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Yonghua Chen, Yuanyuan Hou, Ying Yang, Meixia Pan, Jing Wang, Wenshuang Wang, Ying Zuo, Jianglin Cong, Xiaojie Wang, Nan Mu, Chenglin Zhang, Benjiao Gong, Jianqing Hou, Shaoguang Wang, Liping Xu
BACKGROUND: The efficacy of therapy for cervical cancer is related to the alteration of multiple molecular events and signaling networks during treatment. The aim of this study was to evaluate gene expression alterations in advanced cervical cancers before- and after-trans-uterine arterial chemoembolization- (TUACE). METHODS: Gene expression patterns in three squamous cell cervical cancers before- and after-TUACE were determined using microarray technique. Changes in AKAP12 and CA9 genes following TUACE were validated by quantitative real-time PCR...
February 14, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Maxime J M van der Valk, Floris A Vuijk, Hein Putter, Cornelis J H van de Velde, Geerard L Beets, Denise E Hilling
BACKGROUND: The neoadjuvant rectal score (NAR) was developed as a surrogate endpoint for overall survival in patients with rectal cancer after neoadjuvant treatment. We aimed to validate the NAR score in patients from the Netherlands Cancer Registry database. PATIENTS AND METHODS: We studied patients with rectal cancer treated with long-course neoadjuvant therapy followed by surgery in the Netherlands between 2007 and 2014. The probability of concordance with overall survival and the goodness of fit of several models were evaluated using Harrell's concordance index (c index) and the Akaike information criterion (AIC), which is used to compare the quality of statistical models...
January 19, 2019: Clinical Colorectal Cancer
Mi Jung Kwon, Jae Seung Soh, Sang-Woo Lim, Ho Suk Kang, Hyun Lim
Human epidermal growth factor 2 (HER2) is a candidate therapeutic and prognostic marker for rectal cancer treated with neoadjuvant chemoradiotherapy. The specific frequency and prognostic role of HER2 protein expression and HER2 gene amplification in those rectal cancers has not been fully investigated. Pretreatment biopsied and surgically resected formalin-fixed paraffin-embedded tissues from 74 patients were retrospectively evaluated for HER2 protein expression and HER2 gene copy number using immunohistochemistry (IHC) and silver in situ hybridization (SISH), respectively...
January 28, 2019: Pathology, Research and Practice
Stephanie Cham, Ling Chen, Caryn M St Clair, June Y Hou, Ana I Tergas, Alexander Melamed, Cande V Ananth, Alfred I Neugut, Dawn L Hershman, Jason D Wright
BACKGROUND: Primary cytoreduction followed by platinum based chemotherapy is the primary treatment for advanced ovarian cancer. However neoadjuvant chemotherapy followed by interval debulking is an alternative option, particularly in those who may be poor surgical candidates. OBJECTIVE: The objective of this study was to determine factors associated with short term, significant perioperative morbidity and mortality for women undergoing surgery for ovarian cancer and to create a nomogram to predict the risk of adverse perioperative outcomes...
February 13, 2019: American Journal of Obstetrics and Gynecology
Angel L Guerrero-Zotano, Thomas P Stricker, Luigi Formisano, Katherine E Hutchinson, Daniel G Stover, Kyung-Min Lee, Luis J Schwarz, Jennifer M Giltnane, Monica V Estrada, Valerie M Jansen, Alberto Servetto, Joaquín Gavilá, J Alejandro Perez-Fidalgo, Ana Lluch, Antonio Llombart-Cussac, Mohamed Amine Bayar, Stefan Michiels, Fabrice André, Mónica Arnedos, Vicente Guillem, Amparo Ruiz-Simon, Carlos L Arteaga
No abstract text is available yet for this article.
February 15, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Yen-Ling Lai, Heng-Cheng Hsu, Kuan-Ting Kuo, Yu-Li Chen, Chi-An Chen, Wen-Fang Cheng
The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. The primary clinical presentation was enlarging abdominal masses at previous surgical scars. Four patients underwent initial/primary surgeries with/without adjuvant chemotherapy...
February 14, 2019: International Journal of Environmental Research and Public Health
Milena Cerny, Vincent Dunet, Caterina Rebecchini, Dieter Hahnloser, John Prior, Christine Sempoux, Sabine Schmidt
AIM: To prospectively evaluate histological significance and predictive value of changes in apparent diffusion coefficient (ADC) and 18 F-FDG PET/CT parameters in locally advanced rectal cancer (LARC) after neoadjuvant radiochemotherapy (RCT). METHODS: Twenty-one patients with untreated LARC underwent pre-RCT and post-RCT 18 F-FDG PET/CT and diffusion-weighted magnetic resonance imaging (DW-MRI), followed by surgery. For both datasets, two readers measured the tumor SUVmax, SUVmean, MTV, TLG, ADCmin, ADCmean, and respective differences (∆SUVmax, ∆SUVmean, ∆MTV, ∆TLG, ∆ADCmin, ∆ADCmean) for the whole tumor...
