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Colorectal Neoplasia

Toygar Toydemir, Görkem Özgen, İsmail Çalıkoğlu, Özdal Ersoy, Mehmet Ali Yerdel
INTRODUCTION: Obesity and metabolic syndrome (MetS) are associated with colorectal neoplasia (CRN) and carcinoma (CRC). Whether such subjects must undergo screening colonoscopy (SC) earlier, is unknown. Incidences of CRNs in 40-49- versus 50-65-year-old bariatric patients were compared by SC. No prospective data on SC is available in morbidly obese/MetS. MATERIAL AND METHODS: Surgical weight loss candidates over 39 years of age, asymptomatic, and average-risk for CRC offered SC...
March 15, 2019: Obesity Surgery
Jing Dai, Jing-Wen Mu, Hong Mu
The present study aimed to investigate whether the long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) can promote the migration and invasion of human oral squamous cell carcinoma (OSCC) cells via the regulation of epithelial-mesenchymal transition (EMT). CAL-27 and SCC-15 cells were classified into a control group, a small interfering negative control (si-NC) group (cells transfected with control siRNA) and an si-CRNDE group (cells transfected with CRNDE siRNA). The expression of CRNDE in OSCC tissues and cell lines was detected by in situ hybridization (ISH) and reverse transcription-quantitative polymerase chain reaction...
March 2019: Oncology Letters
Sameen Khalid, Aamer Abbass, Neelam Khetpal, Bo Shen, Udayakumar Navaneethan
BACKGROUND: Patients with ulcerative colitis and Crohn's colitis have an increased risk of developing dysplasia and colorectal cancer as compared to the general population; surveillance colonoscopy is recommended in this patient population. METHODS: This review of the published literature aimed to assess the published evidence. RESULTS: Detection of dysplasia requires examination of mucosa with targeted biopsies of the visible lesions as well as random biopsies to detect invisible lesions...
March 11, 2019: International Journal of Colorectal Disease
Tsung-Ming Chen, Ming-Chih Lai, Yi-Han Li, Ya-Ling Chan, Chih-Hao Wu, Yu-Ming Wang, Chun-Wei Chien, San-Yuan Huang, H Sunny Sun, Shaw-Jenq Tsai
BACKGROUND: Hypoxia suppresses global protein production, yet certain essential proteins are translated through alternative pathways to survive under hypoxic stress. Translation via the internal ribosome entry site (IRES) is a means to produce proteins under stress conditions such as hypoxia; however, the underlying mechanism remains largely uncharacterized. METHODS: Proteomic and bioinformatic analyses were employed to identify hnRNPM as an IRES interacting factor...
March 6, 2019: EBioMedicine
Sam E Mason, Liam Poynter, Zoltan Takats, Ara Darzi, James M Kinross
OBJECTIVES: Accurate, real-time, endoscopic risk stratification of colorectal polyps would improve decision-making and optimize clinical efficiency. Technologies to manipulate endoscopic optical outputs can be used to predict polyp histology in vivo; however, it remains unclear how accuracy has progressed and whether it is sufficient for routine clinical implementation. METHODS: A meta-analysis was conducted by searching MEDLINE, Embase, and the Cochrane Library...
February 26, 2019: American Journal of Gastroenterology
Simeng Gu, Shujuan Lin, Ding Ye, Sangni Qian, Danjie Jiang, Xiaocong Zhang, Qilong Li, Jinhua Yang, Xiaojiang Ying, Zhenjun Li, Mengling Tang, Jianbing Wang, Mingjuan Jin, Kun Chen
BACKGROUND: Epigenetic alternation is a common contributing factor to neoplastic transformation. Although previous studies have reported a cluster of aberrant promoter methylation changes associated with silencing of tumor suppressor genes, little is known concerning their sequential DNA methylation changes during the carcinogenetic process. The aim of the present study was to address a genome-wide search for identifying potentially important methylated changes and investigate the onset and pattern of methylation changes during the progression of colorectal neoplasia...
March 7, 2019: Clinical Epigenetics
Mahesh Gajendran, Priyadarshini Loganathan, Guillermo Jimenez, Anthony P Catinella, Nathaniel Ng, Chandraprakash Umapathy, Nathalie Ziade, Jana G Hashash
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disorder of the colon that causes continuous mucosal inflammation extending from the rectum to the more proximal colon, with variable extents. UC is characterized by a relapsing and remitting course. UC was first described by Samuel Wilks in 1859 and it is more common than Crohn's disease worldwide. The overall incidence and prevalence of UC is reported to be 1.2-20.3 and 7.6-245 cases per 100,000 persons/year respectively. UC has a bimodal age distribution with an incidence peak in the 2nd or 3rd decades and followed by second peak between 50 and 80 years of age...
