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Sita hospital

Reinier L Sluiter, Corine van Marrewijk, Dirk de Jong, Hans Scheffer, Henk-Jan Guchelaar, Luc Derijks, Dennis R Wong, Piet Hooymans, Sita H Vermeulen, André L M Verbeek, Barbara Franke, Gert Jan van der Wilt, Wietske Kievit, Marieke J H Coenen
Background and aims: Decreased thiopurine S-methyltransferase (TPMT) enzyme activity increases the risk of hematologic adverse drug reactions (ADR) in patients treated with thiopurines. Clinical studies have shown that in patients with inflammatory bowel disease (IBD), pharmacogenetic TPMT-guided thiopurine treatment reduces this risk of ADR. The aim of this study was to investigate, whether this intervention impacts on healthcare costs and/or quality of life. Methods: An a priori defined cost-effectiveness analysis was conducted in the Thiopurine response Optimization by Pharmacogenetic testing in Inflammatory bowel disease Clinics (TOPIC) trial, a randomized controlled trial performed in 30 Dutch hospitals...
January 30, 2019: Journal of Crohn's & Colitis
Priska Duana Putri, Agus Dwi Susanto, Achmad Hudoyo, Fariz Nurwidya, Feni Fitriani Taufik, Sita Andarini, Budhi Antariksa
Background: Over 43 million Indonesian children who are exposed to cigarette smoke are at risk of having health hazard and morbidities. Aims: The aim of this study is to identify the correlation between cigarette smoke exposure and respiratory complaints, hospitalization, as well as school absence due to respiratory complaints in elementary school-aged Indonesian children. Materials and Methods: A cross-sectional study was conducted in nonsmoking elementary school-aged children...
October 2018: International Journal of Applied and Basic Medical Research
Giuseppe Gatti, Gianluca Castaldi, Laura Morra, Gabriella Forti, Bernardo Benussi, Gianfranco Sinagra, Aniello Pappalardo
BACKGROUND: Bilateral internal thoracic artery (BITA) grafting is underused in women. METHODS: Outcomes of 798 consecutive women with multivessel coronary disease who underwent isolated coronary surgery (1999-2016) using BITA (n=530, 66.4%) or single internal thoracic artery (SITA) grafting (n=268, 33.6%) were reviewed retrospectively. Differences between BITA and SITA cohort were adjusted by propensity score matching. For both series, late survival was estimated with the Kaplan-Meier method...
September 1, 2018: International Journal of Cardiology
Rodrigo Abreu-Gonzalez, Marta Gonzalez-Hernandez, Cristina Pena-Betancor, Paloma Rodriguez-Esteve, Manuel Gonzalez De La Rosa
PURPOSE: To evaluate the specificity of new perimetric indices based on harmony, alone and in combination with structural data, for glaucoma detection. METHODS: In this prospective observational cross-sectional study, one eye of 105 healthy subjects and 97 early and suspect glaucomas were sequentially included and examined with Cirrus optical coherence tomography, twice with OCULUS Smartfield perimeter (SPARK strategy) and twice with Humphrey Analyzer (24-2 SITA-Fast) at the Ophthalmology Department from the University Hospital La Candelaria...
September 2018: European Journal of Ophthalmology
Carlos Nunez, Visalini Nair-Shalliker, Sam Egger, Freddy Sitas, Adrian Bauman
BACKGROUND: Obesity and physical activity (PA) are predictors of colon (CC) and rectal (RC) cancers. Prolonged sitting is also emerging as a potential predictor for these cancers. Little knowledge exists about the interactive effects of obesity, PA and prolonged sitting on cancer risk. This analysis assessed independent and interactive effects of PA, body mass index (BMI) and sitting time on CC and RC risks. METHODS: This analysis used data from a prospective study of 226,584 participants aged 45 years and over in New South Wales (NSW), Australia, who joined the 45 and Up study between 2006 and 2009...
