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Dorina Lauritano, Alberta Lucchese, Federica Gabrione, Dario Di Stasio, Javier Silvestre Rangil, Francesco Carinci
Introduction : In the different branches of dentistry, the use of laser to solve different clinical situations is increasing due to numerous advantages that have been studied in literature since the 70s. Leucoplakia and hyperkeratosis can benefit from laser-assisted treatment. In most cases biopsy sampling, histological examination and, if no malignant cells are present, the follow-up is needed. However, even if the lesion is free of dysplasia patients often ask to eliminate these white spots that are always a cause of concern...
January 13, 2019: International Journal of Environmental Research and Public Health
Sahji Thomas, Vikram Singh Boparai, Virendra Kumar Tiwari, Bipin T Varghese, P G Balagopal, Elizabeth Mathew Iype, Nebu Abraham George, Deepak Janardhan
A prospective observational study was done at the Regional Cancer Centre, Thiruvananthapuram, a tertiary referral center for cancer care in India with an aim to assess the surgical outcomes of CO2 laser resection of oral lesions in terms of operative time, blood loss, hospital stay, postoperative pain, time to re-epithelization, pathological margins achieved and the postoperative scar. The excision was performed in 30 patients with a diagnosis of either potentially malignant lesions (leucoplakia, erythroplakia) or early cancers, i...
September 2018: Indian Journal of Surgical Oncology
E M Okoturo, J M Risk, A G Schache, R J Shaw, M T Boyd
Proliferative verrucous leukoplakia (PVL) is a potentially premalignant lesion that undergoes malignant transformation in over 40% of cases. Its clinical homogeneity suggests that a single or a small number of molecular pathogenic pathways may exist. Using the Cochrane protocol for systematic reviews, we have looked at the reported evidence of the molecular aetiology and pathogenesis of PVL and compared it with that of conventional oral epithelial dysplasia (OED). Of the 43 papers studied, 19 met the inclusion criteria including 13 proteins assayed in 344 tissues, and genes investigated were TP53, p14ARF, and p16INK4A...
November 2018: British Journal of Oral & Maxillofacial Surgery
T Okamoto, M Tanaka, N Kaibuchi, T Kuwazawa, T Ando
A 75-year-old Japanese man presented at our outpatient clinic with pain on the right side of his tongue. Comparison of histological and dermoscopic images showed that areas with hyperkeratosis were opaque white, areas above the papillary dermis were reddish, and that the lesion looked whiter on dermoscopy the longer the epithelial rete ridges were. A dermatocope shows structural information from the epidermis as well as the upper dermis, and could improve early diagnosis of oral mucosal squamous carcinoma in situ...
October 2018: British Journal of Oral & Maxillofacial Surgery
Giovanna Ribeiro Souto, Michelle Danielle Porto Matias, Laiz Fernandes Mendes Nunes, Raquel Conceição Ferreira, Ricardo Alves Mesquita
OBJECTIVE: To compare the densities of CD1a + immature and CD83+ mature dendritic cells, and inflammatory infiltrate cells between smokers and non-smokers with oral leukoplakia. Parameters associated with malignant transformation were also evaluated. DESIGN: 21 smokers and 23 non-smokers diagnosed with oral leukoplakia were obtained. Densities of inflammatory infiltrate cells were calculated in H&E sections. Immunohistochemistry using anti-CD1a and anti-CD83 was performed and densities were calculated...
July 26, 2018: Archives of Oral Biology
Raghini Mohanraj, Pratibha Ramani, Priya Premkumar, Anuja Natesan, Herald J Sherlin, Gheena Sukumaran
Introduction: Ezrin, also known as cytovillin, is a member of the ERM family of protein. Ezrin cross-links actin filament with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility, and membrane trafficking. Recent analysis reveals their involvement in signaling pathways. Ezrin is highly expressed in several types of human cancers, and correlation between its immunoreactivity and histopathological data as well as the patient outcome has previously been studied...
