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Shupeng Lin, Chenmei Zhang, Sheng Ye
Background Severe infection is life-threatening in children with hematologic malignancies and its treatment is challenging because of an increasing number of multidrug-resistant pathogens. Tigecycline has an expanded antibacterial activity spectrum; some successful cases of tigecycline treatment have been reported in the literature. Objective To examine the efficacy and safety of tigecycline in children. Setting Department of hematologic malignancies in a tertiary hospital. Method A retrospective chart review from May 1, 2012 to May 1, 2017...
October 2018: International Journal of Clinical Pharmacy
Rómel Fabian Gómez, Andres Castillo, Mónica Chávez-Vivas
Introduction: The extensive use of antibiotics has led to the emergence of multi-resistant strains in some species of the genus Acinetobacter . Objective: To investigate the molecular characteristics of multidrug-resistant of Acinetobacter ssp. strains isolated from 52 patients collected between March 2009 and July 2010 in medical intensive care units in Cali - Colombia. Methods: The susceptibility to various classes of antibiotics was determined by disc diffusion method, and the determination of the genomic species was carried out using amplified ribosomal DNA restriction analysis (ARDRA) and by sequencing of the 16s rDNA gene...
December 30, 2017: Colombia Médica: CM
Shupeng Lin, Lingfang Liang, Chenmei Zhang, Sheng Ye
Objective Ventilator-associated pneumonia (VAP) is a life-threatening complication for children who are treated in a paediatric intensive care unit. Tigecycline treatment of children with VAP has not been well studied. This study aimed to describe tigecycline use in children with VAP in a tertiary care hospital. Methods We conducted a retrospective chart review in a tertiary hospital from May 1, 2012 to May 1, 2017. Results Twenty-four children (20 girls) with median age of 8 months (range, 27 days to 6 years and 9 months) were treated with tigecycline...
January 1, 2018: Journal of International Medical Research
Pornpan Koomanachai, Sasima Tongsai, Visanu Thamlikitkul
OBJECTIVE: To compare the effectiveness and safety of generic cefoperazone/sulbactam (Bacticep®) and original cefoperazone/ sulbactam (Sulperazon®) in treatment of infections in hospitalized patients at Siriraj Hospital. MATERIAL AND METHOD: Hospitalized patients aged 18 years and older who received cefoperazone/sulbactam for at least 48 hours were identifed from the Siriraj Hospital pharmacy database. Medical records of identified patients were reviewed and relevant information was extracted and transferred onto pre-printed case record forms...
January 2016: Journal of the Medical Association of Thailand
Tao Pan, Xiaoyun Liu, Shougui Xiang, Wenli Ji
Bacterial infections are common but have become increasingly resistant to drugs. The aim of the present study was to examine the combined treatment of traditional Chinese and Western medicine in 30 cases of pulmonary infection with multidrug resistant Acinetobacter baumannii. Patients were divided into groups A and B according to drug treatments. Cefoperazone or sulbactam and tanreqing were administered in group A, and cefoperazone or sulbactam in group B. The curative effect and prognosis of the two groups were recorded and the remaining treatments were performed routinely in the clinic...
April 2016: Experimental and Therapeutic Medicine
A I Safina, M A Daminova, G A Abdullina
BACKGROUND: The incidence of acute kidney injury (AKI) in neonates in the intensive care units and neonatal intensive care (NICU) according Plotz et al. ranges from 8% to 22% [3]. According to Andreoli, neonatal death due to AKI in NICU amounts up to 10-61% [1]. It should be in the reasons of AKI emphasize.The role of certain drugs, which are widely used in modern neonatology: nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics (aminoglycosides, glycopeptides, carbapenems, 3rd generation cephalosporins), furosemide, enalapril, in contributing to AKI should be emphasized [2]...
2015: International Journal of Risk & Safety in Medicine
Necmettin Turgut, Turgut Akgul, Ufuk Arzu, Sefa Giray Batıbay, Mehmet Ekinci, Cengiz Şen, Murat Korkmaz
INTRODUCTION: There are various pathogens reported for osteomyelitis. Osteomyelitis is bone infection which produces pain and fever, also threatens bone instability. It can lead to nonunion. The purpose of this report was to describe a case with union delay of the tibia due to serratia marcescens osteomyelitis. Serratia marcescens is an unexpected pathogen for subacute osteomyelitis in adolescence. Because of difficulty of diagnosis, treatment can be delayed or the situation can cause complications like nonunion or loss of function...
