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Jian Li, Qi Zhu, Yingying Su, Dongdong Wang, Zipeng Xing, Lei Fang
After depositing nano zinc oxide on the surface of red mud granule material by one-step hydrothermal method, a layer of cationic polyelectrolyte diallyldimethylammonium chloride is coated to obtain nano zinc oxide-cation polyelectrolyte diallyl dimethylammonium chloride (PDDA) modified red mud granule material. The modified granule material were characterized and tested. The results showed that the modified granule material has significant antibacterial activity against E. coli. And maintain a good antibacterial effect in multiple rounds of antibacterial cycle experiments...
February 5, 2019: Colloids and Surfaces. B, Biointerfaces
Tan Tang, Tujun Weng, Hongxing Jia, Sida Luo, Ye Xu, Liuhe Li, Peipei Zhang
The existence of challenging diseases such as cancers, HIV and Zika requires developing new vaccines that can generate tunable and robust immune responses against the diseases. Biomaterials-based techniques have been broadly explored for designing vaccines that can produce controllable and potent immunity. Among the existing biomaterials-based strategies, the layer-by-layer (LbL) assembly technique is remarkably attractive in vaccine design due to its unique features such as programmed and versatile cargo loading, cargo protection, co-delivery, juxtaposing of immune signals, etc...
February 14, 2019: Biomaterials Science
Galina Nifontova, Fernanda Ramos-Gomes, Maria Baryshnikova, Frauke Alves, Igor Nabiev, Alyona Sukhanova
Imaging agents and drug carriers are commonly targeted toward cancer cell through functionalization with specific recognition molecules. Quantum dots (QDs) are fluorescent semiconductor nanocrystals whose extraordinary brightness and photostability make them attractive for direct fluorescent labeling of biomolecules or optical encoding of the membranes and cells. Here, we analyse the cytotoxicity of QD-encoded microcapsules, validate an approach to the activation of the microcapsule's surface for further functionalization with monoclonal antibody Trastuzumab, a humanized monoclonal antibody targeting the extracellular domain of the human epidermal growth factor receptor 2 (HER2) and already in clinical use for the treatment of HER2 positive breast cancer...
2019: Frontiers in Chemistry
Amanda L Martin, Christa M Homenick, Yun Xiang, Elizabeth R Gillies, Naomi Matsuura
Fluorocarbon nanodroplets, ~100 to ~400 nm in diameter, are of immense interest in a variety of medical applications including the imaging and therapy of cancer and inflammatory diseases. However, fluorocarbon molecules are both hydrophobic and lipophobic, so it is challenging to synthesize fluorocarbon nanodroplets with the optimal stability and surface properties without the use of highly specialized surfactants. Here, we hypothesize that we can decouple the control of fluorocarbon nanodroplet size and stability from its surface properties...
February 13, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Sanghyun Bae, Hyunwoo Kim, Dasom Jeon, Jungki Ryu
We studied the kinetics of photoelectrochemical (PEC) water oxidation using a model photoanode BiVO4 modified with various water oxidation catalysts (WOCs) by electrochemical impedance spectroscopy (EIS). In particular, we prepared BiVO4 photoanodes with catalytic multilayers (CMs), where cationic polyelectrolytes and anionic polyoxometalate (POM) WOCs were assembled in a desired amount at a nanoscale precision, and compared their performance with those with well-known WOCs such as cobalt phosphate (CoPi) and NiOOH...
February 13, 2019: ACS Applied Materials & Interfaces
Wontae Joo, Christopher W Bielawski
A 4,5-dithienylimidazolium salt outfitted with pendant styrenyl groups was synthesized and studied. The salt was found to undergo reversible electrocyclization upon UV irradiation; subsequent exposure to visible light reversed the reaction. Acyclic diene metathesis (ADMET) polymerization of the salt afforded a novel fluorescent polyelectrolyte.
February 13, 2019: Organic & Biomolecular Chemistry
Jiang Lu, Weihua Zhuang, Linhua Li, Bo Zhang, Li Yang, Dongping Liu, Hongchi Yu, Rifang Luo, Yunbing Wang
Tunable/sustained drug loading/releasing are of significance in addressing low cytotoxicity, long-term performance and localized mild healing response in biomedical applications. With an ingenious design, a self-healing sandwiched layer-by-layer (LBL) coating was constructed by using chitosan/heparin as the adopted polyelectrolytes with embedding of micelles, in which chitosan backbone was grafted with catechol and the micelle was modified with exposed phenylboronic acid, endowing the coating with enhanced stability by abundant interactions among each coating component (e...