March 6, 2018: BMC Public Health
Daniele Roberto Giacobbe, Matteo Bassetti, Francesco Giuseppe De Rosa, Valerio Del Bono, Paolo Antonio Grossi, Francesco Menichetti, Federico Pea, Gian Maria Rossolini, Mario Tumbarello, Pierluigi Viale, Claudio Viscoli
Ceftolozane/tazobactam (C/T) is a new antibiotic resulting from the combination of a novel cephalosporin, structurally similar to ceftazidime, with tazobactam, a well-known beta-lactamase inhibitor. C/T remains active against extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and multi-drug resistant (MDR) P. aeruginosa, and has been recently approved for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI). A trial on hospital-acquired pneumonia is ongoing...
April 2018: Expert Review of Anti-infective Therapy
Maddalena Giannella, Enrico Maria Trecarichi, Daniele Roberto Giacobbe, Francesco Giuseppe De Rosa, Matteo Bassetti, Alessandro Bartoloni, Michele Bartoletti, Angela Raffaella Losito, Valerio Del Bono, Silvia Corcione, Sara Tedeschi, Francesca Raffaelli, Carolina Saffioti, Teresa Spanu, Gian Maria Rossolini, Anna Marchese, Simone Ambretti, Roberto Cauda, Claudio Viscoli, Russell Edward Lewis, Pierluigi Viale, Mario Tumbarello
OBJECTIVES: To evaluate the impact of high-dose (HD) carbapenem-based combination therapy on clinical outcome in patients with monomicrobial carbapenem-resistant Klebsiella pneumoniae (CR-KP) bloodstream-infection (BSI). METHODS: Post hoc analysis of all adult patients with CR-KP BSI who were treated with a combination antibiotic regimen, collected over a six-year period in six large Italian teaching hospitals. To control for confounding effects of HD carbapenem combination on 14-day mortality, a multivariate Cox regression analysis was performed...
February 2018: International Journal of Antimicrobial Agents
Elizabeth F Wiseman, Kelly Chatten, Sita Shah, Richard R Keld, Yeng S Ang
INTRODUCTION: Provision of single-sex accommodation (SSA) in hospitals is a key National Health Service objective. Department of Health policy to eliminate mixed-sex accommodation (MSA) was implemented in our endoscopy department in 2011. We found no published studies of patients' views on MSA in endoscopy units. AIM: We explored patients' views on MSA and their experience of attending our unit at Royal Albert Edward Infirmary (Wigan, UK) since implementation of the SSA policy...
January 2017: Frontline Gastroenterology
Sajjad Raza, Eugene H Blackstone, Penny L Houghtaling, Marijan Koprivanac, Kirthi Ravichandren, Hoda Javadikasgari, Faisal G Bakaeen, Lars G Svensson, Joseph F Sabik
BACKGROUND: The purpose of this study was to determine in patients with diabetes mellitus whether single internal thoracic artery (SITA) plus radial artery (RA) grafting yields outcomes similar to those of bilateral internal thoracic artery (BITA) grafting. METHODS: From January 1994 to January 2011, 1,325 diabetic patients underwent primary isolated coronary artery bypass graft surgery with either (1) SITA plus RA with or without saphenous vein (SV) grafts (n = 965) or (2) BITA with or without SV grafts (n = 360); an internal thoracic artery was used in all patients to graft the left anterior descending coronary artery...
December 2017: Annals of Thoracic Surgery
Mamadou Kamagaté, Check Oumar Diallo, David Meless, Thérèse Daubrey-Potey, Augustine Kakou, Éric Balayssac, Kanga Sita N'zue, Jean Claude Yavo, Henri Die-Kakou
INTRODUCTION: Prior studies have shown an association between the onset of hepatonephritis and the use of arteminisin-based combination therapy (ACT) during the treatment of uncomplicated malaria. The objective of this study was to identify the risk factors of hepatonephritis occurrence because of the uncertainty regarding the appearance and the aggravation of this syndrome. METHODS: A case-non case study was carried out on 428 notifications of pharmacovigilance extracted from the database of the clinical pharmacology department of the teaching hospital of Cocody from 2008 to 2012...