February 2019: Nuklearmedizin. Nuclear Medicine
Natally Horvat, Camila Carlos Tavares Rocha, Brunna Clemente de Oliveira, Iva Petkovska, Marc J Gollub
Rectal cancer is prone to local recurrence and systemic metastasis. However, owing to improvements in TNM staging and treatment, including a more widespread use of rectal MRI and increased radiologist awareness of the key rectal cancer TNM staging features, the mortality rate of rectal cancer has been declining over the past few decades in adults over 50 years of age. Currently, rectal MRI plays a key role in the pre- and posttreatment evaluation of rectal cancer, assisting the multidisciplinary team in tailoring the most appropriate treatment option...
February 15, 2019: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Dongliang Li, Shingo Toji, Kazue Watanabe, Toshihiko Torigoe, Tomohide Tsukahara
Osteosarcoma is the most common malignancy of bone that affects young people. Neoadjuvant chemotherapy and surgery have significantly improved the prognosis. However, the prognosis of non-responders to chemotherapy is still poor. To develop peptide-based immunotherapy for osteosarcoma, we previously identified CTL epitopes derived from papillomavirus binding factor (PBF) in the context of HLA-A2, HLA-A24 and HLA-B55. In the present study, we identified two novel CTL epitopes, QVT (QVTVWLLEQK) and LSA (LSALPPPLHK), in the context of HLA-A11 using a sequence of screenings based on the predicted affinity of peptides, in vitro folding ability of a peptide/HLA-A11 complex, reactivity of a peptide/HLA-A11 tetramer and IFN-γ production of T cells that was induced by mixed lymphocyte peptide culture under a limiting dilution condition...
February 15, 2019: Cancer Science
Tomofumi Naruse, Souichi Yanamoto, Kohei Okuyama, Keisuke Ohmori, Hiroki Tsuchihashi, Kohei Furukawa, Shin-Ichi Yamada, Masahiro Umeda
While neoadjuvant chemotherapy (NAC) for patients with oral tongue squamous cell carcinoma (OTSCC) may improve tumor microenvironment, it may lead to local immune suppression caused by residual cancer cells. The efficacy of NAC is therefore controversial. In our study, we investigated tumor microenvironments after NAC using immune checkpoint molecules, and evaluated the association between tumor microenvironments, clinicopathological factors and outcomes. We reviewed the records of 121 patients who underwent radical surgery for OTSCC between April 2001 and March 2015...
February 14, 2019: Pathology Oncology Research: POR
Ilavarasi Vanidassane, Aparna Sharma, Aditi Aggarwal, Sudhakar Gunasekar, Adarsh Barwad, Ekta Dhamija, Rambha Pandey, Suryanarayana Deo, Rakesh Garg, Sameer Rastogi
Background: Head-and-neck soft-tissue sarcomas (HNSTS) are extremely rare and lack definite guidelines. Methods: We retrospectively analyzed consecutive adult patients with HNSTS who presented to our sarcoma medical oncology clinic from January 2016 to October 2017. Results: There were a total of 30 patients. Unresectable localized disease was seen in 13 (43%) patients, metastatic disease 10 (34%) patients, while resectable disease in 7 (23%) patients only...
January 2019: South Asian Journal of Cancer
Reshu Agarwal, Anupama Rajanbabu, Pavithran Keechilattu, Indu R Nair, D K Vijaykumar, U G Unnikrishnan
Objective: The objective of this study is to evaluate the pattern of care and survival outcome in patients with malignant ovarian germ cell tumors (MOGCTs). Materials and Methods: Between January 2004 and August 2017, 50 patients with MOGCT were identified at Amrita Institute of Medical Sciences and 48 included in analyses. Histologic subtypes were as follows: dysgerminoma 11; immature teratoma 16; yolk sac tumor 3; and mixed germ cell tumor 18. 31 (64.6% patients belonged to Stage I and 17 (35...
January 2019: South Asian Journal of Cancer
Radek Vrba, David Vrána, Čestmír Neoral, Bohuslav Melichar, René Aujeský, Jana Tesarikova, Jan Cincibuch, Jana Zapletalová, Tomáš Jínek, Martin Stašek
Introduction: Respiratory complications (RC) including respiratory failure and adult respiratory distress syndrome (ARDS) affect the outcomes of esophagectomy substantially. In order to decrease their incidence, identification of important features of RC is necessary. Aim: To evaluate the incidence and risk factors of postoperative RC following hybrid esophagectomy. Material and methods: The retrospective analysis of consecutive hybrid esophagectomies for malignancies (transhiatal laparoscopic or thoracoscopic resection and limited open reconstruction phase) assessed the incidence and outcomes of RC in relation to the patients' age, ASA score, neoadjuvant therapy, type of surgical procedure, TNM stage, the incidence of anastomotic leak and Clavien-Dindo classification...