2015: International Journal of Surgery Case Reports
Qiuyan Shen, Dini Lin, Hong Zhu, Shengjie Ge, Wenjun Wu, Xiaoyan Pan, Xuejiang Gu, Xuemei Gu, Feixia Shen
OBJECTIVE: To explore the microbiological profiles and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers so as to provide selection rationales of antibiotics. METHODS: A retrospective study was conducted on the microbiological profiles and antibiotic susceptibilities in 754 strains of pathogens isolated from 519 patients with diabetic foot ulcers at our hospital from January 2010 to August 2013. The inter-group data were compared by Chi-square test...
April 1, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Yingjie Zhou, Jing Zhang, Beining Guo, Jicheng Yu, Yaoguo Shi, Minggui Wang, Yingyuan Zhang
A rapid and highly sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of cefoperazone sodium and sulbactam sodium in human plasma was developed. The analytes and internal standard (IS), cefuroxime sodium, were extracted from human plasma via liquid-liquid extraction with ethyl acetate and separated on a Waters Xterra C18 column within 3.5 min. Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique, operating in selected reaction monitoring (SRM) and negative ion mode...
November 15, 2010: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Qi-wei Li, Fu Ji
OBJECTIVE: To illustrate the bacteriology and their susceptibility to antibiotics in patients with biliary tract diseases and provide information for antibiotic choices. METHODS: The bile specimens were cultured and pathogens' susceptibility to antibiotics was obtained intraoperatively from 195 patients undergoing operations on biliary tract and 24 healthy liver donors from June 2007 to March 2008. RESULTS: Among 195 bile specimens collected from the patients intraoperatively, 44 ones were found bacterial growth by culture (22...
April 1, 2009: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Sayam Kaewvichit, Songwut Yotsawimonwat, Wandee Taesotikul, Wirat Niwatananun, Chadarat Duangrat, Chokchai Wongsinsup, Satawat Thongsawat, Parichat Salee
OBJECTIVE: To perform a bioequivalence study of the two 1.5 g cefoperazone (1.0 g) and sulbactam (0.5 g) between Cefper and Sulperazon injections. MATERIAL AND METHOD: The present study was performed in 24 Thai healthy male volunteers who were intramuscularly injected a single dose of 1.5 g cefoperazone and sulbactam. A single dose, two periods, two sequences, double blind randomized crossover with a one-week washout period was used. Blood samples were collected before and at 0...
November 2008: Journal of the Medical Association of Thailand
(no author information available yet)
Three-year microbiological and clinical monitoring (2003-2005) confirmed the high clinical and microbiological efficacy of cefoperazone/sulbactame (sulperazone, Pfizer) used in the Hospital for the treatment of infectious complications in the oncologic patients. The empirical use of the drug in the therapy of severe infectious complications undoubtedly proved its value. It should be indicated that the high efficacy of cefoperazone/sulbactam and a great variety of the indications nevertheless require a well-considered approach to its use first of all based on the data of the microbiological monitoring in the hospital...
2006: Antibiotiki i Khimioterapii︠a︡, Antibiotics and Chemoterapy [sic]
Jian-jun Huang, Qiang Zeng, Jia-lu Yu
OBJECTIVE: To evaluate the therapeutic effects and safety of cefepime (Maxipime) and sulbactam/cefoperazone (sulperazone) on moderate and severe respiratory infection in children. METHODS: Totally 100 children hospitalized for pneumonia were randomized equally into 2 groups, namely group A with maxipime treatment at the dose of 50 mg/kg given intravenously twice daily, and group B with sulperazone treatment at 50-100 mg/kg given intravenously twice a day. The therapeutic effects and safety of both medications were observed...
September 2005: Di 1 Jun Yi da Xue Xue Bao, Academic Journal of the First Medical College of PLA
Jie Meng, Wei Xie, An-Hua Wu, Cheng-Ping Hu, Yan-Jin Wang
OBJECTIVE: To determine the antimicrobial resistance and bacterial distribution of nosocomial pneumonia in neurosurgical patients. METHODS: We analyzed and counted the result of sputum culture, drug sensibilities test, and the rate of nosocomial pneumonia after intracranial surgery of all the patients in the Department of in Neurosurgery our hospital in 2002. RESULTS: The rate of nosocomial pneumonia after intracranial surgery was 6.2%. The first 5 strains were pseudomonas aeruginosa, acinetobacter, enterobacteriaceae, klebsiella, and staphylococcus epidermidis...
