Ping-Ping Yao, Zi-Ping Miao, Fang Xu, Hang-Jing Lu, Yi-Sheng Sun, Yong Xia, Chen Chen, Zhang-Nv Yang, Shi-Chang Xia, Jian-Min Jiang, Chong-Gao Hu, Zi-An Mao, Meng Gao, Zhi-Yao Xu, Han-Ning Ying, Chen-Hui Yao, Zhi-Yong Zhu, Han-Ping Zhu, Hai-Qing Xiang
A suitable animal model of CVA16 infection is crucial in order to understand its pathogenesis and to help develop antiviral vaccines or screen therapeutic drugs. The neonatal mouse model has a short sensitivity period to CA16 infection, which is a major limitation. In this study, we demonstrate that adult (60-day-old) gerbils are susceptible to CVA16 infection at high doses (108.0 TCID50 ). A clinical isolate strain of CVA16 was inoculated intraperitoneally into adult gerbils, which subsequently developed significant clinical symptoms, including hind limb weakness, paralysis of one or both hind limbs, tremors, and eventual death from neurological disorders...
August 23, 2019: Vaccine