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JOURNAL ARTICLE
Yi Ding, Su Zhang, Chuangao Tang, Cuntai Guan
Emotion recognition from electroencephalogram (EEG) signals is a critical domain in biomedical research with applications ranging from mental disorder regulation to human-computer interaction. In this paper, we address two fundamental aspects of EEG emotion recognition: continuous regression of emotional states and discrete classification of emotions. While classification methods have garnered significant attention, regression methods remain relatively under-explored. To bridge this gap, we introduce MASA-TCN, a novel unified model that leverages the spatial learning capabilities of Temporal Convolutional Networks (TCNs) for EEG emotion regression and classification tasks...
April 23, 2024: IEEE Journal of Biomedical and Health Informatics
#22
JOURNAL ARTICLE
Wei Liu, Chaofan Ma, Haiyan Wang, Jingjie Sha
The detection and identification of nanoscale molecules are crucial, but traditional technology comes with a high cost and requires skilled operators. Solid-state nanopores are new powerful tools for discerning the three-dimensional shape and size of molecules, enabling the translation of molecular structural information into electric signals. Here, DNA molecules with different shapes were designed to explore the effects of electroosmotic forces (EOF), electrophoretic forces (EPF), and volume exclusion on electric signals within solid-state nanopores...
April 23, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#23
JOURNAL ARTICLE
Pedro Barata, Shuchi Gulati, Andrew Elliott, Hans J Hammers, Earle F Burgess, Benjamin A Gartrell, Sourat Darabi, Mehmet A Bilen, Arnab Basu, Daniel M Geynisman, Nancy A Dawson, Matthew R Zibelman, Tian Zhang, Shuanzeng Wei, Charles J Ryan, Elisabeth I Heath, Kelsey A Poorman, Chadi Nabhan, Rana R McKay
Molecular profiling of clear cell RCC (ccRCC) tumors of clinical trial patients has identified distinct transcriptomic signatures with predictive value, yet data in non-clear cell variants (nccRCC) are lacking. We examined the transcriptional profiles of RCC tumors representing key molecular pathways, from a multi-institutional, real-world patient cohort, including ccRCC (n = 508) and centrally-reviewed nccRCC (n = 149) samples. ccRCC had increased angiogenesis signature scores compared to the heterogeneous group of nccRCC tumors (mean z-score 0...
April 23, 2024: Journal of Clinical Investigation
#24
JOURNAL ARTICLE
Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Michihiro Kono, Mitsuki Sugihara, Yosuke Kawai, Minae Kawashima, Seik-Soon Khor, Kazuhiro Sugi, Hirotaka Kouno, Hiroshi Kouno, Atsushi Naganuma, Satoru Iwamoto, Shinji Katsushima, Kiyoshi Furuta, Toshiki Nikami, Tomohiko Mannami, Tsutomu Yamashita, Keisuke Ario, Tatsuji Komatsu, Fujio Makita, Masaaki Shimada, Noboru Hirashima, Shiro Yokohama, Hideo Nishimura, Rie Sugimoto, Takuya Komura, Hajime Ota, Motoyuki Kojima, Makoto Nakamuta, Naoyuki Fujimori, Kaname Yoshizawa, Yutaka Mano, Hironao Takahashi, Kana Hirooka, Satoru Tsuruta, Takeaki Sato, Kazumi Yamasaki, Yuki Kugiyama, Yasuhide Motoyoshi, Tomoyuki Suehiro, Akira Saeki, Kosuke Matsumoto, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Masahiro Ito, Kazuhito Kawata, Akinobu Takaki, Kuniaki Arai, Teruko Arinaga, Masanori Abe, Masaru Harada, Makiko Taniai, Mikio Zeniya, Hiromasa Ohira, Shinji Shimoda, Atsumasa Komori, Atsushi Tanaka, Kazuyoshi Ishigaki, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
BACKGROUND AIMS: Previous genome-wide association studies (GWAS) have indicated the involvement of shared (population-non-specific) and non-shared (population-specific) susceptibility genes in the pathogenesis of primary biliary cholangitis (PBC) among European and East-Asian populations. Although a meta-analysis of these distinct populations has recently identified more than 20 novel PBC susceptibility loci, analyses of population-specific genetic architecture are still needed for a more comprehensive search for genetic factors in PBC...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#25
JOURNAL ARTICLE
Charlotte Domblides, Steven Crampton, Hong Liu, Juliet M Bartleson, Annie Nguyen, Claudia Champagne, Emily E Landy, Lindsey Spiker, Christopher Proffitt, Sunil Bhattarai, Anissa P Grawe, Matias Fuentealba Valenzuela, Lydia Lartigue, Isabelle Mahouche, Jeremy Dupaul-Chicoine, Kazuho Nishimura, Félix Lefort, Marie Decraecker, Valérie Velasco, Sonia Netzer, Vincent Pitard, Christian Roy, Isabelle Soubeyran, Victor Racine, Patrick Blanco, Julie Déchanet-Merville, Maya Saleh, Scott W Canna, David Furman, Benjamin Faustin
The immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown. Here, we show that NLR family CARD Domain Containing 4 (NLRC4) is downregulated in epithelial tumor cells of colorectal cancer (CRC) patients by using spatial tissue imaging. Strikingly, only the loss of tumor NLRC4 but not stromal is associated with poor immune infiltration (mainly dendritic and CD4+/CD8+ T cells) and accurately predicts progression to metastatic Stage IV and decrease of overall survival...
