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Transfusion Adverse Reactions

Jacques Chiaroni
Transfusion reactions. As with any therapy, blood transfusion may be responsible for side effects that are referred to as «adverse recipient events». They can occur during or within hours of a transfusion or later in the days or weeks after . Their declaration to the haemovigilance device is mandatory. Whether immediate or delayed, there are three main mechanisms are defined: immunological, infectious and overload. The haemovigilance device in proportion to severity and accountability. Their prevention is based on the safety of the prepared products as well as on the compliance with the rules on prescription, selection and transfusion concerning in particular recipient identification...
November 2018: La Revue du Praticien
Linda Tanner, Markus M Müller
Nowadays, management of hemotherapy is regulated in Germany by the transfusion act and several guidelines while the transfusing physician is responsible for correct implementation at the bedside. Indications for blood products have to be carefully adapted to the patient's current clinical situation and pre-existing diseases have to be considered as well. Today, for most perioperative elective surgeries, evidence-based transfusion thresholds for packed red blood cell concentrates (RBC) have been defined and should be considered...
March 2019: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Pierre Moncharmont, Elodie Quittançon, Grégory Barday, Abdelhalim Benamara
BACKGROUND AND OBJECTIVES: Patients with aplastic anaemia or myelodysplastic syndromes frequently receive transfusions in an attempt to correct anaemia and/or thrombocytopenia, putting them at risk of adverse transfusion reactions. The aim of this study is to evaluate the incidence and the types of adverse transfusion reactions in these patients. MATERIALS AND METHODS: Adverse transfusion reaction reported in transfused patients with aplastic anaemia or myelodysplastic syndromes from all the hospitals in the Auvergne-Rhône-Alpes region of France were extracted from the national haemovigilance database system and analysed...
February 28, 2019: Vox Sanguinis
Anna Clebone
PURPOSE OF REVIEW: Although the overall safety of blood transfusion is high, adverse events do still occur. Much research on transfusion reactions was done in nonperioperative patients. Fortunately, important contributions to the perioperative literature have been made in the last several years, specifically in the areas of transfusion-associated circulatory overload and transfusion-related acute lung injury (TRALI). RECENT FINDINGS: An unfavorable reaction occurs in as many as 1% of transfusions overall, although the risk of death with each unit given is between 0...
April 2019: Current Opinion in Anaesthesiology
Ruchika Goel, Aaron A R Tobian, Beth H Shaz
Blood transfusions are lifesaving therapies; however, they can result in adverse events, which can be infectious or more commonly non-infectious. The most common non-infectious reactions include febrile non-hemolytic transfusion reactions, allergic transfusion reactions, transfusion associated circulatory overload, transfusion related acute lung injury, and acute and delayed hemolytic transfusion reactions. These reactions can be asymptomatic, mild or potentially fatal. There are several new methodologies to diagnose, treat and prevent these reactions...
February 26, 2019: Blood
Rebecca Zaremba, Aimee Brooks, Elizabeth Thomovsky
Red blood cell transfusions have become an integral component in the treatment of anemic patients and the number of transfusions continues to increase from year to year in both veterinary and human medicine. Although crucial, red blood cell transfusions are not benign and can lead to serious adverse reactions. Therefore, determining the most appropriate donor unit to use for transfusion can be challenging. As transfusion medicine evolves, greater numbers of blood surface antigens are being documented and pretransfusion testing protocols are becoming more complex...
March 2019: Topics in Companion Animal Medicine
Anna Turkova, Galina V Volynets, Siobhan Crichton, Tamara A Skvortsova, Victoria N Panfilova, Natalia V Rogozina, Anatoly I Khavkin, Elena L Tumanova, Giuseppe Indolfi, Claire Thorne
Russia has one of the highest prevalences of paediatric chronic hepatitis C infection (CHC). Our aim was to provide a detailed characterization of children and adolescents with CHC including treatment outcomes.Thus, an observational study of children with CHC aged <18 years was conducted in three hepatology centres from November 2014 to May 2017. Of 301 children(52% male), 196(65%) acquired HCV vertically, 70(23%) had a history of blood transfusion or invasive procedures, 1 injecting drug use and 34(11%) had no known risk factors...
February 25, 2019: Journal of Viral Hepatitis
William H Merchán, María E Chasoy, Camilo A Alfonso, Lina A Gómez, Ana L Muñoz
Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia and skin ulcers...
