keyword
https://read.qxmd.com/read/38523303/recurrent-severe-hypocalcemia-following-chemotherapy-regimen-changes-in-advanced-breast-cancer-two-case-reports
#1
JOURNAL ARTICLE
Yurina Yanase, Hiroko Bando, Riko Sato, Tomohei Matsuo, Aya Ueda, Mai Okazaki, Sachie Hashimoto, Akiko Iguchi-Manaka, Hisato Hara
BACKGROUND: As an oncologic emergency related to abnormalities in calcium metabolism, hypercalcemia associated with paraneoplastic syndrome and bone metastases is well known. Meanwhile, the incidence of hypocalcemia is low, except in cases associated with bone-modifying agents used for bone metastases. Hypocalcemia induced by bone-modifying agents typically occurs early after the initial administration, and its incidence can be significantly reduced by preventive administration of calcium and vitamin D3 supplements...
March 25, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38467003/long-term-effect-of-randomization-to-calcium-and-vitamin-d-supplementation-on-health-in-older-women-postintervention-follow-up-of-a-randomized-clinical-trial
#2
JOURNAL ARTICLE
Cynthia A Thomson, Aaron K Aragaki, Ross L Prentice, Marcia L Stefanick, JoAnn E Manson, Jean Wactawski-Wende, Nelson B Watts, Linda Van Horn, James M Shikany, Thomas E Rohan, Dorothy S Lane, Robert A Wild, Rogelio Robles-Morales, Aladdin H Shadyab, Nazmus Saquib, Jane Cauley
BACKGROUND: Although calcium and vitamin D (CaD) supplementation may affect chronic disease in older women, evidence of long-term effects on health outcomes is limited. OBJECTIVE: To evaluate long-term health outcomes among postmenopausal women in the Women's Health Initiative CaD trial. DESIGN: Post hoc analysis of long-term postintervention follow-up of the 7-year randomized intervention trial of CaD. (ClinicalTrials.gov: NCT00000611). SETTING: A multicenter ( n = 40) trial across the United States...
March 12, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38360633/dual-effect-of-vitamin-d-3-on-breast-cancer-associated-fibroblasts
#3
JOURNAL ARTICLE
Natalia Łabędź, Artur Anisiewicz, Martyna Stachowicz-Suhs, Joanna Banach, Dagmara Kłopotowska, Adam Maciejczyk, Patrycja Gazińska, Aleksandra Piotrowska, Piotr Dzięgiel, Rafał Matkowski, Joanna Wietrzyk
BACKGROUND: Cancer-associated fibroblasts (CAFs) play an important role in the tumor microenvironment. Despite the well-known in vitro antitumoral effect of vitamin D3 (VD3 ), its impact on breast CAFs is almost unknown. In this study, we analyzed the ex vivo effects of calcitriol on CAFs isolated from breast cancer tissues. METHODS: CAFs were cultured with 1 and 10 nM calcitriol and their phenotype; gene expression, protein expression, and secretion were assessed...
February 15, 2024: BMC Cancer
https://read.qxmd.com/read/38355711/calcitriol-promotes-m2-polarization-of-tumor-associated-macrophages-in-4t1-mouse-mammary-gland-cancer-via-the-induction-of-proinflammatory-cytokines
#4
JOURNAL ARTICLE
Martyna Stachowicz-Suhs, Natalia Łabędź, Artur Anisiewicz, Joanna Banach, Dagmara Kłopotowska, Magdalena Milczarek, Aleksandra Piotrowska, Piotr Dzięgiel, Adam Maciejczyk, Rafał Matkowski, Joanna Wietrzyk
Our research found that vitamin D3 (VD3 ) treatment increased lung metastasis in mice with 4T1 murine breast cancer (BC). This study aims to investigate the impact of VD3 on the activation of tumor-associated macrophages (TAMs) in BC. Mice bearing 4T1, E0771, 67NR BC cells, and healthy mice, were fed diets with varying VD3 contents (100-deficient, 1000-normal, and 5000 IU/kg-elevated). Some mice in the 1000 and 100 IU/kg groups received calcitriol. We studied bone metastasis and characterized TAMs and bone marrow-derived macrophages (BMDMs)...
