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Yaping Liu, Jihui Zhang, Siu Ping Lam, Junying Zhou, Mandy Wai Man Yu, Shirley Xin Li, Joey Wing Yan Chan, Ronald B Postuma, Vincent Chung Tong Mok, Yun Kwok Wing
BACKGROUND: To determine the familial aggregation of idiopathic rapid eye movement sleep behavior disorder (iRBD), neurodegenerative diseases, and related biomarkers. METHODS: A total of 404 and 387 first-degree relatives of 102 patients with iRBD and 89 controls were recruited, respectively. Among them, 204 and 208 relatives of patients and controls underwent face-to-face clinical assessment, while 97 and 75 relatives underwent further video-polysomnographic assessment, respectively...
February 13, 2019: Annals of Neurology
Anna Therese Bjerkreim, Ingeborg Eskerud, Anne Berit Guttormsen, Karl Erik Müller
BAKGRUNN: I 2002 ble Forskerlinjen opprettet for tidlig å rekruttere medisinstudenter til forskning. Vi ønsket å kartlegge hvor mange tidligere forskerlinjestudenter fra Universitetet i Bergen som fortsatte å forske og identifisere faktorer som var assosiert med videre forskning. MATERIALE OG METODE: Alle studenter innrullert i forskerlinjeprogrammet ved Universitetet i Bergen siden oppstart i 2002 som var uteksaminert fra medisinstudiet innen juni 2017 ble kontaktet per e-post med en elektronisk spørreundersøkelse...
February 12, 2019: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Zongzhen He, Junying Zhang, Xiguo Yuan, Jianing Xi, Zhaowen Liu, Yuanyuan Zhang
Breast cancer is a heterogeneous disease. Although gene expression profiling has led to the definition of several subtypes of breast cancer, the precise discovery of the subtypes remains a challenge. Clinical data is another promising source. In this study, clinical variables are utilized and integrated to gene expressions for the stratification of breast cancer. We adopt two phases: gene selection and clustering, where the integration is in the gene selection phase; only genes whose expressions are most relevant to each clinical variable and least redundant among themselves are selected for further clustering...
February 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiaoyu Mu, Junying Wang, Yonghui Li, Fujuan Xu, Wei Long, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Haitao Dai, Qiang Liu, Yuanming Sun, Changlong Liu, Xiao-Dong Zhang
Metal nanozyme has attracted wide interest for biomedicine, and a highly catalytic material in physiological environment is highly desired. However, catalytic selectivity of nanozyme is still highly challenged, limiting its wide application. Here, we show a trimetallic (triM) nanozyme with highly catalytic activity and environmental selectivity. Enzyme-mimicked investigations find that triM system possesses multienzyme mimetics activity for removing reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as 1O2, H2O2, •OH, and •NO...
February 12, 2019: ACS Nano
Changli Sun, Zhijie Yang, Chunyan Zhang, Zhiyong Liu, Jianqiao He, Qing Liu, Tianyu Zhang, Jianhua Ju, Junying Ma
Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin's structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey's method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3...
February 12, 2019: Organic Letters
Zhengjun Shi, Haiyan Yang, Junying Jiao, Fang Wang, Yanyuan Lu, Jia Deng
This study was to evaluate the effect of graft copolymer (CTS-g-SA) of chitosan (CTS) and salicylic acid (SA) on the storability of grapefruit fruits during postharvest storage. Results indicate that the graft copolymer treatment significantly depressed green mold caused by Penicillium digitatum. The graft copolymer application kept fruit firmness without impairing the fruit quality. Moreover, the graft copolymer treatment inhibited the activity and gene expression of cell wall-modifying enzymes such as polygalacturonase, cellulase, pectin methylesterase, α-l-arabinofuranosidase, β-galactosidase, and suppressed the modification of cell wall components including covalently bound polysaccharide (sodium carbonate soluble pectin, 24% KOH-soluble fraction), which were associated with fruit softening...
June 15, 2019: Food Chemistry
Zheming Wu, Yang Geng, Xiaojuan Lu, Yuying Shi, Guowei Wu, Mengmeng Zhang, Bing Shan, Heling Pan, Junying Yuan
Necroptosis and ferroptosis are two distinct necrotic cell death modalities with no known common molecular mechanisms. Necroptosis is activated by ligands of death receptors such as tumor necrosis factor-α (TNF-α) under caspase-deficient conditions, whereas ferroptosis is mediated by the accumulation of lipid peroxides upon the depletion/or inhibition of glutathione peroxidase 4 (GPX4). The molecular mechanism that mediates the execution of ferroptosis remains unclear. In this study, we identified 2-amino-5-chloro-N,3-dimethylbenzamide (CDDO), a compound known to inhibit heat shock protein 90 (HSP90), as an inhibitor of necroptosis that could also inhibit ferroptosis...
