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Yann Cormerais, Marina Pagnuzzi-Boncompagni, Sandra Schrötter, Sandy Giuliano, Eric Tambutté, Hitoshi Endou, Michael F Wempe, Gilles Pagès, Jacques Pouysségur, Vincent Picco
Most cases of medulloblastoma (MB) occur in young children. While the overall survival rate can be relatively high, current treatments combining surgery, chemo- and radiotherapy are very destructive for patient development and quality of life. Moreover, aggressive forms and recurrences of MB cannot be controlled by classical therapies. Therefore, new therapeutic approaches yielding good efficacy and low toxicity for healthy tissues are required to improve patient outcome. Cancer cells sustain their proliferation by optimizing their nutrient uptake capacities...
February 19, 2019: Journal of Cellular and Molecular Medicine
Andrew Emmanuel, Anil Ghosh, Christo Lapa, Shraddha Gulati, Margaret Burt, Bu'Hussain Hayee, Amyn Haji
PURPOSE: Almost any colorectal superficial neoplastic lesion can be treated by endoscopic resection (ER) but very little is known about outcomes of ER leaving circumferential or near-circumferential mucosal defects. We report the outcomes of ER leaving ≥ 75% circumferential mucosal defects performed in a western expert centre. METHODS: Five hundred eighty-seven ERs of large colorectal lesions ≥ 20 mm were grouped according to the extent of the mucosal defect and comparisons made between those with < 75% and ≥ 75% defects...
February 19, 2019: International Journal of Colorectal Disease
Alexios-Fotios A Mentis, Marina Boziki, Nikolaos Grigoriadis, Athanasios G Papavassiliou
Helicobacter pylori (H. pylori) infection affects an estimated 4.4 billion people globally. Moreover, H. pylori presents the most significant risk factor for gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, and it is the first example of bacterial infection linked to carcinogenesis. Here, we contend that H. pylori research, which focuses on a cancer-causing pathogen resident in a relatively accessible organ, the stomach, could constitute an exemplar for microbial-related carcinogenesis in less tractable organs, such as the pancreas and lung...
February 19, 2019: Cellular and Molecular Life Sciences: CMLS
Jumpei Terakawa, Vanida Ann Serna, Makoto Mark Taketo, Takiko Daikoku, Adrian A Suarez, Takeshi Kurita
Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in PTEN , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and CTNNB1 exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. While epithelial cells with a monoallelic mutation in any one of three genes failed to propagate in the endometrium, any combination of two or more mutant alleles promoted the growth of epithelium, causing simple hyperplasia, in a dose-dependent manner...
February 19, 2019: Proceedings of the National Academy of Sciences of the United States of America
Sarvesh K Rai, Rinku Sharma, Rajendra D Patil, Sivakumar Periasamy, Lars H Rasmussen, Yogendra S Padwad, Alka Kumari, Rasbehari Bhar
Enzootic bovine haematuria, caused by long-term ingestion of ferns, is a chronic disease of hill cattle characterized by neoplastic lesions in the urinary bladder. Objectives of this study were to investigate the toxicity potential of long-term feeding of the fern Dryopteris nigropalaceae and effect of allyl isothiocyanate (AITC) to ameliorate fern toxicity and the associated pathological changes. The LC-MS analysis of the fern showed presence of ptaquiloside (4.5 ± 1.0 μg/g) and pterosin B (39 ± 9...
February 16, 2019: Research in Veterinary Science
Luciana De Luca, Ilaria Laurenzana, Stefania Trino, Daniela Lamorte, Antonella Caivano, Pellegrino Musto
Multiple myeloma (MM) is characterized by a clonal proliferation of neoplastic plasma cells (PCs) in bone marrow (BM) and the interplay between MM PCs and the BM microenvironment, which plays a relevant role in its pathogenesis. In this important cross-talk, extracellular vesicles (EVs) are active. EVs, including small and medium/large EVs, are lipid bi-layer particles released in circulation by normal and neoplastic cells. A selected cargo of lipids, proteins, and nucleic acids is loaded into EVs, and delivered locally and to distant sites, thus influencing the physiology of recipient cells...
February 20, 2019: Expert Review of Molecular Diagnostics
Claudio Luparello, Dalia Maria Lucia Asaro, Ilenia Cruciata, Storm Hassell-Hart, Supojjanee Sansook, John Spencer, Fabio Caradonna
We examined the effects of the ferrocene-based histone deacetylase-3 inhibitor Pojamide ( N ¹-(2-aminophenyl)- N ⁸-ferrocenyloctanediamide) and its two derivatives N ¹-(2-aminophenyl)- N ⁶-ferrocenyladipamide and N ¹-(2-aminophenyl)- N ⁸-ferroceniumoctanediamide tetrafluoroborate on triple-negative MDA-MB-231 breast cancer cells. Viability/growth assays indicated that only the first two compounds at 70 μM concentration caused an approximate halving of cell number after 24 h of exposure, whereas the tetrafluoroborate derivative exerted no effect on cell survival nor proliferation...