April 23, 2024: Journal of Clinical Investigation
#26
JOURNAL ARTICLE
Anna Faivre, Milica Bugarski, Anna Rinaldi, Imene B Sakhi, Thomas Verissimo, David Legouis, Sara Correia, Monika Kaminska, Delal Dalga, Daniele Malpetti, Pietro E Cippa, Sophie de Seigneux, Andrew M Hall
BACKGROUND: Large increases in glomerular protein filtration induce major changes in body homeostasis and increase risk of kidney functional decline and cardiovascular disease. We investigated how elevated protein exposure modifies the landscape of tubular function along the entire nephron, to understand the cellular changes that mediate these important clinical phenomena. METHODS: We conducted single nuclei RNA sequencing, functional intravital imaging, and antibody staining to spatially map transport processes along the mouse kidney tubule...
April 24, 2024: Journal of the American Society of Nephrology: JASN
#27
JOURNAL ARTICLE
Fatima Z Saddouk, Andrew P Kuzemczak, Junichi Saito, Daniel M Greif
Mechanisms underlying maintenance of pathological vascular hypermuscularization are poorly delineated. Herein, we investigated retention of smooth muscle cells (SMCs) coating normally unmuscularized distal pulmonary arterioles in pulmonary hypertension (PH) mediated by chronic hypoxia ± Sugen 5416, and reversal of this pathology. With hypoxia in mice or culture, lung endothelial cells (ECs) upregulated hypoxia-inducible factor (Hif)-1a and 2a which induce platelet-derived growth factor-B (PDGF-B), and these factors reduced to normoxic levels with re-normoxia...
April 23, 2024: JCI Insight
#28
JOURNAL ARTICLE
Ananyaa Sridhar, Peter R Flatt, Matthew Draper, Andrei I Tarasov, R Charlotte Moffett, Nigel Irwin, Dawood Khan
OBJECTIVES: Dopamine and related receptors are evidenced in pancreatic endocrine tissue, but the impact on islet β-cell stimulus-secretion as well as (patho)physiological role are unclear. METHODS: The present study has evaluated islet cell signalling pathways and biological effects of dopamine, as well as alterations of islet dopamine in rodent models of diabetes of different aetiology. KEY FINDINGS: The dopamine precursor L-DOPA partially impaired glucose tolerance in mice and attenuated glucose-, exendin-4, and alanine-induced insulin secretion...
April 23, 2024: Journal of Pharmacy and Pharmacology
#29
JOURNAL ARTICLE
Jingrong Chen, Xiaoyi Shi, Yanan Deng, Junlong Dang, Yan Liu, Jun Zhao, Liang Rongzhen, Donglan Zeng, Wenbin Wu, Yiding Xiong, Jia Yuan, Ye Chen, Julie Wang, Weidong Lin, Xiangfang Chen, Weishan Huang, Nancy Olsen, Yunfeng Pan, Qing-Ling Fu, Song Guo Zheng
Mesenchymal stem cells (MSCs) have demonstrated potent immunomodulatory properties that have shown promise in the treatment of autoimmune diseases, including rheumatoid arthritis (RA). However, the inherent heterogeneity of MSCs triggered conflicting therapeutic outcomes, raising safety concerns and limiting their clinical application. This study aimed to investigate the potential of extracellular vesicles derived from human gingival mesenchymal stem cells (GMSC-EVs) as a therapeutic strategy for RA. Through in vivo experiments using an experimental RA model, our results demonstrated that GMSC-EVs selectively homed to inflamed joints and recovered Treg and Th17 cells balance, resulting in the reduction of arthritis progression...