March 2, 2019: Disease-a-month: DM
Mei-Sheng Ku, Jean Ching-Yuan Fann, Sherry Yueh-Hsia Chiu, Hsiu-Hsi Chen, Chen-Yang Hsu
OBJECTIVES: To elucidate the bidirectional temporal relationship between elevated faecal haemoglobin (f-Hb) concentration and metabolic syndrome (MetS). DESIGN: A longitudinal cohort study was conducted by utilising data on community-based periodical screening for colorectal cancer with faecal immunochemical test (FIT) and health check-up for MetS. SETTING: Population-based organised integrated service screening in Keelung city, Taiwan. PARTICIPANTS: We enrolled a total of 62,293 community residents aged 40-79 years...
March 1, 2019: BMJ Open
Won Kim, Dongjae Jeong, Jungwha Chung, Donghyeon Lee, Saekyoung Joo, Eun Sun Jang, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Sook-Hyang Jeong, Nayoung Kim, Dong Ho Lee, Jin-Wook Kim
Alcohol increases the risk of both hepatocellular carcinoma (HCC) and colorectal neoplasia. In this hospital-based case-control and retrospective cohort study, we sought to determine whether development of colorectal neoplasia increases the risk of HCC in patients with alcoholic liver disease (ALD). In the phase I case-control analysis, the association between history of colorectal cancer (CRC) and HCC development was assessed in patients with ALD by logistic regression modeling (n = 1,659). In the phase II retrospective cohort analysis, the relative risk of HCC development was compared in ALD patients with respect to the history of CRC by a Cox model (n = 1,184)...
March 1, 2019: Scientific Reports
Ali Riaz Baqar, Simon Wilkins, Margaret Staples, Chun Hin Angus Lee, Karen Oliva, Paul McMurrick
BACKGROUND: The primary aim of this study was to investigate whether a preoperative elevation in serum CEA is an independent prognostic factor for both 5-year overall and disease-free survival within an Australian patient cohort. MATERIALS AND METHODS: A retrospective study of a prospectively maintained colorectal neoplasia database for patients between January 2010 and June 2016 was performed. Patients were categorized into two groups according to the preoperative serum CEA level: low (<2...
February 26, 2019: International Journal of Surgery
Chan Hyuk Park, Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND AND AIMS: We aimed to develop risk stratification models for advanced colorectal neoplasia (ACRN) and colorectal cancer (CRC) based on fecal hemoglobin (f-Hb) concentration and clinical risk factors. METHODS: We reviewed screenees aged ≥50 years who underwent fecal immunochemical test (FIT) and colonoscopy, and developed risk-scoring models for ACRN and CRC using logistic regression analysis. Participants were classified into low- (risk lower than that in FIT-negative individuals), intermediate- (risk higher than that in FIT-negative but lower than that in FIT-positive individuals), high- (risk similar to that in FIT-positive individuals), and very high- (risk higher than that in FIT-positive individuals) risk groups...
February 25, 2019: Gastrointestinal Endoscopy
Yifeng Zeng, Bin Rao, William C Chapman, Sreyankar Nandy, Rehan Rais, Iván González, Deyali Chatterjee, Matthew Mutch, Quing Zhu
Colorectal cancer diagnosis currently relies on histological detection of endoluminal neoplasia in biopsy specimens. However, clinical visual endoscopy provides no quantitative subsurface cancer information. In this ex vivo study of nine fresh human colon specimens, we report the first use of quantified subsurface scattering coefficient maps acquired by swept-source optical coherence tomography to reveal subsurface abnormities. We generate subsurface scattering coefficient maps with a novel wavelet-based-curve-fitting method that provides significantly improved accuracy...
February 28, 2019: Scientific Reports
Freeha Khan, Bo Shen
PURPOSE OF REVIEW: Ileal pouch-anal anastomosis (IPAA) is the standard restorative procedure after proctocolectomy in patients with inflammatory bowel disease who require colectomy. The ileal pouch is susceptible to a variety of adverse outcomes including mechanical insult, ischemia, and infectious agents. There is also a risk for developing low-grade dysplasia (LGD), high-grade dysplasia (HGD), or even adenocarcinoma in the pouch. The purpose of this review is to highlight risk factors, clinical presentation, surveillance, and treatment of pouch neoplasia...
February 28, 2019: Current Gastroenterology Reports
Abdoulreza Esteghamati, Khadijeh Khanaliha, Farah Bokharaei-Salim, Shirin Sayyahfar, Masoomeh Ghaderipour
Background: Intestinal parasitic infection in immunodeficient patients especially those with impaired cellular immunity, like neoplasia, renal or heart transplant needs careful consideration. The objective of this study is to evaluate the prevalence of intestinal parasites in different group of patients including cancer patients; organ transplants recipients, and primary immunodeficiency patients. Methods: Stool samples from 190 patients including 80 patients with Primary Immunodeficiency, 85 cancer patients and 25 organ transplant recipients were collected; a direct examination with Phosphate buffered saline (PBS) and formalin ether concentration was performed...
