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https://read.qxmd.com/read/30773992/a-novel-orally-available-seleno-purine-molecule-suppresses-triple-negative-breast-cancer-cell-proliferation-and-progression-to-metastasis-by-inducing-cytostatic-autophagy
#1
Chia-Hao Chang, Krikor Bijian, Dominik Wernic, Jie Su, Sabrina Daniela da Silva, Henry Yu, Dinghong Qiu, Mariana Asslan, Moulay A Alaoui-Jamali
Patients with triple-negative breast cancer (TNBC) often have a poor prognosis largely due to lack of effective targeted therapy. Using a library of seleno-purines coupled to a high-throughput biochemical enzymatic assays we identified a potent pharmacological enhancer of autophagy (referred herein as SLLN-15) that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models. SLLN-15 induced a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux...
February 17, 2019: Autophagy
https://read.qxmd.com/read/30770135/patient-preferences-on-the-use-of-technology-in-cancer-surveillance-after-curative-surgery-a-cross-sectional-analysis
#2
Amblessed E Onuma, Elizabeth Palmer Kelly, Jeffery Chakedis, Anghela Z Paredes, Diamantis I Tsilimigras, Brianne Wiemann, Morgan Johnson, Katiuscha Merath, Ozgur Akgul, Jordan Cloyd, Timothy M Pawlik
BACKGROUND: Advances in communication technology have enabled new methods of delivering test results to cancer survivors. We sought to determine patient preferences regarding the use of newer technology in delivering test results during cancer surveillance. METHODS: A single institutional, cross-sectional analysis of the preferences of adult cancer survivors regarding the means (secure digital communication versus phone call or office visit) to receive surveillance test results was undertaken...
February 12, 2019: Surgery
https://read.qxmd.com/read/30759125/alcohol-and-breast-cancer-risk-middle-aged-women-s-logic-and-recommendations-for-reducing-consumption-in-australia
#3
Samantha B Meyer, Kristen Foley, Ian Olver, Paul R Ward, Darlene McNaughton, Lillian Mwanri, Emma R Miller
BACKGROUND: We aimed to understand the factors shaping alcohol consumption patterns in middle-aged women (45-64), and to identify participant-driven population- and policy-level strategies that may be used to addresses alcohol consumption and reduce breast cancer risk. METHODS: Semi-structured interviews (n = 35) were conducted with 'middle-aged' women conversant in English and living in South Australia with no history of breast cancer diagnosis. Data were deductively coded using a co-developed framework including variables relevant to our study objectives...
2019: PloS One
https://read.qxmd.com/read/30755531/dynamically-stiffened-matrix-promotes-malignant-transformation-of-mammary-epithelial-cells-via-collective-mechanical-signaling
#4
Matthew G Ondeck, Aditya Kumar, Jesse K Placone, Christopher M Plunkett, Bibiana F Matte, Kirsten C Wong, Laurent Fattet, Jing Yang, Adam J Engler
Breast cancer development is associated with increasing tissue stiffness over years. To more accurately mimic the onset of gradual matrix stiffening, which is not feasible with conventional static hydrogels, mammary epithelial cells (MECs) were cultured on methacrylated hyaluronic acid hydrogels whose stiffness can be dynamically modulated from "normal" (<150 Pascals) to "malignant" (>3,000 Pascals) via two-stage polymerization. MECs form and remain as spheroids, but begin to lose epithelial characteristics and gain mesenchymal morphology upon matrix stiffening...
February 12, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30741121/interpersonal-positive-reframing-in-the-daily-lives-of-couples-coping-with-breast-cancer
#5
Megan L Robbins, Robert C Wright, Ana María López, Karen Weihs
OBJECTIVES: This study examined word use as an indicator of interpersonal positive reframing in daily conversations of couples coping with breast cancer and as a predictor of stress. DESIGN: The Electronically Activated Recorder (EAR) and Linguistic Inquiry and Word Count (LIWC) were used to examine naturally occurring word use conceptually linked to positive reframing (positive emotion, negative emotion, and cognitive processing words). SAMPLE: Fifty-two couples coping with breast cancer...
February 11, 2019: Journal of Psychosocial Oncology
https://read.qxmd.com/read/30738522/calculating-organ-and-effective-doses-in-paediatric-interventional-cardiac-radiology-based-on-dicom-structured-reports-is-detailed-examination-data-critical-to-dose-estimates
#6
Angeliki Karambatsakidou, Artur Omar, Annette Fransson, Gavin Poludniowski
PURPOSE: To estimate effective dose (E), equivalent organ doses (HT ) and associated conversion coefficients (CCE:KAP  = E/KAP, CCHT:KAP  = HT /KAP; KAP = Kerma-area product) in paediatric cardiac interventions, using detailed exposure data from radiation dose structured reports (RDSR). These "RDSR dose estimations" have been compared with estimations performed using the approach currently implemented in the clinic that is based on a simplified assumptions method (SAM)...
