Kei Oyama, Kei Majima, Yuji Nagai, Yukiko Hori, Toshiyuki Hirabayashi, Mark A G Eldridge, Koki Mimura, Naohisa Miyakawa, Atsushi Fujimoto, Yuki Hori, Haruhiko Iwaoki, Ken-Ichi Inoue, Richard C Saunders, Masahiko Takada, Noriaki Yahata, Makoto Higuchi, Barry J Richmond, Takafumi Minamimoto
To be the most successful, primates must adapt to changing environments and optimize their behavior by making the most beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choice value through direct experience or knowledge-based inference. Here, we identify distinct neural circuitry underlying these two separate abilities. We designed two behavioral tasks in which macaque monkeys updated the values of certain items, either by directly experiencing changes in stimulus-reward associations, or by inferring the value of unexperienced items based on the task's rules...
November 17, 2023: bioRxiv