February 15, 2024: Scientific Reports
https://read.qxmd.com/read/38034665/anticancer-and-anti-metastasis-activity-of-1-25-dihydroxycholecalciferols-and-genistein-in-mcf-7-and-mda-mb-231-breast-cancer-cell-lines
#5
JOURNAL ARTICLE
Fatema Suliman Alatawi, Uzma Faridi
A powerful steroid hormone precursor, 1,25 dihydroxycholecalciferols (1,25(OH)2 D3 ), and dietary phytoestrogen (genistein) are essential compounds that act by binding to nuclear receptors and altering gene expression. They have many biological benefits, some of which have anticancer properties. We studied the impact of 1,25(OH)2 D3 and genistein on the proliferation, progression, and metastasis of MCF-7 and MDA-MB-231 cells when they were used alone or in combination and investigated whether there was a synergistic effect between genistein and 1,25(OH)2 D3 ...
November 2023: Heliyon
https://read.qxmd.com/read/38023986/effect-of-vitamin-d-supplementation-on-inflammatory-markers-and-total-antioxidant-capacity-in-breast-cancer-women-using-a-machine-learning-technique
#6
JOURNAL ARTICLE
Marzieh Tahmasebi, Masoud Veissi, Seyed Ahmad Hosseini, Amir Jamshidnezhad
AIM: This study aimed to establish a learning system using an artificial neural network (ANN) to predict the effects of vitamin D supplementation on the serum levels of vitamin D, inflammatory factors, and total antioxidant capacity (TAC) in women with breast cancer. METHODS: The data set of the current project was created from women with breast cancer who were referred to the Shafa State Hospital of Patients with Cancers in Ahvaz city, Iran. Modeling was implemented using the data set at the serum levels of vitamin D, tumor necrosis factor-α (TNF-α), transforming growth factor β (TGF-β), and TAC, before and after vitamin D3 supplement therapy...
2023: Exploration of targeted anti-tumor therapy
https://read.qxmd.com/read/37835527/vitamin-d3-inhibits-the-viability-of-breast-cancer-cells-in-vitro-and-ehrlich-ascites-carcinomas-in-mice-by-promoting-apoptosis-and-cell-cycle-arrest-and-by-impeding-tumor-angiogenesis
#7
JOURNAL ARTICLE
Prashanth Kumar M Veeresh, Chaithanya G Basavaraju, Siva Dallavalasa, Preethi G Anantharaju, Suma M Natraj, Olga A Sukocheva, SubbaRao V Madhunapantula
The incidence of aggressive and resistant breast cancers is growing at alarming rates, indicating a necessity to develop better treatment strategies. Recent epidemiological and preclinical studies detected low serum levels of vitamin D in cancer patients, suggesting that vitamin D may be effective in mitigating the cancer burden. However, the molecular mechanisms of vitamin D3 (cholecalciferol, vit-D3)-induced cancer cell death are not fully elucidated. The vit-D3 efficacy of cell death activation was assessed using breast carcinoma cell lines in vitro and a widely used Ehrlich ascites carcinoma (EAC) breast cancer model in vivo in Swiss albino mice...
October 2, 2023: Cancers
https://read.qxmd.com/read/37755276/vitamin-d-and-its-metabolites-status-before-and-during-chemotherapy-in-caucasian-breast-cancer-patients
#8
JOURNAL ARTICLE
Małgorzata Kimsa-Furdzik, Anna Bednarek, Grzegorz Hibner, Paulina Czajka-Francuz, Sylwia Cisoń-Jurek, Dobromiła Karawasiecka, Bożena Szymczak, Jerzy Wojnar, Jerzy Chudek, Tomasz Francuz
BACKGROUND: The predictive role of vitamin D (VD) in breast cancer (BC) patients' survival is still being investigated. This paper aims to evaluate the changes in VD metabolites during chemotherapy (CTH) and the predictive role of VD status in Caucasian BC patients treated with CTH. METHODS: Vitamin D and its metabolites were assessed with reference LC-MS/MS methodology in 98 consecutive BC patients starting CHT, after 3 and 6 months, and compared to the control group...