October 2017: Thérapie
Daniele Roberto Giacobbe, Malgorzata Mikulska, Mario Tumbarello, Elisa Furfaro, Marzia Spadaro, Angela Raffaella Losito, Alessio Mesini, Gennaro De Pascale, Anna Marchese, Marco Bruzzone, Paolo Pelosi, Michele Mussap, Alexandre Molin, Massimo Antonelli, Brunella Posteraro, Maurizio Sanguinetti, Claudio Viscoli, Valerio Del Bono
BACKGROUND: This study aimed to assess the combined performance of serum (1,3)-β-D-glucan (BDG) and procalcitonin (PCT) for the differential diagnosis between candidaemia and bacteraemia in three intensive care units (ICUs) in two large teaching hospitals in Italy. METHODS: From June 2014 to December 2015, all adult patients admitted to the ICU who had a culture-proven candidaemia or bacteraemia, as well as BDG and PCT measured closely to the time of the index culture, were included in the study...
July 10, 2017: Critical Care: the Official Journal of the Critical Care Forum
Giuseppe Gatti, Andrea Perrotti, Antonio Fiore, Eric Bergoend, Sidney Chocron, Jean-Paul Couetil, Gianfranco Sinagra, Aniello Pappalardo
BACKGROUND: The use of bilateral internal thoracic artery (BITA) grafting has been proposed for dialysis patients with multivessel coronary artery disease, primarily because of hypothetical long-term survival benefits. AIMS: To investigate the outcome of BITA grafting in dialysis patients. METHODS: This was a retrospective analysis of the use of BITA grafting in 105 consecutive patients with end-stage renal failure on chronic dialysis in three European centres with extensive experience in BITA...
December 2017: Archives of Cardiovascular Diseases
Shailpreet K Sidhu, Sita Malhotra, Pushpa Devi, Arpandeep K Tuli
BACKGROUND AND OBJECTIVES: Coagulase negative Staphylococcus (CoNS) is frequently isolated from blood cultures but their significance is difficult to interpret. CoNS bacteria which are often previously dismissed as culture contaminants are attracting greater importance as true pathogens in the past decades. Clinical evaluation of these isolates suggests that although there is a relative increase of CoNS associated bloodstream infections in recent years, the microorganisms still remain the most common contaminants in blood cultures...
December 2016: Iranian Journal of Microbiology
H S Banger, Anisha Sethi, Sita Malhotra, Suresh Kumar Malhotra, Tejinder Kaur
BACKGROUND: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area. AIMS AND OBJECTIVES: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases...
January 2017: Indian journal of sexually transmitted diseases and AIDS
Brian Le, Peter Eastman, Sita Vij, Fiona McCormack, Cuong Duong, Jennifer Philip
BACKGROUND: Patients with advanced cancer often desire home-based care, placing general practitioners (GPs) at the centre of complex clinical situations. The objective of this article was to determine GPs' needs when providing home-based palliative care in collaboration with existing palliative care services. METHODS: A survey of GPs was conducted to determine knowledge, skills and confidence in providing community-based palliative care. RESULTS: Of the 56 respondents, 82% reported that they were involved in palliative management of at least one cancer patient in the previous year...