January 2019: Physica Medica: PM
https://read.qxmd.com/read/30737031/novel-pharmacological-effects-of-poly-adp-ribose-polymerase-inhibitor-rucaparib-on-the-lactate-dehydrogenase-pathway
#7
Yuma Nonomiya, Kohji Noguchi, Kazuhiro Katayama, Yoshikazu Sugimoto
Poly (ADP-ribose) polymerases (PARPs) are involved in various cellular events, including DNA repair. PARP inhibitors including olaparib and rucaparib, have been specially developed against breast and ovarian cancers deficient in DNA repair systems. In this study, we found that PARP1-defective olaparib-resistant A2780 cells (ola-R cells) cells were still sensitive to two PARP inhibitors, rucaparib and veliparib. Metabolomic analysis revealed that rucaparib suppressed the lactate dehydrogenase (LDH)-mediated conversion of pyruvic acid to lactic acid in A2780 cells, although olaparib did not...
February 5, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30735801/glycerol-monolaurate-in-the-diet-of-broiler-chickens-replacing-conventional-antimicrobials-impact-on-health-performance-and-meat-quality
#8
Bruno F Fortuoso, João H Reis, Roger R Gebert, Mauricio Barreta, Luiz Gustavo Griss, Renata A Casagrande, Thierry G de Cristo, Fábio Santiani, Gabriela Campigotto, Luana Rampazzo, Lenita M Stefani, Marcel M Boiago, Leonardo Q Lopes, Roberto C Santos, Matheus D Baldissera, Régis A Zanette, Thainã Tomasi, Aleksandro S da Silva
Glycerol monolaurate (GML), known as lauric acid, is a chemical compound formed from lauric acid and glycerol that presents strong antimicrobial activity. Therefore, our hypothesis is that MGL can replace conventional antimicrobials, being a new alternative to poultry farming. The aim of this study was to evaluate whether the addition of GML as a replacement for antibiotics could have positive effects on health and performance of broiler chickens. For this, 240, one-day-old, Cobb 500 broiler chicks were weighed and randomly distributed into four groups with four repetitions each (n = 15)...
February 5, 2019: Microbial Pathogenesis
https://read.qxmd.com/read/30734152/pharmacogenomic-pharmacokinetic-study-of-selective-estrogen-receptor-modulators-with-intra-patient-dose-escalation-in-breast-cancer
#9
Hiroshi Ishiguro, Shinji Ohno, Yutaka Yamamoto, Shintaro Takao, Nobuaki Sato, Tomomi Fujisawa, Takayuki Kadoya, Katsumasa Kuroi, Hiroko Bando, Yasufumi Teramura, Hiroji Iwata, Shiro Tanaka, Masakazu Toi
BACKGROUND: An association between CYP2D6 polymorphisms and tamoxifen (TAM) efficacy has not been confirmed, partly due to unreliable prediction of active metabolite exposure solely by CYP2D6 activity. The efficacy of TAM dose escalation appears limited in poor TAM metabolizers. Since the chlorine atom on the side chain of toremifene (TOR) prevents 4-hydroxylation by CYP2D6, its contribution to active conversion of TOR is minor. We examined the role of TOR and its dose escalation among poor TAM metabolizers...
February 7, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30732191/a-systematic-review-of-clinical-outcomes-and-radiotherapy-associated-toxicity-in-multicatheter-accelerated-partial-breast-irradiation
#10
Yang Lv, Lin He, Chao Wang, Lijiu Zhang, Biyuan Zhang, Yuhua Song
BACKGROUND: To integrate relevant clinical data of multicatheter accelerated partial breast irradiation (mAPBI) for reaching a comprehensive conclusion. METHODS: We did 3 meta-analyses for clinical outcomes including 1740 women from 4 articles, for acute radiotherapy (RT)-associated toxicity including 1255 patients from 5 articles, and for late RT-related toxicity involving 1565 patients from 9 papers. Clinical outcomes analyses were stratified by molecular subtypes, lymph nodes status, receptor status, and human epidermal growth factor receptor 2 (HER2) status...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30720232/sohlh2-inhibits-breast-cancer-cell-proliferation-by-suppressing-wnt-%C3%AE-catenin-signaling-pathway
#11
Xiaoli Zhang, Ruihua Liu, Na Zhao, Shufang Ji, Chunyan Hao, Weiwei Cui, Ruihong Zhang, Jing Hao
Sohlh2 belongs to the superfamily of basic helix-loop-helix (bhlh) transcription factors. Aberrant expression of bhlh transcription factors has been shown to be associated with multiple tumorigenesis. We previously identified that sohlh2 functioned as a tumor suppressor in ovarian cancer. Here, we examined the expression levels of sohlh2 in human breast cancer and its potential role in disease pathogenesis. The results of sohlh2 immunohistochemistry (IHC) and Western blot analysis demonstrated the decreased sohlh2 expression in breast cancer specimens as compared to adjacent noncancerous tissues...
