Hadas Ashkenazi-Preiser, Or Reuven, Atara Uzan-Yulzari, Sharon Komisarov, Roy Cirkin, Sondra Turjeman, Carmel Even, Nira Twaik, Kerem Ben-Meir, Ivan Mikula, Leonor Cohen-Daniel, Yaron Meirow, Eli Pikarsky, Yoram Louzoun, Omry Koren, Michal Baniyash
Intestinal chronic inflammation is associated with microbial dysbiosis and accumulation of various immune cells including myeloid-derived suppressor cells (MDSCs), which profoundly impact the immune microenvironment, perturb homeostasis and increase the risk to develop colitis-associated colorectal cancer (CAC). However, the specific MDSCs-dysbiotic microbiota interactions and their collective impact on CAC development remain poorly understood. In this study, using a murine model of CAC, we demonstrate that CAC-bearing mice exhibit significantly elevated levels of highly immunosuppressive MDSCs, accompanied by microbiota alterations...
March 20, 2024: Cancer Res Commun