Ayman M Mousa, Khaled E A Soliman, Fahad A Alhumaydhi, Ahmad Almatroudi, Khaled S Allemailem, Mohammed A Alsahli, Faris Alrumaihi, Mohammad Aljasir, Ameen S S Alwashmi, Ahmed A Ahmed, Arif Khan, Khalid A Al-Regaiey, Naif AlSuhaymi, Mahdi H Alsugoor, Walid A Aljarbou, Abulmaaty M Elsayed
AIMS: Although trastuzumab (TZB)-induced cardiotoxicity is well documented and allicin (one of the main active garlic ingredients) has ameliorating effects against numerous causes of toxicities; however, the influence of allicin on TZB-induced cardiotoxicity has not been investigated yet. Therefore, the current work explored the potential cardioprotective structural, biochemical, and molecular mechanisms of allicin against TZB-induced cardiotoxicity in a rat's model. METHODS: Forty rats were divided into four equal groups and treated for five weeks...
May 20, 2022: Life Sciences