Eileen S Carpenter, Padma Kadiyala, Ahmed M Elhossiny, Samantha B Kemp, Jay Li, Nina G Steele, Rémy Nicolle, Zeribe C Nwosu, Julia Freeman, Henry Dai, Daniel Paglia, Wenting Du, Katelyn Donahue, Jacqueline Morales, Paola I Medina-Cabrera, Monica E Bonilla, Lindsey Harris, Stephanie The, Valerie Gunchick, Nicole Peterson, Kristee Brown, Michael Mattea, Carlos E Espinoza, Jake McGue, Sarah M Kabala, Rachel K Baliira, Nur M Renollet, Ayden G Mooney, Jianhua Liu, Sean Bhalla, Jeremy P Farida, Christopher Ko, Jorge D Machicado, Richard S Kwon, Erik-Jan Wamsteker, Allison Schulman, Michelle A Anderson, Ryan Law, Anoop Prabhu, Pierre A Coulombe, Arvind Rao, Timothy L Frankel, Filip Bednar, Jiaqi Shi, Vaibhav Sahai, Marina Pasca di Magliano
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is generally divided in two subtypes, classical and basal. Recently, single cell RNA sequencing has uncovered the co-existence of basal and classical cancer cells, as well as intermediary cancer cells, in individual tumors. The latter remains poorly understood; here, we sought to characterize them using a multimodal approach. EXPERIMENTAL DESIGN: We performed subtyping on a single cell RNA sequencing dataset containing 18 human PDAC samples to identify multiple intermediary subtypes...
October 18, 2023: Clinical Cancer Research