February 22, 2019: Journal of Tissue Engineering and Regenerative Medicine
Emma L O'Lone, Elisabeth M Hodson, Ionut Nistor, Davide Bolignano, Angela C Webster, Jonathan C Craig
BACKGROUND: The anaemia seen in chronic kidney disease (CKD) may be exacerbated by iron deficiency. Iron can be provided through different routes, with advantages and drawbacks of each route. It remains unclear whether the potential harms and additional costs of intravenous (IV) compared with oral iron are justified. This is an update of a review first published in 2012. OBJECTIVES: To determine the benefits and harms of IV iron supplementation compared with oral iron for anaemia in adults and children with CKD, including participants on dialysis, with kidney transplants and CKD not requiring dialysis...
February 21, 2019: Cochrane Database of Systematic Reviews
X Liu, L F Chen, J M Zhuang, J R Zhang, L Z Tang, Y Chen, W J Yu, X He, S Q Liu, C R Tan
Objective: To reduce the occurrence of adverse events of clinical blood use by analyzing the clinical adverse events of blood use except for the adverse reactions of blood transfusion. Methods: A retrospective analysis was performed on 294 cases of adverse events of clinical blood use other than adverse blood transfusion reactions in Shijitan hospital from January 2014 to December 2017, and a statistical analysis was made on the types of adverse events of clinical blood use, blood transfusion related departments, and internal and surgical blood use...
February 12, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Tara M Crawford, Chad C Andersen, Nicolette A Hodyl, Sarah A Robertson, Michael J Stark
Anaemia of prematurity will affect 90% of all very preterm infants, resulting in at least one red blood cell (RBC) transfusion. A significant proportion of preterm infants require multiple transfusions over the course of hospital admission. Growing evidence supports an association between transfusion exposure and adverse neonatal outcomes. In adults, transfusion-associated sepsis, transfusion-related acute lung injury and haemolytic reactions are the leading causes of transfusion-related morbidity and mortality; however, these are seldom recognised in newborns...
February 8, 2019: Journal of Paediatrics and Child Health
Jingxiang Zhao, Bocong Xu, Gan Chen, Yuhua Zhang, Quan Wang, Lian Zhao, Hong Zhou
BACKGROUND: Cryopreservation in dimethyl sulfoxide and storage at -80 °C extends the shelf life of platelets to at least 2 years, allowing greater availability in rural and military areas. While cryopreserved platelets (CPPs) have been extensively characterized for coagulation and thrombin generation, reports on the mechanism of adverse reactions to CPPs transfusion are scarce. Here, we tested the hypothesis that CPPs facilitate phagocytosis by Kupffer cells and subsequently promote the inflammatory response in Kupffer cells...
February 8, 2019: Transfusion
Gopal Kumar Patidar, Daljit Kaur
BACKGROUND: Auditing and education are the tools for improvement in the transfusion practices. Clinicians are not providing patient's demographic data and medical history to the blood bank that required transfusion. This missing information in blood request forms can lead to transfusion reactions to the patient. So we planned to analyse the blood request forms received at our blood bank and the impact of educational program for the clinicians. METHODS: A total of 6894 blood request forms were received from the month of July 2014 to December 2014 at a blood bank in Amritsar, India...
July 2018: Asian Journal of Transfusion Science
Ankit Mathur, Narasimha Swamy, Samrat Thapa, Santanu Chakraborthy, Latha Jagannathan
BACKGROUND: Platelet additive solutions (PAS) are crystalloid nutrient media used in place of plasma for platelet storage. They replace 60%-70% of plasma in platelet components, so the amount of storage plasma can be decreased. Platelets in PAS have lower risk for allergic transfusion reactions with equivalent clinical efficacy for controlling bleeding. AIM: The aim of this study is to evaluate the clinical and laboratory efficacy of PAS-platelets. MATERIALS AND METHODS: A total of 1674 single donor platelet (SDP) were collected in PAS in the month of June to September 2016 by different apheresis systems...