February 5, 2019: Molecular Carcinogenesis
https://read.qxmd.com/read/30719718/heterogeneity-in-risk-factors-for-ductal-and-lobular-breast-carcinomas-a-case-control-study
#12
Mostafa Dianatinasab, Mohammad Fararouei, Nima Daneshi, Shahab Rezaian, Mohammad Mohammadianpanah, Reza Chaman, Reza Ghiasvand
Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) of the breast are the most common histological subtypes of breast cancer. However, the associations and heterogeneity between histological subtypes and their risk factors are not well established. This study aimed to investigate risk factors for IDC and ILC. This case-control study included 1009 incident breast cancer cases and 1009 hospital controls, frequency-matched by age. Data were obtained from the patients' medical files and an interview administered via a questionnaire...
February 4, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30717608/15-deoxy-%C3%AE-12-14-prostaglandin-j-2-upregulates-the-expression-of-15-hydroxyprostaglandin-dehydrogenase-through-dna-methyltransferase-1-inactivation
#13
Hye-Ok Jang, Ha-Na Lee, Jeong-Hwa Woo, Ja-Young Lee, Areumnuri Kim, Jin Kyung Lee, Do-Hee Kim, Young-Joon Surh, Hye-Kyung Na
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyzes the conversion of prostaglandin E2 to a keto metabolite. The downregulation of 15-PGDH is ubiquitously observed in various human malignancies. However, the molecular mechanisms underlying downregulation of 15-PGDH expression remain largely unknown. 15-Deoxy-△12,14 -prostaglandin J2 (15d-PGJ2 ), an endogenous ligand of peroxisome proliferator-activated receptor γ, has been reported to have anti-inflammatory and anticarcinogenic activities...
February 5, 2019: Free Radical Research
https://read.qxmd.com/read/30717110/detection-and-prognostic-relevance-of-circulating-and-disseminated-tumour-cell-in-dogs-with-metastatic-mammary-carcinoma-a-pilot-study
#14
Laura Marconato, Antonella Facchinetti, Claudia Zanardello, Elisabetta Rossi, Riccardo Vidotto, Katia Capello, Erica Melchiotti, Paola Laganga, Rita Zamarchi, Marta Vascellari
In human breast cancer, both circulating tumour cells (CTCs) in peripheral blood and disseminated tumour cells (DTCs) in the bone marrow are predictive of short survival and may be used as liquid biopsy to guide therapy. Herein we investigate, for the first time, the feasibility to quantify CTCs and DTCs in canine metastatic mammary carcinoma (MMC) with the automated CellSearch platform, which identifies tumour cells by immune-magnetic enrichment and fluorescent labelling. Using this approach before start of treatment, we could detect at least 1 CTC per 7...
February 1, 2019: Cancers
https://read.qxmd.com/read/30714472/prussian-blue-modified-ferritin-nanoparticles-for-effective-tumor-chemo-photothermal-combination-therapy-via-enhancing-reactive-oxygen-species-production
#15
Hao Li, Wei Zhang, Li Ding, Xing-Wang Li, Yang Wu, Jin-Hai Tang
To realize the photothermal therapy ability of Prussian blue-modified ferritin nanoparticles (PB-Ft NPs) and its synergistic effect with chemotherapy, PB-Ft NPs were synthesized by a simple surface double decomposition reaction. Mean sizes of ferritin and PB-Ft NPs were 10.4 nm and 12.6 nm, respectively. The obtained PB-Ft NPs were verified to have both the photothermal conversion ability of Prussian blue and the morphology of ferritin. The in vitro and in vivo photothermal therapy results confirm PB-Ft NPs can successfully inhibit the growth of murine breast cancer cell line (4T1) without any obvious side effect...
February 2, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30712556/fluorescence-enhanced-p19-proteins-conjugated-single-quantum-dot-with-multiplex-antenna-for-one-step-specific-and-sensitive-mirnas-detection
#16
Xueting Ren, Qingwang Xue, Liyuan Wen, Xia Li, Huaisheng Wang
Ideal methods for miRNA detection should be rapid and amplification-free in the mix-and-measure format. Here we report a novel FRET strategy based on fluorescence-enhanced p19 proteins-conjugated single quantum dot (QD) with multiplex antenna for one-step, specific and sensitive miRNAs quantitative analysis. It is simple in design and operation, and possesses high sensitivity and selectivity. In the strategy, RNA-binding viral p19 proteins-conjugated quantum dot (p19-QD) with high fluorescence and multiplex antenna was designed, and exploited for the capture recognition element and the donor...
