Mark Marsland, Amiee Dowdell, Chen Chen Jiang, James S Wilmott, Richard A Scolyer, Xu Dong Zhang, Hubert Hondermarck, Sam Faulkner
There is increasing evidence that nerve growth factor (NGF) and its receptors, the neurotrophic receptor tyrosine kinase 1 (NTRK1/TrkA), the common neurotrophin receptor (NGFR/p75NTR ) and the membrane receptor sortilin, participate in cancer growth. In melanoma, there have been some reports suggesting that NGF, TrkA and p75NTR are dysregulated, but the expression of the NGF precursor (proNGF) and its membrane receptor sortilin is unknown. In this study, we investigated the expression of NGF, proNGF, TrkA, p75NTR and sortilin by immunohistochemistry in a series of human tissue samples ( n = 100), including non-cancerous nevi ( n = 20), primary melanomas ( n = 40), lymph node metastases ( n = 20) and distant metastases ( n = 20)...
April 12, 2022: International Journal of Molecular Sciences