February 4, 2019: Proceedings of the National Academy of Sciences of the United States of America
Chao Zhang, Alan Chen-Yu Hsu, He Pan, Yinuo Gu, Xu Zuo, Bing Dong, Ziyan Wang, Jingtong Zheng, Junying Lu, Ruipeng Zheng, Fang Wang
Columbianadin (CBN) is one of the main bioactive constituents isolated from the root of Angelica pubescens. Although the anti-inflammatory activity of CBN has been reported, the underpinning mechanism of this remains unclear. In this study, we investigated the anti-inflammatory effect of CBN on lipopolysaccharide (LPS)-stimulated THP-1 cells and explored the possible underlying molecular mechanisms. The results showed that CBN suppressed LPS-mediated inflammatory response mainly through the inactivation of the NOD1 and NF- κ B p65 signaling pathways...
February 2, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Enrico Frigoli, Pieter Smits, Pascal Vranckx, Yokio Ozaki, Jan Tijssen, Peter Jüni, Marie-Claude Morice, Yoshinobu Onuma, Stephan Windecker, Andrè Frenk, Christian Spaulding, Bernard Chevalier, Emanuele Barbato, Pim Tonino, David Hildick-Smith, Marco Roffi, Ran Kornowski, Carl Schultz, Maciej Lesiak, Andrés Iñiguez, Antonio Colombo, Mirvat Alasnag, Ajit Mullasari, Stefan James, Goran Stankovic, Paul J L Ong, Alfredo E Rodriguez, Felix Mahfoud, Jozef Bartunek, Aris Moschovitis, Peep Laanmets, Sergio Leonardi, Dik Heg, Mikael Sunnåker, Marco Valgimigli
BACKGROUND: The optimal duration of antiplatelet therapy in high-bleeding risk (HBR) patients with coronary artery disease treated with newer-generation drug-eluting bioresorbable polymer-coated stents remains unclear. DESIGN: MASTER DAPT (clinicaltrial.govNCT03023020) is an investigator-initiated, open-label, multicenter, randomized controlled trial comparing an abbreviated versus a standard duration of antiplatelet therapy after bioresorbable polymer-coated Ultimaster (TANSEI) sirolimus-eluting stent implantation in approximately 4,300 HBR patients recruited from ≥100 interventional cardiology centers globally...
November 22, 2018: American Heart Journal
Xiujuan Wang, Tingzhu Li, Xuerong Su, Jiangyan Li, Wenhua Li, Junying Gan, Tianshu Wu, Lu Kong, Ting Zhang, Meng Tang, Yuying Xue
With the rapid expansion of human exposure to silver nanoparticles (AgNPs), the genotoxicity screening is critical to the biosafety evaluation of nanosilver. This study assessed DNA damage and chromosomal aberration in the human hepatoma cell line (HepG2) as well as the effects on the micronucleus of bone marrow in mice induced by 20 nm polyvinylpyrrolidone-coated nanosilver (PVP-AgNPs) and 20 nm bare nanosilver (AgNPs). Our results showed that the two types of AgNPs, in doses of 20-160 μg/mL, could cause genetic toxicological changes on HepG2 cells...
January 31, 2019: Journal of Applied Toxicology: JAT
Fengfeng Chen, Kui Shen, Junying Chen, Xianfeng Yang, Jie Cui, Yingwei Li
The development of a general synthesis approach for creating fine alloyed nanoparticles (NPs) in the pores of metal-organic frameworks (MOFs) shows great promise for advanced synergetic catalysis but has not been realized so far. Herein, for the first time we proposed a facile and general strategy to immobilize ultrafine alloyed NPs within the pores of an MOF by the galvanic replacement of transition-metal NPs (e.g., Cu, Co, and Ni) with noble-metal ions (e.g., Pd, Ru, and Pt) under high-intensity ultrasound irradiation...
January 23, 2019: ACS Central Science
Martina Rothenbühler, Marco Valgimigli, Ayodele Odutayo, Enrico Frigoli, Sergio Leonardi, Pascal Vranckx, Maurizio Turturo, Luciano Moretti, Francesco Amico, Lucia Uguccioni, Marco Contarini, Joan Antoni Gómez-Hospital, Vicente Mainar, Manuela Creaco, Anna Sonia Petronio, Alberto Cremonesi, Corrado Tamburino, Claudio Fresco, Roberto Bonmassari, José Francisco Díaz Fernández, Enrico Romagnoli, Jan Beyersmann, Dik Heg, Peter Jüni
Aims: In the Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX (MATRIX) trial, adults with acute coronary syndrome undergoing coronary intervention who were allocated to radial access had a lower risk of bleeding, acute kidney injury (AKI), and all-cause mortality, as compared with those allocated to femoral access. The mechanism of the mortality benefit of radial access remained unclear. Methods and results: We used multistate and competing risk models to determine the effects of radial and femoral access on bleeding, AKI and all-cause mortality in the MATRIX trial and to disentangle the relationship between these different types of events...
January 26, 2019: European Heart Journal
Zhifa Zhang, Zhaohui Peng, Junying Cao, Jiaqi Wang, Yongyu Hao, Kai Song, Yan Wang, Wei Hu, Xuesong Zhang
Background: Increasingly evidences suggest that long noncoding RNAs (lncRNAs) play important roles in various cancers. LncRNA PXN-AS1-L is recently revealed to act as on oncogene in liver cancer. However, the expression, functions, and mechanisms of action of PXN-AS-L in non-small cell lung cancer (NSCLC) remain unclear. Methods: The expression of PXN-AS1-L in primary NSCLC tissues, NSCLC bone metastasis tissues, and cell lines was measured by quantitative real-time PCR...