February 13, 2019: International Journal of Molecular Sciences
Sosmitha Girisa, Bano Shabnam, Javadi Monisha, Lu Fan, Clarissa Esmeralda Halim, Frank Arfuso, Kwang Seok Ahn, Gautam Sethi, Ajaikumar B Kunnumakkara
Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Therefore, there is an immediate need for essential alternative therapeutics, which can prove to be beneficial and safe against cancer. Various phytochemicals from natural sources have been found to exhibit beneficial medicinal properties against various human diseases...
February 18, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Catharina Melzer, Juliane von der Ohe, Ralf Hass
Cell fusion as a rare event was observed following the co-culture of human MDA-MB-231cherry breast cancer cells or benign neoplastic MCF10Acherry breast epithelial cells together with different mesenchymal stroma/stem-like cells (MSCGFP ) cultures, respectively, resulting in the generation of double-fluorescing hybrid cells. Analysis of potential molecular mechanisms for the formation of cancer hybrid cells revealed cytoskeletal components, including F-actin. Thus, a sub-lethal concentration of cytochalasin D, which blocks elongation of actin filaments, was able to significantly reduce cancer hybrid cell formation...
February 18, 2019: International Journal of Molecular Sciences
Adrian Catinean, Radu Motocu, Bogdan Fetica, Anita Mezei
We describe a rare case of a severe gastric ulcer of a 66-year-old immunocompetent man who was associated with primary Epstein-Barr virus (EBV) infection and temporarily misdiagnosed with gastric lymphoma. A contrast-enhanced computed tomography (CT-scan) of the thorax, abdomen and pelvis followed by EUS revealed a neoplastic infiltrative-ulcerative semicircumferentialgastric mass and a 1 cm large satellite adenopathy, being classified as T3N1M0 gastric neoplasia. The histological analysis of the ¾ distal stomach and lymph node sthat were resected contradicted the initial biopsy report, suggesting EBV gastric ulcer, etiology confirmed by the in situ hybridization technique...
February 17, 2019: Medical Ultrasonography
Michael Morrice, Gerry Polton, Sam Beck
There is currently a lack of evidence-based guidance when determining surgical margins for small intestinal tumours in dogs. The purpose of this study is to help the surgeon make informed clinical decisions about margins when confronted with a small intestinal mass. Twenty-seven canine small intestinal tumours were histologically diagnosed and then had further histological assessment at every centimeter from the edge of the palpable tumour to the surgical margin in oral, aboral and mesenteric directions. In all 10 carcinomas a 3 cm tissue margin in oral, aboral and mesenteric directions would have resulted in complete tumour resection...
February 19, 2019: Veterinary Medicine and Science
Matteo Provasi, Filippo Bagnoli, Daniele Fanoni, Silvia Alberti-Violetti, Dario Tomasini, Emilio Berti
Intravascular large B-cell lymphoma (IVLBCL) is one of the rarest B-cell non Hodgkin lymphomas (NHL), with an aggressive clinical behavior and a poor prognosis; in fact, its treatment is still an unmet clinical need, with a 3-year overall survival (OS) rate of 60-81%, and a central nervous system relapse rate of 25%. It usually presents as a widespread disease at diagnosis with multi-organ involvement. Previously considered as a diffuse large B-cell lymphoma variant, it now represents a different extranodal large B-cell lymphoma entity in the last WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues...
February 18, 2019: Journal of Cutaneous Pathology
Junyi Hu, Lijie Zhou, Zhengshuai Song, Ming Xiong, Youpeng Zhang, Yu Yang, Ke Chen, Zhaohui Chen
Bladder cancer (BC) is one of the most common neoplastic diseases worldwide. With the highest recurrence rate among all cancers, treatment of BC only improved a little in the last 30 years. Available biomarkers are not sensitive enough for the diagnosis of BC, whereas the standard diagnostic method, cystoscopy, is an invasive test and expensive. Hence, seeking new biomarkers of BC is urgent and challenging. With that order, we screened the overlapped differentially expressed genes (DEGs) of GSE13507 and TCGA BLCA datasets...
February 18, 2019: Journal of Cellular Physiology
L Di Renzo, M Marchetti, G Cioccoloni, S Gratteri, G Capria, L Romano, L Soldati, M C Mele, G Merra, M Cintoni, A De Lorenzo
OBJECTIVE: Neoplastic disease is frequently associated with poor nutritional status or severe malnutrition. Diet and nutritional intervention are becoming increasingly important for prognosis and quality of life in cancer patients. Accessible and repeatable tools for assessing nutritional status with body composition techniques seems to be fundamental. The aim of this study was to evaluate the effects of immunonutrition on body composition parameters, inflammatory response and nutritional status in patients at stage III of head and neck squamous carcinoma (HNSCC)...