November 2017: Journal of Pharmacy & Bioallied Sciences
A D da Silva, N B Daroit, F B Cardoso, N K Laureano, B J Maraschin, L Bündrich, C K Danilevicz, A S Magnusson, F Visioli, P V Rados
OBJECTIVE: To assess the level of maturation and proliferation of epithelial cells and the correlation with immunocytochemical expression of adhesion (E-cadherin) and cell differentiation (involucrin) markers. METHODS: Cytopathological samples were obtained from four groups of patients: control (CG, n=30); alcohol/tobacco (ATG, n=31), leucoplakia (LG, n=31), and squamous cell carcinoma (SCCG, n=22). Cytopathological smears were collected from all groups for AgNOR, Papanicolaou and immunocytochemical staining...
February 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Liana P Webber, Vivian P Wagner, Marina Curra, Pablo A Vargas, Luise Meurer, Vinícius C Carrard, Cristiane H Squarize, Rogério M Castilho, Manoela D Martins
AIMS: Epigenetics refers to changes in cell characteristics that occur independently of modifications to the DNA sequence. Oral carcinogenesis is influenced by modifications in epigenetic mechanisms, including changes in histones, which are proteins that support chromatin remodelling for the dynamic regulation of gene expression and silencing. The dysregulation of histone acetylation can lead to the uncontrolled activity of different genes, thereby triggering events associated with malignant transformation...
August 2017: Histopathology
Daniel G E Thiem, Schamiem Schneider, Narayan T Venkatraman, Vinay V Kumar, Jürgen Brieger, Bernhard Frerich, Peer W Kämmerer
BACKGROUND: Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leucoplakia (OL). MATERIALS AND METHODS: A total of 131 histological preparations [oral leukoplakia/hyperkeratosis without dysplasia (OL; n = 49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n = 33), with moderate dysplasia (OL-SIN2; n = 13) and leukoplakia-derived oral squamous cell carcinoma (OL-OSCC; n = 36)] were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF-A) expression...
October 2017: Journal of Oral Pathology & Medicine
I Karagyozov
AIM: A short presentation of the method--laser microsurgery and analysis of the achieved results. MATERIALS AND METHODS: 631 laser procedures were done for 3 years (2008- 2011) at Tokuda hospital outpatient department. These procedures were divided as follows: 607 laser vaporizations and 24 laser conisations. Indications for vaporizations were: CINI-114 patients, CIN II--26 patients, CIN III (without invasion of the cervical os) -26 patients and 422 patients were done laser vaporization for different reasons-papiloma, leucoplakia, atypical vessels and so on...
2015: Akusherstvo i Ginekologii︠a︡
A Ottavioli, F Campana, J-H Catherine, E Massereau, J Del Grande, U Ordioni
BACKGROUND: The aim of this study was to collect epidemiological, aetiopathogenic, clinical, histological and therapeutic data concerning proliferative verrucous leucoplakia (PVL) and to report three new cases. PATIENTS AND METHODS: A literature review performed using the Medline database enabled us to collate 39 studies involving 607 cases. Three new cases were added. RESULTS: PVL is a rare disease characterized by extensive and multifocal oral leucoplakic lesions...
March 2016: Annales de Dermatologie et de Vénéréologie
Álvaro Fernández-Valle, Juan Pablo Rodrigo, Juana M García-Pedrero, Tania Rodríguez-Santamarta, Eva Allonca, Paloma Lequerica-Fernández, Juan Carlos de Vicente
AIMS: The expression of the voltage-gated potassium channel Kv3.4 was investigated in both oral squamous cell carcinomas (OSCC) and oral leucoplakias to establish its clinical significance during the development and progression of OSCC. MATERIALS AND METHODS: Tissue specimens from 62 patients with oral leucoplakia were collected prospectively and 100 patients with OSCC who underwent surgical treatment were collected retrospectively, and Kv3.4 expression was analysed by immunohistochemistry...
July 2016: Histopathology
E Vigarios, J-C Fricain, F Projetti, M Boulanger, V Sibaud
BACKGROUND: Oral hairy leukoplakia (OHL) is an EBV-associated condition of the oral mucosa, which is often painless. It is found predominantly in HIV-positive patients and is considered a clinical indicator of immunosuppression. OHL has rarely been described in HIV-negative patients, being found most often in association with iatrogenic immunosuppression. OHL induced by topical steroids remains extremely rare. PATIENTS AND METHODS: An 81-year-old HIV-negative woman, treated for 3 months with topical steroids for oral lichen planus, developed an asymptomatic white, corrugated, non-removable plaque with vertical folds on the lateral edge of the tongue...