January 2019: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Hideyuki Omoto, Mamoru Takada, Shota Fujii, Hiroshi Ito, Sumio Yamashita
We report the case of a 60-year-old woman with right breast cancer. Approximately 18 years had passed since the treatment for left breast cancer without recurrence. She became aware of the right breast tumor with mild pain 5 months before she came to the hospital. The diagnosis was right-sided breast cancer, cT2N0M0, StageⅡA, ER(-), PgR(-), HER2(-). Neoadjuvant chemotherapy was chosen, and then combined treatment with epirubicin(EPI)and cyclophosphamide(CPA) was started. The breast tumor had become smaller, but she complained of shortness of breath during the third course of chemotherapy...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kazushi Yamashita, Tsuyoshi Chiku, Wataru Sano, Takahiro Hashiba, Kimio Shinoda, Yasuhiro Togawa
We reported 2 cases of colorectal cancer receiving neoadjuvant chemotherapy(NAC)with the aim of curative resection or anal preservation. Case 1: A 50-year-old man was diagnosed with locally advanced rectal cancer with sacral invasion. Because of the sacral invasion, we performed preoperative chemotherapy. He was treated with 12 courses of CapeOX plus Bmab and 3 courses of capecitabine plus radiation therapy(45 Gy in total). After chemoradiation therapy, a lower anterior resection was performed. The pathological finding was pT3pN0pM0, pStage Ⅱ...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Tetsutaro Nemoto, Shungo Endo, Noriyuki Isohata, Daisuke Takayanagi, Daiki Nemoto, Masato Aizawa, Kenichi Utano, Kazutomo Togashi, Kotaro Endo, Ikuro Oshibe, Nobutoshi Soeta, Takuro Saito
A 53-year-old woman was referred to our hospital with melena. Examinations revealed advanced rectal cancer involving the anal canal with invasion of the left-sided levator ani muscle. Neoadjuvant chemotherapy was administered to preserve anal function. A first course of capecitabine and oxaliplatin(CapeOX)plus bevacizumab was administered. CapeOX plus panitumumab was administered from the 2nd to the 8th courses after confirming the absence of RAS mutation. Endoscopy and computed tomography confirmed the disappearance of the tumor after completion of the chemotherapy...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Gloria Salvo, Pedro T Ramirez, Mario Leitao, David Cibula, Christina Fotopoulou, Ali Kucukmetin, Gabriel Rendon, Myriam Perrotta, Reitan Ribeiro, Marcelo Vieira, Glauco Baiocchi, Henrik Falconer, Jan Persson, Xiaohua Wu, Mihai Emil Căpilna, Nicolae Ioanid, Berit Jul Mosgaard, Igor Berlev, Dilyara Kaidarova, Alexander Babatunde Olawaiye, Kaijiang Liu, Silvana Pedra Nobre, Roman Kocian, Srdjan Saso, Stuart Rundle, Florencia Noll, Audrey Tieko Tsunoda, Kolbrun Palsdottir, Xiaoqi Li, Elena Ulrikh, Zhijun Hu, Rene Pareja
BACKGROUND: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy. PRIMARY OBJECTIVE: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy...
February 13, 2019: International Journal of Gynecological Cancer
Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Ryohei Kobayashi, Masaki Ueno, Shinya Hayami, Kensuke Tanioka, Hiroki Yamaue
BACKGROUND: The impact of systemic immune inflammatory markers to predict survival in patients receiving neoadjuvant therapy for borderline resectable pancreatic cancer has not been sufficiently investigated. This study aims to evaluate whether systemic immune inflammatory markers after neoadjuvant therapy followed by pancreatectomy become preoperative prognostic factors to predict survival in patients with borderline resectable pancreatic cancer. METHODS: We retrospectively reviewed 67 borderline resectable pancreatic cancer patients receiving neoadjuvant therapy and 58 borderline resectable pancreatic cancer patients undergoing upfront surgery between 2010 and 2016...
February 11, 2019: Surgery
M Slavik, T Kazda, I Selingerová, J Šána, P Ahmad, D Gurín, M Hermanová, T Novotný, R Červená, R Dymáčková, P Burkoň, O Slabý, P Šlampa
BACKGROUND: Oropharyngeal squamous cell tumors associated with human papillomavirus infection (p16 positive tumors) have better prognosis than p16 negative tumors regardless of the more advanced stage of the disease. Tumor volume (GTVt+n) is generally an important factor affecting treatment results of ionizing radiation. The aim of this prospective non-randomized study is to evaluate the effect of tumor volume on the (chemo)radiation treatment results in a group of patients with p16 negative and p16 positive oropharyngeal tumors...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
B Mrinakova, M Ondrušová, M Švantnerová, D Ondruš
BACKGROUND: Penile cancer belongs to group of relatively rare malignancies. It represents, on average, 0.5-1% of all tumours in males globally and occurs predominantly in older individuals (> 65 years). The geographical distribution of malignant cancer of the penis is reported. A higher incidence is observed in less developed parts of the world, particularly in South America, Southeast Asia, and some areas of Africa (> 2.0/100,000). In Slovakia, there has been a recent increase in incidence (1...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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