September 6, 2023: Metabolites
https://read.qxmd.com/read/37595382/enhancing-vitamin-d-3-iron-blends-via-twin-screw-dry-granulation-microstructural-properties-and-cellular-uptake-analysis-of-vitamin-d-3
#9
JOURNAL ARTICLE
Jasim Ahmed, Mohammed Arshad Reza, Linu Thomas, Syed S Bin Qasim, Abdullah Alazemi
The aim of this study was to develop vitamin D3 (VD3 ) and iron (Fe) blended granules using Neusilin® US2 as an excipient. A central composite design of experiments was used for the continuous manufacturing process, considering VD3 and iron as independent variables and the bulk density, flow index, oil holding capacity, and color difference as response variables. The addition of VD3 had a significant effect on the powder flow properties. The X-ray diffraction and Scanning electron microscopy-energy dispersive X-ray analysis validated the presence of VD3 and Fe in the granules, whereas the variations in porosity and roughness were demonstrated by tomography and atomic force microscopy, respectively...
August 12, 2023: Food Chemistry
https://read.qxmd.com/read/37445934/brk-ptk6-and-involucrin-expression-may-predict-breast-cancer-cell-responses-to-vitamin-d3
#10
JOURNAL ARTICLE
Carol Box, Caroline Pennington, Stephen Hare, Sarah Porter, Dylan Edwards, Suzanne Eccles, Mark Crompton, Amanda Harvey
The process of human embryonic mammary development gives rise to the structures in which mammary cells share a developmental lineage with skin epithelial cells such as keratinocytes. As some breast carcinomas have previously been shown to express high levels of involucrin, a marker of keratinocyte differentiation, we hypothesised that some breast tumours may de-differentiate to a keratinocyte-derived 'evolutionary history'. To confirm our hypothesis, we investigated the frequency of involucrin expression along with that of Brk, a tyrosine kinase expressed in up to 86% of breast carcinomas whose normal expression patterns are restricted to differentiating epithelial cells, most notably those in the skin (keratinocytes) and the gastrointestinal tract...
June 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37244301/local-production-of-active-vitamin-d-3-metabolites-in-breast-cancer-cells-by-cyp24a1-and-cyp27b1
#11
JOURNAL ARTICLE
Cydney Dennis, Jonathan Dillon, David J Cohen, Matthew S Halquist, Adam C Pearcy, Zvi Schwartz, Barbara D Boyan
The role of vitamin D3 and its metabolites in cancer and especially as a treatment option has been widely disputed. Clinicians noting low serum 25-hydroxyvitamin D3 [25(OH)D3 ] levels in their patients, recommend vitamin D3 supplementation as a method of reducing the risk of cancer; however, data supporting this are inconsistent. These studies rely on systemic 25(OH)D3 as an indicator of hormone status, but 25(OH)D3 is further metabolized in the kidney and other tissues under regulation by several factors. This study examined if breast cancer cells also possess the ability to metabolize 25(OH)D3 , and if so, whether the resulting metabolites are secreted locally; if this ability reflects ERα66 status; and if they possess vitamin D receptors (VDR)...
May 25, 2023: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/37189612/evidence-that-increasing-serum-25-oh-d-concentrations-to-30-ng-ml-in-the-kingdom-of-saudi-arabia-and-the-united-arab-emirates-could-greatly-improve-health-outcomes
#12
REVIEW
William B Grant, Fatme Al Anouti, Barbara J Boucher, Hana M A Fakhoury, Meis Moukayed, Stefan Pilz, Nasser M Al-Daghri
Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer's disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, and Mendelian randomization studies...