February 2019: European Review for Medical and Pharmacological Sciences
N Tokuzen, H Goda, K Nakashiro
Mammary analogue secretory carcinoma (MASC) has recently been recognized as a salivary gland tumour that is characterized by the ETV6-NTRK3 fusion gene. A case of locally advanced MASC of the parotid gland in a 67-year-old man is presented here. The patient visited the hospital due to a large right infra-auricular mass, which had been enlarging gradually over a period of 2years. Contrast-enhanced computed tomography (CT) demonstrated a multilocular mass, 75×63mm in size, containing a fluid component with non-uniform contrast effects in the interior portion...
February 15, 2019: International Journal of Oral and Maxillofacial Surgery
Yi-Lin Chiu, Yi-Ying Wu, Robert B Barndt, Yee Hui Yeo, Yu-Wen Lin, Hou-Ping Sytwo, Huan-Cheng Liu, Yuan Xu, Bailing Jia, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin
Matriptase is ectopically expressed in neoplastic B-cells, in which matriptase activity is enhanced by negligible expression of its endogenous inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. HAI-1, however, is also involved in matriptase synthesis and intracellular trafficking. The lack of HAI-1 indicates that other related inhibitor, such as HAI-2, might be expressed. Here, we show that HAI-2 is commonly co-expressed in matriptase-expressing neoplastic B-cells. The level of active matriptase shed after induction of matriptase zymogen activation in 7 different neoplastic B-cells was next determined and characterised...
December 2019: Journal of Enzyme Inhibition and Medicinal Chemistry
Marcelo Chávez, Gonzalo Ziegler, José Cotrina, José Galarreta, Miguel de la Cruz, Raúl Mantilla
INTRODUCTION: Soft tissue sarcomas (SFT) are a group of rare and heterogeneous neoplasms (representing less than 1% of cancer in adults and 15% in pediatric patients), for which there is no updated records in the Latin American population. This study aims to describe the current situation of patients treated at a cancer institute in Latin America. METHODS: We obtained records from 250 patients with a diagnosis of SFT, treated at the National Institute of Neoplastic Diseases of Peru (INEN) during the period 2009-2013, with a mean follow-up of 62 months...
February 16, 2019: Cirugía Española
Suyash Mohan, Sumei Wang, Gokcen Coban, Feride Kural, Sanjeev Chawla, Donald M O'Rourke, Harish Poptani
OBJECTIVE: Corpus callosum (CC) involvement is a poor prognostic factor in patients with glioblastoma (GBM). The purpose of this study was to determine whether diffusion tensor imaging (DTI) can quantify occult tumor infiltration in the CC and predict the overall survival in GBM patients. METHODS: Forty-eight patients with pathologically proven GBM and 17 normal subjects were included in this retrospective study. Patients were divided into four groups based on CC invasion and overall survival: long survivors without CC invasion; short survivors without CC invasion; long survivors with CC invasion; short survivors with CC invasion...
March 2019: European Journal of Radiology
Brianne J Sullivan, Nathan Bolton, Umut Sarpel, Deepa Magge
BACKGROUND: Pseudomyxoma peritonei (PMP) is an uncommon condition characterized by diffuse mucinous material in the abdomen and pelvis, generally arising from a perforated epithelial neoplasm. Typically, the disease presents as suspected acute appendicitis, ovarian mass, abdominal distension, or ventral hernia. Our case represents a very rare presentation of superinfected PMP. CASE PRESENTATION: A 46-year-old female with a past medical history notable for depression, asthma, and uterine leiomyomas presented to an urgent care with 5 days of progressive abdominal pain, bloating, nausea, and subjective fevers...
February 18, 2019: World Journal of Surgical Oncology
Marlone Cunha-Silva, Daniel Ferraz de Campos Mazo, Igor Logetto Caetité Gomes, Marcello Rabello Imbrizi, Tiago Sevá-Pereira, Nayana Fonseca Vaz, Mariana Sandoval Lourenço, Larissa Bastos Eloy da Costa, Cecilia Amelia Fazzio Escanhoela, Jazon Romilson de Souza Almeida
The differential diagnosis of hepatic focal lesions is challenging because the etiology can be inflammatory, infectious, and even neoplastic. A rare cause of metastatic liver nodules is cardiac angiosarcoma. We report a case of this tumor, which was diagnosed only after autopsy. A 26-year-old Caucasian man was admitted for progressive dyspnea and cough over the past 3 weeks. Physical examination showed only hypophonetic heart sounds. Laboratory analysis demonstrated anemia and elevated inflammatory markers, despite normal biochemical parameters and liver function...
October 2018: Autopsy & Case Reports
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