August 2004: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
H Bijie, S Kulpradist, M Manalaysay, A Soebandrio
Due to their wide spectrum of activity, good pharmacokinetics, established clinical efficacy and high tolerability, cephalosporins are among the most widely used antibiotics worldwide. The third and fourth generation cephalosporins are predominantly parenteral agents, administered two or three times daily, used in the treatment of a wide range of moderate to severe infections. Ceftriaxone, a third generation cephalosporin, is unique in exhibiting an unusually long elimination half-life that allows for once-daily administration...
February 2005: Journal of Chemotherapy
Xiao-si Zhou, Sheng-quan Zou, Jia-hong Dong, Wei-ze Wu, Yang-de Zhang, Tong-lin Zhang, Zhong Zeng, Nian-feng Li, Guo-tong Man
OBJECTIVE: To compare the efficacy of ceftriaxone and that of cefoperazone plus sulbactam (sulperazon) in controlling infection, in scavenging bacteria from bile, and in their costs when treating acute suppurative cholangitis with choledochostomy. METHODS: Patients were randomly assigned to two groups: the ceftriaxone group (R-group, n=95) and sulperazon group (S-group, n=95). Before choledochostomy, both groups received one intravenous dose of the corresponding antibiotics: and 2 g ceftriaxnoe for the R-group, 2 g sulperazon, containing 1 g cefoperazone and 1 g sulbactam, for the S-group...
November 17, 2004: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Z H Abd El-Wahab, M R El-Sarrag
We report the synthesis and structural characterization of series of tetra- and hexacoordinate metal chelate complexes of phosphate Schiff base ligands having the general composition LMX(n).H(2)O and L(2)MX(n) (L=phosphate Schiff base ligand; M=Ag(+), Mn(2+), Cu(2+), Zn(2+), Cd(2+), Hg(2+), or Fe(3+) and X=NO(3)(-), Br(-) or Cl(-)). The structure of the prepared compounds was investigated using elemental analysis, IR, 1H and 31P NMR, UV-vis, mass spectra, solid reflectance, magnetic susceptibility and conductance measurements as well as conductometric titration...
January 2004: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
S D Mitrokhin
For the evaluation of rational sulperazone position in oncological hospital and elaboration of its implementation criteria investigation was performed. The trial included 193 patients (88 patients with injuries, 66 with hospital pneumonia, 39 with urinary track infection). From different clinical material of the patients were isolated 136 straines of Gram-negative bacteria. Suseptibile to sulperazone were 67 per cent of P. aeruginosa, 78-86 per cent of P. vulgaris, Klebsiella and E. coli isolates, 66 [symbol: see text] 60 per cent of Enterobacter and Serratia isolates subsequently...
2003: Antibiotiki i Khimioterapii︠a︡, Antibiotics and Chemoterapy [sic]
F S Li, Z X Xu, H B Xiao, X M Liang
A reversed-phase, isocratic high performance liquid chromatographic method with acid mobile phase can separate sulbactam and cafoperazone within 12 minutes. Column packed with Hypersil ODS2(250 mm x 4.6 mm i.d., 5 microns) was manufactured by Dalian Elite Company. Mobile phase is composed of water (adjusted to pH 4.0 with 1% phosphoric acid) and acetonitrile (80:20, V/V). The detection was performed at 210 nm and the injection volume was 2 microL. Cefoperazone and sulbactam have good linearity in the ranges of 100 mg/L to 800 mg/L and 100 mg/L to 1,000 mg/L with the correlation coefficients of 0...
November 2000: Se Pu, Chinese Journal of Chromatography
V K Lim, M Y Halijah
The in vitro activity of sulperazon (cefoperazone/sulbactam) was tested against 94 ceftazidime-resistant strains of bacteria isolated from mostly seriously ill patients in critical care units. Acinetobacter baumanii, Pseudomonas aeruginosa and Klebsiella pneumoniae made up 80% of the pathogens studied; 90% of the Klebsiella strains were producers of extended-spectrum beta-lactamases (ESBL). The MIC90 of sulperazon for Klebsiella was 12 mg/l (range 1.5-16 mg/l), indicating that this drug may be a useful alternative for the treatment of ceftazidime-resistant, ESBL-producing Klebsiella...
September 2001: Medical Journal of Malaysia
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