January 2017: Australian Family Physician
Francisco J Pasquel, Roma Gianchandani, Daniel J Rubin, Kathleen M Dungan, Isabel Anzola, Patricia C Gomez, Limin Peng, Israel Hodish, Tim Bodnar, David Wesorick, Vijay Balakrishnan, Kwame Osei, Guillermo E Umpierrez
BACKGROUND: The role of incretin-based drugs in the treatment of patients with type 2 diabetes admitted to hospital has not been extensively assessed. In this study, we compared the safety and efficacy of a dipeptidyl peptidase-4 inhibitor (sitagliptin) plus basal insulin with a basal-bolus insulin regimen for the management of patients with type 2 diabetes in general medicine and surgery in hospitals. METHODS: We did a multicentre, prospective, open-label, non-inferiority randomised clinical trial (Sita-Hospital) in five hospitals in the USA, enrolling patients aged 18-80 years with type 2 diabetes and a random blood glucose concentration of 7·8-22·2 mmol/L who were being treated with diet or oral antidiabetic drugs or had a total daily insulin dose of 0·6 units per kg or less, admitted to general medicine and surgery services...
February 2017: Lancet Diabetes & Endocrinology
D R Giacobbe, V Del Bono, P Bruzzi, S Corcione, M Giannella, A Marchese, L Magnasco, A E Maraolo, N Pagani, C Saffioti, S Ambretti, C S Cardellino, E Coppo, F G De Rosa, P Viale, C Viscoli
INTRODUCTION: the purpose of this retrospective multicenter study was to assess whether the risk of developing bloodstream infections (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP) in colonized patients is influenced by the occurrence of BSI due to other pathogens. METHODS: from January 2012 to March 2014, all patients with at least one rectal swab positive for CRKP and at least 30 days of previous hospital stay were included in the study. The primary outcome measure was CRKP BSI, defined as a time-to-event endpoint...
April 2017: European Journal of Clinical Microbiology & Infectious Diseases
Juan M Vrancic, Fernando Piccinini, Mariano Camporrotondo, Juan C Espinoza, Juan I Camou, Francisco Nacinovich, Pablo Fernandez Oses, Daniel Navia
BACKGROUND: There is controversy about the risk of mediastinitis associated with the use of both internal thoracic arteries (ITA). METHODS: We performed a case-control study of patients operated on at a single institution from January 2003 to December 2014. A total of 3,118 consecutive patients undergoing isolated coronary artery bypass graft surgery were included; 81.3% (n = 2,533) underwent bilateral ITA (BITA) grafts exclusively and constitute the BITA group, and 18...
March 2017: Annals of Thoracic Surgery
Ying Hong, Nobuyuki Shoji, Tetsuya Morita, Kazunori Hirasawa, Kazuhiro Matsumura, Masayuki Kasahara, Kimiya Shimizu
AIM: To compare the corneal biomechanical properties difference by ocular response analyzer (ORA) in normal tension glaucoma (NTG) patients with different visual field (VF) progression speed. METHODS: NTG patients with well-controlled Goldmann applanation tonometer (GAT) who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled. GAT and ORA parameters including corneal compensated intraocular pressure (IOPcc), Goldmann estimated intraocular pressure (IOPg), corneal hysteresis (CH), corneal resistance factor (CRF) were recorded...
2016: International Journal of Ophthalmology
Luigia Scudeller, Matteo Bassetti, Ercole Concia, Salvatore Corrao, Francesco Cristini, Francesco Giuseppe De Rosa, Valerio Del Bono, Emanuele Durante-Mangoni, Marco Falcone, Francesco Menichetti, Carlo Tascini, Mario Tumbarello, Mario Venditti, Pierluigi Viale, Claudio Viscoli, Antonino Mazzone
INTRODUCTION: A majority of invasive Candida infections occur in medical wards; however, evidence for management in this setting is scarce and based primarily on the intensive care or surgical setting. On behalf of the Italian Society for Anti-Infective Therapy (SITA) and the Italian Federation of Associations of Hospital Doctors on Internal Medicine (FADOI), the MEDICAL group produced practical management algorithms for patients in internal medicine wards. METHODS: The MEDICAL group panel, composed of 30 members from internal medicine, infectious disease, clinical pharmacology, clinical microbiology and clinical epidemiology, provided expert opinion through the RAND/UCLA method...
October 2016: European Journal of Internal Medicine
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