March 23, 2023: Biomedicines
https://read.qxmd.com/read/37153919/quercetin-activates-vitamin-d-receptor-and-ameliorates-breast-cancer-induced-hepatic-inflammation-and-fibrosis
#13
JOURNAL ARTICLE
Nirmala G Sannappa Gowda, Varsha D Shiragannavar, Lakshana D Puttahanumantharayappa, Ashwini Tumkur Shivakumar, Siva Dallavalasa, Chaithanya G Basavaraju, Smitha S Bhat, Shashanka K Prasad, Ravishankar M Vamadevaiah, SubbaRao V Madhunapantula, Prasanna K Santhekadur
AIMS: To explore the hepatoprotective role of quercetin and its novel molecular mechanism of action on breast cancer associated hepatic inflammation and fibrosis via Vitamin D receptor (VDR). MAIN METHODS: We used Ehrlich Ascites Carcinoma (mouse mammary carcinoma) model for our in-vivo experiments and human breast cancer cell lines for in-vitro assays. We inoculated 1.5 × 106 Ehrlich ascites carcinoma cells into female Swiss albino mice. Quercetin (50 mg/kg) was administered intraperitoneally for 15 days...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37147988/serum-vitamin-d-status-and-vdr-foki-polymorphism-association-study-in-pakistani-females-with-breast-cancer
#14
JOURNAL ARTICLE
Mariam Faiz, Amna Younus, Abida Yasmin
BACKGROUND: Breast cancer is most common in Pakistani women at young age compared to West where it is most common after 60 years of age. Variations in genes controlling vitamin D activity would play a role in determining the risk of breast cancer in women at early age. PURPOSE: To determine the association of vitamin D receptors (VDR) gene polymorphisms (FokI) with breast cancer risk in Pakistani women. METHODS: FokI polymorphisms were studied through the polymerase chain reaction-restriction fragment length polymorphism technique on blood samples of 300 breast cancer and 300 healthy women...
April 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/37130176/human-papilloma-virus-profiles-in-breast-cancer-in-correlation-with-vitamin-d
#15
JOURNAL ARTICLE
Hasna Azmi, Imane Saif, Kawtar Nabil, Mohammed El Mzibri, Saber Boutayeb, Ramin Lak, Moulay Mustapha Ennaji Ennaji
The major roles of vitamin D in the genesis of breast cancer and as an immunomodulator against acute and chronic infections have been the subject of much research in recent years. A low vitamin D status could decrease the function of blocking the cell multiplication cycle of the cancer process and weaken the immune system. In this context, we were interested in the implication of vitamin D status in women with human papilloma virus (HPV)-induced breast cancer. Our study included 63 women, 53 with breast cancer and 10 healthy women, and we measured the plasma 25(OH)D3 level and looked for the presence of HPV by PCR in our population...
December 31, 2022: Cellular and Molecular Biology
https://read.qxmd.com/read/37030416/vitamin-k2-enhances-the-tumor-suppressive-effects-of-1-25-oh-2-d-3-in-triple-negative-breast-cancer-cells
#16
JOURNAL ARTICLE
Carmen J Narvaez, Min Ji Bak, Natalia Salman, JoEllen Welsh
K vitamins are well known as essential cofactors for hepatic γ-carboxylation of coagulation factors, but their potential role in chronic diseases including cancer is understudied. K2, the most abundant form of vitamin K in tissues, exerts anti-cancer effects via diverse mechanisms which are not completely understood. Our studies were prompted by previous work demonstrating that the K2 precursor menadione synergized with 1,25 dihydroxyvitamin D3 (1,25(OH)2 D3 ) to inhibit growth of MCF7 luminal breast cancer cells...