July 2018: Asian Journal of Transfusion Science
Sudipta Sekhar Das, Ritam Chakrabarty, R U Zaman
BACKGROUND AND AIM: Patients with warm autoimmune hemolytic anemia (AIHA) may carry immunoglobulin (Ig) M antibodies that react at room temperature and are nonpathological, but few may have cold agglutinins that react at or above 30°C and are referred to as "mixed" AIHA (MAIHA). Here, we present our experience on characterizing MAIHA both clinically and serologically. MATERIALS AND METHODS: Out of 134 AIHA patients, 13 diagnosed as MAIHA were subjected to detailed immunohematological characterization...
July 2018: Asian Journal of Transfusion Science
Kelly J Norsworthy, Lola Luo, Vicky Hsu, Ramadevi Gudi, Sarah E Dorff, Donna Przepiorka, Albert Deisseroth, Yuan Li Shen, Christopher M Sheth, Rosane Charlab, Gene M Williams, Kirsten B Goldberg, Ann T Farrell, Richard Pazdur
The Food and Drug Administration approved ivosidenib (Tibsovo; Agios, Cambridge, MA), a small molecule inhibitor of isocitrate dehydrogenase (IDH)1 on July 20, 2018, for treatment of adults with relapsed or refractory acute myeloid leukemia (R/R AML) with susceptible IDH1 mutation as detected by an FDA-approved test. The efficacy of ivosidenib was established based on complete remission (CR) + CR with partial hematologic recovery (CRh) rate, duration of CR+CRh, and conversion from transfusion-dependence (TD) to transfusion-independence (TI) in the single-arm Study AG120-C-001...
January 28, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Emi Ikebe, Sahoko Matsuoka, Asashi Tanaka, Yuji Yonemura, Yasuhiko Fujii, Akimichi Ohsaka, Hitoshi Okazaki, Junichi Kitazawa, Shinichi Ohtani, Takayuki Nakayama, Shun-Ya Momose, Izumi Miwa, Rikizo Taira, Kuro Toyota, Shuichi Kino, Hidefumi Kato, Isao Hamaguchi
Plasma removal by washing platelet concentrates (PCs) is effective in preventing adverse reactions to PC transfusions. The Japanese Red Cross Society (JRCS) started releasing washed PCs (WPCs) as a commercially approved blood product in September 2016. This retrospective multicenter study investigated the change in the number of transfused WPCs and the impact on the incidence of adverse reactions to PCs before and after the release. The numbers and types of transfused PCs and the adverse reactions to the PCs for a year before the start of the WPC release and for a year after the release were reported by 27 medical institutes in Japan...
January 6, 2019: Transfusion and Apheresis Science
Madeleine Lu, Dalia L Lezzar, Eszter Vörös, Sergey S Shevkoplyas
Millions of blood components including red blood cells, platelets, and granulocytes are transfused each year in the United States. The transfusion of these blood products may be associated with adverse clinical outcomes in some patients due to residual proteins and other contaminants that accumulate in blood units during processing and storage. Blood products are, therefore, often washed in normal saline or other media to remove the contaminants and improve the quality of blood cells before transfusion. While there are numerous methods for washing and volume reducing blood components, a vast majority utilize centrifugation-based processing, such as manual centrifugation, open and closed cell processing systems, and cell salvage/autotransfusion devices...
2019: Journal of Blood Medicine
Anna Clebone
PURPOSE OF REVIEW: Although the overall safety of blood transfusion is high, adverse events do still occur. Much research on transfusion reactions was done in nonperioperative patients. Fortunately, important contributions to the perioperative literature have been made in the last several years, specifically in the areas of transfusion-associated circulatory overload and transfusion-related acute lung injury (TRALI). RECENT FINDINGS: An unfavorable reaction occurs in as many as 1% of transfusions overall, although the risk of death with each unit given is between 0...
January 7, 2019: Current Opinion in Anaesthesiology
María Jesús Laso-Morales, Roser Vives, Andrea Vallejo-Tarrat, Novella Caló, Anna Valle-Beltran, Caridad Pontes
BACKGROUND: Patients with colorectal cancer (CRC) often present with associated anaemia which is usually present at the time of diagnosis and is aggravated during the postoperative period due to blood loss during the surgery process. Several guidelines advocate for the treatment of postoperative anaemia in these patients in order to prevent complications and allogeneic blood transfusions. However, there are no publications to shed light on the effectiveness of intravenous iron (IVI) administration after CRC surgery and the optimal dose and regimen...
January 7, 2019: Trials
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