October 2015: Annales de Dermatologie et de Vénéréologie
Payal P Khincha, Ingrid M Wentzensen, Neelam Giri, Blanche P Alter, Sharon A Savage
Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome and telomere biology disorder characterized by dysplastic nails, reticular skin pigmentation and oral leucoplakia. Androgens are a standard therapeutic option for bone marrow failure in those patients with DC who are unable to undergo haematopoietic stem cell transplantation, but there are no systematic data on its use in those patients. We evaluated haematological response and side effects of androgen therapy in 16 patients with DC in our observational cohort study...
May 2014: British Journal of Haematology
J B Powell, I Dokal, R Carr, S Taibjee, B Cave, C Moss
Dyskeratosis congenita (DC) is a clinically and genetically heterogeneous multisystem bone marrow failure disorder of telomere maintenance, which may present with dermatological features. The main cause of mortality is bone marrow failure, often developing in the second decade of life, although pulmonary disease and malignancies such as squamous cell carcinomas (SCCs) may also prove fatal. We report the case of a 28-year-old man with X-linked DC and confirmed DKC1 gene mutation. In addition to the classic triad of nail dystrophy, hyperpigmentation and oral leucoplakia, the patient had actinic keratosis (AK) and photodamaged skin, hitherto under-recognized features of this condition...
April 2014: Clinical and Experimental Dermatology
M Pentenero, M Meleti, P Vescovi, S Gandolfo
Proliferative verrucous leucoplakia (PVL) is a distinct, particularly aggressive form of oral leucoplakia. Given the low prevalence of PVL, data are sparse and are mostly from case reports, case series and only a few case-control studies, meaning that the literature is able to provide only weak evidence. The present systematic literature review aims to collate the available evidence on the following issues: patient demographics, aetiology, lesion location(s), malignant potential, location and histopathological features of transformed lesions, disease-specific survival rates and treatment response...
May 2014: British Journal of Dermatology
Emily Iacovou, Petros V Vlastarakos, George Papacharalampous, George Kampessis, Thomas P Nikolopoulos
Almost 30 years after its first description, HIV still remains a global pandemic. The present paper aims to review the current knowledge on the ear, nose and throat (ENT) manifestations of HIV infection, and present the available diagnostic and treatment options. A literature review was conducted in Medline and other available database sources. Information from related books was also included in the data analysis. It is well acknowledged that up to 80% of HIV-infected patients eventually develop ENT manifestations; among which, oral disease appears to be the most common...
January 2, 2012: Infectious Disease Reports
Aladim Gomes Lameira, Flávia Sirotheau Corrêa Pontes, Douglas Magno Guimarães, Ana Carolina Garcia Alves, Adriana Souza de Jesus, Hélder Antônio Rebelo Pontes, Décio Dos Santos Pinto
BACKGROUND: The aim of this study was to identify the expression of MCM3, Ki-67 and p27 in normal mucosa, leucoplakia and oral squamous cell carcinoma (OSCC) and determine whether altered expression could serve as a prognostic marker of a malignant progression of dysplastic lesions. METHODS: The samples were collected from 37 patients with oral leucoplakia (13 with mild dysplasia - MLD, 12 with moderate dysplasia - MD and 12 with severe dysplasia - SD). Eleven samples of mouth floor mucocele (M) and 50 floor mouth and tongue samples OSCC of untreated patients were included in this study...
July 2014: Journal of Oral Pathology & Medicine
Melissa W Taggart, Asif Rashid, William A Ross, Susan C Abraham
AIMS: Oesophageal hyperkeratosis is rarely described. In contrast to hyperkeratosis of orolaryngeal mucosa, where its risk factors and association with squamous neoplasia are well-studied, the prevalence and clinicopathological features of oesophageal hyperkeratosis are unknown. METHODS AND RESULTS: We reviewed prospectively 1845 oesophageal biopsies and found hyperkeratosis in 37 (2.0%). Among 98 patients studied, hyperkeratosis occurred in two distinct settings: group 1 [within Barrett's oesophagus (BO)/adenocarcinoma, n = 61, 62%] and group 2 (outside BO/adenocarcinoma, n = 37, 38%)...
October 2013: Histopathology
D Velázquez, I Casado, P de la Cueva, J M Hernanz
No abstract text is available yet for this article.
July 2013: Clinical and Experimental Dermatology
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