2019: Cancer Cell International
Masanori Sakamoto, Tokuhisa Kawawaki, Masato Kimura, Junie Jhon M Vequizo, Hironori Matsunaga, Chandana Sampath Kumara Ranasinghe, Akira Yamakata, Hiroyuki Matsuzaki, Akihiro Furube, Toshiharu Teranishi
Infrared-light-induced carrier transfer is a key technology for 'invisible' optical devices for information communication systems and energy devices. However, clear and colourless photo-induced carrier transfer has not yet been demonstrated in the field of photochemistry, to the best of our knowledge. Here, we resolve this problem by employing short-wavelength-infrared (1400-4000 nm) localized surface plasmon resonance-induced electron injection from indium tin oxide nanocrystals to transparent metal oxides...
January 24, 2019: Nature Communications
Xin Chen, Chen Lv, Xiongbai Zhu, Wenjun Lin, Lu Wang, Zhengxiang Huang, Shengwu Yang, Junying Sun
Chemoresistance implicates the therapeutic value of cisplatin and remains a primary obstacle to its clinical use. MicroRNAs (miRs) negatively modulate the expression of their target genes and are associated with the occurrence and progression of various types of tumor. The abnormal expression of miR-504 has been reported in certain types of human tumor and has been associated with tumor prognosis. However, the association between miR-504 and cisplatin in human osteosarcoma remains unclear. The present study therefore aimed to assess the in vitro effects and possible mechanism of miR-504 in cell proliferation, apoptosis and cisplatin resistance in MG63 osteosarcoma cells...
February 2019: Oncology Letters
Hesham Y A Darwish, Seyed Benyamin Dalirsefat, Xianggui Dong, Guoying Hua, Jianfei Chen, Yuanyuan Zhang, Jianxiong Li, Jiansheng Xu, Junying Li, Xuemei Deng, Changxin Wu
The eggshell blueness is an interesting object for chicken genetic studies and blue-shelled chicken industry, especially after the discovery of the causative mutation of chicken blue eggshell. In the present study, genome wide association study (GWAS) was conducted in Chinese Dongxiang blue-shelled chicken underlying four traits of blue eggshell pigments: quantity of biliverdin (QB), quantity of protoporphyrin (QP), quantity of total pigment (QT), and color density trait (CD). A total of 139 individuals were randomly collected for GWAS...
2019: PloS One
Yunchang Xie, Qinglian Li, Xiangjing Qin, Jianhua Ju, Junying Ma
Three atypical regulatory genes, hmtABD have been discovered within the himastatin biosynthetic gene cluster (BGC) in Streptomyces hygroscopicus ATCC 53653 and the roles of their products have been identified. HmtA and HmtD do not show any structurally distinct features characteristic of regulatory function yet were shown to play important repressive and stimulatory roles, respectively, related to himastatin biosynthesis. HmtB encodes a conserved acetylglutamate kinase; new member of this family serves as repressor of secondary metabolism...
June 2019: Metabolic Engineering Communications
Franz-Josef Neumann, Miguel Sousa-Uva, Anders Ahlsson, Fernando Alfonso, Adrian P Banning, Umberto Benedetto, Robert A Byrne, Jean-Philippe Collet, Volkmar Falk, Stuart J Head, Peter Jüni, Adnan Kastrati, Akos Koller, Steen D Kristensen, Josef Niebauer, Dimitrios J Richter, Petar M Seferović, Dirk Sibbing, Giulio G Stefanini, Stephan Windecker, Rashmi Yadav, Michael O Zembala
No abstract text is available yet for this article.
January 15, 2019: EuroIntervention
O A Bolarinwa, M H Juni, M Z Nor Afiah, M S Salmiah, T M Akande
Background: Health-related quality of life (HRQoL) is an important clinical outcome assessment in hypertension management, given the lifelong (chronicity) nature and the need for daily self-management for hypertensive patents. Of some of the studies that implemented home-based interventions on hypertension globally, the HRQoL is rarely used as a primary outcome measure. This study developed, implemented, and assessed the impact of home-based follow-up care (HBFC) on HRQoL of hypertensive patients attending outpatients' clinics in Ilorin, Nigeria...
January 2019: Nigerian Journal of Clinical Practice
Luca Lepidi, Zhaozhao Chen, Andrea Ravida, Tingting Lan, Hom-Lay Wang, Junying Li
Mounting casts accurately on an articulator is a prerequisite for the treatment planning/execution of complex dental cases that require occlusal rehabilitation. A full digital approach to transfer the position of maxillary dentition to a virtual articulator, by using intraoral scans and cone beam computed tomography (CBCT) files is presented. This technique offers reduced chairside time and the flexibility of choosing the orientation plane. It can be used in orthognathic surgeries, complex interdisciplinary treatments requiring a CBCT scan with a large field of view, or treatment that already have the head CT or CBCT scans from previous diagnosis/treatment...
January 20, 2019: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
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