July 2023: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/36813159/significant-association-of-poly-a-and-fok1-polymorphic-alleles-of-the-vitamin-d-receptor-with-vitamin-d-serum-levels-and-incidence-of-squamous-cutaneous-neoplasia
#17
JOURNAL ARTICLE
Taylor A Bullock, Judith A Mack, Jeffrey Negrey, Urvashi Kaw, Bo Hu, Sanjay Anand, Tayyaba Hasan, Christine B Warren, Edward V Maytin
Vitamin D3, a prohormone, is converted to circulating calcidiol and then to calcitriol, the hormone that binds to the Vitamin D receptor (VDR, a nuclear transcription factor). Polymorphic genetic variants of the VDR are associated with increased risk of breast cancer and melanoma. However, the relationship between VDR allelic variants and risk of squamous cell carcinoma (SCC) and actinic keratoses (AK) remains unclear. We examined associations between two VDR polymorphic sites, Fok1 and Poly-A, versus serum calcidiol levels, AK lesion incidence, and history of cutaneous SCC in 137 serially enrolled patients...
February 20, 2023: Journal of Investigative Dermatology
https://read.qxmd.com/read/36567009/1-25-oh-2-d-3-induced-vitamin-d-receptor-signaling-negatively-regulates-endoplasmic-reticulum-associated-degradation-erad-and-androgen-receptor-signaling-in-human-prostate-cancer-cells
#18
JOURNAL ARTICLE
Yalcin Erzurumlu, Esra Aydogdu, Hatice Kubra Dogan, Deniz Catakli, Muhammed Tilahun Muhammed, Buket Buyuksandic
Steroid hormone signaling is critical in the tumor progression and the regulation of physiological mechanisms such as Endoplasmic reticulum-associated degradation (ERAD) and unfolded protein response (UPR) in prostate cancer. 1,25(OH)2 D3 is an active metabolite of vitamin D classified as a steroid hormone. It exhibits anti-tumor effects including angiogenesis and suppression of cell cycle progression. Moreover, progressively reducing expression levels of vitamin D receptor (VDR) are observed in many cancer types, including the prostate...
December 22, 2022: Cellular Signalling
https://read.qxmd.com/read/36308290/phytochemical-profiling-of-clerodendrum-paniculatum-leaf-extracts-gc-ms-lc-ms-analysis-and-comparative-evaluation-of-antimicrobial-antioxidant-cytotoxic-effects
#19
JOURNAL ARTICLE
Namratha P Hegde, Basavaraj S Hungund
The present study evaluates the phytochemical content and biological activities of eight Clerodendrum paniculatum leaf extracts obtained using four solvents of varying polarity and two extraction methods. GC-HRMS analysis of the hexane extract predicted presence of phytol, 22-tritetracontanone, and 6,9,12-octadecatrienoic acid, phenyl methyl ester, (ZZZ)-as major compounds, and ethyl acetate extract was predicted to contain phytol. LC-HRMS analysis of methanolic extract exhibited the presence of 8',10'-dihydroxydihydroergotamine, Khayanthone, Galactonic acid, Calotropin, and 26,26,26,27,27,27-hexafluoro-1alpha,24-dihydroxy vitamin D3 as significant fractions...
October 29, 2022: Natural Product Research
https://read.qxmd.com/read/36230508/modulation-of-fibroblast-activity-via-vitamin-d-3-is-dependent-on-tumor-type-studies-on-mouse-mammary-gland-cancer
#20
JOURNAL ARTICLE
Natalia Łabędź, Martyna Stachowicz-Suhs, Mateusz Psurski, Artur Anisiewicz, Joanna Banach, Aleksandra Piotrowska, Piotr Dzięgiel, Adam Maciejczyk, Rafał Matkowski, Joanna Wietrzyk
Vitamin D3 and its analogs are known to modulate the activity of fibroblasts under various disease conditions. However, their impact on cancer-associated fibroblasts (CAFs) is yet to be fully investigated. The aim of this study was to characterize CAFs and normal fibroblasts (NFs) from the lung of mice bearing 4T1, 67NR, and E0771 cancers and healthy mice fed vitamin-D3 -normal (1000 IU), -deficient (100 IU), and -supplemented (5000 IU) diets. The groups receiving control (1000 IU) and deficient diets (100 IU) were gavaged with calcitriol (+cal)...
September 21, 2022: Cancers
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