February 12, 2019: ACS Applied Materials & Interfaces
Mumuni Sumaila, Poornima Ramburrun, Pradeep Kumar, Yahya E Choonara, Viness Pillay
Anti-tuberculosis drug delivery has remained a challenge due to inconsistent bioavailability and inadequate sustained-release properties leading to treatment failure. To resolve these drawbacks, a lipopolysaccharide polyelectrolyte complex (PEC) encapsulated with rifampicin (RIF) (as the model drug) was fabricated, using the solvent injection technique (SIT), with soy lecithin (SLCT), and low-molecular-weight chitosan (LWCT). The average particle size and surface charge of RIF-loaded PEC particulates was 151...
February 11, 2019: AAPS PharmSciTech
Emeric Jeamet, Jean Septavaux, Alexandre Héloin, Marion Donnier-Maréchal, Melissa Dumartin, Benjamin Ourri, Pradeep Mandal, Ivan Huc, Emmanuelle Bignon, Elise Dumont, Christophe Morell, Jean-Patrick Francoia, Florent Perret, Laurent Vial, Julien Leclaire
By using a combination of readily accessible experimental and computational experiments in water, we explored the factors governing the association between polyanionic dyn[4]arene and a series of α,ω-alkyldiammonium ions of increasing chain length. We found that the lock-and-key concept based on the best match between the apolar and polar regions of the molecular partners failed to explain the observed selectivities. Instead, the dissection of the energetic and structural contributions demonstrated that the binding events were actually guided by two crucial solvent-related phenomena as the chain length of the guest increases: the expected decrease of the enthalpic cost of guest desolvation and the unexpected increase of the favourable enthalpy of complex solvation...
January 7, 2019: Chemical Science
Bing Yin, Chaohong Liu
Contact antimicrobial coatings have been a subject of increasing interest partly because of the contribution of biocide release coatings to antibiotic resistance. The surface hydrophobicity of these coatings can enhance their effectiveness and stability. In this work, polyethyleneimine (PEI) was quaternized with 1-bromoalkane and iodomethane, and a concept for antimicrobial coatings was developed on the basis of the polyelectrolyte multilayered films. The multilayered films were endowed with antibacterial property by grafting modified polycation (higher charge density) and with fouling-release property by constructing microstructures and nanostructures with low surface energy (long alkyl chains)...
June 1, 2019: Journal of Nanoscience and Nanotechnology
Mayu Tsukamoto, Kazuki Ebata, Hiroshi Sakiyama, Shunsuke Yamamoto, Masaya Mitsuishi, Tokuji Miyashita, Jun Matsui
In this paper, we report a biomimetic polyelectrolyte based on amphiphilic polymer nanosheet multilayer films. Copolymers of poly (N-dodecylacrylamide-co-vinyl phosphonic acid) [p(DDA/VPA)] form a uniform monolayer at the air-water interface. By depositing such monolayers onto solid substrates using the Langmuir - Blodgett (LB) method, multilayer lamellae films with a structure similar to a bilayer membrane were fabricated. The proton conductivity at the hydrophilic interlayer of the lamellar multilayer films was studied by impedance spectroscopy under temperature- and humidity-controlled conditions...
February 11, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Gustav Ferrand-Drake Del Castillo, Meike König, Martin Müller, Klaus-Jochen Eichhorn, Manfred Stamm, Petra Uhlmann, Andreas B Dahlin
Catalysis by enzymes on surfaces has many applications. However, strategies for efficient enzyme immobilization with preserved activity are still in need of further development. In this work we investigate polyelectrolyte brushes prepared by both grafting-to and grafting-from with the aim to achieve high catalytic activity. For comparison, self-assembled monolayers that bind enzymes with the same chemical interactions are included. We use the model enzyme glucose oxidase and two kinds of polymers: anionic poly(acrylic acid) and cationic poly(diethylamino)methyl methacrylate...
February 11, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Hao Li, Zhiqiang Feng, Kang Zhao, Zihao Wang, Jiahang Liu, Jie Liu, Hongzan Song
A novel type of chemically crosslinked liquid crystalline nanocomposite ionogel electrolyte based on poly(ionic liquid) (PIL) with superior ionic conductivity and high anisotropic conductivity was designed and synthesized using the in situ photopolymerization of sheared soft ionogels containing charged halloysite nanotubes (HNTs) and ionic liquid monomers. The oriented structure was investigated using scanning electron microscopy (SEM) and small-angle X-ray scattering (SAXS). The chemically crosslinked backbone of the PIL and the addition of HNTs endowed the flexible ionogels with a combined very high modulus (up to 26...
