggested to be androgen dependent, which can reportedly be controlled by androgen deprivation therapy. However, the effectiveness and underlying molecular mechanisms of androgen deprivation therapy for salivary duct carcinoma remain unknown. We report a salivary duct carcinoma case (65-year-old man) arising from the parotid gland with metastasis to the neck lymph nodes and lungs...
2018: Rare Tumors
https://read.qxmd.com/read/30224202/guidelines-for-clinical-target-volume-definition-for-perineural-spread-of-major-salivary-gland-cancers
#36
JOURNAL ARTICLE
K Armstrong, J Ward, N M Hughes, A Mihai, A Blayney, C Mascott, R Kileen, J Armstrong
AIMS: Postoperative radiotherapy is the standard of care for resected major salivary cancers that are at risk of locoregional recurrence. Of the various histological subtypes, perineural invasion is most common in adenoidcystic carcinomas of the three major salivary glands - parotid, submandibular and sublingual. The clinical target volume (CTV) for these cases must include the relevant cranial nerve pathways at risk. A contouring atlas was devised for delineation of the CTV of the nerves supplying the major salivary glands...
December 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://read.qxmd.com/read/29688836/pediatric-salivary-cancer-epidemiology-treatment-trends-and-association-of-treatment-modality-with-survival
#37
COMPARATIVE STUDY
Elliot Morse, Rance J T Fujiwara, Zain Husain, Benjamin Judson, Saral Mehra
Objective To characterize the epidemiology of pediatric salivary cancer and associate patient, tumor, and treatment factors with treatment modality and survival. Study Design Cross-sectional analysis. Setting US national database. Subjects and Methods We identified 588 patients 19 years or younger diagnosed with salivary cancer in the National Cancer Database 2004-2013. We characterized patient, tumor, and treatment factors as proportions and associated these factors with treatment modality and overall survival via multivariable logistic regression and multivariable Cox proportional hazards regression, respectively...
September 2018: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/29491609/adenoid-cystic-carcinoma-of-palate-report-of-a-solid-variant
#38
JOURNAL ARTICLE
Anchal Chandraprakash Srivastava, Suresh R Barpande, Jyoti D Bhavthankar, Mandakini S Mandale
Adenoid cystic carcinomas (ADCCs) are uncommon tumors, comprising < 1% of all head-and-neck cancers and 20%-25% of all salivary cancers. The most common presenting symptom of the lesion is a slowly growing mass followed by pain due to the propensity of these tumors for perineural invasion. The tumor is most often clinically deceptive by its small size and slow growth, which actually overlies its extensive subclinical invasion and marked ability for early metastasis making the prognosis questionable, aptly referred as "wolf in sheep's clothing...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://read.qxmd.com/read/29460669/treatment-times-in-salivary-gland-cancer-national-patterns-and-association-with-survival
#39
JOURNAL ARTICLE
Elliot Morse, Rance J T Fujiwara, Benjamin Judson, Saral Mehra
Objective To characterize treatment times in salivary cancer; associate treatment times with patient, tumor, and treatment characteristics; and examine the association of treatment times and overall survival. Study Design Retrospective cohort. Setting Commission-on-Cancer Accredited Hospitals 2004-2013. Subjects and Methods In total, 5953 patients with salivary cancer included in the National Cancer Database were identified. For each treatment interval, patients in the fourth quartile ("prolonged") were compared to patients in the first and second quartiles ("not prolonged")...
August 2018: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/28614209/newly-described-entities-in-salivary-gland-pathology
#40
REVIEW
Alena Skálová, Douglas R Gnepp, James S Lewis, Jennifer L Hunt, Justin A Bishop, Henrik Hellquist, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito
Salivary glands may give rise to a wide spectrum of different tumors. This review concentrates on 4 salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma, cribriform adenocarcinoma of minor salivary glands (CASG), sclerosing polycystic adenosis/adenoma (SPA), and the mucinous/secretory variant of myoepithelioma. Mammary analog secretory carcinoma is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25), resulting in an ETV6-NTRK3 fusion...
August 2017: American Journal of Surgical Pathology
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