April 11, 2019: Analytica Chimica Acta
https://read.qxmd.com/read/30708944/the-efficiency-of-xylanase-in-broiler-chickens-fed-with-increasing-dietary-levels-of-rye
#17
Anna Arczewska-Wlosek, Sylwester Swiatkiewicz, Dorota Bederska-Lojewska, Sylwia Orczewska-Dudek, Witold Szczurek, Danuta Boros, Anna Fras, Ewa Tomaszewska, Piotr Dobrowolski, Siemowit Muszynski, Małgorzata Kwiecien, Tomasz Schwarz
In this paper, we present a study on the evaluation of the effect of xylanase addition to a diet with an increasing content of modern hybrid rye (Brasetto variety) on the performance indices and viscosity of small intestine content in broiler chickens. A total of 560 1-day-old male Ross 308 chickens were randomly assigned to 1 of 10 treatments, each comprising 7 replicate cages, with 8 male birds per cage. A 5 × 2 factorial arrangement was employed, with five dietary levels of ground rye (0%, 5%, 10%, 15%, and 20%)...
January 31, 2019: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/30707555/boosting-the-radiosensitizing-and-photothermal-performance-of-cu-2-x-se-nanocrystals-for-synergetic-radiophotothermal-therapy-of-orthotopic-breast-cancer
#18
Qian Huang, Shaohua Zhang, Hao Zhang, Yaobao Han, Hanghang Liu, Feng Ren, Qiao Sun, Zhen Li, Mingyuan Gao
The small difference between tumor and normal tissues in their responses to ionizing radiation has been a significant issue for radiotherapy of tumors. Herein, we report that dumbbell-shaped heterogeneous copper selenide-gold nanocrystals can serve as an efficient radiosensitizer for enhanced radiotherapy. The mean lethal dose of X-rays to 4T1 tumor cells can be drastically decreased about 40%, i.e., decreasing from 1.81 Gy to 1.10 Gy after culture with heterostructures. Due to the synergetic effect of heterostructures, the dose of X-rays is also much lower than those obtained from mixture of Cu2-x Se + Au nanoparticles (1...
February 1, 2019: ACS Nano
https://read.qxmd.com/read/30704493/radiologic-complete-response-rcr-in-contrast-enhanced-magnetic-resonance-imaging-ce-mri-after-neoadjuvant-chemotherapy-for-early-breast-cancer-predicts-recurrence-free-survival-but-not-pathologic-complete-response-pcr
#19
Simon Peter Gampenrieder, Andreas Peer, Christian Weismann, Matthias Meissnitzer, Gabriel Rinnerthaler, Johanna Webhofer, Theresa Westphal, Marina Riedmann, Thomas Meissnitzer, Heike Egger, Frederike Klaassen Federspiel, Roland Reitsamer, Cornelia Hauser-Kronberger, Katharina Stering, Klaus Hergan, Brigitte Mlineritsch, Richard Greil
BACKGROUND: Patients with early breast cancer (EBC) achieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) have a favorable prognosis. Breast surgery might be avoided in patients in whom the presence of residual tumor can be ruled out with high confidence. Here, we investigated the diagnostic accuracy of contrast-enhanced MRI (CE-MRI) in predicting pCR and long-term outcome after NACT. METHODS: Patients with EBC, including patients with locally advanced disease, who had undergone CE-MRI after NACT, were retrospectively analyzed (n = 246)...
January 31, 2019: Breast Cancer Research: BCR
https://read.qxmd.com/read/30700319/serum-erythropoietin-levels-breast-cancer-and-breast-cancer-initiating-cells
#20
Kruttika Bhat, Kiri Sandler, Sara Duhachek-Muggy, Claudia Alli, Fei Cheng, Neda A Moatamed, Clara E Magyar, Lin Du, Gang Li, Susan McCloskey, Erina Vlashi, Frank Pajonk
BACKGROUND: Cancer is frequently associated with tumor-related anemia, and many chemotherapeutic agents impair hematopoiesis, leading to impaired quality of life for affected patients. The use of erythropoiesis-stimulating agents has come under scrutiny after prospective clinical trials using recombinant erythropoietin to correct anemia reported increased incidence of thromboembolic events and cancer-related deaths. Furthermore, previous preclinical reports indicated expansion of the pool of breast cancer-initiating cells when erythropoietin was combined with ionizing radiation...
January 30, 2019: Breast Cancer Research: BCR
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