February 11, 2019: Nanoscale
Pedro J Rivero, Javier Goicoechea, Francisco J Arregui
The ability to tune the composition of nanostructured thin films is a hot topic for the design of functional coatings with advanced properties for sensing applications. The control of the structure at the nanoscale level enables an improvement of intrinsic properties (optical, chemical or physical) in comparison with the traditional bulk materials. In this sense, among all the known nanofabrication techniques, the layer-by-layer (LbL) nano-assembly method is a flexible, easily-scalable and versatile approach which makes possible precise control of the coating thickness, composition and structure...
February 7, 2019: Sensors
Natalia Farkas, Puthupparampil V Scaria, Martin C Woodle, John A Dagata
Improvements in dimensional metrology and innovations in physical-chemical characterization of functionalized nanoparticles are critically important for the realization of enhanced performance and benefits of nanomaterials. Toward this goal, we propose a multi-technique measurement approach, in which correlated atomic force microscopy, dynamic light scattering, high performance liquid chromatography and mass spectroscopy measurements are used to assess molecular and structural properties of self-assembled polyplex nanoparticles with a core-shell structure...
February 7, 2019: Scientific Reports
Svetlana V Kononova, Elena V Kruchinina, Valentina A Petrova, Yulia G Baklagina, Vera V Klechkovskaya, Anton S Orekhov, Elena N Vlasova, Elena N Popova, Galina N Gubanova, Yury A Skorik
Self-supporting multilayer films containing a polyelectrolyte complex (PEC) were prepared by the sequential layering of sodium hyaluronate (HA, MW 5.4 × 104 ) and chitosan (CS, MW 1.6 × 105 , the degree of deacetylation 0.80) in different orders. Imaging with low-voltage scanning electron microscopy (LVSEM) showed that the CS/HA films had a multilayer structure, while X-ray diffraction (XRD) indicated significant structuring of the CS layer near the PEC-CS region. Analysis of the thermal properties of the CS/HA films revealed differences in the structural organization and morphological features of the polymer layers and high thermal stability of the PEC layer...
April 1, 2019: Carbohydrate Polymers
Ethan Daley, Jochen Kuttig, Jan P Stegemann
Treatment of full-thickness osteochondral defects is challenging because of the need to integrate reparative materials with two separate tissue types. This study demonstrates a modular tissue engineering approach in which multiphase osteochondral tissues are built from hydrogel microbeads (50-150 µm in diameter) into which mesenchymal stromal cells (MSC) and specific matrix compositions were encapsulated. Chondrogenic microbeads consisted of an agarose base containing a polyelectrolyte complex of chondroitin sulfate and chitosan...
February 6, 2019: Tissue Engineering. Part C, Methods
Tao Zhu, Luyao Zheng, Xiang Yao, Lei Liu, Fei Huang, Yong Cao, Xiong Gong
Broadband photodetectors have important applications in both scientific and industrial sectors. In this study, we report room-temperature operated solution-processed photodetectors by PbSe quantum dots (QDs) with spectral response from 350 nm to 2500 nm. In order to boost both external quantum efficiency (EQE) and projected detectivity (D*), the hole-trap assisted photomultiplication effect through EDT-PbSe QDs/TABI PbSe QDs double-thin-layer thin film, where EDT-PbSe QDs is 1, 2-ethanedithiol (EDT) capped PbSe QDs and TABI-PbSe QDs is tetrabutylammonium (TABI) capped PbSe QDs, is applied...
February 5, 2019: ACS Applied Materials & Interfaces
Katia Rubini, Elisa Boanini, Adriana Bigi
Dicalcium phosphate dihydrate (DCPD) is one of the mineral phases indicated as possible precursors of biological apatites and it is widely employed in the preparation of calcium phosphate bone cements. Herein, we investigated the possibility to functionalize DCPD with aspartic acid (ASP) and poly-aspartic acid (PASP), as models of the acidic macromolecules of biomineralized tissues, and studied their influence on DCPD hydrolysis. To this aim, the synthesis of DCPD was performed in aqueous solution in the presence of increasing concentrations of PASP and ASP, whereas the hydrolysis reaction was carried out in physiological solution up to three days...
February 1, 2019: Journal of Functional Biomaterials
Marc Zimmermann, Dmitry Grigoriev, Nikolay Puretskiy, Alexander Böker
This publication demonstrates the abilities of a precise and straightforward microcontact printing approach for the preparation of patchy silica particles. In a broad particle size range, it is possible to finely tune the number and parameters of three-dimensional patches like diameter and thickness using only polyethyleneimine ink, poly(dimethoxysilane) as stamp material and a suitable release solvent.
November 27, 2018: RSC Advances
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