April 23, 2024: JCI Insight
#30
JOURNAL ARTICLE
Ioannis Papaioannou, Athina Dritsoula, Ping Kang, Reshma S Baliga, Sarah L Trinder, Emma Cook, Shiwen Xu, Adrian Hobbs, Christopher P Denton, David J Abraham, Markella Ponticos
NKX2-5 is a member of the homeobox-containing transcription factors critical in regulating tissue differentiation in development. Here, we report a role for NKX2-5 in vascular smooth muscle cell phenotypic modulation in vitro and in vascular remodelling in vivo. NKX2-5 is up-regulated in scleroderma (SSc) patients with pulmonary arterial hypertension. Suppression of NKX2-5 expression in smooth muscle cells, halted vascular smooth muscle proliferation and migration, enhanced contractility and blocked the expression of the extracellular matrix genes...
April 23, 2024: JCI Insight
#31
JOURNAL ARTICLE
Deepika V Karade, Vo Quang Huy Phan, H V Rasika Dias
Phenanthroline-based ligands with bulky aryl groups flanking the metal binding pocket enabled the synthesis and detailed investigation of ethylene complexes of copper(I), silver(I), and gold(I), including structural data of [{2,9-bis(2,4,6-triisopropylphenyl)-1,10-phenanthroline}M(C2 H4 )][SbF6 ] (M = Cu, Ag, Au), Additionally, a related copper(I)-ethylene complex with a highly fluorinated ligand is also reported. Gold(I) affects the ethylene moiety significantly as evident from the notable upfield coordination shifts of ethylene carbon signals in the NMR and lengthening of the ethylene CC bond length...
April 23, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
#32
JOURNAL ARTICLE
Kahabi Ganka Isangula, Rogers John Haule
BACKGROUND: Respiratory diseases, including active tuberculosis (TB), asthma, and chronic obstructive pulmonary disease (COPD), constitute substantial global health challenges, necessitating timely and accurate diagnosis for effective treatment and management. OBJECTIVE: This research seeks to develop and evaluate a noninvasive user-friendly artificial intelligence (AI)-powered cough audio classifier for detecting these respiratory conditions in rural Tanzania. METHODS: This is a nonexperimental cross-sectional research with the primary objective of collection and analysis of cough sounds from patients with active TB, asthma, and COPD in outpatient clinics to generate and evaluate a noninvasive cough audio classifier...
April 23, 2024: JMIR Research Protocols
#33
REVIEW
Abby P Chiu, Catherine Chia, Lars Arendt-Nielsen, Michele Curatolo
Intervertebral disc degeneration is characterized by deterioration in structural support that is potentially followed by stimulated neuronal ingrowth, and dysfunction of cellular physiology in the disc. Discogenic low back pain originates from nociceptors within the intervertebral disc or the cartilage endplate. This narrative review examines the mechanisms of disc degeneration, the association between degeneration and pain, and the current diagnosis and treatment of discogenic low back pain. Mechanisms of disc degeneration include dysregulated homeostasis of the extracellular matrix of the disc, altered spine mechanics, DNA damage, oxidative stress, perturbed cell signaling pathways, and cellular senescence...
April 2024: Minerva Anestesiologica
#34
JOURNAL ARTICLE
Daoyuan Li, Hengsheng Wang, Naidong Chen, Haiyang Jiang, Naifu Chen
To investigate the impact of Poa alpigena Lindm on rhizosphere and bulk soil microorganisms in Haixin Mountain, Qinghai Lake, this study employed metagenomics technology to analyze the microbial communities of the samples. Results showed that 65 phyla, 139 classes, 278 orders, 596 families, 2376 genera, and 5545 species of soil microorganisms were identified from rhizosphere and bulk soil samples. Additionally, a microbial gene library specific to Poa alpigena Lindm was established for Qinghai Lake. Through α-diversity analysis, the richness and diversity of bulk microorganisms both significantly had a higher value than that in rhizosphere soil...
April 23, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#35
JOURNAL ARTICLE
Na Yan, Zhiwei Hu, Lingling Zhang
The development of a bio-sensing strategy based on CRISPR/Cas that is exceptionally sensitive is crucial for the identification of trace molecules. Colorimetric miRNA detection utilizing CRISPR/Cas13a-triggered DNAzyme signal amplification was described in this article. The developed strategy was implemented for miRNA-21 detection as a proof of concept. The cleavage activity of Cas13a was triggered when the target molecule bonded to the Cas13a-crRNA complex and cleaved uracil ribonucleotides (rU) in the substrate probe...