February 26, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Meta C J van Lanschot, Monique E van Leerdam, Iris Lansdorp-Vogelaar, Sharon Doets, Iris D Nagtegaal, Hermien W Schreurs, René W M van der Hulst, Beatriz Carvalho, Evelien Dekker, Anne-Marie van Berkel
BACKGROUND & AIMS: Endoscopic surveillance after curative colorectal cancer (CRC) resection is routine. However, there is controversy whether the 1-year interval between pre- and postoperative colonoscopy is justified, due to improved colonoscopy standards. We aimed to assess the yield of surveillance colonoscopies 1 year after CRC surgery. METHODS: We performed a retrospective cohort study of 572 patients (54.9% male, mean age 66.2 (±9.9) years), who underwent curative surgical resection of a first CRC from June 2013 through April 2016 in the Northwest region of the Netherlands...
February 22, 2019: Clinical Gastroenterology and Hepatology
Xian-Rui Wu, Xiao-Bin Zheng, Yan Huang, Qian Cao, Hong-Jie Zhang, Ying-Lei Miao, Kai-Fang Zou, Min Chen, Fa-Ming Zhang, Qiao Mei, David Gonzalo, Daniela Allende, Pin-Jin Hu, Bo Shen, Xiu-Li Liu, Ping Lan
Background: This study sought to evaluate the risk factors for the development of colitis-associated neoplasia (CAN) in Chinese patients with inflammatory bowel disease (IBD). Methods: IBD patients who developed CAN between 1999 and 2016 were identified from eight medical centers. In addition to initial pathology evaluation, a CAN diagnosis was confirmed by two expert pathologists. Patients with CAN ( n  = 29) were compared with non-CAN controls ( n  = 87)...
February 2019: Gastroenterology Report
Mark P Molloy, Alexander Engel
No abstract text is available yet for this article.
December 2018: Expert Review of Gastroenterology & Hepatology
Daniel Bushyhead, Otto S T Lin, Richard A Kozarek
The national incidence of colorectal cancer is increasing in people younger than 50 years old. Although diagnostic colonoscopy is detecting more sporadic adenomas in young adults, there are no guidelines for post-polypectomy surveillance. The aim of this review was to survey the medical literature on the prevalence of sporadic adenomas in young adults, subsequent risk of metachronous neoplasia, and lastly to provide several concluding recommendations for clinical practice. We found that the prevalence of sporadic adenomas in young adults is greater than initially estimated and dependent upon factors such as colonoscopy indication and age...
February 20, 2019: Digestive Diseases and Sciences
Daiki Hirano, Yuji Urabe, Shinji Tanaka, Koki Nakamura, Yuki Ninomiya, Ryo Yuge, Ryohei Hayashi, Shiro Oka, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
Serrated adenocarcinoma (SAC) is considered the end stage of the serrated neoplasia pathway. Although SAC prognosis is not widely recognized, the serrated pathway-associated subtype consistently exhibits unfavorable prognosis in genetic studies. Herein, we classified molecularly distinct subtypes of serrated adenocarcinomas and clarified their associated clinicopathological characteristics and genetic changes. We examined 38 early-stage colorectal SACs. Of these, 24 were classified into three molecularly distinct groups by colon cancer subtyping (CCS)...
2019: PloS One
Yuhua Tian, Jiuzhi Xu, Yuan Li, Ran Zhao, Sujuan Du, Cong Lv, Wei Wu, Ruiqi Liu, Xiaole Sheng, Yongli Song, Xueyun Bi, Guilin Li, Mengzhen Li, Xi Wu, Pengbo Lou, Huiwen You, Wei Cui, Jinyue Sun, Jianwei Shuai, Fazheng Ren, Bing Zhang, Mingzhou Guo, Xiaohua Hou, Kaichun Wu, Lixiang Xue, Hongquan Zhang, Maksim V Plikus, Yingzi Cong, Christopher J Lengner, Zhanju Liu, Zhengquan Yu
BACKGROUND & AIMS: Levels of microRNA 31 (MIR31) are increased in intestinal tissues from patients with inflammatory bowel diseases and colitis-associated neoplasias. We investigated the effects of this microRNA on intestinal inflammation by studying mice with colitis. METHODS: We obtained colon biopsy samples from 82 patients with ulcerative colitis (UC), 79 patients with Crohn's disease (CD), and 34 healthy individuals (controls) at Shanghai Tenth People's Hospital...
February 16, 2019: Gastroenterology
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