April 23, 2024: Applied Biochemistry and Biotechnology
#36
REVIEW
Yanchen Feng, Xue Dang, Pan Zheng, Yali Liu, Diyan Liu, Zhiying Che, Jianping Yao, Zixuan Lin, Ziyun Liao, Xingyuan Nie, Feixiang Liu, Yunke Zhang
PURPOSE OF REVIEW: This review aims to provide a theoretical basis and insights for quercetin's clinical application in the prevention and treatment of osteoporosis (OP), analyzing its roles in bone formation promotion, bone resorption inhibition, anti-inflammation, antioxidant effects, and potential mechanisms. RECENT FINDINGS: OP, a prevalent bone disorder, is marked by reduced bone mineral density and impaired bone architecture, elevating the risk of fractures in patients...
April 23, 2024: Current Osteoporosis Reports
#37
JOURNAL ARTICLE
Yi Gao, Shuai Li, Xueyan Liu, Daoyuan Si, Weiwei Chen, Fenghua Yang, Huan Sun, Ping Yang
The effect of Ryanodine receptor2 (RyR2) and its stabilizer on cardiac hypertrophy is not well known. C57/BL6 mice underwent transverse aortic contraction (TAC) or sham surgery were administered dantrolene, the RyR2 stabilizer, or control drug. Dantrolene significantly alleviated TAC-induced cardiac hypertrophy in mice, and RNA sequencing was performed implying calcineurin/NFAT3 and TNF-α/NF-κB/NLRP3 as critical signaling pathways. Further expression analysis and Western blot with heart tissue as well as neonatal rat cardiomyocyte (NRCM) model confirmed dantrolene decreases the activation of calcineurin/NFAT3 signaling pathway and TNF-α/NF-κB/NLRP3 signaling pathway, which was similar to FK506 and might be attenuated by calcineurin overexpression...
April 23, 2024: Journal of Cardiovascular Translational Research
#38
REVIEW
Amirhossein Bahmanpour, Seyed Majid Ghoreishian, Azadeh Sepahvandi
There are numerous effective procedures for cell signaling, in which humans directly transmit detectable signals to cells to govern their essential behaviors. From a biomedical perspective, the cellular response to the combined influence of electrical and magnetic fields holds significant promise in various domains, such as cancer treatment, targeted drug delivery, gene therapy, and wound healing. Among these modern cell signaling methods, electromagnetic fields (EMFs) play a pivotal role; however, there remains a paucity of knowledge concerning the effects of EMFs across all wavelengths...
April 23, 2024: Annals of Biomedical Engineering
#39
JOURNAL ARTICLE
Chunjuan Yang, Yue Zhao, Shuang Jiang, Xiaomeng Sun, Xiaotong Wang, Zhibin Wang, Yanli Wu, Jing Wu, Yang Li
A perennial challenge in harnessing the rich biological activity of medicinal and edible plants is the accurate identification and sensitive detection of their active compounds. In this study, an innovative, ultra-sensitive detection platform for plant chemical profiling is created using surface-enhanced Raman spectroscopy (SERS) technology. The platform uses silver nanoparticles as the enhancing substrate, excess sodium borohydride prevents substrate oxidation, and methanol enables the tested molecules to be better adsorbed onto the silver nanoparticles...
April 23, 2024: Mikrochimica Acta
#40
JOURNAL ARTICLE
Zeinab Dehghan, Seyed Amir Mirmotalebisohi, Maryam Mozafar, Marzieh Sameni, Fatemeh Saberi, Amin Derakhshanfar, Javad Moaedi, Hassan Zohrevand, Hakimeh Zali
PURPOSE: Identifying the molecular mechanisms behind SARS-CoV-2 disparities and similarities will help find new treatments. The present study determines networks' shared and non-shared (specific) crucial elements in response to HCoV-229E and SARS-CoV-2 viruses to recommend candidate medications. METHODS: We retrieved the omics data on respiratory cells infected with HCoV-229E and SARS-CoV-2, constructed PPIN and GRN, and detected clusters and motifs. Using a drug-gene interaction network, we determined the similarities and disparities of mechanisms behind their host response and drug-repurposed...
April 23, 2024: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
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